Danio rerio

35 known processes

mvp

major vault protein

(Aliases: cb771,wu:fb52b05,wu:fc02g01)

mvp biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuron differentiation GO:0030182 353 0.432
p38mapk cascade GO:0038066 1 0.335
organic substance biosynthetic process GO:1901576 289 0.299
regulation of p38mapk cascade GO:1900744 1 0.296
somite development GO:0061053 96 0.258
negative regulation of cellular process GO:0048523 283 0.251
Human
response to stress GO:0006950 263 0.251
immune system process GO:0002376 241 0.243
cellular biosynthetic process GO:0044249 286 0.236
response to antibiotic GO:0046677 1 0.231
regulation of biological quality GO:0065008 263 0.216
heterocycle metabolic process GO:0046483 290 0.200
cellular aromatic compound metabolic process GO:0006725 295 0.182
apoptotic process GO:0006915 116 0.182
hematopoietic or lymphoid organ development GO:0048534 191 0.173
regulation of response to oxidative stress GO:1902882 2 0.171
response to organic substance GO:0010033 153 0.163
single organism metabolic process GO:0044710 217 0.146
Mouse
response to external stimulus GO:0009605 264 0.142
protein metabolic process GO:0019538 183 0.141
Human Mouse
chordate embryonic development GO:0043009 271 0.139
response to ketone GO:1901654 1 0.134
regulation of macromolecule metabolic process GO:0060255 317 0.128
Human
death GO:0016265 121 0.117
segmentation GO:0035282 97 0.117
positive regulation of cellular process GO:0048522 201 0.117
regulation of response to stimulus GO:0048583 269 0.116
sensory organ development GO:0007423 393 0.115
regulation of metabolic process GO:0019222 359 0.114
Human
eye development GO:0001654 277 0.112
positive regulation of macromolecule metabolic process GO:0010604 93 0.112
regulation of nitrogen compound metabolic process GO:0051171 251 0.111
cell death GO:0008219 121 0.111
anterior posterior pattern specification GO:0009952 152 0.109
nitrogen compound metabolic process GO:0006807 319 0.106
cellular macromolecule biosynthetic process GO:0034645 224 0.103
neuron development GO:0048666 262 0.102
response to chemical GO:0042221 320 0.101
response to inorganic substance GO:0010035 38 0.098
generation of neurons GO:0048699 385 0.097
regulation of signaling GO:0023051 235 0.093
Human
regulation of response to stress GO:0080134 36 0.092
aging GO:0007568 2 0.091
regulation of cellular metabolic process GO:0031323 320 0.088
Human
regulation of primary metabolic process GO:0080090 311 0.085
Human
epithelial cell differentiation GO:0030855 116 0.085
positive regulation of biological process GO:0048518 253 0.082
cellular macromolecule metabolic process GO:0044260 391 0.081
Human
regulation of gene expression GO:0010468 265 0.080
somitogenesis GO:0001756 87 0.080
signal transduction GO:0007165 455 0.078
Human
positive regulation of metabolic process GO:0009893 108 0.077
brain development GO:0007420 293 0.076
neuron projection development GO:0031175 180 0.076
hemopoiesis GO:0030097 183 0.076
regulation of establishment of protein localization GO:0070201 4 0.073
cofactor metabolic process GO:0051186 15 0.073
embryonic hemopoiesis GO:0035162 53 0.073
cognition GO:0050890 1 0.071
immune system development GO:0002520 191 0.065
regulation of apoptotic process GO:0042981 98 0.064
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.064
tube morphogenesis GO:0035239 349 0.063
axonogenesis GO:0007409 152 0.062
response to hexose GO:0009746 3 0.061
response to metal ion GO:0010038 34 0.061
axon development GO:0061564 166 0.061
positive regulation of stress activated mapk cascade GO:0032874 3 0.060
regulation of binding GO:0051098 3 0.060
biosynthetic process GO:0009058 294 0.057
cellular response to stress GO:0033554 62 0.055
positive regulation of transport GO:0051050 2 0.054
regulation of nucleocytoplasmic transport GO:0046822 2 0.054
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.054
regulation of intracellular protein transport GO:0033157 3 0.053
phosphorus metabolic process GO:0006793 109 0.053
Human
heterocycle biosynthetic process GO:0018130 215 0.053
organic cyclic compound biosynthetic process GO:1901362 223 0.053
central nervous system development GO:0007417 387 0.052
organonitrogen compound biosynthetic process GO:1901566 47 0.050
positive regulation of jnk cascade GO:0046330 3 0.050
hindbrain development GO:0030902 91 0.050
response to organic cyclic compound GO:0014070 51 0.050
response to carbohydrate GO:0009743 3 0.049
system process GO:0003008 185 0.049
nucleobase containing compound metabolic process GO:0006139 274 0.048
cellular nitrogen compound biosynthetic process GO:0044271 218 0.047
phosphate containing compound metabolic process GO:0006796 108 0.047
Human
angiogenesis GO:0001525 158 0.047
gene expression GO:0010467 252 0.046
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.045
head development GO:0060322 303 0.045
camera type eye development GO:0043010 222 0.045
protein localization to plasma membrane GO:0072659 1 0.044
extrinsic apoptotic signaling pathway GO:0097191 3 0.044
regulation of macromolecule biosynthetic process GO:0010556 225 0.043
lipid storage GO:0019915 1 0.043
positive regulation of signal transduction GO:0009967 56 0.043
embryo development ending in birth or egg hatching GO:0009792 271 0.043
intracellular signal transduction GO:0035556 85 0.042
macromolecule modification GO:0043412 111 0.042
Human
fatty acid transport GO:0015908 1 0.042
regulation of protein import into nucleus GO:0042306 2 0.042
protein modification process GO:0036211 100 0.041
Human
regulation of developmental process GO:0050793 247 0.040
myeloid cell differentiation GO:0030099 86 0.040
regulation of cell communication GO:0010646 232 0.040
regulation of signal transduction GO:0009966 225 0.040
adult behavior GO:0030534 2 0.040
regulation of intracellular signal transduction GO:1902531 57 0.039
neuron projection morphogenesis GO:0048812 161 0.039
rna metabolic process GO:0016070 219 0.039
response to amino acid GO:0043200 2 0.039
negative regulation of biological process GO:0048519 304 0.039
Human
regulation of multicellular organismal process GO:0051239 277 0.039
response to cadmium ion GO:0046686 14 0.038
cellular sodium ion homeostasis GO:0006883 1 0.038
blood vessel morphogenesis GO:0048514 216 0.038
eye morphogenesis GO:0048592 144 0.038
response to wounding GO:0009611 116 0.037
primitive hemopoiesis GO:0060215 27 0.037
cellular protein metabolic process GO:0044267 129 0.036
Human
response to glucocorticoid GO:0051384 1 0.036
regulation of cell shape GO:0008360 1 0.036
response to glucose GO:0009749 3 0.036
maintenance of epithelial cell apical basal polarity GO:0045199 5 0.036
phosphorylation GO:0016310 69 0.036
Human
organic cyclic compound metabolic process GO:1901360 301 0.036
single organism localization GO:1902578 225 0.035
protein stabilization GO:0050821 2 0.035
cellular protein modification process GO:0006464 100 0.035
Human
nuclear transport GO:0051169 4 0.034
positive regulation of signaling GO:0023056 56 0.034
negative regulation of kinase activity GO:0033673 4 0.033
Human
regulation of cell death GO:0010941 103 0.033
behavior GO:0007610 74 0.032
embryonic organ development GO:0048568 381 0.032
positive regulation of cellular metabolic process GO:0031325 94 0.032
nucleic acid templated transcription GO:0097659 181 0.031
retina development in camera type eye GO:0060041 146 0.031
morphogenesis of an epithelium GO:0002009 333 0.031
regionalization GO:0003002 274 0.031
regulation of striated muscle contraction GO:0006942 2 0.031
regulation of cellular response to oxidative stress GO:1900407 2 0.031
single fertilization GO:0007338 3 0.031
regulation of epithelial cell proliferation GO:0050678 3 0.031
organic acid metabolic process GO:0006082 31 0.030
glucose homeostasis GO:0042593 1 0.030
macromolecule biosynthetic process GO:0009059 227 0.030
regulation of protein transport GO:0051223 3 0.030
long chain fatty acid transport GO:0015909 1 0.030
organonitrogen compound metabolic process GO:1901564 74 0.030
cell projection organization GO:0030030 284 0.030
neuron projection regeneration GO:0031102 16 0.030
biological adhesion GO:0022610 40 0.030
regulation of nucleic acid templated transcription GO:1903506 213 0.030
hatching GO:0035188 4 0.029
osteoclast development GO:0036035 1 0.029
camera type eye morphogenesis GO:0048593 108 0.029
oxoacid metabolic process GO:0043436 31 0.029
response to oxygen containing compound GO:1901700 55 0.029
protein import GO:0017038 3 0.028
maintenance of location GO:0051235 4 0.028
regulation of protein metabolic process GO:0051246 56 0.028
Human
ameboidal type cell migration GO:0001667 143 0.028
regulation of localization GO:0032879 104 0.027
skin development GO:0043588 54 0.027
regulation of protein localization to nucleus GO:1900180 2 0.027
ectodermal cell fate specification GO:0001715 2 0.027
regulation of blood pressure GO:0008217 1 0.027
sensory organ morphogenesis GO:0090596 200 0.027
regulation of rna biosynthetic process GO:2001141 213 0.027
positive regulation of apoptotic signaling pathway GO:2001235 1 0.027
nucleobase containing compound biosynthetic process GO:0034654 205 0.027
regulation of cellular amino acid metabolic process GO:0006521 0 0.026
regulation of metal ion transport GO:0010959 4 0.026
retina morphogenesis in camera type eye GO:0060042 79 0.025
response to oxygen levels GO:0070482 25 0.025
regulation of transcription dna templated GO:0006355 213 0.025
long chain fatty acid metabolic process GO:0001676 1 0.025
taxis GO:0042330 109 0.025
response to monosaccharide GO:0034284 3 0.025
cellular response to organic substance GO:0071310 105 0.025
response to lipid GO:0033993 60 0.025
regulation of cellular biosynthetic process GO:0031326 245 0.024
programmed cell death GO:0012501 119 0.024
cell morphogenesis involved in differentiation GO:0000904 195 0.024
multicellular organism growth GO:0035264 4 0.024
response to corticosteroid GO:0031960 1 0.024
regulation of inflammatory response GO:0050727 2 0.024
cellular amide metabolic process GO:0043603 4 0.023
intestinal absorption GO:0050892 2 0.023
aromatic compound biosynthetic process GO:0019438 217 0.023
cell motility GO:0048870 244 0.023
response to nutrient GO:0007584 3 0.023
establishment of protein localization to organelle GO:0072594 4 0.023
cellular component movement GO:0006928 335 0.023
transcription dna templated GO:0006351 181 0.022
negative regulation of cell death GO:0060548 60 0.022
organism emergence from protective structure GO:0071684 4 0.022
cell surface receptor signaling pathway GO:0007166 325 0.022
Human
regulation of neurogenesis GO:0050767 87 0.022
morphogenesis of an epithelial sheet GO:0002011 49 0.022
epidermis development GO:0008544 48 0.022
regulation of anatomical structure morphogenesis GO:0022603 130 0.022
regulation of sodium ion transport GO:0002028 2 0.022
protein import into nucleus GO:0006606 3 0.021
cell morphogenesis GO:0000902 289 0.021
establishment or maintenance of bipolar cell polarity GO:0061245 12 0.021
regulation of nucleotide catabolic process GO:0030811 2 0.021
response to abiotic stimulus GO:0009628 122 0.021
blood circulation GO:0008015 87 0.021
regulation of protein targeting GO:1903533 2 0.021
cellular response to biotic stimulus GO:0071216 3 0.020
positive regulation of catabolic process GO:0009896 4 0.020
cellular response to chemical stimulus GO:0070887 157 0.020
regulation of cytoplasmic transport GO:1903649 4 0.020
actin filament based movement GO:0030048 1 0.020
positive regulation of cellular catabolic process GO:0031331 3 0.020
nuclear import GO:0051170 3 0.020
multi organism process GO:0051704 134 0.020
circulatory system process GO:0003013 87 0.020
regulation of multicellular organism growth GO:0040014 4 0.019
activation of mapkkk activity GO:0000185 1 0.019
cell projection morphogenesis GO:0048858 244 0.019
cellular response to external stimulus GO:0071496 2 0.019
hemoglobin biosynthetic process GO:0042541 8 0.019
negative regulation of protein kinase activity GO:0006469 4 0.019
Human
fertilization GO:0009566 3 0.019
cell migration GO:0016477 237 0.019
locomotory behavior GO:0007626 34 0.019
rna biosynthetic process GO:0032774 181 0.019
multicellular organism reproduction GO:0032504 35 0.018
negative regulation of protein phosphorylation GO:0001933 4 0.018
Human
cellular response to oxygen levels GO:0071453 1 0.018
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.018
heme metabolic process GO:0042168 9 0.018
protein targeting to nucleus GO:0044744 3 0.018
muscle tissue development GO:0060537 110 0.018
peptide metabolic process GO:0006518 1 0.018
gtp catabolic process GO:0006184 2 0.018
regulation of cytokine production GO:0001817 3 0.018
anion transport GO:0006820 38 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
peptidyl serine modification GO:0018209 2 0.018
membrane fusion GO:0061025 2 0.018
mitochondrion organization GO:0007005 4 0.018
cell proliferation GO:0008283 80 0.018
Mouse
cellular nitrogen compound metabolic process GO:0034641 290 0.018
epithelial tube morphogenesis GO:0060562 148 0.018
regulation of protein catabolic process GO:0042176 1 0.017
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.017
centrosome cycle GO:0007098 1 0.017
localization of cell GO:0051674 244 0.017
ion transport GO:0006811 114 0.017
actin polymerization or depolymerization GO:0008154 2 0.017
guanosine containing compound metabolic process GO:1901068 4 0.017
negative regulation of epithelial cell proliferation GO:0050680 1 0.017
larval development GO:0002164 2 0.017
meiotic nuclear division GO:0007126 4 0.017
cellular protein catabolic process GO:0044257 4 0.017
mesenchyme development GO:0060485 127 0.016
negative regulation of cellular metabolic process GO:0031324 77 0.016
Human
regulation of programmed cell death GO:0043067 101 0.016
neurotransmitter secretion GO:0007269 2 0.016
mesoderm development GO:0007498 88 0.016
regulation of cellular protein metabolic process GO:0032268 52 0.016
Human
regulation of calcium ion transport GO:0051924 2 0.016
regulation of catalytic activity GO:0050790 55 0.016
Human
regulation of rna metabolic process GO:0051252 224 0.016
carboxylic acid metabolic process GO:0019752 22 0.016
macromolecule localization GO:0033036 54 0.016
cofactor biosynthetic process GO:0051188 10 0.016
multicellular organismal reproductive process GO:0048609 35 0.016
cellular response to toxic substance GO:0097237 1 0.016
transcription from rna polymerase ii promoter GO:0006366 80 0.016
cellular component morphogenesis GO:0032989 336 0.016
multi organism reproductive process GO:0044703 36 0.016
establishment of protein localization to plasma membrane GO:0090002 1 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.016
carbohydrate derivative metabolic process GO:1901135 61 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.016
peptide transport GO:0015833 1 0.016
neurotransmitter transport GO:0006836 2 0.016
erythrocyte homeostasis GO:0034101 55 0.015
negative regulation of apoptotic process GO:0043066 55 0.015
multicellular organismal metabolic process GO:0044236 2 0.015
small molecule metabolic process GO:0044281 77 0.015
i kappab kinase nf kappab signaling GO:0007249 4 0.015
tyrosine phosphorylation of stat protein GO:0007260 1 0.015
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.015
regulation of nucleoside metabolic process GO:0009118 2 0.015
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.015
synaptic growth at neuromuscular junction GO:0051124 2 0.015
gtp metabolic process GO:0046039 4 0.015
meiotic cell cycle process GO:1903046 3 0.015
adherens junction organization GO:0034332 4 0.015
response to drug GO:0042493 3 0.015
beta amyloid metabolic process GO:0050435 1 0.014
amyloid precursor protein metabolic process GO:0042982 1 0.014
regulation of cell motility GO:2000145 46 0.014
vasculature development GO:0001944 278 0.014
energy reserve metabolic process GO:0006112 2 0.014
sodium ion transport GO:0006814 24 0.014
cellular response to starvation GO:0009267 1 0.014
developmental growth GO:0048589 166 0.014
cardiac conduction GO:0061337 3 0.014
regulation of cellular response to stress GO:0080135 20 0.014
mitochondrial transport GO:0006839 2 0.014
regulation of oxidative stress induced cell death GO:1903201 2 0.014
negative regulation of metabolic process GO:0009892 86 0.014
Human
regulation of dendrite development GO:0050773 3 0.014
regulation of multicellular organismal development GO:2000026 223 0.014
chromosome organization involved in meiosis GO:0070192 1 0.014
single organism cell adhesion GO:0098602 29 0.014
protein phosphorylation GO:0006468 47 0.014
Human
homeostatic process GO:0042592 142 0.014
positive regulation of cell death GO:0010942 29 0.014
cytokinesis GO:0000910 3 0.014
response to alcohol GO:0097305 14 0.014
medulla oblongata development GO:0021550 4 0.013
carbohydrate homeostasis GO:0033500 1 0.013
cellular response to lipopolysaccharide GO:0071222 3 0.013
hemoglobin metabolic process GO:0020027 12 0.013
apoptotic signaling pathway GO:0097190 23 0.013
regulation of cellular protein catabolic process GO:1903362 1 0.013
digestive tract morphogenesis GO:0048546 231 0.013
cell part morphogenesis GO:0032990 246 0.013
beta amyloid formation GO:0034205 1 0.013
heart contraction GO:0060047 71 0.013
toxin transport GO:1901998 2 0.013
regulation of cardiac muscle cell contraction GO:0086004 1 0.013
positive regulation of protein metabolic process GO:0051247 23 0.013
mononuclear cell proliferation GO:0032943 1 0.013
single organism membrane fusion GO:0044801 2 0.013
regulation of actin filament based movement GO:1903115 1 0.013
response to vitamin GO:0033273 3 0.013
regulation of protein complex assembly GO:0043254 3 0.013
positive regulation of nucleoside metabolic process GO:0045979 1 0.013
purine nucleoside monophosphate catabolic process GO:0009128 4 0.013
positive regulation of gene expression GO:0010628 71 0.013
tube formation GO:0035148 25 0.013
erythrocyte differentiation GO:0030218 54 0.013
regeneration GO:0031099 91 0.012
posterior lateral line development GO:0048916 38 0.012
regulation of cell differentiation GO:0045595 142 0.012
regulation of synaptic plasticity GO:0048167 1 0.012
regulation of cell migration GO:0030334 40 0.012
establishment of localization GO:0051234 244 0.012
cell death in response to oxidative stress GO:0036473 2 0.012
regulation of muscle contraction GO:0006937 3 0.012
regulation of protein polymerization GO:0032271 2 0.012
collagen metabolic process GO:0032963 2 0.012
negative regulation of cytoplasmic transport GO:1903650 2 0.012
myeloid cell homeostasis GO:0002262 56 0.012
single organismal cell cell adhesion GO:0016337 29 0.012
heart morphogenesis GO:0003007 156 0.012
response to external biotic stimulus GO:0043207 97 0.012
response to hydrogen peroxide GO:0042542 3 0.012
positive regulation of response to stimulus GO:0048584 80 0.012
single organism nuclear import GO:1902593 3 0.012
regulation of gtp catabolic process GO:0033124 2 0.012
negative regulation of blood vessel endothelial cell migration GO:0043537 1 0.012
nucleic acid metabolic process GO:0090304 244 0.012
hormone transport GO:0009914 2 0.012
single organism carbohydrate metabolic process GO:0044723 12 0.012
cellular carbohydrate metabolic process GO:0044262 4 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.011
regulation of phosphorylation GO:0042325 26 0.011
Human
blood vessel development GO:0001568 246 0.011
regulation of jak stat cascade GO:0046425 3 0.011
metal ion transport GO:0030001 58 0.011
cytoskeleton dependent cytokinesis GO:0061640 3 0.011
carbohydrate metabolic process GO:0005975 12 0.011
regulation of synapse assembly GO:0051963 3 0.011
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
action potential GO:0001508 19 0.011
liver development GO:0001889 96 0.011
regulation of multicellular organismal metabolic process GO:0044246 2 0.011
extracellular structure organization GO:0043062 27 0.011
carbohydrate derivative biosynthetic process GO:1901137 43 0.011
positive regulation of biosynthetic process GO:0009891 68 0.011
cellular amino acid metabolic process GO:0006520 7 0.011
cellular response to endogenous stimulus GO:0071495 68 0.011
organelle organization GO:0006996 227 0.011
negative regulation of intracellular protein transport GO:0090317 3 0.011
autophagy GO:0006914 4 0.011
regulation of neurotransmitter secretion GO:0046928 1 0.011
homeostasis of number of cells GO:0048872 62 0.011
epithelial cell morphogenesis GO:0003382 2 0.011
positive regulation of gtp catabolic process GO:0033126 1 0.011
negative regulation of cytokine production GO:0001818 1 0.011
negative regulation of multi organism process GO:0043901 3 0.010
lamellipodium assembly GO:0030032 1 0.010
response to steroid hormone GO:0048545 35 0.010
maternal determination of anterior posterior axis embryo GO:0008358 4 0.010
positive regulation of blood circulation GO:1903524 2 0.010
embryonic pattern specification GO:0009880 44 0.010
neural tube development GO:0021915 62 0.010
regulation of locomotion GO:0040012 55 0.010
protein localization to nucleus GO:0034504 3 0.010
nerve development GO:0021675 45 0.010
regulation of response to external stimulus GO:0032101 31 0.010
transport GO:0006810 220 0.010
centrosome organization GO:0051297 1 0.010
sex determination GO:0007530 1 0.010
cellular catabolic process GO:0044248 27 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.010
negative regulation of intracellular transport GO:0032387 3 0.010

mvp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.059
muscular disease DOID:0080000 0 0.059
heart disease DOID:114 0 0.059
cardiomyopathy DOID:0050700 0 0.059
disease of anatomical entity DOID:7 0 0.059
cardiovascular system disease DOID:1287 0 0.059
musculoskeletal system disease DOID:17 0 0.059
muscle tissue disease DOID:66 0 0.059
intrinsic cardiomyopathy DOID:0060036 0 0.028
nervous system disease DOID:863 0 0.024
disease of metabolism DOID:0014667 0 0.015
lysosomal storage disease DOID:3211 0 0.015
inherited metabolic disorder DOID:655 0 0.015