Danio rerio

0 known processes

six4.3

sine oculis homeobox homolog 4.3

six4.3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
chordate embryonic development GO:0043009 271 0.599
signal transduction GO:0007165 455 0.517
positive regulation of biological process GO:0048518 253 0.437
central nervous system development GO:0007417 387 0.371
Zebrafish
digestive system development GO:0055123 289 0.315
Zebrafish Worm
immune system process GO:0002376 241 0.296
localization of cell GO:0051674 244 0.287
digestive tract development GO:0048565 265 0.278
Zebrafish Worm
larval development GO:0002164 2 0.269
regulation of cellular component organization GO:0051128 86 0.256
sensory organ development GO:0007423 393 0.244
Zebrafish Mouse
regulation of multicellular organismal development GO:2000026 223 0.236
Zebrafish
regulation of signaling GO:0023051 235 0.232
negative regulation of signal transduction GO:0009968 94 0.231
blood vessel morphogenesis GO:0048514 216 0.229
organic cyclic compound metabolic process GO:1901360 301 0.218
Zebrafish Mouse
response to chemical GO:0042221 320 0.217
vasculature development GO:0001944 278 0.217
regulation of cell communication GO:0010646 232 0.213
cell proliferation GO:0008283 80 0.211
Zebrafish Mouse
establishment of localization GO:0051234 244 0.211
positive regulation of signal transduction GO:0009967 56 0.207
nitrogen compound metabolic process GO:0006807 319 0.207
Zebrafish Mouse
regulation of cellular biosynthetic process GO:0031326 245 0.206
Zebrafish Mouse
positive regulation of cellular process GO:0048522 201 0.200
cellular component movement GO:0006928 335 0.198
cell migration GO:0016477 237 0.192
positive regulation of cellular metabolic process GO:0031325 94 0.191
organic cyclic compound biosynthetic process GO:1901362 223 0.185
Zebrafish Mouse
hemopoiesis GO:0030097 183 0.185
response to wounding GO:0009611 116 0.182
Zebrafish
regulation of signal transduction GO:0009966 225 0.180
regulation of primary metabolic process GO:0080090 311 0.179
Zebrafish Mouse
neuron projection morphogenesis GO:0048812 161 0.176
Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.174
Zebrafish Mouse
cell motility GO:0048870 244 0.173
phosphorylation GO:0016310 69 0.168
stem cell differentiation GO:0048863 117 0.167
generation of neurons GO:0048699 385 0.166
Zebrafish Fly
cellular component assembly GO:0022607 170 0.161
regulation of macromolecule metabolic process GO:0060255 317 0.157
Zebrafish Mouse
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.157
Zebrafish Mouse
macromolecule biosynthetic process GO:0009059 227 0.146
Zebrafish Mouse
heterocycle biosynthetic process GO:0018130 215 0.144
Zebrafish Mouse
gene expression GO:0010467 252 0.141
Zebrafish Mouse
negative regulation of response to stimulus GO:0048585 104 0.140
biosynthetic process GO:0009058 294 0.137
Zebrafish Mouse
regulation of establishment of protein localization GO:0070201 4 0.135
aromatic compound biosynthetic process GO:0019438 217 0.134
Zebrafish Mouse
regulation of nucleic acid templated transcription GO:1903506 213 0.134
Zebrafish Mouse
phagocytosis GO:0006909 3 0.133
nucleic acid templated transcription GO:0097659 181 0.133
Zebrafish Mouse
regulation of developmental process GO:0050793 247 0.130
Zebrafish
embryo development ending in birth or egg hatching GO:0009792 271 0.128
cellular macromolecule metabolic process GO:0044260 391 0.128
Zebrafish Mouse
positive regulation of cell communication GO:0010647 56 0.127
blood vessel development GO:0001568 246 0.125
intracellular signal transduction GO:0035556 85 0.125
brain development GO:0007420 293 0.123
Zebrafish
regulation of biological quality GO:0065008 263 0.121
positive regulation of signaling GO:0023056 56 0.120
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.119
Zebrafish Mouse
transcription dna templated GO:0006351 181 0.118
Zebrafish Mouse
striated muscle cell differentiation GO:0051146 129 0.118
Zebrafish Fly
regulation of biosynthetic process GO:0009889 250 0.115
Zebrafish Mouse
cellular biosynthetic process GO:0044249 286 0.113
Zebrafish Mouse
regulation of response to stimulus GO:0048583 269 0.112
hematopoietic or lymphoid organ development GO:0048534 191 0.112
enzyme linked receptor protein signaling pathway GO:0007167 106 0.111
positive regulation of response to stimulus GO:0048584 80 0.111
positive regulation of transport GO:0051050 2 0.110
cognition GO:0050890 1 0.110
locomotion GO:0040011 313 0.109
regulation of molecular function GO:0065009 70 0.109
regulation of rna metabolic process GO:0051252 224 0.108
Zebrafish Mouse
cellular aromatic compound metabolic process GO:0006725 295 0.106
Zebrafish Mouse
cellular macromolecule biosynthetic process GO:0034645 224 0.106
Zebrafish Mouse
regulation of nervous system development GO:0051960 90 0.105
Zebrafish
cellular nitrogen compound metabolic process GO:0034641 290 0.105
Zebrafish Mouse
cellular localization GO:0051641 97 0.105
regulation of cell differentiation GO:0045595 142 0.104
Zebrafish
regulation of multicellular organismal process GO:0051239 277 0.103
Zebrafish
stem cell proliferation GO:0072089 4 0.103
cell surface receptor signaling pathway GO:0007166 325 0.101
protein phosphorylation GO:0006468 47 0.091
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.090
axonogenesis GO:0007409 152 0.087
negative regulation of protein phosphorylation GO:0001933 4 0.087
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.087
Mouse
digestive tract morphogenesis GO:0048546 231 0.087
Worm
heart development GO:0007507 313 0.083
transcription from rna polymerase ii promoter GO:0006366 80 0.082
Zebrafish
wnt signaling pathway GO:0016055 80 0.082
regulation of cellular component size GO:0032535 30 0.082
head development GO:0060322 303 0.082
Zebrafish
autophagy GO:0006914 4 0.079
regulation of gene expression GO:0010468 265 0.079
Zebrafish Mouse
dorsal ventral pattern formation GO:0009953 125 0.078
developmental growth GO:0048589 166 0.077
Zebrafish
positive regulation of cellular component biogenesis GO:0044089 3 0.077
aging GO:0007568 2 0.076
cell projection morphogenesis GO:0048858 244 0.076
Fly
positive regulation of cellular biosynthetic process GO:0031328 68 0.075
response to lipid GO:0033993 60 0.074
positive regulation of metabolic process GO:0009893 108 0.074
taxis GO:0042330 109 0.074
phosphorus metabolic process GO:0006793 109 0.074
response to stress GO:0006950 263 0.073
Zebrafish
regulation of stem cell differentiation GO:2000736 4 0.073
positive regulation of catabolic process GO:0009896 4 0.073
peptidyl serine phosphorylation GO:0018105 1 0.072
determination of left right symmetry GO:0007368 179 0.071
stem cell maintenance GO:0019827 4 0.071
hormone transport GO:0009914 2 0.071
regulation of cell proliferation GO:0042127 37 0.070
Zebrafish Mouse
establishment of localization in cell GO:0051649 77 0.070
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.068
regulation of metabolic process GO:0019222 359 0.068
Zebrafish Mouse
nucleobase containing compound biosynthetic process GO:0034654 205 0.067
Zebrafish Mouse
protein metabolic process GO:0019538 183 0.067
nucleobase containing compound metabolic process GO:0006139 274 0.066
Zebrafish Mouse
carboxylic acid metabolic process GO:0019752 22 0.066
guanosine containing compound catabolic process GO:1901069 2 0.066
negative regulation of signaling GO:0023057 96 0.066
regulation of neurogenesis GO:0050767 87 0.066
Zebrafish
muscle structure development GO:0061061 196 0.065
Zebrafish Fly
cellular response to chemical stimulus GO:0070887 157 0.064
regulation of multicellular organism growth GO:0040014 4 0.064
morphogenesis of an epithelium GO:0002009 333 0.064
retina development in camera type eye GO:0060041 146 0.063
regulation of cellular metabolic process GO:0031323 320 0.063
Zebrafish Mouse
single organism transport GO:0044765 206 0.061
positive regulation of macromolecule metabolic process GO:0010604 93 0.061
regulation of cytokine production GO:0001817 3 0.061
organic substance biosynthetic process GO:1901576 289 0.061
Zebrafish Mouse
negative regulation of cellular process GO:0048523 283 0.060
Mouse
regulation of rna biosynthetic process GO:2001141 213 0.060
Zebrafish Mouse
single organism localization GO:1902578 225 0.060
regulation of transcription dna templated GO:0006355 213 0.060
Zebrafish Mouse
rna metabolic process GO:0016070 219 0.060
Zebrafish Mouse
multicellular organism reproduction GO:0032504 35 0.060
Mouse
embryonic organ development GO:0048568 381 0.059
Zebrafish
muscle cell differentiation GO:0042692 139 0.059
Zebrafish Fly
nucleic acid metabolic process GO:0090304 244 0.058
Zebrafish Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.058
Zebrafish
heterocycle metabolic process GO:0046483 290 0.057
Zebrafish Mouse
negative regulation of metabolic process GO:0009892 86 0.057
Mouse
cell morphogenesis GO:0000902 289 0.057
Fly
neuron projection development GO:0031175 180 0.057
Fly
guanosine containing compound metabolic process GO:1901068 4 0.057
cellular nitrogen compound biosynthetic process GO:0044271 218 0.057
Zebrafish Mouse
embryonic organ morphogenesis GO:0048562 274 0.057
Zebrafish
regulation of oocyte development GO:0060281 3 0.056
endocytosis GO:0006897 16 0.056
gastrulation with mouth forming second GO:0001702 44 0.056
immune response GO:0006955 28 0.056
cell projection organization GO:0030030 284 0.055
Fly
cellular component biogenesis GO:0044085 178 0.055
embryonic skeletal system development GO:0048706 97 0.054
transport GO:0006810 220 0.054
axon development GO:0061564 166 0.054
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.053
Mouse
protein modification process GO:0036211 100 0.053
cell migration involved in gastrulation GO:0042074 79 0.053
camera type eye development GO:0043010 222 0.053
Zebrafish Mouse
regulation of cellular amino acid metabolic process GO:0006521 0 0.051
peptidyl serine modification GO:0018209 2 0.051
response to external stimulus GO:0009605 264 0.050
regulation of cell death GO:0010941 103 0.050
cellular response to organic substance GO:0071310 105 0.049
regulation of cell shape GO:0008360 1 0.048
stem cell development GO:0048864 82 0.048
homeostatic process GO:0042592 142 0.048
regulation of cell development GO:0060284 100 0.048
Zebrafish
phosphate containing compound metabolic process GO:0006796 108 0.047
convergent extension GO:0060026 118 0.047
regulation of localization GO:0032879 104 0.047
regulation of phosphorus metabolic process GO:0051174 43 0.047
regulation of cell projection organization GO:0031344 44 0.047
gastrulation GO:0007369 208 0.047
Worm
melanin metabolic process GO:0006582 2 0.046
angiogenesis GO:0001525 158 0.046
cell cell signaling GO:0007267 52 0.045
ras protein signal transduction GO:0007265 7 0.045
morphogenesis of an epithelial sheet GO:0002011 49 0.045
neuron projection guidance GO:0097485 86 0.044
protein localization to nucleus GO:0034504 3 0.044
cellular protein modification process GO:0006464 100 0.044
negative regulation of cell communication GO:0010648 96 0.043
rna biosynthetic process GO:0032774 181 0.043
Zebrafish Mouse
endoderm development GO:0007492 49 0.043
small gtpase mediated signal transduction GO:0007264 8 0.043
embryonic limb morphogenesis GO:0030326 2 0.043
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.043
cellular component morphogenesis GO:0032989 336 0.043
Fly
positive regulation of cellular catabolic process GO:0031331 3 0.043
determination of bilateral symmetry GO:0009855 204 0.042
chemotaxis GO:0006935 104 0.042
cellular response to molecule of bacterial origin GO:0071219 3 0.042
regulation of reproductive process GO:2000241 4 0.041
gtp catabolic process GO:0006184 2 0.041
immune system development GO:0002520 191 0.041
regulation of gtp catabolic process GO:0033124 2 0.041
response to organic cyclic compound GO:0014070 51 0.040
blood circulation GO:0008015 87 0.040
cell part morphogenesis GO:0032990 246 0.040
Fly
tube morphogenesis GO:0035239 349 0.040
Worm
growth GO:0040007 174 0.039
Zebrafish
response to carbohydrate GO:0009743 3 0.039
negative regulation of secretion GO:0051048 2 0.039
negative regulation of biological process GO:0048519 304 0.038
Mouse
epiboly GO:0090504 41 0.038
oxoacid metabolic process GO:0043436 31 0.038
myotube differentiation GO:0014902 45 0.038
Zebrafish Fly
somitogenesis GO:0001756 87 0.038
action potential GO:0001508 19 0.038
membrane invagination GO:0010324 1 0.038
cardiac cell fate commitment GO:0060911 1 0.038
exocytosis GO:0006887 1 0.038
protein localization GO:0008104 40 0.037
protein secretion GO:0009306 1 0.037
small molecule metabolic process GO:0044281 77 0.037
negative regulation of rna metabolic process GO:0051253 48 0.037
Mouse
cation transport GO:0006812 81 0.037
macromolecule modification GO:0043412 111 0.037
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 11 0.036
axon guidance GO:0007411 86 0.036
determination of heart left right asymmetry GO:0061371 117 0.036
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.036
single organism organelle organization GO:1902589 199 0.036
mesoderm development GO:0007498 88 0.036
Worm Fly
regulation of embryonic development GO:0045995 47 0.036
response to organic substance GO:0010033 153 0.035
regulation of meiotic cell cycle GO:0051445 1 0.035
embryonic pattern specification GO:0009880 44 0.035
positive regulation of rna biosynthetic process GO:1902680 57 0.035
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.034
Mouse
hepaticobiliary system development GO:0061008 98 0.034
epithelial tube morphogenesis GO:0060562 148 0.034
lipid storage GO:0019915 1 0.034
regulation of macromolecule biosynthetic process GO:0010556 225 0.034
Zebrafish Mouse
organic acid metabolic process GO:0006082 31 0.034
positive regulation of transcription dna templated GO:0045893 57 0.033
positive regulation of map kinase activity GO:0043406 3 0.033
axon extension GO:0048675 45 0.033
cellular amine metabolic process GO:0044106 2 0.033
regulation of protein transport GO:0051223 3 0.033
sensory organ morphogenesis GO:0090596 200 0.033
Zebrafish
wound healing GO:0042060 90 0.033
Zebrafish
cell death GO:0008219 121 0.033
Worm
cellular amino acid metabolic process GO:0006520 7 0.032
regeneration GO:0031099 91 0.032
Zebrafish
striated muscle cell development GO:0055002 108 0.032
Zebrafish
skeletal system development GO:0001501 181 0.032
regulation of intracellular signal transduction GO:1902531 57 0.031
macromolecule localization GO:0033036 54 0.031
biological adhesion GO:0022610 40 0.031
metal ion transport GO:0030001 58 0.031
positive regulation of multicellular organismal process GO:0051240 52 0.031
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.031
bmp signaling pathway GO:0030509 52 0.030
embryonic skeletal system morphogenesis GO:0048704 93 0.030
regulation of locomotion GO:0040012 55 0.030
neuron differentiation GO:0030182 353 0.030
Zebrafish Fly
post embryonic morphogenesis GO:0009886 4 0.030
heart contraction GO:0060047 71 0.030
cellular response to nutrient levels GO:0031669 2 0.029
sexual reproduction GO:0019953 36 0.029
Mouse
positive regulation of gene expression GO:0010628 71 0.029
regulation of blood circulation GO:1903522 32 0.029
cellular response to biotic stimulus GO:0071216 3 0.029
embryonic heart tube development GO:0035050 133 0.029
cellular response to external stimulus GO:0071496 2 0.029
positive regulation of molecular function GO:0044093 33 0.028
positive regulation of nucleic acid templated transcription GO:1903508 57 0.028
cellular ketone metabolic process GO:0042180 11 0.028
negative regulation of cellular biosynthetic process GO:0031327 55 0.028
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.028
system process GO:0003008 185 0.028
extrinsic apoptotic signaling pathway GO:0097191 3 0.027
ion transport GO:0006811 114 0.027
programmed cell death GO:0012501 119 0.027
Worm
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.027
regulation of neuron projection development GO:0010975 40 0.027
homeostasis of number of cells GO:0048872 62 0.027
circulatory system process GO:0003013 87 0.027
myeloid cell homeostasis GO:0002262 56 0.027
determination of dorsal ventral asymmetry GO:0048262 34 0.026
gtp metabolic process GO:0046039 4 0.026
modification dependent macromolecule catabolic process GO:0043632 3 0.026
gland development GO:0048732 143 0.026
Zebrafish
gamete generation GO:0007276 33 0.026
Mouse
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 15 0.026
cellular carbohydrate metabolic process GO:0044262 4 0.026
anterior posterior pattern specification GO:0009952 152 0.026
skeletal system morphogenesis GO:0048705 102 0.026
internal protein amino acid acetylation GO:0006475 2 0.026
positive regulation of developmental process GO:0051094 50 0.025
regulation of phosphate metabolic process GO:0019220 43 0.025
myeloid cell differentiation GO:0030099 86 0.025
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.025
cellular response to lipid GO:0071396 39 0.025
multicellular organism growth GO:0035264 4 0.025
protein import into nucleus GO:0006606 3 0.025
heart looping GO:0001947 94 0.025
regulation of cell motility GO:2000145 46 0.025
regulation of cell morphogenesis GO:0022604 42 0.025
phagocytosis engulfment GO:0006911 1 0.024
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.024
regulation of protein metabolic process GO:0051246 56 0.024
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.024
negative regulation of macromolecule metabolic process GO:0010605 76 0.024
Mouse
response to oxygen containing compound GO:1901700 55 0.024
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.024
organic substance transport GO:0071702 58 0.024
negative regulation of developmental process GO:0051093 65 0.024
single organism membrane fusion GO:0044801 2 0.024
response to bacterium GO:0009617 58 0.024
eye development GO:0001654 277 0.024
Zebrafish Mouse
regulation of inflammatory response GO:0050727 2 0.023
regulation of axon extension GO:0030516 24 0.023
embryonic eye morphogenesis GO:0048048 30 0.023
Zebrafish
single organism nuclear import GO:1902593 3 0.023
response to endogenous stimulus GO:0009719 83 0.023
regulation of metal ion transport GO:0010959 4 0.023
fin regeneration GO:0031101 51 0.023
cytoskeleton organization GO:0007010 96 0.023
bmp signaling pathway involved in heart development GO:0061312 15 0.023
cartilage development GO:0051216 96 0.023
actin filament bundle assembly GO:0051017 6 0.023
cellular response to oxygen levels GO:0071453 1 0.023
negative regulation of rna biosynthetic process GO:1902679 45 0.023
Mouse
neuroblast proliferation GO:0007405 2 0.023
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 17 0.023
embryonic cranial skeleton morphogenesis GO:0048701 90 0.023
hindbrain development GO:0030902 91 0.023
regulation of autophagy GO:0010506 3 0.022
neuron development GO:0048666 262 0.022
Zebrafish Fly
muscle tissue development GO:0060537 110 0.022
Zebrafish
muscle cell development GO:0055001 115 0.022
Zebrafish
regulation of receptor activity GO:0010469 2 0.022
regulation of cell size GO:0008361 29 0.022
apoptotic process GO:0006915 116 0.022
Worm
positive regulation of reproductive process GO:2000243 2 0.022
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.022
positive regulation of phosphorus metabolic process GO:0010562 21 0.021
cell growth GO:0016049 57 0.021
regulation of ion transmembrane transporter activity GO:0032412 2 0.021
regulation of catalytic activity GO:0050790 55 0.021
regulation of protein modification process GO:0031399 29 0.021
regulation of cellular component movement GO:0051270 55 0.021
negative regulation of ras protein signal transduction GO:0046580 1 0.020
organelle localization GO:0051640 49 0.020
regulation of membrane potential GO:0042391 23 0.020
negative regulation of biosynthetic process GO:0009890 55 0.020
Mouse
connective tissue development GO:0061448 99 0.020
Fly
response to external biotic stimulus GO:0043207 97 0.020
maintenance of location GO:0051235 4 0.020
negative regulation of phosphate metabolic process GO:0045936 13 0.020
negative regulation of cellular metabolic process GO:0031324 77 0.020
Mouse
regulation of protein complex assembly GO:0043254 3 0.020
regulation of axonogenesis GO:0050770 32 0.020
cellular protein metabolic process GO:0044267 129 0.020
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.020
regulation of cell migration GO:0030334 40 0.020
response to hexose GO:0009746 3 0.020
negative regulation of kinase activity GO:0033673 4 0.020
protein complex assembly GO:0006461 30 0.020
ear morphogenesis GO:0042471 64 0.019
cellular response to retinoic acid GO:0071300 1 0.019
epidermis development GO:0008544 48 0.019
nucleocytoplasmic transport GO:0006913 4 0.019
regulation of transporter activity GO:0032409 2 0.019
muscle fiber development GO:0048747 52 0.019
Zebrafish
regulation of anatomical structure size GO:0090066 33 0.019
erk1 and erk2 cascade GO:0070371 4 0.019
lymphocyte proliferation GO:0046651 1 0.019
regulation of protein localization to nucleus GO:1900180 2 0.019
ubiquitin dependent protein catabolic process GO:0006511 3 0.019
regulation of nucleoside metabolic process GO:0009118 2 0.019
regulation of cell activation GO:0050865 1 0.018
response to alkaloid GO:0043279 2 0.018
regulation of nucleotide catabolic process GO:0030811 2 0.018
regulation of exocytosis GO:0017157 1 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.018
regulation of system process GO:0044057 40 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.018
negative regulation of reproductive process GO:2000242 3 0.018
oogenesis GO:0048477 14 0.018
neuron projection extension GO:1990138 45 0.018
apoptotic process involved in morphogenesis GO:0060561 2 0.018
response to decreased oxygen levels GO:0036293 25 0.018
muscle organ development GO:0007517 101 0.018
Zebrafish
regionalization GO:0003002 274 0.018
striated muscle tissue development GO:0014706 110 0.018
Zebrafish
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.018
positive regulation of cellular component movement GO:0051272 11 0.018
peptidyl lysine acetylation GO:0018394 2 0.018
regulation of transport GO:0051049 45 0.018
response to glucose GO:0009749 3 0.018
endodermal cell fate determination GO:0007493 2 0.018
regulation of gtpase activity GO:0043087 2 0.018
post embryonic organ development GO:0048569 4 0.018
locomotor rhythm GO:0045475 3 0.018
single organism cellular localization GO:1902580 46 0.017
cellular response to lipopolysaccharide GO:0071222 3 0.017
response to abiotic stimulus GO:0009628 122 0.017
embryonic heart tube morphogenesis GO:0003143 108 0.017
regulation of phospholipase c activity GO:1900274 1 0.017
skeletal muscle tissue development GO:0007519 67 0.017
Zebrafish
regulation of protein phosphorylation GO:0001932 18 0.017
regulation of cell cycle GO:0051726 52 0.017
organonitrogen compound metabolic process GO:1901564 74 0.017
regulation of erk1 and erk2 cascade GO:0070372 4 0.017
positive regulation of immune system process GO:0002684 17 0.017
hormone secretion GO:0046879 2 0.017
neurological system process GO:0050877 62 0.017
convergent extension involved in gastrulation GO:0060027 71 0.017
regulation of sodium ion transport GO:0002028 2 0.017
regulation of neural precursor cell proliferation GO:2000177 3 0.017
ear development GO:0043583 127 0.017
Zebrafish
internal peptidyl lysine acetylation GO:0018393 2 0.017
negative regulation of wnt signaling pathway GO:0030178 30 0.017
nuclear import GO:0051170 3 0.016
regulation of cellular protein metabolic process GO:0032268 52 0.016
mesenchymal cell differentiation GO:0048762 87 0.016
somatic stem cell maintenance GO:0035019 1 0.016
cellular response to endogenous stimulus GO:0071495 68 0.016
positive regulation of rna metabolic process GO:0051254 59 0.016
regulation of anatomical structure morphogenesis GO:0022603 130 0.016
erythrocyte homeostasis GO:0034101 55 0.016
single organismal cell cell adhesion GO:0016337 29 0.016
liver development GO:0001889 96 0.016
cell substrate adhesion GO:0031589 4 0.016
positive regulation of protein metabolic process GO:0051247 23 0.016
regulation of bmp signaling pathway GO:0030510 39 0.016
negative regulation of cell proliferation GO:0008285 8 0.016
Mouse
collagen metabolic process GO:0032963 2 0.016
ion transmembrane transport GO:0034220 91 0.016
extracellular structure organization GO:0043062 27 0.016
microtubule cytoskeleton organization GO:0000226 33 0.016
negative regulation of protein kinase activity GO:0006469 4 0.016
positive regulation of apoptotic signaling pathway GO:2001235 1 0.016
regulation of cytoplasmic transport GO:1903649 4 0.016
compound eye development GO:0048749 2 0.015
regulation of phosphorylation GO:0042325 26 0.015
protein acylation GO:0043543 3 0.015
regulation of response to external stimulus GO:0032101 31 0.015
protein acetylation GO:0006473 2 0.015
positive regulation of locomotion GO:0040017 14 0.015
actin filament based process GO:0030029 64 0.015
thrombocyte differentiation GO:0002574 4 0.015
regulation of stem cell proliferation GO:0072091 2 0.015
regulation of reactive oxygen species metabolic process GO:2000377 2 0.015
neuromuscular synaptic transmission GO:0007274 2 0.015
regulation of cellular amine metabolic process GO:0033238 0 0.015
canonical wnt signaling pathway GO:0060070 48 0.015
cellular response to growth factor stimulus GO:0071363 39 0.015
nucleoside phosphate metabolic process GO:0006753 28 0.015
single organism metabolic process GO:0044710 217 0.015
positive regulation of protein complex assembly GO:0031334 2 0.015
negative regulation of nucleic acid templated transcription GO:1903507 45 0.015
Mouse
positive regulation of secretion GO:0051047 1 0.015
respiratory system development GO:0060541 5 0.015
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.014
regulation of binding GO:0051098 3 0.014
cell morphogenesis involved in differentiation GO:0000904 195 0.014
apoptotic process involved in development GO:1902742 2 0.014
embryonic skeletal joint development GO:0072498 3 0.014
female sex differentiation GO:0046660 4 0.014
regulation of jak stat cascade GO:0046425 3 0.014
reactive oxygen species metabolic process GO:0072593 6 0.014
protein targeting to nucleus GO:0044744 3 0.014
mononuclear cell proliferation GO:0032943 1 0.014
primary neural tube formation GO:0014020 1 0.014
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.014
regulation of receptor mediated endocytosis GO:0048259 4 0.013
regulation of behavior GO:0050795 24 0.013
leukocyte proliferation GO:0070661 1 0.013
regulation of transmembrane transport GO:0034762 18 0.013
dna templated transcription initiation GO:0006352 1 0.013
alpha amino acid metabolic process GO:1901605 3 0.013
nuclear transport GO:0051169 4 0.013
epidermal cell differentiation GO:0009913 36 0.013
appendage development GO:0048736 80 0.013
negative regulation of cytokine production GO:0001818 1 0.013
cellular response to starvation GO:0009267 1 0.013
renal system development GO:0072001 94 0.013
Zebrafish

six4.3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.183
bone development disease DOID:0080006 0 0.041
bone disease DOID:0080001 0 0.041
musculoskeletal system disease DOID:17 0 0.041
connective tissue disease DOID:65 0 0.041
cardiovascular system disease DOID:1287 0 0.023
immune system disease DOID:2914 0 0.014
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013