Danio rerio

10 known processes

cx45.6

connexin 45.6

(Aliases: zgc:195347,zgc:195362)

cx45.6 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 2 0.528
embryonic organ development GO:0048568 381 0.528
embryonic organ morphogenesis GO:0048562 274 0.344
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.304
regulation of multicellular organismal process GO:0051239 277 0.290
multicellular organismal signaling GO:0035637 22 0.223
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.211
transmembrane transport GO:0055085 120 0.166
neuron neuron synaptic transmission GO:0007270 1 0.153
sensory organ morphogenesis GO:0090596 200 0.137
regulation of nitrogen compound metabolic process GO:0051171 251 0.134
cation transmembrane transport GO:0098655 65 0.122
cellular biosynthetic process GO:0044249 286 0.112
oxidative demethylation GO:0070989 1 0.109
immune system process GO:0002376 241 0.107
specification of symmetry GO:0009799 204 0.096
digestive tract development GO:0048565 265 0.096
regulation of response to oxidative stress GO:1902882 2 0.093
sensory organ development GO:0007423 393 0.092
cell death in response to oxidative stress GO:0036473 2 0.092
cellular respiration GO:0045333 3 0.089
regulation of cellular response to oxidative stress GO:1900407 2 0.086
neuron differentiation GO:0030182 353 0.080
organic anion transport GO:0015711 15 0.077
erythrocyte differentiation GO:0030218 54 0.075
determination of heart left right asymmetry GO:0061371 117 0.074
system process GO:0003008 185 0.073
regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 1 0.072
nitrogen compound metabolic process GO:0006807 319 0.072
erythrocyte homeostasis GO:0034101 55 0.072
cellular aromatic compound metabolic process GO:0006725 295 0.071
organic substance biosynthetic process GO:1901576 289 0.069
angiogenesis GO:0001525 158 0.068
response to arsenic containing substance GO:0046685 5 0.067
regulation of membrane repolarization GO:0060306 1 0.067
actin filament based movement GO:0030048 1 0.065
circulatory system process GO:0003013 87 0.065
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.064
nucleic acid metabolic process GO:0090304 244 0.064
regulation of biological quality GO:0065008 263 0.062
regulation of primary metabolic process GO:0080090 311 0.062
regulation of cellular biosynthetic process GO:0031326 245 0.061
cardiac conduction GO:0061337 3 0.058
regulation of oxidative stress induced cell death GO:1903201 2 0.058
nucleobase containing compound biosynthetic process GO:0034654 205 0.057
heterocycle metabolic process GO:0046483 290 0.055
regulation of membrane potential GO:0042391 23 0.053
determination of left right symmetry GO:0007368 179 0.053
synaptic transmission glycinergic GO:0060012 1 0.052
muscle hypertrophy GO:0014896 2 0.051
regulation of inhibitory postsynaptic membrane potential GO:0060080 1 0.048
regulation of stem cell proliferation GO:0072091 2 0.047
organic cyclic compound biosynthetic process GO:1901362 223 0.046
regulation of transcription dna templated GO:0006355 213 0.046
blood vessel development GO:0001568 246 0.045
regulation of muscle contraction GO:0006937 3 0.045
tube morphogenesis GO:0035239 349 0.044
sarcomerogenesis GO:0048769 4 0.043
multicellular organism growth GO:0035264 4 0.042
digestive system development GO:0055123 289 0.042
ion transmembrane transport GO:0034220 91 0.040
heart looping GO:0001947 94 0.040
determination of bilateral symmetry GO:0009855 204 0.040
membrane repolarization GO:0086009 2 0.039
action potential GO:0001508 19 0.039
single organism localization GO:1902578 225 0.038
negative regulation of dna metabolic process GO:0051053 4 0.038
monovalent inorganic cation transport GO:0015672 42 0.037
transcription from rna polymerase ii promoter GO:0006366 80 0.035
myeloid cell differentiation GO:0030099 86 0.034
centrosome organization GO:0051297 1 0.034
cardiac muscle tissue development GO:0048738 48 0.034
positive regulation of biological process GO:0048518 253 0.033
anion transport GO:0006820 38 0.033
organic cyclic compound metabolic process GO:1901360 301 0.032
inorganic cation transmembrane transport GO:0098662 50 0.032
myeloid cell homeostasis GO:0002262 56 0.031
inner ear development GO:0048839 126 0.031
cellular nitrogen compound metabolic process GO:0034641 290 0.029
heterocycle biosynthetic process GO:0018130 215 0.029
heart contraction GO:0060047 71 0.029
macromolecule biosynthetic process GO:0009059 227 0.028
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.028
posterior lateral line development GO:0048916 38 0.027
biosynthetic process GO:0009058 294 0.027
inorganic ion transmembrane transport GO:0098660 57 0.027
heart morphogenesis GO:0003007 156 0.027
sodium ion transmembrane transport GO:0035725 21 0.027
cellular macromolecule biosynthetic process GO:0034645 224 0.026
cellular nitrogen compound biosynthetic process GO:0044271 218 0.026
locomotion GO:0040011 313 0.026
hematopoietic or lymphoid organ development GO:0048534 191 0.026
eye development GO:0001654 277 0.026
vasculature development GO:0001944 278 0.025
heart development GO:0007507 313 0.025
neuron development GO:0048666 262 0.025
embryonic hemopoiesis GO:0035162 53 0.025
negative regulation of cellular process GO:0048523 283 0.025
blood vessel morphogenesis GO:0048514 216 0.024
small molecule catabolic process GO:0044282 3 0.024
regulation of mesenchymal cell proliferation GO:0010464 1 0.023
cell projection organization GO:0030030 284 0.023
striated muscle tissue development GO:0014706 110 0.023
glomerulus vasculature development GO:0072012 2 0.023
regulation of cell communication GO:0010646 232 0.023
amino acid transport GO:0006865 2 0.023
kidney vasculature development GO:0061440 2 0.022
morphogenesis of an epithelium GO:0002009 333 0.022
cellular macromolecule metabolic process GO:0044260 391 0.022
rna biosynthetic process GO:0032774 181 0.022
cell part morphogenesis GO:0032990 246 0.021
nucleobase containing compound metabolic process GO:0006139 274 0.021
cell cell signaling GO:0007267 52 0.021
generation of neurons GO:0048699 385 0.021
glial cell proliferation GO:0014009 4 0.020
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.020
cation transport GO:0006812 81 0.020
regulation of cellular metabolic process GO:0031323 320 0.020
artery development GO:0060840 22 0.020
eye morphogenesis GO:0048592 144 0.020
negative regulation of dna recombination GO:0045910 2 0.020
regulation of signaling GO:0023051 235 0.020
response to chemical GO:0042221 320 0.020
synaptic growth at neuromuscular junction GO:0051124 2 0.019
heart process GO:0003015 71 0.019
regulation of protein ubiquitination GO:0031396 3 0.019
single organism metabolic process GO:0044710 217 0.019
adult behavior GO:0030534 2 0.019
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 8 0.019
stem cell proliferation GO:0072089 4 0.018
ear development GO:0043583 127 0.018
inner ear morphogenesis GO:0042472 63 0.018
cardiac muscle cell development GO:0055013 20 0.018
homeostasis of number of cells GO:0048872 62 0.018
stem cell division GO:0017145 1 0.018
meiotic nuclear division GO:0007126 4 0.018
regulation of metal ion transport GO:0010959 4 0.018
regulation of blood vessel size GO:0050880 2 0.018
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.018
negative regulation of biological process GO:0048519 304 0.018
regulation of multicellular organism growth GO:0040014 4 0.018
cardiac atrium morphogenesis GO:0003209 2 0.018
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.017
monoamine transport GO:0015844 1 0.017
left right pattern formation GO:0060972 19 0.017
regulation of cell death GO:0010941 103 0.017
transcription dna templated GO:0006351 181 0.016
response to immobilization stress GO:0035902 1 0.016
regulation of binding GO:0051098 3 0.016
regulation of nucleoside metabolic process GO:0009118 2 0.016
negative regulation of oxidative stress induced cell death GO:1903202 2 0.016
negative regulation of response to stimulus GO:0048585 104 0.016
signal transduction GO:0007165 455 0.016
mitochondrion organization GO:0007005 4 0.015
regulation of blood pressure GO:0008217 1 0.015
ion transport GO:0006811 114 0.015
somatic muscle development GO:0007525 4 0.015
cellular component morphogenesis GO:0032989 336 0.015
regulation of macromolecule metabolic process GO:0060255 317 0.015
hemopoiesis GO:0030097 183 0.014
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.014
cellular response to oxygen levels GO:0071453 1 0.014
larval development GO:0002164 2 0.014
regulation of response to stimulus GO:0048583 269 0.014
regulation of cardiac muscle contraction GO:0055117 2 0.014
mitochondrial atp synthesis coupled electron transport GO:0042775 1 0.014
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 0 0.013
regulation of rna biosynthetic process GO:2001141 213 0.013
water homeostasis GO:0030104 4 0.013
ear morphogenesis GO:0042471 64 0.013
mitotic recombination GO:0006312 2 0.013
negative regulation of macromolecule metabolic process GO:0010605 76 0.013
fin development GO:0033333 77 0.013
muscle system process GO:0003012 20 0.013
cell projection assembly GO:0030031 64 0.013
endosomal transport GO:0016197 2 0.013
regulation of biosynthetic process GO:0009889 250 0.013
regulation of system process GO:0044057 40 0.013
response to hydrogen peroxide GO:0042542 3 0.013
embryonic heart tube morphogenesis GO:0003143 108 0.012
posterior lateral line neuromast primordium migration GO:0048920 12 0.012
lipid storage GO:0019915 1 0.012
nucleotide metabolic process GO:0009117 28 0.012
regulation of dendrite development GO:0050773 3 0.012
homeostatic process GO:0042592 142 0.012
positive regulation of catabolic process GO:0009896 4 0.012
regulation of apoptotic process GO:0042981 98 0.012
apoptotic process GO:0006915 116 0.012
gene expression GO:0010467 252 0.012
positive regulation of cellular catabolic process GO:0031331 3 0.012
cellular component movement GO:0006928 335 0.012
neurotransmitter transport GO:0006836 2 0.012
metal ion homeostasis GO:0055065 26 0.012
regulation of metabolic process GO:0019222 359 0.012
rna metabolic process GO:0016070 219 0.012
phosphate containing compound metabolic process GO:0006796 108 0.011
neurotransmitter secretion GO:0007269 2 0.011
cardiac myofibril assembly GO:0055003 9 0.011
response to stress GO:0006950 263 0.011
gastrulation GO:0007369 208 0.011
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
regulation of tube size GO:0035150 2 0.011
gland development GO:0048732 143 0.011
synaptic vesicle localization GO:0097479 1 0.011
myelination in peripheral nervous system GO:0022011 4 0.011
regulation of transmembrane transporter activity GO:0022898 2 0.011
actin mediated cell contraction GO:0070252 1 0.011
regulation of nucleotide catabolic process GO:0030811 2 0.011
negative regulation of protein kinase activity GO:0006469 4 0.011
organelle assembly GO:0070925 110 0.011
regulation of rna metabolic process GO:0051252 224 0.011
response to abiotic stimulus GO:0009628 122 0.011
neurological system process GO:0050877 62 0.010
positive regulation of transport GO:0051050 2 0.010
cardiac muscle cell contraction GO:0086003 1 0.010
regulation of jak stat cascade GO:0046425 3 0.010
cardiac cell development GO:0055006 21 0.010
positive regulation of jak stat cascade GO:0046427 2 0.010
synaptic transmission cholinergic GO:0007271 4 0.010
camera type eye development GO:0043010 222 0.010

cx45.6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.031
myopathy DOID:423 0 0.015
muscular disease DOID:0080000 0 0.015
heart disease DOID:114 0 0.015
cardiomyopathy DOID:0050700 0 0.015
intrinsic cardiomyopathy DOID:0060036 0 0.015
cardiovascular system disease DOID:1287 0 0.015
musculoskeletal system disease DOID:17 0 0.015
muscle tissue disease DOID:66 0 0.015