Danio rerio

11 known processes

rpgr

retinitis pigmentosa GTPase regulator protein 1

rpgr biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
signal transduction GO:0007165 455 0.237
single organism transport GO:0044765 206 0.197
sensory organ morphogenesis GO:0090596 200 0.158
embryonic organ morphogenesis GO:0048562 274 0.145
single organism localization GO:1902578 225 0.145
retina development in camera type eye GO:0060041 146 0.110
photoreceptor cell differentiation GO:0046530 55 0.107
neural retina development GO:0003407 49 0.107
positive regulation of transport GO:0051050 2 0.106
photoreceptor cell development GO:0042461 40 0.100
eye photoreceptor cell development GO:0042462 30 0.096
sensory organ development GO:0007423 393 0.095
determination of bilateral symmetry GO:0009855 204 0.087
cilium organization GO:0044782 71 0.087
camera type eye development GO:0043010 222 0.087
determination of left right symmetry GO:0007368 179 0.086
camera type eye morphogenesis GO:0048593 108 0.086
neuron differentiation GO:0030182 353 0.085
generation of neurons GO:0048699 385 0.084
eye photoreceptor cell differentiation GO:0001754 45 0.081
specification of symmetry GO:0009799 204 0.081
neuron projection development GO:0031175 180 0.080
establishment of localization GO:0051234 244 0.080
muscle cell differentiation GO:0042692 139 0.077
neurological system process GO:0050877 62 0.076
eye morphogenesis GO:0048592 144 0.076
retina layer formation GO:0010842 24 0.070
positive regulation of biological process GO:0048518 253 0.070
cilium movement GO:0003341 26 0.069
cell part morphogenesis GO:0032990 246 0.068
regulation of signaling GO:0023051 235 0.068
larval development GO:0002164 2 0.065
response to chemical GO:0042221 320 0.065
eye development GO:0001654 277 0.065
cytoskeleton dependent intracellular transport GO:0030705 10 0.062
maintenance of location GO:0051235 4 0.061
retina morphogenesis in camera type eye GO:0060042 79 0.059
visual perception GO:0007601 17 0.058
ubiquitin dependent protein catabolic process GO:0006511 3 0.056
negative regulation of protein kinase activity GO:0006469 4 0.055
nitrogen compound metabolic process GO:0006807 319 0.055
cell surface receptor signaling pathway GO:0007166 325 0.055
cellular biosynthetic process GO:0044249 286 0.055
lipid catabolic process GO:0016042 4 0.053
macromolecule biosynthetic process GO:0009059 227 0.052
synaptic growth at neuromuscular junction GO:0051124 2 0.052
cellular component movement GO:0006928 335 0.051
cilium morphogenesis GO:0060271 85 0.049
regulation of establishment of protein localization GO:0070201 4 0.049
transport GO:0006810 220 0.048
regulation of synapse organization GO:0050807 3 0.048
cellular localization GO:0051641 97 0.047
cognition GO:0050890 1 0.047
aging GO:0007568 2 0.046
cellular component morphogenesis GO:0032989 336 0.046
protein import into nucleus GO:0006606 3 0.046
system process GO:0003008 185 0.044
brain development GO:0007420 293 0.043
regulation of cell communication GO:0010646 232 0.043
cellular macromolecule metabolic process GO:0044260 391 0.042
protein localization to nucleus GO:0034504 3 0.042
microtubule based movement GO:0007018 33 0.041
chemosensory behavior GO:0007635 1 0.040
single organism metabolic process GO:0044710 217 0.040
regulation of cellular metabolic process GO:0031323 320 0.040
retinal rod cell development GO:0046548 4 0.039
neuron development GO:0048666 262 0.038
adherens junction organization GO:0034332 4 0.038
lipid storage GO:0019915 1 0.037
cell projection organization GO:0030030 284 0.037
striated muscle cell development GO:0055002 108 0.037
cellular amine metabolic process GO:0044106 2 0.037
biosynthetic process GO:0009058 294 0.037
positive regulation of cellular component biogenesis GO:0044089 3 0.036
head development GO:0060322 303 0.036
positive regulation of secretion GO:0051047 1 0.036
single organism organelle organization GO:1902589 199 0.036
morphogenesis of an epithelium GO:0002009 333 0.035
regulation of cellular amine metabolic process GO:0033238 0 0.034
cellular protein catabolic process GO:0044257 4 0.034
cell projection morphogenesis GO:0048858 244 0.034
chordate embryonic development GO:0043009 271 0.034
muscle cell development GO:0055001 115 0.034
regulation of protein complex assembly GO:0043254 3 0.034
embryonic heart tube morphogenesis GO:0003143 108 0.033
positive regulation of catabolic process GO:0009896 4 0.033
positive regulation of secretion by cell GO:1903532 1 0.033
adult behavior GO:0030534 2 0.032
amine metabolic process GO:0009308 2 0.032
regulation of response to stimulus GO:0048583 269 0.032
heart development GO:0007507 313 0.032
epithelial tube morphogenesis GO:0060562 148 0.032
regulation of synaptic plasticity GO:0048167 1 0.031
regulation of nucleocytoplasmic transport GO:0046822 2 0.031
establishment of localization in cell GO:0051649 77 0.031
nucleocytoplasmic transport GO:0006913 4 0.031
phagocytosis GO:0006909 3 0.031
negative regulation of protein phosphorylation GO:0001933 4 0.031
heterocycle metabolic process GO:0046483 290 0.030
nuclear transport GO:0051169 4 0.030
regulation of synapse assembly GO:0051963 3 0.030
regulation of biosynthetic process GO:0009889 250 0.030
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.029
response to stress GO:0006950 263 0.028
negative regulation of cellular process GO:0048523 283 0.028
regulation of protein catabolic process GO:0042176 1 0.028
regionalization GO:0003002 274 0.028
protein targeting to nucleus GO:0044744 3 0.028
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.028
stem cell proliferation GO:0072089 4 0.027
nuclear import GO:0051170 3 0.027
water homeostasis GO:0030104 4 0.027
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.027
regulation of reproductive process GO:2000241 4 0.027
regulation of protein transport GO:0051223 3 0.026
multicellular organism growth GO:0035264 4 0.026
developmental growth GO:0048589 166 0.026
cellular nitrogen compound metabolic process GO:0034641 290 0.026
organelle organization GO:0006996 227 0.026
regulation of primary metabolic process GO:0080090 311 0.026
modification dependent macromolecule catabolic process GO:0043632 3 0.026
negative regulation of biological process GO:0048519 304 0.026
modification dependent protein catabolic process GO:0019941 3 0.026
embryonic organ development GO:0048568 381 0.026
regulation of protein localization to nucleus GO:1900180 2 0.026
segmentation GO:0035282 97 0.026
positive regulation of cellular catabolic process GO:0031331 3 0.025
regulation of nitrogen compound metabolic process GO:0051171 251 0.025
regulation of transmembrane transporter activity GO:0022898 2 0.025
organic substance biosynthetic process GO:1901576 289 0.025
stem cell maintenance GO:0019827 4 0.025
transcription dna templated GO:0006351 181 0.025
localization of cell GO:0051674 244 0.025
regulation of cellular biosynthetic process GO:0031326 245 0.025
negative regulation of kinase activity GO:0033673 4 0.025
cell morphogenesis GO:0000902 289 0.025
response to drug GO:0042493 3 0.024
regulation of multicellular organismal process GO:0051239 277 0.024
proteasomal protein catabolic process GO:0010498 2 0.024
cellular macromolecule biosynthetic process GO:0034645 224 0.024
somite development GO:0061053 96 0.024
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.024
anterior posterior pattern specification GO:0009952 152 0.024
rna biosynthetic process GO:0032774 181 0.024
regulation of cytoplasmic transport GO:1903649 4 0.023
cellular ketone metabolic process GO:0042180 11 0.023
positive regulation of nucleoside metabolic process GO:0045979 1 0.023
hair cell differentiation GO:0035315 32 0.023
determination of heart left right asymmetry GO:0061371 117 0.023
somitogenesis GO:0001756 87 0.022
locomotion GO:0040011 313 0.022
regulation of metal ion transport GO:0010959 4 0.022
cellular carbohydrate metabolic process GO:0044262 4 0.022
cell morphogenesis involved in differentiation GO:0000904 195 0.022
regulation of cellular protein catabolic process GO:1903362 1 0.022
response to hexose GO:0009746 3 0.022
regulation of cellular amino acid metabolic process GO:0006521 0 0.022
regulation of protein targeting GO:1903533 2 0.022
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.022
guanosine containing compound metabolic process GO:1901068 4 0.022
muscle structure development GO:0061061 196 0.022
tube morphogenesis GO:0035239 349 0.022
neuron neuron synaptic transmission GO:0007270 1 0.022
mitochondrion organization GO:0007005 4 0.022
regulation of metabolic process GO:0019222 359 0.021
protein metabolic process GO:0019538 183 0.021
hormone secretion GO:0046879 2 0.021
blood vessel development GO:0001568 246 0.021
regulation of hormone secretion GO:0046883 2 0.021
neurotransmitter transport GO:0006836 2 0.021
establishment of protein localization to organelle GO:0072594 4 0.021
regulation of carbohydrate metabolic process GO:0006109 4 0.021
g protein coupled receptor signaling pathway GO:0007186 74 0.021
nucleobase containing compound metabolic process GO:0006139 274 0.021
cellular component assembly GO:0022607 170 0.021
regulation of protein import into nucleus GO:0042306 2 0.021
exocytosis GO:0006887 1 0.021
regulation of dendrite development GO:0050773 3 0.021
ion transport GO:0006811 114 0.020
single organism nuclear import GO:1902593 3 0.020
cellular response to external stimulus GO:0071496 2 0.020
regulation of biological quality GO:0065008 263 0.020
central nervous system development GO:0007417 387 0.020
epithelial cilium movement GO:0003351 15 0.020
negative regulation of catabolic process GO:0009895 3 0.020
peptide transport GO:0015833 1 0.020
negative regulation of cytoplasmic transport GO:1903650 2 0.020
organic cyclic compound biosynthetic process GO:1901362 223 0.020
hormone transport GO:0009914 2 0.020
regulation of multicellular organismal development GO:2000026 223 0.019
epithelial cilium movement involved in determination of left right asymmetry GO:0060287 8 0.019
regulation of cellular ketone metabolic process GO:0010565 7 0.019
heterocycle biosynthetic process GO:0018130 215 0.019
carboxylic acid metabolic process GO:0019752 22 0.019
cellular nitrogen compound biosynthetic process GO:0044271 218 0.019
skeletal system development GO:0001501 181 0.019
nucleic acid templated transcription GO:0097659 181 0.019
carbohydrate homeostasis GO:0033500 1 0.018
skin development GO:0043588 54 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
mechanoreceptor differentiation GO:0042490 37 0.018
urogenital system development GO:0001655 97 0.018
negative regulation of intracellular transport GO:0032387 3 0.017
guanosine containing compound catabolic process GO:1901069 2 0.017
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.017
lateral line system development GO:0048925 76 0.017
rna localization GO:0006403 4 0.017
oxoacid metabolic process GO:0043436 31 0.017
response to carbohydrate GO:0009743 3 0.017
positive regulation of cell cycle GO:0045787 3 0.017
cell substrate adhesion GO:0031589 4 0.017
intracellular signal transduction GO:0035556 85 0.017
regulation of intracellular protein transport GO:0033157 3 0.017
regulation of macromolecule biosynthetic process GO:0010556 225 0.017
regulation of nucleoside metabolic process GO:0009118 2 0.017
regulation of nucleotide catabolic process GO:0030811 2 0.017
neurotransmitter secretion GO:0007269 2 0.017
stem cell development GO:0048864 82 0.017
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.016
striated muscle cell differentiation GO:0051146 129 0.016
regulation of tube size GO:0035150 2 0.016
cellular amino acid metabolic process GO:0006520 7 0.016
regulation of anatomical structure morphogenesis GO:0022603 130 0.016
gastrulation GO:0007369 208 0.016
small molecule metabolic process GO:0044281 77 0.016
transmembrane transport GO:0055085 120 0.016
regulation of macromolecule metabolic process GO:0060255 317 0.016
mesenchymal cell differentiation GO:0048762 87 0.016
embryonic heart tube development GO:0035050 133 0.016
regulation of localization GO:0032879 104 0.016
sensory system development GO:0048880 76 0.016
regulation of signal transduction GO:0009966 225 0.016
organic cyclic compound metabolic process GO:1901360 301 0.016
regulation of ion transmembrane transporter activity GO:0032412 2 0.015
neuroblast proliferation GO:0007405 2 0.015
regulation of cell death GO:0010941 103 0.015
cellular amide metabolic process GO:0043603 4 0.015
regulation of multicellular organism growth GO:0040014 4 0.015
sodium ion transport GO:0006814 24 0.015
regulation of cell activation GO:0050865 1 0.015
behavior GO:0007610 74 0.015
cranial nerve development GO:0021545 42 0.015
protein import GO:0017038 3 0.015
rna metabolic process GO:0016070 219 0.015
protein polymerization GO:0051258 4 0.015
kidney development GO:0001822 92 0.015
multicellular organismal metabolic process GO:0044236 2 0.015
membrane invagination GO:0010324 1 0.015
fat soluble vitamin metabolic process GO:0006775 4 0.015
cytokinesis GO:0000910 3 0.015
extrinsic apoptotic signaling pathway GO:0097191 3 0.015
amino acid transport GO:0006865 2 0.015
alcohol biosynthetic process GO:0046165 2 0.015
spindle assembly GO:0051225 2 0.015
cytoskeleton organization GO:0007010 96 0.015
response to glucose GO:0009749 3 0.015
aromatic compound biosynthetic process GO:0019438 217 0.015
axon development GO:0061564 166 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.015
gtp metabolic process GO:0046039 4 0.015
golgi vesicle transport GO:0048193 3 0.015
digestive system development GO:0055123 289 0.015
digestive tract morphogenesis GO:0048546 231 0.015
regulation of calcium ion transport GO:0051924 2 0.014
cellular component biogenesis GO:0044085 178 0.014
regulation of transporter activity GO:0032409 2 0.014
response to nutrient GO:0007584 3 0.014
peptide metabolic process GO:0006518 1 0.014
positive regulation of blood circulation GO:1903524 2 0.014
growth GO:0040007 174 0.014
negative regulation of nuclear division GO:0051784 3 0.014
cellular protein metabolic process GO:0044267 129 0.014
sensory perception of pain GO:0019233 1 0.014
organic substance transport GO:0071702 58 0.014
negative regulation of signaling GO:0023057 96 0.014
regulation of developmental process GO:0050793 247 0.014
regulation of translational initiation GO:0006446 1 0.014
cell migration GO:0016477 237 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.014
cellular component assembly involved in morphogenesis GO:0010927 107 0.014
regulation of muscle contraction GO:0006937 3 0.014
positive regulation of cellular process GO:0048522 201 0.014
gene expression GO:0010467 252 0.013
protein localization to plasma membrane GO:0072659 1 0.013
actomyosin structure organization GO:0031032 53 0.013
phosphate containing compound metabolic process GO:0006796 108 0.013
endocrine process GO:0050886 2 0.013
positive regulation of nucleotide catabolic process GO:0030813 1 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.013
meiotic cell cycle process GO:1903046 3 0.013
protein secretion GO:0009306 1 0.013
regulation of blood pressure GO:0008217 1 0.013
ribonucleoside monophosphate catabolic process GO:0009158 4 0.013
regulation of sodium ion transport GO:0002028 2 0.013
regulation of blood vessel size GO:0050880 2 0.013
regulation of dna replication GO:0006275 3 0.013
epiboly GO:0090504 41 0.013
regulation of reactive oxygen species metabolic process GO:2000377 2 0.013
inner ear morphogenesis GO:0042472 63 0.013
organic acid metabolic process GO:0006082 31 0.013
germ line stem cell maintenance GO:0030718 2 0.013
carbohydrate derivative metabolic process GO:1901135 61 0.013
negative regulation of chromosome organization GO:2001251 1 0.013
negative regulation of cellular catabolic process GO:0031330 3 0.013
translational initiation GO:0006413 3 0.013
negative regulation of secretion GO:0051048 2 0.013
cell cell signaling GO:0007267 52 0.013
stem cell division GO:0017145 1 0.012
erk1 and erk2 cascade GO:0070371 4 0.012
single organism biosynthetic process GO:0044711 71 0.012
death GO:0016265 121 0.012
regulation of erk1 and erk2 cascade GO:0070372 4 0.012
positive regulation of inflammatory response GO:0050729 1 0.012
cell death GO:0008219 121 0.012
centrosome organization GO:0051297 1 0.012
cellular aromatic compound metabolic process GO:0006725 295 0.012
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.012
interspecies interaction between organisms GO:0044419 4 0.012
epidermis development GO:0008544 48 0.012
response to monosaccharide GO:0034284 3 0.012
pigmentation GO:0043473 85 0.012
regulation of nervous system development GO:0051960 90 0.012
atp catabolic process GO:0006200 4 0.012
regulation of inflammatory response GO:0050727 2 0.012
regulation of neurogenesis GO:0050767 87 0.012
sensory perception of light stimulus GO:0050953 19 0.012
heart looping GO:0001947 94 0.012
gtp catabolic process GO:0006184 2 0.012
embryonic skeletal system development GO:0048706 97 0.012
protein complex localization GO:0031503 1 0.012
small molecule catabolic process GO:0044282 3 0.012
response to vitamin GO:0033273 3 0.012
regulation of neural precursor cell proliferation GO:2000177 3 0.012
glucose homeostasis GO:0042593 1 0.012
stem cell differentiation GO:0048863 117 0.012
monovalent inorganic cation transport GO:0015672 42 0.012
single organism intracellular transport GO:1902582 25 0.012
organonitrogen compound metabolic process GO:1901564 74 0.012
epidermal cell differentiation GO:0009913 36 0.012
positive regulation of cell division GO:0051781 2 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
phosphorylation GO:0016310 69 0.012
synaptic vesicle localization GO:0097479 1 0.011
regulation of dendrite morphogenesis GO:0048814 3 0.011
nucleobase containing compound biosynthetic process GO:0034654 205 0.011
secondary metabolic process GO:0019748 3 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.011
cellular response to extracellular stimulus GO:0031668 2 0.011
homeostatic process GO:0042592 142 0.011
intracellular mrna localization GO:0008298 1 0.011
regulation of epithelial cell proliferation GO:0050678 3 0.011
phagocytosis engulfment GO:0006911 1 0.011
protein complex assembly GO:0006461 30 0.011
neuronal action potential GO:0019228 18 0.011
cellular response to light stimulus GO:0071482 4 0.011
regulation of programmed cell death GO:0043067 101 0.011
spermatid differentiation GO:0048515 2 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
intracellular transport GO:0046907 32 0.011
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.011
negative regulation of reproductive process GO:2000242 3 0.011
regulation of cell shape GO:0008360 1 0.011
cellular aldehyde metabolic process GO:0006081 4 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
ovulation cycle GO:0042698 2 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.011
regulation of neuron differentiation GO:0045664 56 0.011
nucleic acid metabolic process GO:0090304 244 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.011
negative regulation of metabolic process GO:0009892 86 0.011
cellular response to chemical stimulus GO:0070887 157 0.011
embryonic cranial skeleton morphogenesis GO:0048701 90 0.011
vasculature development GO:0001944 278 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.011
macromolecule modification GO:0043412 111 0.011
nuclear export GO:0051168 1 0.011
maternal determination of anterior posterior axis embryo GO:0008358 4 0.011
neural crest cell development GO:0014032 62 0.011
regulation of circadian rhythm GO:0042752 4 0.011
development of primary female sexual characteristics GO:0046545 4 0.011
morphogenesis of an epithelial sheet GO:0002011 49 0.011
regulation of response to nutrient levels GO:0032107 1 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.011
negative regulation of secretion by cell GO:1903531 2 0.011
negative regulation of protein transport GO:0051224 3 0.011
regulation of stem cell proliferation GO:0072091 2 0.010
regulation of rna biosynthetic process GO:2001141 213 0.010
regulation of rna metabolic process GO:0051252 224 0.010
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.010
fertilization GO:0009566 3 0.010
positive regulation of cytoskeleton organization GO:0051495 3 0.010
embryonic limb morphogenesis GO:0030326 2 0.010
fluid transport GO:0042044 17 0.010
nerve development GO:0021675 45 0.010
embryonic pattern specification GO:0009880 44 0.010
protein homooligomerization GO:0051260 3 0.010
establishment of protein localization to plasma membrane GO:0090002 1 0.010
microtubule based transport GO:0010970 10 0.010
immune system process GO:0002376 241 0.010
sensory perception GO:0007600 39 0.010
purine nucleoside monophosphate catabolic process GO:0009128 4 0.010
negative regulation of multi organism process GO:0043901 3 0.010
cell fate commitment GO:0045165 99 0.010
positive regulation of chromosome organization GO:2001252 1 0.010
positive regulation of chromatin modification GO:1903310 1 0.010
ion transmembrane transport GO:0034220 91 0.010
lipid homeostasis GO:0055088 3 0.010
cation transmembrane transport GO:0098655 65 0.010
positive regulation of synapse assembly GO:0051965 1 0.010

rpgr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.121
sensory system disease DOID:0050155 0 0.022
eye and adnexa disease DOID:1492 0 0.022
nervous system disease DOID:863 0 0.022
eye disease DOID:5614 0 0.022
immune system disease DOID:2914 0 0.018
disease of metabolism DOID:0014667 0 0.017
musculoskeletal system disease DOID:17 0 0.016
disease of cellular proliferation DOID:14566 0 0.012
cancer DOID:162 0 0.012
muscular disease DOID:0080000 0 0.011
muscle tissue disease DOID:66 0 0.011