Danio rerio

0 known processes

lin54

lin-54 homolog

(Aliases: MGC152921,zgc:152921)

lin54 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular aromatic compound metabolic process GO:0006725 295 0.155
Fly
regulation of biosynthetic process GO:0009889 250 0.128
Fly
regulation of cellular biosynthetic process GO:0031326 245 0.128
Fly
regulation of primary metabolic process GO:0080090 311 0.119
Fly
aging GO:0007568 2 0.116
Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.110
Fly
nitrogen compound metabolic process GO:0006807 319 0.106
Fly
heterocycle biosynthetic process GO:0018130 215 0.104
Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.099
Fly
embryo development ending in birth or egg hatching GO:0009792 271 0.095
regulation of transcription dna templated GO:0006355 213 0.095
Fly
multicellular organism growth GO:0035264 4 0.094
cellular macromolecule biosynthetic process GO:0034645 224 0.093
Fly
cellular macromolecule metabolic process GO:0044260 391 0.090
Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.090
Fly
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.089
Fly
heterocycle metabolic process GO:0046483 290 0.086
Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.083
Fly
rna metabolic process GO:0016070 219 0.082
Fly
gene expression GO:0010467 252 0.081
Fly
positive regulation of cell cycle GO:0045787 3 0.080
regulation of biological quality GO:0065008 263 0.078
regulation of metabolic process GO:0019222 359 0.076
Fly
larval development GO:0002164 2 0.072
cellular nitrogen compound metabolic process GO:0034641 290 0.070
Fly
regulation of cellular metabolic process GO:0031323 320 0.069
Fly
organic cyclic compound metabolic process GO:1901360 301 0.069
Fly
internal peptidyl lysine acetylation GO:0018393 2 0.068
regulation of gene expression GO:0010468 265 0.067
Fly
meiotic nuclear division GO:0007126 4 0.066
regulation of rna biosynthetic process GO:2001141 213 0.065
Fly
tube morphogenesis GO:0035239 349 0.064
macromolecule biosynthetic process GO:0009059 227 0.062
Fly
cellular biosynthetic process GO:0044249 286 0.057
Fly
nucleic acid templated transcription GO:0097659 181 0.055
Fly
modification dependent protein catabolic process GO:0019941 3 0.054
nucleic acid metabolic process GO:0090304 244 0.054
Fly
single organism metabolic process GO:0044710 217 0.053
gastrulation GO:0007369 208 0.052
protein acetylation GO:0006473 2 0.049
neuron differentiation GO:0030182 353 0.049
transcription dna templated GO:0006351 181 0.048
Fly
regulation of macromolecule metabolic process GO:0060255 317 0.048
Fly
rna localization GO:0006403 4 0.047
aromatic compound biosynthetic process GO:0019438 217 0.045
Fly
cell part morphogenesis GO:0032990 246 0.044
positive regulation of cellular process GO:0048522 201 0.044
locomotion GO:0040011 313 0.044
Fly
protein acylation GO:0043543 3 0.043
establishment of protein localization to organelle GO:0072594 4 0.042
digestive tract morphogenesis GO:0048546 231 0.040
positive regulation of transport GO:0051050 2 0.040
regulation of macromolecule biosynthetic process GO:0010556 225 0.040
Fly
cell morphogenesis GO:0000902 289 0.040
regulation of intracellular protein transport GO:0033157 3 0.040
regulation of rna metabolic process GO:0051252 224 0.039
Fly
regulation of protein complex assembly GO:0043254 3 0.039
internal protein amino acid acetylation GO:0006475 2 0.039
organic substance biosynthetic process GO:1901576 289 0.038
Fly
organelle organization GO:0006996 227 0.038
nucleocytoplasmic transport GO:0006913 4 0.037
stem cell maintenance GO:0019827 4 0.037
maintenance of location GO:0051235 4 0.037
cellular response to extracellular stimulus GO:0031668 2 0.037
cell projection organization GO:0030030 284 0.036
single organism nuclear import GO:1902593 3 0.036
positive regulation of cellular component biogenesis GO:0044089 3 0.036
development of primary female sexual characteristics GO:0046545 4 0.035
peptidyl lysine acetylation GO:0018394 2 0.035
protein targeting to nucleus GO:0044744 3 0.035
nuclear import GO:0051170 3 0.035
meiotic cell cycle process GO:1903046 3 0.035
transcription from rna polymerase ii promoter GO:0006366 80 0.035
Fly
histone h3 k4 methylation GO:0051568 2 0.034
negative regulation of catabolic process GO:0009895 3 0.034
regulation of cytoplasmic transport GO:1903649 4 0.034
nucleobase containing compound metabolic process GO:0006139 274 0.034
Fly
positive regulation of cellular metabolic process GO:0031325 94 0.034
protein localization to nucleus GO:0034504 3 0.034
regulation of establishment of protein localization GO:0070201 4 0.033
regionalization GO:0003002 274 0.033
positive regulation of cell activation GO:0050867 1 0.033
nuclear transport GO:0051169 4 0.032
female gonad development GO:0008585 4 0.032
regulation of dna recombination GO:0000018 2 0.032
cellular component assembly GO:0022607 170 0.032
regulation of multicellular organism growth GO:0040014 4 0.031
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.031
meiotic chromosome segregation GO:0045132 3 0.030
positive regulation of biological process GO:0048518 253 0.030
dna templated transcription elongation GO:0006354 3 0.030
regulation of cell activation GO:0050865 1 0.030
modification dependent macromolecule catabolic process GO:0043632 3 0.030
chordate embryonic development GO:0043009 271 0.030
regulation of protein localization to nucleus GO:1900180 2 0.029
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.029
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.029
regulation of protein transport GO:0051223 3 0.029
anterior posterior pattern specification GO:0009952 152 0.029
regulation of dna templated transcription elongation GO:0032784 3 0.029
g1 s transition of mitotic cell cycle GO:0000082 1 0.029
cellular response to starvation GO:0009267 1 0.029
negative regulation of cellular catabolic process GO:0031330 3 0.029
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.028
Fly
cellular amine metabolic process GO:0044106 2 0.028
cellular ketone metabolic process GO:0042180 11 0.028
chromosome organization GO:0051276 31 0.027
cell cycle process GO:0022402 53 0.027
organonitrogen compound metabolic process GO:1901564 74 0.027
dorsal ventral pattern formation GO:0009953 125 0.027
double strand break repair GO:0006302 3 0.027
cell migration GO:0016477 237 0.027
cellular protein metabolic process GO:0044267 129 0.026
ubiquitin dependent protein catabolic process GO:0006511 3 0.026
protein heterooligomerization GO:0051291 1 0.026
regulation of cellular ketone metabolic process GO:0010565 7 0.026
establishment of localization GO:0051234 244 0.026
peptidyl serine modification GO:0018209 2 0.026
amine metabolic process GO:0009308 2 0.026
autophagy GO:0006914 4 0.026
spermatid development GO:0007286 2 0.026
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.026
positive regulation of rna metabolic process GO:0051254 59 0.026
positive regulation of gene expression GO:0010628 71 0.026
response to external stimulus GO:0009605 264 0.025
cell motility GO:0048870 244 0.025
Fly
cell morphogenesis involved in differentiation GO:0000904 195 0.025
regulation of protein targeting GO:1903533 2 0.025
regulation of stem cell differentiation GO:2000736 4 0.025
cellular response to nutrient levels GO:0031669 2 0.025
regulation of cellular amino acid metabolic process GO:0006521 0 0.024
biosynthetic process GO:0009058 294 0.024
Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.024
Fly
macromolecular complex assembly GO:0065003 35 0.024
protein import into nucleus GO:0006606 3 0.024
cell cycle g1 s phase transition GO:0044843 1 0.024
embryonic organ morphogenesis GO:0048562 274 0.024
phagocytosis GO:0006909 3 0.023
regulation of multicellular organismal process GO:0051239 277 0.023
positive regulation of transcription dna templated GO:0045893 57 0.023
cell proliferation GO:0008283 80 0.023
digestive tract development GO:0048565 265 0.023
positive regulation of immune effector process GO:0002699 3 0.023
b cell mediated immunity GO:0019724 3 0.023
regulation of organelle assembly GO:1902115 4 0.023
cellular component morphogenesis GO:0032989 336 0.023
regulation of binding GO:0051098 3 0.023
cell substrate adhesion GO:0031589 4 0.023
immune system development GO:0002520 191 0.022
regulation of protein catabolic process GO:0042176 1 0.022
cell projection morphogenesis GO:0048858 244 0.022
somatic muscle development GO:0007525 4 0.022
exocytosis GO:0006887 1 0.022
axis specification GO:0009798 43 0.022
cellular response to external stimulus GO:0071496 2 0.022
hematopoietic or lymphoid organ development GO:0048534 191 0.022
gtp metabolic process GO:0046039 4 0.022
positive regulation of catabolic process GO:0009896 4 0.022
guanosine containing compound catabolic process GO:1901069 2 0.021
carboxylic acid metabolic process GO:0019752 22 0.021
lipid storage GO:0019915 1 0.021
primary neural tube formation GO:0014020 1 0.021
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.021
macromolecular complex subunit organization GO:0043933 74 0.021
small molecule metabolic process GO:0044281 77 0.021
regulation of protein import into nucleus GO:0042306 2 0.021
somatic stem cell maintenance GO:0035019 1 0.021
positive regulation of macromolecule metabolic process GO:0010604 93 0.021
rna transport GO:0050658 2 0.021
vasculature development GO:0001944 278 0.021
positive regulation of secretion by cell GO:1903532 1 0.020
axon development GO:0061564 166 0.020
female sex differentiation GO:0046660 4 0.020
axonogenesis GO:0007409 152 0.020
microtubule organizing center organization GO:0031023 1 0.020
b cell activation GO:0042113 2 0.020
localization of cell GO:0051674 244 0.020
Fly
blood vessel morphogenesis GO:0048514 216 0.020
negative regulation of protein phosphorylation GO:0001933 4 0.020
protein metabolic process GO:0019538 183 0.020
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.020
rna biosynthetic process GO:0032774 181 0.019
Fly
cell cycle GO:0007049 93 0.019
tube closure GO:0060606 1 0.019
leukocyte proliferation GO:0070661 1 0.019
cellular protein catabolic process GO:0044257 4 0.019
positive regulation of nucleic acid templated transcription GO:1903508 57 0.019
heart development GO:0007507 313 0.019
gtp catabolic process GO:0006184 2 0.019
regulation of meiotic cell cycle GO:0051445 1 0.019
negative regulation of biological process GO:0048519 304 0.019
Fly
peptidyl serine phosphorylation GO:0018105 1 0.018
generation of neurons GO:0048699 385 0.018
centrosome organization GO:0051297 1 0.018
somatic cell dna recombination GO:0016444 1 0.018
hemopoiesis GO:0030097 183 0.018
macroautophagy GO:0016236 1 0.018
cellular component movement GO:0006928 335 0.018
Fly
immune system process GO:0002376 241 0.018
immunoglobulin mediated immune response GO:0016064 3 0.018
regulation of cellular amine metabolic process GO:0033238 0 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.018
protein import GO:0017038 3 0.018
cellular component biogenesis GO:0044085 178 0.017
nucleic acid transport GO:0050657 2 0.017
guanosine containing compound metabolic process GO:1901068 4 0.017
single organism organelle organization GO:1902589 199 0.017
organic acid metabolic process GO:0006082 31 0.017
membrane fusion GO:0061025 2 0.017
ribonucleoside monophosphate catabolic process GO:0009158 4 0.017
protein complex localization GO:0031503 1 0.017
regulation of protein metabolic process GO:0051246 56 0.017
positive regulation of dna templated transcription elongation GO:0032786 1 0.017
regulation of cellular component organization GO:0051128 86 0.017
regulation of synapse assembly GO:0051963 3 0.017
cellular amino acid metabolic process GO:0006520 7 0.017
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.017
digestive system development GO:0055123 289 0.017
negative regulation of ras protein signal transduction GO:0046580 1 0.016
response to chemical GO:0042221 320 0.016
negative regulation of chromosome organization GO:2001251 1 0.016
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.016
axon guidance GO:0007411 86 0.016
proteasomal protein catabolic process GO:0010498 2 0.016
regulation of cell proliferation GO:0042127 37 0.016
regulation of cell substrate adhesion GO:0010810 1 0.016
eye development GO:0001654 277 0.016
positive regulation of cell adhesion GO:0045785 1 0.016
transport GO:0006810 220 0.016
regulation of response to nutrient levels GO:0032107 1 0.016
developmental growth GO:0048589 166 0.016
positive regulation of cellular catabolic process GO:0031331 3 0.016
positive regulation of exocytosis GO:0045921 1 0.016
regulation of production of molecular mediator of immune response GO:0002700 1 0.016
response to drug GO:0042493 3 0.016
homeostatic process GO:0042592 142 0.016
positive regulation of cytoskeleton organization GO:0051495 3 0.016
negative regulation of dna metabolic process GO:0051053 4 0.016
purine nucleoside monophosphate catabolic process GO:0009128 4 0.016
nucleoside monophosphate catabolic process GO:0009125 4 0.016
positive regulation of reproductive process GO:2000243 2 0.016
neuron development GO:0048666 262 0.016
negative regulation of cytokine production GO:0001818 1 0.016
signal transduction GO:0007165 455 0.016
multi organism process GO:0051704 134 0.016
Fly
i kappab kinase nf kappab signaling GO:0007249 4 0.015
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.015
regulation of response to extracellular stimulus GO:0032104 1 0.015
oxoacid metabolic process GO:0043436 31 0.015
determination of bilateral symmetry GO:0009855 204 0.015
regulation of organelle organization GO:0033043 29 0.015
cilium morphogenesis GO:0060271 85 0.015
taxis GO:0042330 109 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
nuclear export GO:0051168 1 0.015
response to carbohydrate GO:0009743 3 0.015
protein stabilization GO:0050821 2 0.015
photoreceptor cell fate commitment GO:0046552 1 0.015
positive regulation of metabolic process GO:0009893 108 0.015
neuron projection morphogenesis GO:0048812 161 0.015
positive regulation of secretion GO:0051047 1 0.015
mrna transport GO:0051028 2 0.015
embryonic digestive tract morphogenesis GO:0048557 3 0.015
cell matrix adhesion GO:0007160 4 0.015
negative regulation of gene expression GO:0010629 65 0.015
Fly
angiogenesis GO:0001525 158 0.015
response to uv GO:0009411 3 0.014
production of molecular mediator of immune response GO:0002440 2 0.014
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.014
establishment of rna localization GO:0051236 3 0.014
lymphocyte proliferation GO:0046651 1 0.014
chemotaxis GO:0006935 104 0.014
sleep GO:0030431 1 0.014
b cell differentiation GO:0030183 1 0.014
morphogenesis of an epithelium GO:0002009 333 0.014
regulation of dna replication GO:0006275 3 0.014
protein dephosphorylation GO:0006470 3 0.014
single organism membrane fusion GO:0044801 2 0.014
organelle assembly GO:0070925 110 0.014
cytokinesis GO:0000910 3 0.014
regulation of cellular protein catabolic process GO:1903362 1 0.014
determination of left right symmetry GO:0007368 179 0.014
negative regulation of mapk cascade GO:0043409 4 0.014
neuronal stem cell maintenance GO:0097150 2 0.014
positive regulation of notch signaling pathway GO:0045747 3 0.014
embryonic digestive tract development GO:0048566 4 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.014
Fly
regulation of nucleocytoplasmic transport GO:0046822 2 0.014
circadian sleep wake cycle GO:0042745 2 0.014
g2 m transition of mitotic cell cycle GO:0000086 4 0.013
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.013
regulation of cellular component size GO:0032535 30 0.013
stem cell proliferation GO:0072089 4 0.013
regulation of melanocyte differentiation GO:0045634 2 0.013
locomotor rhythm GO:0045475 3 0.013
regulation of cytokine production GO:0001817 3 0.013
atp catabolic process GO:0006200 4 0.013
negative regulation of epithelial cell proliferation GO:0050680 1 0.013
rna export from nucleus GO:0006405 1 0.013
immunoglobulin production GO:0002377 1 0.013
embryonic organ development GO:0048568 381 0.013
regulation of epithelial cell proliferation GO:0050678 3 0.013
regulation of cell cycle GO:0051726 52 0.013
regulation of nucleoside metabolic process GO:0009118 2 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.013
negative regulation of intracellular transport GO:0032387 3 0.013
peptide transport GO:0015833 1 0.013
oocyte anterior posterior axis specification GO:0007314 4 0.013
positive regulation of biosynthetic process GO:0009891 68 0.013
mononuclear cell proliferation GO:0032943 1 0.013
notch signaling pathway GO:0007219 35 0.013
protein modification process GO:0036211 100 0.013
sensory organ morphogenesis GO:0090596 200 0.013
sensory organ development GO:0007423 393 0.013
enzyme linked receptor protein signaling pathway GO:0007167 106 0.013
regulation of skeletal muscle fiber development GO:0048742 2 0.013
regulation of protein binding GO:0043393 3 0.012
negative regulation of metabolic process GO:0009892 86 0.012
Fly
interspecies interaction between organisms GO:0044419 4 0.012
ovulation cycle process GO:0022602 2 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
negative regulation of kinase activity GO:0033673 4 0.012
regulation of inflammatory response GO:0050727 2 0.012
regeneration GO:0031099 91 0.012
negative regulation of cytoplasmic transport GO:1903650 2 0.012
pharyngeal muscle development GO:0043282 4 0.012
epithelial cell differentiation GO:0030855 116 0.012
spermatid differentiation GO:0048515 2 0.012
ovulation cycle GO:0042698 2 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
response to glucose GO:0009749 3 0.012
neurotransmitter secretion GO:0007269 2 0.012
regulation of mrna splicing via spliceosome GO:0048024 3 0.012
regulation of response to stimulus GO:0048583 269 0.012
regulation of histone methylation GO:0031060 3 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.012
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.012
regulation of synapse organization GO:0050807 3 0.012
response to hexose GO:0009746 3 0.012
somite development GO:0061053 96 0.012
regulation of microtubule cytoskeleton organization GO:0070507 3 0.012
response to vitamin GO:0033273 3 0.012
female meiotic division GO:0007143 2 0.012
actin filament polymerization GO:0030041 2 0.012
regulation of cellular protein metabolic process GO:0032268 52 0.012
sexual reproduction GO:0019953 36 0.012
Fly
regulation of myotube differentiation GO:0010830 2 0.012
regulation of cell shape GO:0008360 1 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.012
circadian sleep wake cycle sleep GO:0050802 1 0.012
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
Fly
negative regulation of histone modification GO:0031057 1 0.012
specification of symmetry GO:0009799 204 0.012
cellular localization GO:0051641 97 0.011
ovarian follicle development GO:0001541 2 0.011
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
hematopoietic stem cell migration GO:0035701 4 0.011
positive regulation of dna metabolic process GO:0051054 1 0.011
regulation of chromosome segregation GO:0051983 1 0.011
negative regulation of cellular process GO:0048523 283 0.011
Fly
mrna export from nucleus GO:0006406 1 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.011
centrosome duplication GO:0051298 1 0.011
intracellular signal transduction GO:0035556 85 0.011
maternal determination of anterior posterior axis embryo GO:0008358 4 0.011
membrane invagination GO:0010324 1 0.011
protein polyubiquitination GO:0000209 4 0.011
cellular response to lipopolysaccharide GO:0071222 3 0.011
microtubule based process GO:0007017 60 0.011
positive regulation of cellular biosynthetic process GO:0031328 68 0.011
response to monosaccharide GO:0034284 3 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.011
negative regulation of protein localization to nucleus GO:1900181 2 0.011
transmission of nerve impulse GO:0019226 19 0.011
nucleobase containing compound transport GO:0015931 2 0.011
extrinsic apoptotic signaling pathway GO:0097191 3 0.011
positive regulation of rna biosynthetic process GO:1902680 57 0.011
neuron projection guidance GO:0097485 86 0.011
cellular protein modification process GO:0006464 100 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.011
negative regulation of rna metabolic process GO:0051253 48 0.011
Fly
growth GO:0040007 174 0.011
positive regulation of multi organism process GO:0043902 3 0.011
anterior posterior axis specification GO:0009948 20 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.011
Fly
cellular response to stress GO:0033554 62 0.011
muscle cell development GO:0055001 115 0.011
protein localization to plasma membrane GO:0072659 1 0.011
negative regulation of multi organism process GO:0043901 3 0.011
positive regulation of cytokine production GO:0001819 2 0.010
negative regulation of synapse assembly GO:0051964 2 0.010
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.010
cartilage development GO:0051216 96 0.010
system process GO:0003008 185 0.010
regulation of purine nucleotide catabolic process GO:0033121 2 0.010
negative regulation of biosynthetic process GO:0009890 55 0.010
Fly
regulation of neurotransmitter secretion GO:0046928 1 0.010
negative regulation of defense response GO:0031348 2 0.010
positive regulation of nucleotide catabolic process GO:0030813 1 0.010
cellular response to radiation GO:0071478 4 0.010
positive regulation of protein polymerization GO:0032273 2 0.010
positive regulation of apoptotic signaling pathway GO:2001235 1 0.010
determination of heart left right asymmetry GO:0061371 117 0.010
secondary metabolic process GO:0019748 3 0.010
positive regulation of neuron apoptotic process GO:0043525 1 0.010
stem cell division GO:0017145 1 0.010
meiosis i GO:0007127 1 0.010
stem cell differentiation GO:0048863 117 0.010
post embryonic organ development GO:0048569 4 0.010
regulation of cell size GO:0008361 29 0.010
negative regulation of muscle cell differentiation GO:0051148 1 0.010
negative regulation of stem cell differentiation GO:2000737 2 0.010

lin54 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
cancer DOID:162 0 0.024
disease of cellular proliferation DOID:14566 0 0.024
organ system cancer DOID:0050686 0 0.024
nervous system disease DOID:863 0 0.014
musculoskeletal system disease DOID:17 0 0.011
cardiovascular system disease DOID:1287 0 0.010