Danio rerio

0 known processes

pgpep1

pyroglutamyl-peptidase I

(Aliases: FLJ20208,MGC109902,im:6904079,zgc:109902)

pgpep1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.074
aging GO:0007568 2 0.049
establishment of protein localization to organelle GO:0072594 4 0.044
maintenance of location GO:0051235 4 0.044
phagocytosis GO:0006909 3 0.044
endosomal transport GO:0016197 2 0.040
positive regulation of transport GO:0051050 2 0.038
nitrogen compound metabolic process GO:0006807 319 0.037
guanosine containing compound metabolic process GO:1901068 4 0.035
cellular response to external stimulus GO:0071496 2 0.034
multicellular organism growth GO:0035264 4 0.033
guanosine containing compound catabolic process GO:1901069 2 0.033
cellular response to nutrient levels GO:0031669 2 0.032
organelle fusion GO:0048284 3 0.032
golgi vesicle transport GO:0048193 3 0.032
protein localization to plasma membrane GO:0072659 1 0.031
cytokinesis GO:0000910 3 0.031
membrane fusion GO:0061025 2 0.031
gtp metabolic process GO:0046039 4 0.031
lipid storage GO:0019915 1 0.031
autophagy GO:0006914 4 0.031
meiotic nuclear division GO:0007126 4 0.030
cellular protein catabolic process GO:0044257 4 0.030
cellular response to extracellular stimulus GO:0031668 2 0.030
meiotic chromosome segregation GO:0045132 3 0.030
regulation of mrna splicing via spliceosome GO:0048024 3 0.030
gtp catabolic process GO:0006184 2 0.030
mitochondrion organization GO:0007005 4 0.030
regulation of protein transport GO:0051223 3 0.029
positive regulation of catabolic process GO:0009896 4 0.029
proteasomal protein catabolic process GO:0010498 2 0.029
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.028
amine metabolic process GO:0009308 2 0.028
ubiquitin dependent protein catabolic process GO:0006511 3 0.028
regulation of protein complex assembly GO:0043254 3 0.028
single organism membrane fusion GO:0044801 2 0.028
regulation of establishment of protein localization GO:0070201 4 0.027
nucleocytoplasmic transport GO:0006913 4 0.027
regulation of protein catabolic process GO:0042176 1 0.027
modification dependent protein catabolic process GO:0019941 3 0.027
cellular amine metabolic process GO:0044106 2 0.026
cellular response to starvation GO:0009267 1 0.026
cellular macromolecule metabolic process GO:0044260 391 0.026
positive regulation of cell cycle GO:0045787 3 0.026
modification dependent macromolecule catabolic process GO:0043632 3 0.026
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.026
response to drug GO:0042493 3 0.026
positive regulation of cellular component biogenesis GO:0044089 3 0.026
regulation of multicellular organism growth GO:0040014 4 0.026
positive regulation of cellular catabolic process GO:0031331 3 0.025
regulation of synaptic plasticity GO:0048167 1 0.025
regulation of cytokine production GO:0001817 3 0.025
meiotic cell cycle process GO:1903046 3 0.025
single organism nuclear import GO:1902593 3 0.024
central nervous system development GO:0007417 387 0.024
stem cell maintenance GO:0019827 4 0.024
protein import GO:0017038 3 0.024
transport GO:0006810 220 0.023
heterocycle metabolic process GO:0046483 290 0.023
regulation of binding GO:0051098 3 0.023
regulation of cell shape GO:0008360 1 0.023
positive regulation of secretion GO:0051047 1 0.023
establishment of localization GO:0051234 244 0.023
organonitrogen compound metabolic process GO:1901564 74 0.023
macroautophagy GO:0016236 1 0.023
nuclear import GO:0051170 3 0.022
regulation of reactive oxygen species metabolic process GO:2000377 2 0.022
regulation of protein targeting GO:1903533 2 0.022
cellular nitrogen compound biosynthetic process GO:0044271 218 0.022
response to stress GO:0006950 263 0.022
rna localization GO:0006403 4 0.021
spermatid development GO:0007286 2 0.021
spermatid differentiation GO:0048515 2 0.021
nucleobase containing compound metabolic process GO:0006139 274 0.021
regulation of cellular amine metabolic process GO:0033238 0 0.021
vasculature development GO:0001944 278 0.021
signal transduction GO:0007165 455 0.021
centrosome organization GO:0051297 1 0.021
protein import into nucleus GO:0006606 3 0.021
regulation of mrna processing GO:0050684 3 0.021
regulation of cytoplasmic transport GO:1903649 4 0.021
biosynthetic process GO:0009058 294 0.021
nuclear transport GO:0051169 4 0.021
brain development GO:0007420 293 0.021
single organism localization GO:1902578 225 0.021
organic cyclic compound metabolic process GO:1901360 301 0.021
cellular nitrogen compound metabolic process GO:0034641 290 0.020
cellular biosynthetic process GO:0044249 286 0.020
negative regulation of protein phosphorylation GO:0001933 4 0.020
cellular component morphogenesis GO:0032989 336 0.020
protein acetylation GO:0006473 2 0.020
cell cycle g1 s phase transition GO:0044843 1 0.020
positive regulation of secretion by cell GO:1903532 1 0.020
negative regulation of biological process GO:0048519 304 0.020
rna metabolic process GO:0016070 219 0.020
cellular component movement GO:0006928 335 0.020
response to chemical GO:0042221 320 0.020
regulation of intracellular protein transport GO:0033157 3 0.020
regulation of protein localization to nucleus GO:1900180 2 0.020
immune system process GO:0002376 241 0.020
regulation of synapse assembly GO:0051963 3 0.020
tube morphogenesis GO:0035239 349 0.020
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.019
translational initiation GO:0006413 3 0.019
regulation of cellular amino acid metabolic process GO:0006521 0 0.019
regulation of metal ion transport GO:0010959 4 0.019
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.019
positive regulation of protein complex assembly GO:0031334 2 0.019
regulation of protein import into nucleus GO:0042306 2 0.019
protein targeting to nucleus GO:0044744 3 0.019
production of molecular mediator of immune response GO:0002440 2 0.019
g1 s transition of mitotic cell cycle GO:0000082 1 0.019
single organism transport GO:0044765 206 0.019
cellular component disassembly GO:0022411 1 0.019
regulation of nucleotide catabolic process GO:0030811 2 0.019
response to uv GO:0009411 3 0.019
regulation of meiotic cell cycle GO:0051445 1 0.018
cell projection organization GO:0030030 284 0.018
cellular amino acid metabolic process GO:0006520 7 0.018
regulation of biological quality GO:0065008 263 0.018
morphogenesis of an epithelium GO:0002009 333 0.018
cell part morphogenesis GO:0032990 246 0.018
regulation of neural precursor cell proliferation GO:2000177 3 0.018
peptidyl lysine acetylation GO:0018394 2 0.018
locomotion GO:0040011 313 0.018
single organism organelle organization GO:1902589 199 0.018
regulation of cell activation GO:0050865 1 0.018
protein secretion GO:0009306 1 0.018
regulation of macromolecule metabolic process GO:0060255 317 0.018
single organism metabolic process GO:0044710 217 0.018
membrane invagination GO:0010324 1 0.018
sensory organ development GO:0007423 393 0.018
protein polymerization GO:0051258 4 0.018
synaptic vesicle localization GO:0097479 1 0.018
stem cell proliferation GO:0072089 4 0.018
cell migration GO:0016477 237 0.018
organelle organization GO:0006996 227 0.018
head development GO:0060322 303 0.017
regulation of synapse organization GO:0050807 3 0.017
cytoskeleton dependent cytokinesis GO:0061640 3 0.017
internal protein amino acid acetylation GO:0006475 2 0.017
actin polymerization or depolymerization GO:0008154 2 0.017
alternative mrna splicing via spliceosome GO:0000380 1 0.017
rna biosynthetic process GO:0032774 181 0.017
protein acylation GO:0043543 3 0.017
gene expression GO:0010467 252 0.017
cellular carbohydrate metabolic process GO:0044262 4 0.017
negative regulation of protein complex assembly GO:0031333 1 0.017
regulation of multicellular organismal process GO:0051239 277 0.017
regulation of nucleoside metabolic process GO:0009118 2 0.017
generation of neurons GO:0048699 385 0.017
regulation of purine nucleotide catabolic process GO:0033121 2 0.017
protein complex disassembly GO:0043241 1 0.017
exocytosis GO:0006887 1 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.016
internal peptidyl lysine acetylation GO:0018393 2 0.016
response to external stimulus GO:0009605 264 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.016
regulation of primary metabolic process GO:0080090 311 0.016
neuron differentiation GO:0030182 353 0.016
cognition GO:0050890 1 0.016
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.016
nucleic acid metabolic process GO:0090304 244 0.016
macromolecular complex disassembly GO:0032984 1 0.016
embryonic organ development GO:0048568 381 0.016
regulation of cellular biosynthetic process GO:0031326 245 0.016
regulation of production of molecular mediator of immune response GO:0002700 1 0.016
nucleic acid templated transcription GO:0097659 181 0.016
i kappab kinase nf kappab signaling GO:0007249 4 0.016
cellular aromatic compound metabolic process GO:0006725 295 0.016
vacuolar transport GO:0007034 2 0.016
actin filament polymerization GO:0030041 2 0.016
regulation of response to biotic stimulus GO:0002831 2 0.016
oxoacid metabolic process GO:0043436 31 0.016
regulation of cellular ketone metabolic process GO:0010565 7 0.016
regulation of developmental process GO:0050793 247 0.016
positive regulation of cytoskeleton organization GO:0051495 3 0.016
cytosolic calcium ion transport GO:0060401 3 0.015
organic acid metabolic process GO:0006082 31 0.015
synaptic growth at neuromuscular junction GO:0051124 2 0.015
cell morphogenesis GO:0000902 289 0.015
development of primary female sexual characteristics GO:0046545 4 0.015
macromolecule biosynthetic process GO:0009059 227 0.015
female sex differentiation GO:0046660 4 0.015
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.015
extrinsic apoptotic signaling pathway GO:0097191 3 0.015
regulation of metabolic process GO:0019222 359 0.015
protein localization to nucleus GO:0034504 3 0.015
protein metabolic process GO:0019538 183 0.015
nuclear export GO:0051168 1 0.015
positive regulation of cell activation GO:0050867 1 0.015
regulation of gtpase activity GO:0043087 2 0.015
regulation of nucleocytoplasmic transport GO:0046822 2 0.015
cellular component biogenesis GO:0044085 178 0.015
peptidyl serine modification GO:0018209 2 0.015
digestive tract morphogenesis GO:0048546 231 0.015
post golgi vesicle mediated transport GO:0006892 1 0.015
blood vessel development GO:0001568 246 0.015
cellular response to topologically incorrect protein GO:0035967 2 0.015
cell substrate adhesion GO:0031589 4 0.015
cell cycle g2 m phase transition GO:0044839 4 0.015
stem cell division GO:0017145 1 0.015
small molecule metabolic process GO:0044281 77 0.015
regulation of biosynthetic process GO:0009889 250 0.015
gastrulation GO:0007369 208 0.015
interspecies interaction between organisms GO:0044419 4 0.015
negative regulation of catabolic process GO:0009895 3 0.015
cellular ketone metabolic process GO:0042180 11 0.015
positive regulation of dna metabolic process GO:0051054 1 0.015
female meiotic division GO:0007143 2 0.014
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
cell motility GO:0048870 244 0.014
regulation of sequestering of calcium ion GO:0051282 4 0.014
locomotor rhythm GO:0045475 3 0.014
regulation of protein ubiquitination GO:0031396 3 0.014
synaptic vesicle transport GO:0048489 1 0.014
lateral inhibition GO:0046331 1 0.014
phagocytosis engulfment GO:0006911 1 0.014
protein dephosphorylation GO:0006470 3 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.014
peptidyl serine phosphorylation GO:0018105 1 0.014
antimicrobial humoral response GO:0019730 2 0.014
peptide transport GO:0015833 1 0.014
cellular response to biotic stimulus GO:0071216 3 0.014
regulation of gtp catabolic process GO:0033124 2 0.014
determination of bilateral symmetry GO:0009855 204 0.014
regulation of transcription dna templated GO:0006355 213 0.014
regulation of cellular protein catabolic process GO:1903362 1 0.014
transcription dna templated GO:0006351 181 0.014
sequestering of calcium ion GO:0051208 3 0.014
cell matrix adhesion GO:0007160 4 0.014
regulation of gene expression GO:0010468 265 0.014
localization of cell GO:0051674 244 0.014
microtubule organizing center organization GO:0031023 1 0.014
determination of left right symmetry GO:0007368 179 0.014
compound eye development GO:0048749 2 0.014
nucleobase containing compound biosynthetic process GO:0034654 205 0.014
gland development GO:0048732 143 0.014
immune system development GO:0002520 191 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.014
female gonad development GO:0008585 4 0.014
cellular amide metabolic process GO:0043603 4 0.014
regulation of organelle assembly GO:1902115 4 0.014
regulation of stem cell proliferation GO:0072091 2 0.014
ear development GO:0043583 127 0.014
embryonic organ morphogenesis GO:0048562 274 0.014
aromatic compound biosynthetic process GO:0019438 217 0.014
carboxylic acid metabolic process GO:0019752 22 0.014
liver development GO:0001889 96 0.014
cellular localization GO:0051641 97 0.013
positive regulation of immune effector process GO:0002699 3 0.013
negative regulation of kinase activity GO:0033673 4 0.013
positive regulation of nucleotide catabolic process GO:0030813 1 0.013
cellular response to radiation GO:0071478 4 0.013
positive regulation of nucleoside metabolic process GO:0045979 1 0.013
regulation of cell communication GO:0010646 232 0.013
positive regulation of translation GO:0045727 1 0.013
blood vessel morphogenesis GO:0048514 216 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.013
negative regulation of cellular process GO:0048523 283 0.013
response to unfolded protein GO:0006986 2 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.013
positive regulation of cell adhesion GO:0045785 1 0.013
positive regulation of gtp catabolic process GO:0033126 1 0.013
negative regulation of protein kinase activity GO:0006469 4 0.013
mitotic dna integrity checkpoint GO:0044774 4 0.013
protein polyubiquitination GO:0000209 4 0.013
leukocyte proliferation GO:0070661 1 0.013
double strand break repair GO:0006302 3 0.013
positive regulation of stress activated mapk cascade GO:0032874 3 0.013
nucleic acid transport GO:0050657 2 0.013
negative regulation of cellular catabolic process GO:0031330 3 0.013
regulation of cellular metabolic process GO:0031323 320 0.013
regulation of rna metabolic process GO:0051252 224 0.013
neuroblast proliferation GO:0007405 2 0.013
regulation of nitrogen compound metabolic process GO:0051171 251 0.013
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.013
chemosensory behavior GO:0007635 1 0.013
organic cyclic compound biosynthetic process GO:1901362 223 0.013
negative regulation of intracellular transport GO:0032387 3 0.013
regulation of jak stat cascade GO:0046425 3 0.013
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.013
heterocycle biosynthetic process GO:0018130 215 0.013
system process GO:0003008 185 0.013
digestive system development GO:0055123 289 0.013
regulation of reproductive process GO:2000241 4 0.013
hepaticobiliary system development GO:0061008 98 0.013
response to topologically incorrect protein GO:0035966 2 0.013
cell projection morphogenesis GO:0048858 244 0.013
regulation of macromolecule biosynthetic process GO:0010556 225 0.013
spindle assembly GO:0051225 2 0.012
regionalization GO:0003002 274 0.012
neuron development GO:0048666 262 0.012
tissue remodeling GO:0048771 4 0.012
establishment of synaptic vesicle localization GO:0097480 1 0.012
cell surface receptor signaling pathway GO:0007166 325 0.012
negative regulation of protein localization to nucleus GO:1900181 2 0.012
regulation of autophagy GO:0010506 3 0.012
heart development GO:0007507 313 0.012
response to carbohydrate GO:0009743 3 0.012
neurotransmitter secretion GO:0007269 2 0.012
digestive tract development GO:0048565 265 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.012
activation of mapk activity GO:0000187 3 0.012
establishment of localization in cell GO:0051649 77 0.012
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.012
b cell activation GO:0042113 2 0.012
sequestering of metal ion GO:0051238 3 0.012
negative regulation of cytoplasmic transport GO:1903650 2 0.012
organic substance biosynthetic process GO:1901576 289 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.012
regulation of anatomical structure morphogenesis GO:0022603 130 0.012
regulation of neurotransmitter secretion GO:0046928 1 0.012
positive regulation of cytokine production GO:0001819 2 0.012
specification of symmetry GO:0009799 204 0.012
small molecule catabolic process GO:0044282 3 0.012
inner ear development GO:0048839 126 0.012
cellular response to molecule of bacterial origin GO:0071219 3 0.012
regulation of multicellular organismal development GO:2000026 223 0.012
ribonucleoside monophosphate catabolic process GO:0009158 4 0.012
cellular response to chemical stimulus GO:0070887 157 0.012
dna templated transcription elongation GO:0006354 3 0.012
calcium ion transport into cytosol GO:0060402 3 0.012
cell substrate junction assembly GO:0007044 2 0.012
neurotransmitter transport GO:0006836 2 0.012
cell death GO:0008219 121 0.011
regulation of cell substrate adhesion GO:0010810 1 0.011
response to alkaloid GO:0043279 2 0.011
atp catabolic process GO:0006200 4 0.011
cellular macromolecule biosynthetic process GO:0034645 224 0.011
primary neural tube formation GO:0014020 1 0.011
positive regulation of gtpase activity GO:0043547 1 0.011
regulation of transporter activity GO:0032409 2 0.011
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.011
regulation of protein complex disassembly GO:0043244 1 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.011
positive regulation of map kinase activity GO:0043406 3 0.011
nucleobase containing compound transport GO:0015931 2 0.011
germ line stem cell maintenance GO:0030718 2 0.011
negative regulation of cytokine production GO:0001818 1 0.011
regulation of erk1 and erk2 cascade GO:0070372 4 0.011
regulation of cell projection assembly GO:0060491 4 0.011
pigment granule localization GO:0051875 25 0.011
er to golgi vesicle mediated transport GO:0006888 1 0.011
hematopoietic or lymphoid organ development GO:0048534 191 0.011
positive regulation of biological process GO:0048518 253 0.011
release of sequestered calcium ion into cytosol GO:0051209 3 0.011
mononuclear cell proliferation GO:0032943 1 0.011
mitotic cell cycle embryonic GO:0045448 2 0.011
establishment of rna localization GO:0051236 3 0.011
regulation of exocytosis GO:0017157 1 0.011
cellular component assembly GO:0022607 170 0.011
g2 m transition of mitotic cell cycle GO:0000086 4 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.011
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.011
viral process GO:0016032 1 0.011
apoptotic process GO:0006915 116 0.011
regulation of signaling GO:0023051 235 0.011
lymphocyte proliferation GO:0046651 1 0.011
carbohydrate homeostasis GO:0033500 1 0.011
cellular protein metabolic process GO:0044267 129 0.011
angiogenesis GO:0001525 158 0.011
phosphate containing compound metabolic process GO:0006796 108 0.011
positive regulation of cellular process GO:0048522 201 0.011
regulation of hormone secretion GO:0046883 2 0.011
synaptic vesicle recycling GO:0036465 1 0.011
death GO:0016265 121 0.011
protein targeting to membrane GO:0006612 1 0.011
response to nutrient GO:0007584 3 0.011
regulation of nucleic acid templated transcription GO:1903506 213 0.011
sensory organ morphogenesis GO:0090596 200 0.011
single fertilization GO:0007338 3 0.010
negative regulation of immune response GO:0050777 2 0.010
meiosis i GO:0007127 1 0.010
g2 dna damage checkpoint GO:0031572 3 0.010
adult behavior GO:0030534 2 0.010
hormone secretion GO:0046879 2 0.010
centrosome cycle GO:0007098 1 0.010
negative regulation of multi organism process GO:0043901 3 0.010
mitotic cytokinesis GO:0000281 3 0.010
response to monosaccharide GO:0034284 3 0.010
rna export from nucleus GO:0006405 1 0.010
golgi organization GO:0007030 1 0.010
axon development GO:0061564 166 0.010
positive regulation of leukocyte differentiation GO:1902107 1 0.010
positive regulation of multi organism process GO:0043902 3 0.010
transmission of nerve impulse GO:0019226 19 0.010
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.010
eye development GO:0001654 277 0.010
lamellipodium organization GO:0097581 1 0.010
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.010
regulation of response to stimulus GO:0048583 269 0.010
homeostatic process GO:0042592 142 0.010
peptide metabolic process GO:0006518 1 0.010
positive regulation of jun kinase activity GO:0043507 2 0.010
cellular response to lipopolysaccharide GO:0071222 3 0.010
cellular response to unfolded protein GO:0034620 2 0.010

pgpep1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.037
nervous system disease DOID:863 0 0.025
musculoskeletal system disease DOID:17 0 0.018
cardiovascular system disease DOID:1287 0 0.017
disease of metabolism DOID:0014667 0 0.014
myopathy DOID:423 0 0.013
muscular disease DOID:0080000 0 0.013
muscle tissue disease DOID:66 0 0.013
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012
heart disease DOID:114 0 0.011
cardiomyopathy DOID:0050700 0 0.011
intrinsic cardiomyopathy DOID:0060036 0 0.011
inherited metabolic disorder DOID:655 0 0.011