Danio rerio

0 known processes

greb1

growth regulation by estrogen in breast cancer 1

(Aliases: zgc:158681)

greb1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of signal transduction GO:0009966 225 0.234
regulation of metabolic process GO:0019222 359 0.173
negative regulation of cellular process GO:0048523 283 0.167
cellular biosynthetic process GO:0044249 286 0.159
regulation of signaling GO:0023051 235 0.150
regulation of macromolecule metabolic process GO:0060255 317 0.129
signal transduction GO:0007165 455 0.115
endothelial cell fate commitment GO:0060839 3 0.107
regulation of nucleic acid templated transcription GO:1903506 213 0.102
negative regulation of biological process GO:0048519 304 0.093
neuron differentiation GO:0030182 353 0.092
cell surface receptor signaling pathway GO:0007166 325 0.091
regulation of cell communication GO:0010646 232 0.087
regionalization GO:0003002 274 0.082
regulation of primary metabolic process GO:0080090 311 0.078
biological adhesion GO:0022610 40 0.078
regulation of cellular metabolic process GO:0031323 320 0.073
neuron development GO:0048666 262 0.069
positive regulation of map kinase activity GO:0043406 3 0.068
heterocycle biosynthetic process GO:0018130 215 0.067
organic cyclic compound metabolic process GO:1901360 301 0.065
positive regulation of biological process GO:0048518 253 0.061
heart development GO:0007507 313 0.060
protein import into nucleus GO:0006606 3 0.059
production of molecular mediator of immune response GO:0002440 2 0.059
defense response to other organism GO:0098542 33 0.059
cellular component movement GO:0006928 335 0.058
regulation of response to stimulus GO:0048583 269 0.057
nuclear transport GO:0051169 4 0.057
interaction with host GO:0051701 4 0.054
neuron neuron synaptic transmission GO:0007270 1 0.053
heterocycle metabolic process GO:0046483 290 0.053
nucleobase containing compound biosynthetic process GO:0034654 205 0.052
mesenchyme development GO:0060485 127 0.052
single organism organelle organization GO:1902589 199 0.052
startle response GO:0001964 4 0.051
regulation of establishment of protein localization GO:0070201 4 0.051
angioblast cell migration involved in selective angioblast sprouting GO:0035475 4 0.051
regulation of stem cell differentiation GO:2000736 4 0.049
mesenchymal cell differentiation GO:0048762 87 0.049
protein import GO:0017038 3 0.048
positive regulation of stress activated mapk cascade GO:0032874 3 0.047
cell projection morphogenesis GO:0048858 244 0.047
nucleic acid templated transcription GO:0097659 181 0.047
nucleocytoplasmic transport GO:0006913 4 0.045
regulation of cell activation GO:0050865 1 0.045
cellular aromatic compound metabolic process GO:0006725 295 0.044
notch signaling pathway GO:0007219 35 0.044
negative regulation of axon guidance GO:1902668 1 0.044
central nervous system development GO:0007417 387 0.043
cellular nitrogen compound biosynthetic process GO:0044271 218 0.043
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.042
protein targeting to nucleus GO:0044744 3 0.042
regulation of protein import into nucleus GO:0042306 2 0.042
regulation of filopodium assembly GO:0051489 2 0.042
proximal distal pattern formation GO:0009954 1 0.041
stem cell differentiation GO:0048863 117 0.041
regulation of rna metabolic process GO:0051252 224 0.041
positive regulation of cellular process GO:0048522 201 0.040
regulation of cellular biosynthetic process GO:0031326 245 0.040
cellular component morphogenesis GO:0032989 336 0.039
nucleobase containing compound metabolic process GO:0006139 274 0.039
larval development GO:0002164 2 0.039
gene expression GO:0010467 252 0.039
positive regulation of gtp catabolic process GO:0033126 1 0.037
regulation of cytokine production GO:0001817 3 0.037
digestive system development GO:0055123 289 0.037
organic substance biosynthetic process GO:1901576 289 0.036
positive regulation of nucleoside metabolic process GO:0045979 1 0.036
regulation of protein targeting GO:1903533 2 0.036
organic cyclic compound biosynthetic process GO:1901362 223 0.035
protein metabolic process GO:0019538 183 0.035
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.035
brain development GO:0007420 293 0.034
negative regulation of protein localization to nucleus GO:1900181 2 0.034
guanosine containing compound metabolic process GO:1901068 4 0.034
establishment of protein localization to organelle GO:0072594 4 0.033
positive regulation of transport GO:0051050 2 0.033
positive regulation of gtpase activity GO:0043547 1 0.033
single organism localization GO:1902578 225 0.033
cellular amine metabolic process GO:0044106 2 0.033
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.033
regulation of oligodendrocyte differentiation GO:0048713 1 0.033
embryonic organ development GO:0048568 381 0.033
specification of axis polarity GO:0065001 4 0.033
lymphangiogenesis GO:0001946 25 0.033
developmental maturation GO:0021700 34 0.033
axon development GO:0061564 166 0.032
regulation of nucleotide catabolic process GO:0030811 2 0.032
regulation of purine nucleotide catabolic process GO:0033121 2 0.032
regulation of multicellular organism growth GO:0040014 4 0.032
regulation of biological quality GO:0065008 263 0.031
stem cell proliferation GO:0072089 4 0.031
rna biosynthetic process GO:0032774 181 0.031
regulation of protein transport GO:0051223 3 0.031
regulation of cytoplasmic transport GO:1903649 4 0.031
rhombomere morphogenesis GO:0021593 17 0.030
regulation of nucleocytoplasmic transport GO:0046822 2 0.030
cell projection organization GO:0030030 284 0.030
gtp metabolic process GO:0046039 4 0.030
activation of mapk activity GO:0000187 3 0.030
protein polymerization GO:0051258 4 0.030
negative regulation of signaling GO:0023057 96 0.030
regulation of nitrogen compound metabolic process GO:0051171 251 0.030
neuron remodeling GO:0016322 1 0.030
cellular ketone metabolic process GO:0042180 11 0.029
phagocytosis GO:0006909 3 0.029
synaptic transmission GO:0007268 35 0.029
dorsal ventral pattern formation GO:0009953 125 0.029
positive regulation of apoptotic signaling pathway GO:2001235 1 0.028
neuron projection development GO:0031175 180 0.028
regulation of cellular response to growth factor stimulus GO:0090287 35 0.028
cellular nitrogen compound metabolic process GO:0034641 290 0.028
regulation of chemotaxis GO:0050920 18 0.028
single organism metabolic process GO:0044710 217 0.028
regulation of biosynthetic process GO:0009889 250 0.028
regulation of gtp catabolic process GO:0033124 2 0.028
regulation of cellular amine metabolic process GO:0033238 0 0.027
regulation of protein localization to nucleus GO:1900180 2 0.027
amine metabolic process GO:0009308 2 0.027
regulation of cellular amino acid metabolic process GO:0006521 0 0.027
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.027
segment specification GO:0007379 12 0.027
cell motility GO:0048870 244 0.027
cellular protein catabolic process GO:0044257 4 0.027
ubiquitin dependent protein catabolic process GO:0006511 3 0.026
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.026
ameboidal type cell migration GO:0001667 143 0.025
regulation of molecular function GO:0065009 70 0.025
digestive tract morphogenesis GO:0048546 231 0.025
multicellular organism growth GO:0035264 4 0.025
signal transduction in absence of ligand GO:0038034 1 0.025
positive regulation of jnk cascade GO:0046330 3 0.025
nucleic acid metabolic process GO:0090304 244 0.025
mesoderm formation GO:0001707 43 0.025
regulation of myelination GO:0031641 1 0.025
rhombomere development GO:0021546 19 0.025
rhombomere formation GO:0021594 12 0.025
cellular macromolecule metabolic process GO:0044260 391 0.024
generation of neurons GO:0048699 385 0.024
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.024
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.024
head development GO:0060322 303 0.024
cell morphogenesis GO:0000902 289 0.024
muscle structure development GO:0061061 196 0.024
hypothalamus cell differentiation GO:0021979 4 0.024
transport GO:0006810 220 0.024
negative regulation of protein phosphorylation GO:0001933 4 0.023
protein localization to nucleus GO:0034504 3 0.023
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.023
actin filament based process GO:0030029 64 0.023
regulation of intracellular protein transport GO:0033157 3 0.023
negative regulation of response to stimulus GO:0048585 104 0.023
single organism nuclear import GO:1902593 3 0.023
somite development GO:0061053 96 0.023
response to external stimulus GO:0009605 264 0.022
establishment of localization GO:0051234 244 0.022
aging GO:0007568 2 0.022
negative regulation of axonogenesis GO:0050771 7 0.022
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.022
negative regulation of intracellular transport GO:0032387 3 0.022
transcription dna templated GO:0006351 181 0.022
axonogenesis GO:0007409 152 0.022
proteasomal protein catabolic process GO:0010498 2 0.021
small molecule metabolic process GO:0044281 77 0.021
immune system process GO:0002376 241 0.021
positive regulation of catalytic activity GO:0043085 25 0.021
gtp catabolic process GO:0006184 2 0.021
regulation of skeletal muscle fiber development GO:0048742 2 0.021
regulation of notch signaling pathway GO:0008593 16 0.020
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.020
regulation of metal ion transport GO:0010959 4 0.020
formation of anatomical boundary GO:0048859 14 0.020
striated muscle cell differentiation GO:0051146 129 0.020
negative regulation of gliogenesis GO:0014014 1 0.020
organonitrogen compound metabolic process GO:1901564 74 0.020
regulation of cell adhesion GO:0030155 15 0.020
nephron morphogenesis GO:0072028 2 0.020
positive regulation of jun kinase activity GO:0043507 2 0.020
nitrogen compound metabolic process GO:0006807 319 0.020
sequestering of metal ion GO:0051238 3 0.020
positive regulation of cell adhesion GO:0045785 1 0.020
extrinsic apoptotic signaling pathway GO:0097191 3 0.020
regulation of gtpase activity GO:0043087 2 0.020
regulation of sequestering of calcium ion GO:0051282 4 0.020
macromolecular complex subunit organization GO:0043933 74 0.020
regulation of developmental process GO:0050793 247 0.020
regulation of cell projection assembly GO:0060491 4 0.019
lymphocyte proliferation GO:0046651 1 0.019
stem cell division GO:0017145 1 0.019
negative regulation of sequestering of calcium ion GO:0051283 4 0.019
nuclear import GO:0051170 3 0.019
sequestering of calcium ion GO:0051208 3 0.019
regulation of transcription dna templated GO:0006355 213 0.019
regulation of receptor mediated endocytosis GO:0048259 4 0.019
interspecies interaction between organisms GO:0044419 4 0.019
protein complex subunit organization GO:0071822 46 0.019
carboxylic acid metabolic process GO:0019752 22 0.019
modification dependent protein catabolic process GO:0019941 3 0.019
actin cytoskeleton organization GO:0030036 63 0.018
cell adhesion GO:0007155 40 0.018
regulation of protein complex assembly GO:0043254 3 0.018
cellular component assembly GO:0022607 170 0.018
regulation of catalytic activity GO:0050790 55 0.018
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.018
diterpenoid metabolic process GO:0016101 15 0.018
rna metabolic process GO:0016070 219 0.018
organelle organization GO:0006996 227 0.018
organic acid metabolic process GO:0006082 31 0.018
positive regulation of programmed cell death GO:0043068 29 0.018
positive regulation of cellular catabolic process GO:0031331 3 0.018
regulation of cell development GO:0060284 100 0.018
regulation of macromolecule biosynthetic process GO:0010556 225 0.018
macromolecule biosynthetic process GO:0009059 227 0.018
regulation of muscle contraction GO:0006937 3 0.018
activation of jun kinase activity GO:0007257 2 0.018
heart morphogenesis GO:0003007 156 0.017
organelle localization GO:0051640 49 0.017
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.017
macromolecule modification GO:0043412 111 0.017
negative regulation of cellular metabolic process GO:0031324 77 0.017
nephron epithelium morphogenesis GO:0072088 1 0.017
tube morphogenesis GO:0035239 349 0.017
negative regulation of protein import into nucleus GO:0042308 2 0.017
lipid storage GO:0019915 1 0.017
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.017
regulation of transcription from rna polymerase iii promoter GO:0006359 1 0.017
hematopoietic or lymphoid organ development GO:0048534 191 0.017
negative regulation of protein transport GO:0051224 3 0.017
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.017
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.017
cellular protein modification process GO:0006464 100 0.017
canonical wnt signaling pathway GO:0060070 48 0.017
radial glial cell differentiation GO:0060019 2 0.017
cellular hormone metabolic process GO:0034754 19 0.017
nephron tubule morphogenesis GO:0072078 1 0.017
intracellular signal transduction GO:0035556 85 0.017
erk1 and erk2 cascade GO:0070371 4 0.016
cell migration GO:0016477 237 0.016
cellular component disassembly GO:0022411 1 0.016
oxoacid metabolic process GO:0043436 31 0.016
positive regulation of nucleotide catabolic process GO:0030813 1 0.016
morphogenesis of an epithelium GO:0002009 333 0.016
membrane invagination GO:0010324 1 0.016
lipid metabolic process GO:0006629 52 0.016
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.016
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.016
negative regulation of metabolic process GO:0009892 86 0.016
regulation of microtubule cytoskeleton organization GO:0070507 3 0.015
leukocyte proliferation GO:0070661 1 0.015
regulation of nucleoside metabolic process GO:0009118 2 0.015
positive regulation of immune effector process GO:0002699 3 0.015
regulation of cell cell adhesion GO:0022407 13 0.015
negative regulation of protein kinase activity GO:0006469 4 0.015
positive regulation of cell activation GO:0050867 1 0.015
regulation of binding GO:0051098 3 0.015
adult behavior GO:0030534 2 0.015
establishment of organelle localization GO:0051656 45 0.015
locomotion GO:0040011 313 0.015
cellular macromolecule biosynthetic process GO:0034645 224 0.015
blood vessel development GO:0001568 246 0.015
regulation of cellular component movement GO:0051270 55 0.015
response to biotic stimulus GO:0009607 97 0.015
hemopoiesis GO:0030097 183 0.015
lymph vessel development GO:0001945 27 0.015
glucose import GO:0046323 2 0.014
positive regulation of catabolic process GO:0009896 4 0.014
transcription from rna polymerase iii promoter GO:0006383 1 0.014
homeostasis of number of cells within a tissue GO:0048873 4 0.014
phagocytosis engulfment GO:0006911 1 0.014
positive regulation of notch signaling pathway GO:0045747 3 0.014
negative regulation of cytokine production GO:0001818 1 0.014
single organism transport GO:0044765 206 0.014
protein secretion GO:0009306 1 0.014
negative regulation of cell communication GO:0010648 96 0.014
negative regulation of signal transduction GO:0009968 94 0.014
regulation of multicellular organismal process GO:0051239 277 0.014
negative regulation of macromolecule metabolic process GO:0010605 76 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.014
maintenance of location GO:0051235 4 0.014
negative regulation of intracellular protein transport GO:0090317 3 0.014
lamellipodium assembly GO:0030032 1 0.014
regulation of growth rate GO:0040009 1 0.014
connective tissue development GO:0061448 99 0.014
muscle cell development GO:0055001 115 0.014
regulation of catenin import into nucleus GO:0035412 2 0.014
epithelium migration GO:0090132 25 0.014
specification of symmetry GO:0009799 204 0.014
negative regulation of cytoplasmic transport GO:1903650 2 0.014
regulation of epithelial to mesenchymal transition GO:0010717 3 0.014
neuron projection guidance GO:0097485 86 0.014
ras protein signal transduction GO:0007265 7 0.013
wnt signaling pathway GO:0016055 80 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.013
epithelial cell differentiation GO:0030855 116 0.013
cell proliferation in dorsal spinal cord GO:0010456 2 0.013
regulation of cell migration GO:0030334 40 0.013
positive regulation of neurogenesis GO:0050769 24 0.013
response to decreased oxygen levels GO:0036293 25 0.013
secondary metabolic process GO:0019748 3 0.013
release of sequestered calcium ion into cytosol GO:0051209 3 0.013
axon guidance GO:0007411 86 0.013
inner ear receptor cell fate commitment GO:0060120 4 0.013
regulation of fatty acid metabolic process GO:0019217 1 0.013
regulation of cell killing GO:0031341 2 0.013
negative regulation of wnt signaling pathway GO:0030178 30 0.013
heart contraction GO:0060047 71 0.013
regulation of canonical wnt signaling pathway GO:0060828 34 0.013
neurological system process GO:0050877 62 0.013
regulation of cellular component organization GO:0051128 86 0.013
neural tube development GO:0021915 62 0.013
intracellular receptor signaling pathway GO:0030522 30 0.013
single organism cellular localization GO:1902580 46 0.013
regulation of dendrite morphogenesis GO:0048814 3 0.013
localization of cell GO:0051674 244 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
positive regulation of cell cycle GO:0045787 3 0.013
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.012
negative regulation of stem cell differentiation GO:2000737 2 0.012
response to vitamin b3 GO:0033552 2 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.012
regulation of reproductive process GO:2000241 4 0.012
neuron projection morphogenesis GO:0048812 161 0.012
regulation of gene expression GO:0010468 265 0.012
regulation of neurogenesis GO:0050767 87 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.012
cellular response to retinoic acid GO:0071300 1 0.012
positive regulation of gliogenesis GO:0014015 2 0.012
cell proliferation in hindbrain GO:0021534 4 0.012
embryonic limb morphogenesis GO:0030326 2 0.012
positive regulation of multi organism process GO:0043902 3 0.012
regeneration GO:0031099 91 0.012
protein modification process GO:0036211 100 0.012
heart process GO:0003015 71 0.012
cell morphogenesis involved in differentiation GO:0000904 195 0.012
macromolecule deacylation GO:0098732 3 0.012
epithelial cell morphogenesis GO:0003382 2 0.012
cellular component biogenesis GO:0044085 178 0.012
regulation of glial cell differentiation GO:0045685 4 0.012
cellular amino acid metabolic process GO:0006520 7 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.012
b cell activation GO:0042113 2 0.012
guanosine containing compound catabolic process GO:1901069 2 0.012
post embryonic organ development GO:0048569 4 0.012
viral process GO:0016032 1 0.012
positive regulation of cytokine production GO:0001819 2 0.012
growth GO:0040007 174 0.011
chordate embryonic development GO:0043009 271 0.011
digestive tract development GO:0048565 265 0.011
peripheral nervous system neuron axonogenesis GO:0048936 13 0.011
regulation of natural killer cell mediated immunity GO:0002715 1 0.011
tissue migration GO:0090130 37 0.011
sister chromatid cohesion GO:0007062 2 0.011
negative regulation of multicellular organismal process GO:0051241 69 0.011
homeostatic process GO:0042592 142 0.011
regulation of production of molecular mediator of immune response GO:0002700 1 0.011
regulation of cell migration involved in sprouting angiogenesis GO:0090049 3 0.011
renal tubule morphogenesis GO:0061333 1 0.011
blood vessel morphogenesis GO:0048514 216 0.011
regulation of myotube differentiation GO:0010830 2 0.011
transmission of nerve impulse GO:0019226 19 0.011
axon ensheathment in central nervous system GO:0032291 2 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.011
rhombomere boundary formation GO:0021654 10 0.011
gland development GO:0048732 143 0.011
gastrulation GO:0007369 208 0.011
lateral inhibition GO:0046331 1 0.011
regulation of rna biosynthetic process GO:2001141 213 0.011
segmentation GO:0035282 97 0.010
aromatic compound biosynthetic process GO:0019438 217 0.010
regulation of cell substrate adhesion GO:0010810 1 0.010
regulation of histone deacetylation GO:0031063 2 0.010
negative regulation of ras protein signal transduction GO:0046580 1 0.010
negative regulation of synapse assembly GO:0051964 2 0.010
mononuclear cell proliferation GO:0032943 1 0.010
vasculogenesis GO:0001570 41 0.010
multicellular organismal response to stress GO:0033555 2 0.010
calcium ion transport into cytosol GO:0060402 3 0.010
cell killing GO:0001906 2 0.010
multi organism cellular process GO:0044764 2 0.010
cytosolic calcium ion transport GO:0060401 3 0.010
regulation of nervous system development GO:0051960 90 0.010

greb1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.032
nervous system disease DOID:863 0 0.024
musculoskeletal system disease DOID:17 0 0.018
connective tissue disease DOID:65 0 0.018
bone disease DOID:0080001 0 0.017
bone development disease DOID:0080006 0 0.013