Danio rerio

0 known processes

e2f4

E2F transcription factor 4

(Aliases: wu:fb72f07,wu:fe05f06,fb72f07,zgc:63815)

e2f4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular nitrogen compound biosynthetic process GO:0044271 218 0.366
Mouse Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.240
Human Mouse Fly
larval development GO:0002164 2 0.180
Worm
nucleobase containing compound metabolic process GO:0006139 274 0.179
Mouse Fly
gene expression GO:0010467 252 0.173
Mouse Fly
cellular macromolecule metabolic process GO:0044260 391 0.170
Mouse Fly
nucleic acid templated transcription GO:0097659 181 0.165
Mouse Fly
cellular nitrogen compound metabolic process GO:0034641 290 0.161
Mouse Fly
regulation of macromolecule metabolic process GO:0060255 317 0.157
Human Mouse Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.154
Human Mouse Fly
aging GO:0007568 2 0.154
organic cyclic compound biosynthetic process GO:1901362 223 0.152
Mouse Fly
hemopoiesis GO:0030097 183 0.150
regulation of nucleic acid templated transcription GO:1903506 213 0.143
Human Mouse Fly
nitrogen compound metabolic process GO:0006807 319 0.133
Mouse Fly
nucleic acid metabolic process GO:0090304 244 0.128
Mouse Fly
organic cyclic compound metabolic process GO:1901360 301 0.123
Mouse Fly
transcription from rna polymerase ii promoter GO:0006366 80 0.116
Mouse Fly
negative regulation of cellular process GO:0048523 283 0.113
Worm Fly
immune system process GO:0002376 241 0.107
rna biosynthetic process GO:0032774 181 0.101
Mouse Fly
regulation of primary metabolic process GO:0080090 311 0.096
Human Mouse Fly
heterocycle biosynthetic process GO:0018130 215 0.096
Mouse Fly
maintenance of location GO:0051235 4 0.088
nucleobase containing compound biosynthetic process GO:0034654 205 0.087
Mouse Fly
organic substance biosynthetic process GO:1901576 289 0.086
Mouse Fly
immune system development GO:0002520 191 0.084
protein targeting to nucleus GO:0044744 3 0.082
regulation of biological quality GO:0065008 263 0.080
Mouse
positive regulation of macromolecule metabolic process GO:0010604 93 0.077
Mouse
regulation of rna metabolic process GO:0051252 224 0.076
Human Mouse Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.076
Mouse Fly
regulation of transcription dna templated GO:0006355 213 0.076
Human Mouse Fly
regulation of metabolic process GO:0019222 359 0.075
Human Mouse Fly
regulation of protein complex assembly GO:0043254 3 0.072
nucleocytoplasmic transport GO:0006913 4 0.071
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.071
Mouse
protein stabilization GO:0050821 2 0.070
regulation of gene expression GO:0010468 265 0.067
Human Mouse Fly
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.065
Mouse
regulation of developmental process GO:0050793 247 0.065
Worm
nuclear transport GO:0051169 4 0.065
cellular biosynthetic process GO:0044249 286 0.064
Mouse Fly
hematopoietic or lymphoid organ development GO:0048534 191 0.063
regulation of establishment of protein localization GO:0070201 4 0.063
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.062
Human Mouse Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.061
Mouse
chordate embryonic development GO:0043009 271 0.060
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.059
Human Mouse Fly
positive regulation of metabolic process GO:0009893 108 0.059
Mouse
positive regulation of cell cycle GO:0045787 3 0.057
regulation of rna biosynthetic process GO:2001141 213 0.053
Human Mouse Fly
embryo development ending in birth or egg hatching GO:0009792 271 0.052
Worm
positive regulation of transcription dna templated GO:0045893 57 0.051
Mouse
regulation of cell shape GO:0008360 1 0.051
regulation of intracellular protein transport GO:0033157 3 0.051
negative regulation of nuclear division GO:0051784 3 0.050
protein import GO:0017038 3 0.048
negative regulation of biological process GO:0048519 304 0.048
Worm Fly
developmental growth GO:0048589 166 0.047
regulation of protein transport GO:0051223 3 0.044
meiotic nuclear division GO:0007126 4 0.043
regulation of signal transduction GO:0009966 225 0.043
Worm
regulation of multicellular organism growth GO:0040014 4 0.043
regulation of biosynthetic process GO:0009889 250 0.041
Human Mouse Fly
mitotic cell cycle GO:0000278 64 0.041
Mouse Fly
heart development GO:0007507 313 0.041
regulation of cellular metabolic process GO:0031323 320 0.041
Human Mouse Fly
response to stress GO:0006950 263 0.041
protein import into nucleus GO:0006606 3 0.040
negative regulation of cellular metabolic process GO:0031324 77 0.040
Fly
nuclear import GO:0051170 3 0.040
ameboidal type cell migration GO:0001667 143 0.039
rna metabolic process GO:0016070 219 0.039
Mouse Fly
regulation of cellular biosynthetic process GO:0031326 245 0.039
Human Mouse Fly
digestive system development GO:0055123 289 0.038
Worm
regulation of cell cycle process GO:0010564 20 0.038
Fly
eye development GO:0001654 277 0.037
negative regulation of kinase activity GO:0033673 4 0.037
positive regulation of nucleic acid templated transcription GO:1903508 57 0.035
Mouse
cellular component movement GO:0006928 335 0.035
positive regulation of biological process GO:0048518 253 0.035
Mouse
regulation of cell cycle GO:0051726 52 0.035
Fly
single organism nuclear import GO:1902593 3 0.035
regulation of protein targeting GO:1903533 2 0.034
macromolecule biosynthetic process GO:0009059 227 0.034
Mouse Fly
negative regulation of mitosis GO:0045839 3 0.034
regulation of response to stimulus GO:0048583 269 0.034
Worm
organelle organization GO:0006996 227 0.033
Mouse
tube morphogenesis GO:0035239 349 0.033
Worm
cytokinesis GO:0000910 3 0.033
positive regulation of cellular component biogenesis GO:0044089 3 0.032
regulation of meiotic cell cycle GO:0051445 1 0.032
positive regulation of biosynthetic process GO:0009891 68 0.031
Mouse
biosynthetic process GO:0009058 294 0.030
Mouse Fly
regulation of cytoplasmic transport GO:1903649 4 0.030
protein metabolic process GO:0019538 183 0.029
positive regulation of transport GO:0051050 2 0.029
multicellular organism growth GO:0035264 4 0.029
digestive tract development GO:0048565 265 0.029
Worm
aromatic compound biosynthetic process GO:0019438 217 0.029
Mouse Fly
cellular component morphogenesis GO:0032989 336 0.029
Mouse
digestive tract morphogenesis GO:0048546 231 0.028
Worm
protein acetylation GO:0006473 2 0.028
cellular component biogenesis GO:0044085 178 0.027
Mouse
transcription dna templated GO:0006351 181 0.027
Mouse Fly
embryonic organ morphogenesis GO:0048562 274 0.027
Worm
negative regulation of cellular biosynthetic process GO:0031327 55 0.027
Fly
regulation of signaling GO:0023051 235 0.026
Worm
negative regulation of gene expression GO:0010629 65 0.026
Fly
regulation of protein localization to nucleus GO:1900180 2 0.026
embryonic organ development GO:0048568 381 0.026
Worm
gastrulation GO:0007369 208 0.025
cell death GO:0008219 121 0.025
Fly
primary neural tube formation GO:0014020 1 0.025
cellular ketone metabolic process GO:0042180 11 0.025
cellular protein metabolic process GO:0044267 129 0.025
sensory organ morphogenesis GO:0090596 200 0.025
regulation of cellular ketone metabolic process GO:0010565 7 0.025
sensory organ development GO:0007423 393 0.025
heterocycle metabolic process GO:0046483 290 0.025
Mouse Fly
locomotion GO:0040011 313 0.024
cellular response to chemical stimulus GO:0070887 157 0.024
morphogenesis of an epithelium GO:0002009 333 0.024
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.023
positive regulation of cellular biosynthetic process GO:0031328 68 0.023
Mouse
regulation of cell fate specification GO:0042659 20 0.023
regulation of stem cell proliferation GO:0072091 2 0.023
organism emergence from protective structure GO:0071684 4 0.023
amine metabolic process GO:0009308 2 0.022
reciprocal dna recombination GO:0035825 1 0.022
positive regulation of rna biosynthetic process GO:1902680 57 0.022
Mouse
death GO:0016265 121 0.022
Fly
rna modification GO:0009451 2 0.022
positive regulation of cytoskeleton organization GO:0051495 3 0.022
cell morphogenesis GO:0000902 289 0.021
Mouse
cell cycle g2 m phase transition GO:0044839 4 0.021
angiogenesis GO:0001525 158 0.021
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.021
lipid storage GO:0019915 1 0.021
protein acylation GO:0043543 3 0.021
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.020
Worm
signal transduction GO:0007165 455 0.020
Worm
female sex differentiation GO:0046660 4 0.020
response to amino acid GO:0043200 2 0.020
regulation of cellular component organization GO:0051128 86 0.020
establishment of protein localization to organelle GO:0072594 4 0.020
regulation of protein import into nucleus GO:0042306 2 0.019
stem cell maintenance GO:0019827 4 0.019
stem cell differentiation GO:0048863 117 0.019
development of primary female sexual characteristics GO:0046545 4 0.019
cytoskeleton organization GO:0007010 96 0.019
cellular aromatic compound metabolic process GO:0006725 295 0.019
Mouse Fly
stem cell proliferation GO:0072089 4 0.019
extrinsic apoptotic signaling pathway GO:0097191 3 0.019
cell projection organization GO:0030030 284 0.018
Mouse
positive regulation of cellular metabolic process GO:0031325 94 0.018
Mouse
organic acid metabolic process GO:0006082 31 0.018
regulation of cell communication GO:0010646 232 0.018
Worm
myeloid cell differentiation GO:0030099 86 0.018
negative regulation of transcription dna templated GO:0045892 45 0.018
Fly
negative regulation of chromosome organization GO:2001251 1 0.018
homeostasis of number of cells GO:0048872 62 0.017
internal peptidyl lysine acetylation GO:0018393 2 0.017
female gonad development GO:0008585 4 0.017
regulation of nucleocytoplasmic transport GO:0046822 2 0.017
g2 m transition of mitotic cell cycle GO:0000086 4 0.017
spindle assembly GO:0051225 2 0.017
regulation of microtubule cytoskeleton organization GO:0070507 3 0.017
homeostatic process GO:0042592 142 0.017
Mouse
cell motility GO:0048870 244 0.016
regulation of cell differentiation GO:0045595 142 0.016
positive regulation of dna metabolic process GO:0051054 1 0.016
cell cycle process GO:0022402 53 0.016
Mouse Fly
nuclear export GO:0051168 1 0.016
response to chemical GO:0042221 320 0.016
regulation of cellular amine metabolic process GO:0033238 0 0.016
peptidyl lysine acetylation GO:0018394 2 0.016
positive regulation of chromosome organization GO:2001252 1 0.016
cell morphogenesis involved in differentiation GO:0000904 195 0.016
negative regulation of mrna metabolic process GO:1903312 3 0.016
carboxylic acid metabolic process GO:0019752 22 0.016
macromolecule modification GO:0043412 111 0.016
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
mesenchymal cell differentiation GO:0048762 87 0.015
modification dependent protein catabolic process GO:0019941 3 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
rna 3 end processing GO:0031123 2 0.015
negative regulation of biosynthetic process GO:0009890 55 0.015
Fly
cell part morphogenesis GO:0032990 246 0.015
Mouse
regulation of binding GO:0051098 3 0.015
interspecies interaction between organisms GO:0044419 4 0.015
regulation of metal ion transport GO:0010959 4 0.015
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.015
Fly
positive regulation of catabolic process GO:0009896 4 0.015
negative regulation of rna biosynthetic process GO:1902679 45 0.015
Fly
cellular component assembly GO:0022607 170 0.015
Mouse
single organism metabolic process GO:0044710 217 0.015
Fly
stem cell development GO:0048864 82 0.015
regulation of anatomical structure morphogenesis GO:0022603 130 0.015
regulation of cell death GO:0010941 103 0.015
Fly
adult behavior GO:0030534 2 0.015
negative regulation of metabolic process GO:0009892 86 0.014
Fly
response to wounding GO:0009611 116 0.014
negative regulation of ras protein signal transduction GO:0046580 1 0.014
Worm
positive regulation of cell activation GO:0050867 1 0.014
internal protein amino acid acetylation GO:0006475 2 0.014
cellular response to radiation GO:0071478 4 0.014
regulation of histone methylation GO:0031060 3 0.014
cellular amine metabolic process GO:0044106 2 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.014
Fly
ubiquitin dependent protein catabolic process GO:0006511 3 0.014
meiotic cell cycle process GO:1903046 3 0.014
cell cycle GO:0007049 93 0.014
Mouse Fly
small molecule metabolic process GO:0044281 77 0.014
mitotic nuclear division GO:0007067 18 0.014
apoptotic process GO:0006915 116 0.014
Fly
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.014
regulation of wound healing GO:0061041 2 0.014
single organism organelle organization GO:1902589 199 0.014
Mouse
proteasomal protein catabolic process GO:0010498 2 0.014
negative regulation of catabolic process GO:0009895 3 0.014
mitotic cell cycle process GO:1903047 48 0.014
Mouse Fly
programmed cell death GO:0012501 119 0.014
Fly
microtubule organizing center organization GO:0031023 1 0.014
translational initiation GO:0006413 3 0.014
positive regulation of apoptotic signaling pathway GO:2001235 1 0.014
negative regulation of nucleic acid templated transcription GO:1903507 45 0.013
Fly
positive regulation of chromatin modification GO:1903310 1 0.013
regulation of protein metabolic process GO:0051246 56 0.013
regulation of cellular protein catabolic process GO:1903362 1 0.013
cellular carbohydrate metabolic process GO:0044262 4 0.013
meiotic chromosome segregation GO:0045132 3 0.013
regulation of protein catabolic process GO:0042176 1 0.013
neuron differentiation GO:0030182 353 0.013
cell proliferation GO:0008283 80 0.013
Mouse
protein localization to nucleus GO:0034504 3 0.013
skeletal system development GO:0001501 181 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
regulation of intracellular signal transduction GO:1902531 57 0.013
Worm
pancreas development GO:0031016 84 0.013
post embryonic organ development GO:0048569 4 0.013
Worm
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.013
transport GO:0006810 220 0.013
positive regulation of rna metabolic process GO:0051254 59 0.013
Mouse
dna templated transcription elongation GO:0006354 3 0.013
b cell activation GO:0042113 2 0.013
phagocytosis GO:0006909 3 0.013
regulation of organelle assembly GO:1902115 4 0.013
regulation of multicellular organismal process GO:0051239 277 0.012
Worm
negative regulation of protein kinase activity GO:0006469 4 0.012
camera type eye development GO:0043010 222 0.012
eye morphogenesis GO:0048592 144 0.012
cell fate specification GO:0001708 68 0.012
central nervous system development GO:0007417 387 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.012
Fly
growth GO:0040007 174 0.012
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
Fly
gland development GO:0048732 143 0.012
cellular macromolecule biosynthetic process GO:0034645 224 0.012
Mouse Fly
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.012
mesenchyme development GO:0060485 127 0.012
polarized epithelial cell differentiation GO:0030859 4 0.012
carbohydrate biosynthetic process GO:0016051 1 0.012
regulation of cell activation GO:0050865 1 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.012
Mouse
cell projection morphogenesis GO:0048858 244 0.012
Mouse
glucose homeostasis GO:0042593 1 0.012
intracellular signal transduction GO:0035556 85 0.012
Worm
cellular response to organic substance GO:0071310 105 0.012
response to uv GO:0009411 3 0.012
macromolecular complex assembly GO:0065003 35 0.011
localization of cell GO:0051674 244 0.011
oxoacid metabolic process GO:0043436 31 0.011
negative regulation of cellular catabolic process GO:0031330 3 0.011
mrna 3 end processing GO:0031124 2 0.011
generation of neurons GO:0048699 385 0.011
compound eye development GO:0048749 2 0.011
single organism transport GO:0044765 206 0.011
organonitrogen compound metabolic process GO:1901564 74 0.011
erythrocyte homeostasis GO:0034101 55 0.011
positive regulation of gene expression GO:0010628 71 0.011
Mouse
positive regulation of gtp catabolic process GO:0033126 1 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.011
erythrocyte differentiation GO:0030218 54 0.011
cellular amino acid metabolic process GO:0006520 7 0.010
cytosolic calcium ion transport GO:0060401 3 0.010
cellular response to external stimulus GO:0071496 2 0.010
negative regulation of cytoplasmic transport GO:1903650 2 0.010
convergent extension involved in gastrulation GO:0060027 71 0.010
positive regulation of cellular catabolic process GO:0031331 3 0.010
positive regulation of response to stimulus GO:0048584 80 0.010
regulation of apoptotic process GO:0042981 98 0.010
Fly
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.010
centrosome duplication GO:0051298 1 0.010
retina morphogenesis in camera type eye GO:0060042 79 0.010
sensory system development GO:0048880 76 0.010
positive regulation of carbohydrate metabolic process GO:0045913 1 0.010
negative regulation of signal transduction GO:0009968 94 0.010
Worm
cellular protein catabolic process GO:0044257 4 0.010
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.010
neuron development GO:0048666 262 0.010
lymphocyte proliferation GO:0046651 1 0.010
somitogenesis GO:0001756 87 0.010
negative regulation of response to stimulus GO:0048585 104 0.010
Worm

e2f4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
nervous system disease DOID:863 0 0.021
disease of metabolism DOID:0014667 0 0.019
sensory system disease DOID:0050155 0 0.013
eye and adnexa disease DOID:1492 0 0.013
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013
eye disease DOID:5614 0 0.012