Danio rerio

0 known processes

zgc:103506

zgc:103506

(Aliases: spire2)

zgc:103506 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.063
aging GO:0007568 2 0.059
cellular macromolecule metabolic process GO:0044260 391 0.054
heterocycle metabolic process GO:0046483 290 0.046
stem cell maintenance GO:0019827 4 0.044
nitrogen compound metabolic process GO:0006807 319 0.043
organic cyclic compound metabolic process GO:1901360 301 0.042
cellular nitrogen compound metabolic process GO:0034641 290 0.042
multicellular organism growth GO:0035264 4 0.039
regulation of cellular amine metabolic process GO:0033238 0 0.038
amine metabolic process GO:0009308 2 0.038
cellular amine metabolic process GO:0044106 2 0.036
regulation of metabolic process GO:0019222 359 0.036
cognition GO:0050890 1 0.035
regulation of macromolecule metabolic process GO:0060255 317 0.035
positive regulation of cell cycle GO:0045787 3 0.035
rna metabolic process GO:0016070 219 0.034
regulation of primary metabolic process GO:0080090 311 0.034
signal transduction GO:0007165 455 0.033
gene expression GO:0010467 252 0.033
eye development GO:0001654 277 0.033
cellular biosynthetic process GO:0044249 286 0.033
cellular aromatic compound metabolic process GO:0006725 295 0.032
positive regulation of cellular catabolic process GO:0031331 3 0.032
cytokinesis GO:0000910 3 0.032
regulation of cellular ketone metabolic process GO:0010565 7 0.031
positive regulation of catabolic process GO:0009896 4 0.031
regulation of nitrogen compound metabolic process GO:0051171 251 0.031
generation of neurons GO:0048699 385 0.030
heterocycle biosynthetic process GO:0018130 215 0.030
regulation of cellular amino acid metabolic process GO:0006521 0 0.030
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.030
single organism metabolic process GO:0044710 217 0.030
maintenance of location GO:0051235 4 0.030
nucleic acid templated transcription GO:0097659 181 0.030
regulation of cellular metabolic process GO:0031323 320 0.029
regulation of multicellular organism growth GO:0040014 4 0.029
cellular nitrogen compound biosynthetic process GO:0044271 218 0.029
immune system process GO:0002376 241 0.029
nucleic acid metabolic process GO:0090304 244 0.029
nucleobase containing compound metabolic process GO:0006139 274 0.029
cellular protein catabolic process GO:0044257 4 0.028
cellular component movement GO:0006928 335 0.028
ubiquitin dependent protein catabolic process GO:0006511 3 0.028
biosynthetic process GO:0009058 294 0.028
positive regulation of transport GO:0051050 2 0.028
modification dependent protein catabolic process GO:0019941 3 0.027
meiotic nuclear division GO:0007126 4 0.027
phagocytosis GO:0006909 3 0.027
establishment of protein localization to organelle GO:0072594 4 0.026
modification dependent macromolecule catabolic process GO:0043632 3 0.026
regulation of establishment of protein localization GO:0070201 4 0.026
organic substance biosynthetic process GO:1901576 289 0.026
organonitrogen compound metabolic process GO:1901564 74 0.026
cellular ketone metabolic process GO:0042180 11 0.026
synaptic growth at neuromuscular junction GO:0051124 2 0.026
ribonucleoside monophosphate catabolic process GO:0009158 4 0.025
mitochondrion organization GO:0007005 4 0.025
cell surface receptor signaling pathway GO:0007166 325 0.025
negative regulation of protein phosphorylation GO:0001933 4 0.025
cellular amino acid metabolic process GO:0006520 7 0.025
guanosine containing compound metabolic process GO:1901068 4 0.024
guanosine containing compound catabolic process GO:1901069 2 0.024
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.024
oxoacid metabolic process GO:0043436 31 0.024
gtp catabolic process GO:0006184 2 0.024
cell migration GO:0016477 237 0.024
negative regulation of protein kinase activity GO:0006469 4 0.024
positive regulation of cellular amine metabolic process GO:0033240 0 0.024
gtp metabolic process GO:0046039 4 0.024
macromolecule biosynthetic process GO:0009059 227 0.024
nuclear transport GO:0051169 4 0.024
response to chemical GO:0042221 320 0.024
regulation of protein catabolic process GO:0042176 1 0.024
regulation of gene expression GO:0010468 265 0.023
transcription dna templated GO:0006351 181 0.023
aromatic compound biosynthetic process GO:0019438 217 0.023
proteasomal protein catabolic process GO:0010498 2 0.023
nucleobase containing compound biosynthetic process GO:0034654 205 0.023
regulation of reproductive process GO:2000241 4 0.023
regulation of biosynthetic process GO:0009889 250 0.023
protein heterooligomerization GO:0051291 1 0.023
organic acid metabolic process GO:0006082 31 0.023
immune system development GO:0002520 191 0.023
small molecule metabolic process GO:0044281 77 0.023
regulation of binding GO:0051098 3 0.023
regulation of meiotic cell cycle GO:0051445 1 0.022
organic cyclic compound biosynthetic process GO:1901362 223 0.022
positive regulation of cellular component biogenesis GO:0044089 3 0.022
protein acetylation GO:0006473 2 0.022
regulation of macromolecule biosynthetic process GO:0010556 225 0.022
neuron development GO:0048666 262 0.022
regulation of metal ion transport GO:0010959 4 0.022
carboxylic acid metabolic process GO:0019752 22 0.022
stem cell proliferation GO:0072089 4 0.022
negative regulation of cellular process GO:0048523 283 0.021
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.021
regulation of cytokine production GO:0001817 3 0.021
nucleocytoplasmic transport GO:0006913 4 0.021
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.021
regulation of cellular biosynthetic process GO:0031326 245 0.021
cellular component morphogenesis GO:0032989 336 0.021
protein localization to nucleus GO:0034504 3 0.021
rna biosynthetic process GO:0032774 181 0.021
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.021
tube morphogenesis GO:0035239 349 0.021
cell motility GO:0048870 244 0.021
organelle organization GO:0006996 227 0.021
Human
localization of cell GO:0051674 244 0.021
autophagy GO:0006914 4 0.021
regulation of protein complex assembly GO:0043254 3 0.021
neuron differentiation GO:0030182 353 0.021
regulation of cytoplasmic transport GO:1903649 4 0.021
cytoskeleton dependent cytokinesis GO:0061640 3 0.021
cellular macromolecule biosynthetic process GO:0034645 224 0.020
embryonic organ development GO:0048568 381 0.020
establishment of localization GO:0051234 244 0.020
Human
transport GO:0006810 220 0.020
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.020
peptidyl lysine acetylation GO:0018394 2 0.020
response to stress GO:0006950 263 0.020
cellular response to external stimulus GO:0071496 2 0.020
protein metabolic process GO:0019538 183 0.020
spermatid differentiation GO:0048515 2 0.020
exocytosis GO:0006887 1 0.020
lipid catabolic process GO:0016042 4 0.020
cellular response to extracellular stimulus GO:0031668 2 0.020
regulation of biological quality GO:0065008 263 0.020
response to external stimulus GO:0009605 264 0.020
internal protein amino acid acetylation GO:0006475 2 0.020
chemosensory behavior GO:0007635 1 0.020
sensory organ development GO:0007423 393 0.020
adult behavior GO:0030534 2 0.020
neurotransmitter secretion GO:0007269 2 0.020
negative regulation of kinase activity GO:0033673 4 0.020
single organism localization GO:1902578 225 0.019
Human
digestive system development GO:0055123 289 0.019
regulation of signaling GO:0023051 235 0.019
compound eye development GO:0048749 2 0.019
protein import GO:0017038 3 0.019
regulation of synapse organization GO:0050807 3 0.019
meiotic cell cycle process GO:1903046 3 0.019
Human
cell projection organization GO:0030030 284 0.019
lipid storage GO:0019915 1 0.019
regulation of cell activation GO:0050865 1 0.019
regulation of rna biosynthetic process GO:2001141 213 0.019
locomotion GO:0040011 313 0.019
cell part morphogenesis GO:0032990 246 0.019
internal peptidyl lysine acetylation GO:0018393 2 0.018
protein acylation GO:0043543 3 0.018
atp catabolic process GO:0006200 4 0.018
morphogenesis of an epithelium GO:0002009 333 0.018
camera type eye development GO:0043010 222 0.018
regulation of signal transduction GO:0009966 225 0.018
negative regulation of biological process GO:0048519 304 0.018
neurotransmitter transport GO:0006836 2 0.018
neuron neuron synaptic transmission GO:0007270 1 0.018
hemopoiesis GO:0030097 183 0.018
cellular amide metabolic process GO:0043603 4 0.018
nuclear import GO:0051170 3 0.018
protein localization to plasma membrane GO:0072659 1 0.018
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.018
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.018
cell projection morphogenesis GO:0048858 244 0.018
purine nucleoside monophosphate catabolic process GO:0009128 4 0.017
regulation of rna metabolic process GO:0051252 224 0.017
regulation of protein ubiquitination GO:0031396 3 0.017
regulation of mrna splicing via spliceosome GO:0048024 3 0.017
golgi vesicle transport GO:0048193 3 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
cellular component assembly GO:0022607 170 0.017
extrinsic apoptotic signaling pathway GO:0097191 3 0.017
transcription from rna polymerase ii promoter GO:0006366 80 0.017
regulation of protein transport GO:0051223 3 0.017
cell morphogenesis GO:0000902 289 0.017
response to carbohydrate GO:0009743 3 0.017
homeostatic process GO:0042592 142 0.017
response to drug GO:0042493 3 0.016
regulation of cell shape GO:0008360 1 0.016
single fertilization GO:0007338 3 0.016
response to monosaccharide GO:0034284 3 0.016
cellular response to lipopolysaccharide GO:0071222 3 0.016
regulation of nucleoside metabolic process GO:0009118 2 0.016
central nervous system development GO:0007417 387 0.016
positive regulation of biological process GO:0048518 253 0.016
erk1 and erk2 cascade GO:0070371 4 0.016
leukocyte proliferation GO:0070661 1 0.016
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.016
regulation of stem cell proliferation GO:0072091 2 0.016
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
hematopoietic or lymphoid organ development GO:0048534 191 0.016
regulation of nucleotide catabolic process GO:0030811 2 0.016
cellular carbohydrate metabolic process GO:0044262 4 0.016
regulation of transcription dna templated GO:0006355 213 0.016
regulation of synapse assembly GO:0051963 3 0.016
locomotor rhythm GO:0045475 3 0.016
regulation of mrna processing GO:0050684 3 0.016
female sex differentiation GO:0046660 4 0.016
cellular response to nutrient levels GO:0031669 2 0.016
response to hexose GO:0009746 3 0.016
single organism transport GO:0044765 206 0.016
regulation of neural precursor cell proliferation GO:2000177 3 0.016
regulation of erk1 and erk2 cascade GO:0070372 4 0.016
regulation of dna replication GO:0006275 3 0.015
regulation of nucleic acid templated transcription GO:1903506 213 0.015
antimicrobial humoral response GO:0019730 2 0.015
negative regulation of nuclear division GO:0051784 3 0.015
protein import into nucleus GO:0006606 3 0.015
mitotic cell cycle embryonic GO:0045448 2 0.015
rna localization GO:0006403 4 0.015
negative regulation of catabolic process GO:0009895 3 0.015
single organism nuclear import GO:1902593 3 0.015
cellular protein metabolic process GO:0044267 129 0.015
protein targeting to nucleus GO:0044744 3 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.015
vasculature development GO:0001944 278 0.015
adherens junction organization GO:0034332 4 0.015
fertilization GO:0009566 3 0.015
muscle structure development GO:0061061 196 0.015
centrosome cycle GO:0007098 1 0.015
positive regulation of protein complex assembly GO:0031334 2 0.015
regulation of synaptic plasticity GO:0048167 1 0.015
cytokinetic process GO:0032506 2 0.015
regulation of developmental process GO:0050793 247 0.015
regulation of response to stimulus GO:0048583 269 0.015
regulation of nucleocytoplasmic transport GO:0046822 2 0.015
small molecule catabolic process GO:0044282 3 0.015
regulation of cell communication GO:0010646 232 0.015
protein secretion GO:0009306 1 0.015
cellular response to biotic stimulus GO:0071216 3 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.015
chordate embryonic development GO:0043009 271 0.015
sequestering of metal ion GO:0051238 3 0.015
positive regulation of cell activation GO:0050867 1 0.015
regulation of multicellular organismal process GO:0051239 277 0.015
nucleoside monophosphate catabolic process GO:0009125 4 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.014
negative regulation of sequestering of calcium ion GO:0051283 4 0.014
endosomal transport GO:0016197 2 0.014
organelle fusion GO:0048284 3 0.014
synaptic vesicle localization GO:0097479 1 0.014
mitochondrial transport GO:0006839 2 0.014
spermatid development GO:0007286 2 0.014
cell cycle g1 s phase transition GO:0044843 1 0.014
carbohydrate homeostasis GO:0033500 1 0.014
single organism organelle organization GO:1902589 199 0.014
Human
digestive tract development GO:0048565 265 0.014
peptide transport GO:0015833 1 0.014
peptide metabolic process GO:0006518 1 0.014
b cell activation GO:0042113 2 0.014
lateral inhibition GO:0046331 1 0.014
germ line stem cell maintenance GO:0030718 2 0.014
retina development in camera type eye GO:0060041 146 0.014
regionalization GO:0003002 274 0.014
positive regulation of dna metabolic process GO:0051054 1 0.014
digestive tract morphogenesis GO:0048546 231 0.014
growth GO:0040007 174 0.014
cellular component biogenesis GO:0044085 178 0.014
regulation of intracellular protein transport GO:0033157 3 0.014
phagocytosis engulfment GO:0006911 1 0.014
cellular response to chemical stimulus GO:0070887 157 0.014
response to uv GO:0009411 3 0.014
sequestering of calcium ion GO:0051208 3 0.014
response to glucose GO:0009749 3 0.014
membrane fusion GO:0061025 2 0.014
regulation of multicellular organismal development GO:2000026 223 0.014
blood vessel development GO:0001568 246 0.014
system process GO:0003008 185 0.014
somatic muscle development GO:0007525 4 0.014
positive regulation of apoptotic signaling pathway GO:2001235 1 0.014
positive regulation of cytoskeleton organization GO:0051495 3 0.014
glucose homeostasis GO:0042593 1 0.014
cellular response to molecule of bacterial origin GO:0071219 3 0.014
negative regulation of protein transport GO:0051224 3 0.013
positive regulation of cellular process GO:0048522 201 0.013
membrane invagination GO:0010324 1 0.013
positive regulation of nucleotide catabolic process GO:0030813 1 0.013
homeostasis of number of cells GO:0048872 62 0.013
eye morphogenesis GO:0048592 144 0.013
mononuclear cell proliferation GO:0032943 1 0.013
regulation of sequestering of calcium ion GO:0051282 4 0.013
regulation of inflammatory response GO:0050727 2 0.013
regulation of jak stat cascade GO:0046425 3 0.013
lymphocyte proliferation GO:0046651 1 0.013
regulation of protein localization to nucleus GO:1900180 2 0.013
regulation of calcium ion transport GO:0051924 2 0.013
cellular response to light stimulus GO:0071482 4 0.013
regulation of ion transmembrane transporter activity GO:0032412 2 0.013
cell morphogenesis involved in differentiation GO:0000904 195 0.013
regulation of transporter activity GO:0032409 2 0.013
cell substrate adhesion GO:0031589 4 0.013
microtubule organizing center organization GO:0031023 1 0.013
cellular response to starvation GO:0009267 1 0.013
post embryonic organ development GO:0048569 4 0.013
tissue remodeling GO:0048771 4 0.013
regulation of gtpase activity GO:0043087 2 0.013
sensory organ morphogenesis GO:0090596 200 0.013
axonogenesis GO:0007409 152 0.013
meiotic chromosome segregation GO:0045132 3 0.013
positive regulation of gtp catabolic process GO:0033126 1 0.013
peptidyl serine modification GO:0018209 2 0.013
heart development GO:0007507 313 0.013
regulation of gtp catabolic process GO:0033124 2 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.013
cellular protein modification process GO:0006464 100 0.013
development of primary female sexual characteristics GO:0046545 4 0.013
protein stabilization GO:0050821 2 0.013
cytoplasm organization GO:0007028 4 0.013
cellular response to radiation GO:0071478 4 0.013
establishment of synaptic vesicle localization GO:0097480 1 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.012
negative regulation of mapk cascade GO:0043409 4 0.012
interspecies interaction between organisms GO:0044419 4 0.012
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.012
neuron projection development GO:0031175 180 0.012
amino acid transport GO:0006865 2 0.012
negative regulation of cytokine production GO:0001818 1 0.012
cellular response to organic substance GO:0071310 105 0.012
production of molecular mediator of immune response GO:0002440 2 0.012
oocyte anterior posterior axis specification GO:0007314 4 0.012
positive regulation of chromosome organization GO:2001252 1 0.012
embryo development ending in birth or egg hatching GO:0009792 271 0.012
regulation of protein targeting GO:1903533 2 0.012
regulation of cellular protein catabolic process GO:1903362 1 0.012
regulation of cell differentiation GO:0045595 142 0.012
synaptic vesicle transport GO:0048489 1 0.012
protein polymerization GO:0051258 4 0.012
positive regulation of secretion GO:0051047 1 0.012
developmental growth GO:0048589 166 0.012
establishment of protein localization to plasma membrane GO:0090002 1 0.012
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
positive regulation of gtpase activity GO:0043547 1 0.012
organic acid catabolic process GO:0016054 3 0.012
release of sequestered calcium ion into cytosol GO:0051209 3 0.012
camera type eye morphogenesis GO:0048593 108 0.012
intracellular mrna localization GO:0008298 1 0.012
regulation of neurotransmitter transport GO:0051588 1 0.012
positive regulation of immune effector process GO:0002699 3 0.012
macromolecule modification GO:0043412 111 0.012
muscle organ development GO:0007517 101 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.012
female gonad development GO:0008585 4 0.012
single organism membrane fusion GO:0044801 2 0.012
positive regulation of chromatin modification GO:1903310 1 0.012
mesenchyme development GO:0060485 127 0.012
neuroblast proliferation GO:0007405 2 0.012
cellular component disassembly GO:0022411 1 0.012
positive regulation of secretion by cell GO:1903532 1 0.012
regulation of epithelial cell proliferation GO:0050678 3 0.012
ion transmembrane transport GO:0034220 91 0.012
negative regulation of secretion GO:0051048 2 0.012
cellular respiration GO:0045333 3 0.011
lipid homeostasis GO:0055088 3 0.011
specification of symmetry GO:0009799 204 0.011
gastrulation GO:0007369 208 0.011
neuron projection morphogenesis GO:0048812 161 0.011
protein homooligomerization GO:0051260 3 0.011
peptidyl serine phosphorylation GO:0018105 1 0.011
neuromuscular synaptic transmission GO:0007274 2 0.011
response to nutrient GO:0007584 3 0.011
regulation of protein import into nucleus GO:0042306 2 0.011
regulation of dendrite development GO:0050773 3 0.011
positive regulation of nucleoside metabolic process GO:0045979 1 0.011
multi organism process GO:0051704 134 0.011
multi organism cellular process GO:0044764 2 0.011
centrosome organization GO:0051297 1 0.011
brain development GO:0007420 293 0.011
cation transport GO:0006812 81 0.011
head development GO:0060322 303 0.011
positive regulation of map kinase activity GO:0043406 3 0.011
actin filament polymerization GO:0030041 2 0.011
actin polymerization or depolymerization GO:0008154 2 0.011
positive regulation of macromolecule metabolic process GO:0010604 93 0.011
response to other organism GO:0051707 97 0.011
secondary metabolic process GO:0019748 3 0.011
protein modification process GO:0036211 100 0.011
protein dephosphorylation GO:0006470 3 0.011
er to golgi vesicle mediated transport GO:0006888 1 0.011
positive regulation of metabolic process GO:0009893 108 0.011
negative regulation of metabolic process GO:0009892 86 0.011
vacuolar transport GO:0007034 2 0.011
ion transport GO:0006811 114 0.011
nuclear export GO:0051168 1 0.011
ameboidal type cell migration GO:0001667 143 0.011
regulation of neurotransmitter secretion GO:0046928 1 0.011
regulation of neuronal synaptic plasticity GO:0048168 1 0.011
response to external biotic stimulus GO:0043207 97 0.011
regulation of autophagy GO:0010506 3 0.011
death GO:0016265 121 0.011
cytosolic calcium ion transport GO:0060401 3 0.011
mitotic cytokinesis GO:0000281 3 0.011
response to biotic stimulus GO:0009607 97 0.011
anterior posterior pattern specification GO:0009952 152 0.011
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.011
pancreas development GO:0031016 84 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
developmental programmed cell death GO:0010623 4 0.011
macromolecular complex disassembly GO:0032984 1 0.011
regulation of circadian rhythm GO:0042752 4 0.011
negative regulation of defense response GO:0031348 2 0.010
g1 s transition of mitotic cell cycle GO:0000082 1 0.010
positive regulation of leukocyte differentiation GO:1902107 1 0.010
regulation of dendrite morphogenesis GO:0048814 3 0.010
embryonic organ morphogenesis GO:0048562 274 0.010
protein complex disassembly GO:0043241 1 0.010
response to organic substance GO:0010033 153 0.010
regulation of nervous system development GO:0051960 90 0.010
regulation of transmembrane transporter activity GO:0022898 2 0.010
stem cell development GO:0048864 82 0.010
striated muscle cell development GO:0055002 108 0.010
determination of bilateral symmetry GO:0009855 204 0.010
negative regulation of secretion by cell GO:1903531 2 0.010
catecholamine metabolic process GO:0006584 2 0.010
phosphate containing compound metabolic process GO:0006796 108 0.010
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.010
cell cycle arrest GO:0007050 1 0.010
cortical cytoskeleton organization GO:0030865 1 0.010
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.010
negative regulation of multi organism process GO:0043901 3 0.010
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.010
positive regulation of histone modification GO:0031058 1 0.010

zgc:103506 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.045
nervous system disease DOID:863 0 0.020
musculoskeletal system disease DOID:17 0 0.018
disease of metabolism DOID:0014667 0 0.017
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.015
immune system disease DOID:2914 0 0.014
inherited metabolic disorder DOID:655 0 0.012
muscular disease DOID:0080000 0 0.011