Danio rerio

46 known processes

cad

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

(Aliases: wu:fc33d01,wu:fc67g02,si:dkey-221h15.3,cb456,wu:fc30c12)

cad biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.931
Worm
locomotion GO:0040011 313 0.907
Worm
organic substance biosynthetic process GO:1901576 289 0.817
biosynthetic process GO:0009058 294 0.754
organic cyclic compound biosynthetic process GO:1901362 223 0.717
nucleobase containing compound metabolic process GO:0006139 274 0.621
cellular biosynthetic process GO:0044249 286 0.611
embryo development ending in birth or egg hatching GO:0009792 271 0.590
Worm
regulation of cellular biosynthetic process GO:0031326 245 0.587
chordate embryonic development GO:0043009 271 0.537
cellular nitrogen compound biosynthetic process GO:0044271 218 0.534
negative regulation of biological process GO:0048519 304 0.520
regulation of metabolic process GO:0019222 359 0.504
heterocycle biosynthetic process GO:0018130 215 0.495
regulation of cellular metabolic process GO:0031323 320 0.436
heterocycle metabolic process GO:0046483 290 0.418
axon development GO:0061564 166 0.407
cellular macromolecule metabolic process GO:0044260 391 0.406
single organism organelle organization GO:1902589 199 0.399
developmental growth GO:0048589 166 0.388
single organism biosynthetic process GO:0044711 71 0.375
macromolecule biosynthetic process GO:0009059 227 0.375
localization of cell GO:0051674 244 0.357
cellular nitrogen compound metabolic process GO:0034641 290 0.336
negative regulation of cellular process GO:0048523 283 0.325
cellular aromatic compound metabolic process GO:0006725 295 0.310
response to chemical GO:0042221 320 0.308
organelle organization GO:0006996 227 0.300
regulation of apoptotic process GO:0042981 98 0.298
cellular component morphogenesis GO:0032989 336 0.286
rna biosynthetic process GO:0032774 181 0.268
nucleic acid templated transcription GO:0097659 181 0.268
regulation of cell death GO:0010941 103 0.267
cellular component biogenesis GO:0044085 178 0.266
cellular response to chemical stimulus GO:0070887 157 0.265
rna metabolic process GO:0016070 219 0.262
aromatic compound biosynthetic process GO:0019438 217 0.262
regulation of rna biosynthetic process GO:2001141 213 0.257
nitrogen compound metabolic process GO:0006807 319 0.256
cell projection organization GO:0030030 284 0.253
regulation of nucleic acid templated transcription GO:1903506 213 0.249
cell morphogenesis involved in differentiation GO:0000904 195 0.234
cellular component movement GO:0006928 335 0.227
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.220
regulation of primary metabolic process GO:0080090 311 0.218
nucleobase containing compound biosynthetic process GO:0034654 205 0.214
gene expression GO:0010467 252 0.212
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.208
cellular macromolecule biosynthetic process GO:0034645 224 0.201
regulation of macromolecule metabolic process GO:0060255 317 0.200
apoptotic process GO:0006915 116 0.187
regulation of gene expression GO:0010468 265 0.183
protein metabolic process GO:0019538 183 0.183
regulation of nitrogen compound metabolic process GO:0051171 251 0.178
neuron projection development GO:0031175 180 0.175
multi organism process GO:0051704 134 0.174
regulation of macromolecule biosynthetic process GO:0010556 225 0.173
transport GO:0006810 220 0.172
regulation of biosynthetic process GO:0009889 250 0.172
response to endogenous stimulus GO:0009719 83 0.169
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.161
cell cycle process GO:0022402 53 0.155
organic cyclic compound metabolic process GO:1901360 301 0.155
establishment of localization GO:0051234 244 0.151
generation of neurons GO:0048699 385 0.143
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.142
small molecule metabolic process GO:0044281 77 0.139
cell motility GO:0048870 244 0.136
reproductive process GO:0022414 40 0.133
cell morphogenesis GO:0000902 289 0.133
regulation of transcription dna templated GO:0006355 213 0.123
aging GO:0007568 2 0.123
neuron projection morphogenesis GO:0048812 161 0.120
cell death GO:0008219 121 0.117
digestive system development GO:0055123 289 0.109
Worm
nuclear transport GO:0051169 4 0.108
eye development GO:0001654 277 0.105
sensory organ development GO:0007423 393 0.104
death GO:0016265 121 0.103
regulation of developmental process GO:0050793 247 0.101
neuron development GO:0048666 262 0.098
transcription dna templated GO:0006351 181 0.097
negative regulation of macromolecule metabolic process GO:0010605 76 0.097
single organism transport GO:0044765 206 0.095
cell part morphogenesis GO:0032990 246 0.095
regulation of programmed cell death GO:0043067 101 0.091
regulation of multicellular organism growth GO:0040014 4 0.090
regulation of multicellular organismal process GO:0051239 277 0.090
dna metabolic process GO:0006259 27 0.089
cellular response to organic substance GO:0071310 105 0.089
embryonic organ morphogenesis GO:0048562 274 0.085
neuron differentiation GO:0030182 353 0.085
positive regulation of cellular process GO:0048522 201 0.085
multicellular organism growth GO:0035264 4 0.085
programmed cell death GO:0012501 119 0.085
positive regulation of cellular metabolic process GO:0031325 94 0.085
carbohydrate derivative biosynthetic process GO:1901137 43 0.084
negative regulation of metabolic process GO:0009892 86 0.082
cell migration GO:0016477 237 0.081
positive regulation of biosynthetic process GO:0009891 68 0.080
negative regulation of cellular metabolic process GO:0031324 77 0.076
protein localization GO:0008104 40 0.075
negative regulation of apoptotic process GO:0043066 55 0.074
positive regulation of metabolic process GO:0009893 108 0.073
organonitrogen compound metabolic process GO:1901564 74 0.069
nucleic acid metabolic process GO:0090304 244 0.069
regulation of cellular amine metabolic process GO:0033238 0 0.068
meiotic nuclear division GO:0007126 4 0.066
immune system process GO:0002376 241 0.066
positive regulation of macromolecule metabolic process GO:0010604 93 0.064
regulation of localization GO:0032879 104 0.063
protein import GO:0017038 3 0.063
embryonic cranial skeleton morphogenesis GO:0048701 90 0.061
growth GO:0040007 174 0.060
negative regulation of cell death GO:0060548 60 0.059
cytoskeleton organization GO:0007010 96 0.058
cellular localization GO:0051641 97 0.057
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.057
cell cycle GO:0007049 93 0.056
mitotic cell cycle process GO:1903047 48 0.056
macromolecule modification GO:0043412 111 0.054
behavior GO:0007610 74 0.053
cellular macromolecule localization GO:0070727 21 0.053
multicellular organism reproduction GO:0032504 35 0.053
regulation of response to stimulus GO:0048583 269 0.053
organonitrogen compound biosynthetic process GO:1901566 47 0.052
brain development GO:0007420 293 0.051
phagocytosis GO:0006909 3 0.051
negative regulation of cellular biosynthetic process GO:0031327 55 0.050
regulation of histone h3 k9 methylation GO:0051570 2 0.050
cellular component assembly GO:0022607 170 0.049
maturation of ssu rrna GO:0030490 1 0.049
cellular protein metabolic process GO:0044267 129 0.049
protein localization to nucleus GO:0034504 3 0.049
regulation of protein localization to nucleus GO:1900180 2 0.049
muscle structure development GO:0061061 196 0.048
skeletal system development GO:0001501 181 0.048
exocrine pancreas development GO:0031017 28 0.048
cellular ketone metabolic process GO:0042180 11 0.047
gland development GO:0048732 143 0.047
camera type eye development GO:0043010 222 0.047
single organism metabolic process GO:0044710 217 0.047
amine metabolic process GO:0009308 2 0.047
regulation of cell cycle GO:0051726 52 0.046
retina development in camera type eye GO:0060041 146 0.046
cellular response to endogenous stimulus GO:0071495 68 0.045
response to hormone GO:0009725 48 0.045
chromosome organization GO:0051276 31 0.045
embryonic skeletal system morphogenesis GO:0048704 93 0.045
oxoacid metabolic process GO:0043436 31 0.044
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000462 1 0.043
hepaticobiliary system development GO:0061008 98 0.043
regulation of blood vessel size GO:0050880 2 0.042
phosphorus metabolic process GO:0006793 109 0.042
axonogenesis GO:0007409 152 0.042
embryonic viscerocranium morphogenesis GO:0048703 52 0.042
negative regulation of gene expression GO:0010629 65 0.041
digestive tract development GO:0048565 265 0.041
Worm
regulation of establishment of protein localization GO:0070201 4 0.041
nuclear export GO:0051168 1 0.041
positive regulation of cell cycle GO:0045787 3 0.041
response to amino acid GO:0043200 2 0.041
positive regulation of biological process GO:0048518 253 0.041
reproduction GO:0000003 40 0.040
macromolecule localization GO:0033036 54 0.039
cellular amino acid metabolic process GO:0006520 7 0.038
g1 s transition of mitotic cell cycle GO:0000082 1 0.038
head development GO:0060322 303 0.038
negative regulation of biosynthetic process GO:0009890 55 0.038
single organism reproductive process GO:0044702 40 0.038
meiotic cell cycle process GO:1903046 3 0.037
mitotic cell cycle GO:0000278 64 0.037
pyrimidine containing compound biosynthetic process GO:0072528 2 0.037
cell proliferation GO:0008283 80 0.037
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.037
type i interferon production GO:0032606 2 0.036
nuclear import GO:0051170 3 0.036
regulation of gene expression epigenetic GO:0040029 11 0.036
dna methylation on cytosine GO:0032776 3 0.036
axon guidance GO:0007411 86 0.034
response to steroid hormone GO:0048545 35 0.034
chemotaxis GO:0006935 104 0.033
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.033
cellular component disassembly GO:0022411 1 0.033
ribosomal small subunit biogenesis GO:0042274 2 0.032
taxis GO:0042330 109 0.032
regulation of organelle organization GO:0033043 29 0.032
regulation of mrna processing GO:0050684 3 0.032
oxidation reduction process GO:0055114 41 0.032
carboxylic acid metabolic process GO:0019752 22 0.031
response to organic substance GO:0010033 153 0.031
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.030
macromolecular complex assembly GO:0065003 35 0.030
g2 dna damage checkpoint GO:0031572 3 0.030
intracellular signal transduction GO:0035556 85 0.029
cellular response to lipid GO:0071396 39 0.029
regulation of cellular amino acid metabolic process GO:0006521 0 0.029
regulation of nucleocytoplasmic transport GO:0046822 2 0.028
nucleocytoplasmic transport GO:0006913 4 0.028
cell projection morphogenesis GO:0048858 244 0.028
regulation of cytoplasmic transport GO:1903649 4 0.028
neuron projection guidance GO:0097485 86 0.028
negative regulation of rna metabolic process GO:0051253 48 0.028
regulation of cytokine production GO:0001817 3 0.028
protein targeting to nucleus GO:0044744 3 0.028
connective tissue development GO:0061448 99 0.027
embryonic skeletal system development GO:0048706 97 0.027
organic acid metabolic process GO:0006082 31 0.027
establishment of protein localization to organelle GO:0072594 4 0.027
cell surface receptor signaling pathway GO:0007166 325 0.026
skeletal system morphogenesis GO:0048705 102 0.026
positive regulation of transport GO:0051050 2 0.026
microtubule polymerization GO:0046785 2 0.026
regulation of protein metabolic process GO:0051246 56 0.026
response to estrogen GO:0043627 27 0.025
regulation of catalytic activity GO:0050790 55 0.025
central nervous system development GO:0007417 387 0.025
negative regulation of histone methylation GO:0031061 1 0.025
positive regulation of gtp catabolic process GO:0033126 1 0.024
renal system development GO:0072001 94 0.024
regulation of intracellular protein transport GO:0033157 3 0.024
positive regulation of apoptotic process GO:0043065 29 0.024
homeostatic process GO:0042592 142 0.023
cellular response to extracellular stimulus GO:0031668 2 0.023
response to wounding GO:0009611 116 0.023
cellular amine metabolic process GO:0044106 2 0.023
lipid storage GO:0019915 1 0.023
posttranscriptional gene silencing by rna GO:0035194 3 0.023
striated muscle cell differentiation GO:0051146 129 0.023
positive regulation of cellular biosynthetic process GO:0031328 68 0.023
protein import into nucleus GO:0006606 3 0.023
negative regulation of programmed cell death GO:0043069 58 0.023
heart development GO:0007507 313 0.022
tissue remodeling GO:0048771 4 0.022
regulation of biological quality GO:0065008 263 0.022
response to abiotic stimulus GO:0009628 122 0.022
actomyosin structure organization GO:0031032 53 0.021
protein processing GO:0016485 12 0.021
positive regulation of translation GO:0045727 1 0.021
post embryonic morphogenesis GO:0009886 4 0.021
positive regulation of cellular catabolic process GO:0031331 3 0.021
cellular response to starvation GO:0009267 1 0.021
regulation of rna metabolic process GO:0051252 224 0.021
positive regulation of gene expression GO:0010628 71 0.020
response to nutrient GO:0007584 3 0.020
cell cycle g1 s phase transition GO:0044843 1 0.020
positive regulation of multicellular organismal process GO:0051240 52 0.020
single organism cellular localization GO:1902580 46 0.020
zymogen activation GO:0031638 3 0.020
macromolecular complex subunit organization GO:0043933 74 0.020
organic substance transport GO:0071702 58 0.020
regulation of cellular protein metabolic process GO:0032268 52 0.020
pancreas development GO:0031016 84 0.020
regulation of dna replication GO:0006275 3 0.020
gene silencing by rna GO:0031047 4 0.020
multi organism reproductive process GO:0044703 36 0.020
cellular protein modification process GO:0006464 100 0.020
eye morphogenesis GO:0048592 144 0.020
positive regulation of chromatin modification GO:1903310 1 0.019
cellular response to nutrient levels GO:0031669 2 0.019
ventricular cardiac muscle tissue development GO:0003229 3 0.019
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.019
synaptic growth at neuromuscular junction GO:0051124 2 0.019
response to organic cyclic compound GO:0014070 51 0.019
cartilage development GO:0051216 96 0.019
protein modification process GO:0036211 100 0.019
negative regulation of multicellular organismal process GO:0051241 69 0.018
reproductive system development GO:0061458 5 0.018
single organism localization GO:1902578 225 0.018
chromatin modification GO:0016568 21 0.018
regulation of signal transduction GO:0009966 225 0.018
response to external stimulus GO:0009605 264 0.018
establishment of localization in cell GO:0051649 77 0.017
signal transduction GO:0007165 455 0.017
cellular response to oxidative stress GO:0034599 5 0.017
rna localization GO:0006403 4 0.017
positive regulation of type i interferon production GO:0032481 1 0.017
regulation of protein transport GO:0051223 3 0.017
negative regulation of cell differentiation GO:0045596 46 0.017
hematopoietic or lymphoid organ development GO:0048534 191 0.017
regulation of molecular function GO:0065009 70 0.017
lymphocyte proliferation GO:0046651 1 0.017
negative regulation of histone modification GO:0031057 1 0.017
gtp catabolic process GO:0006184 2 0.017
positive regulation of nucleotide catabolic process GO:0030813 1 0.017
positive regulation of rna biosynthetic process GO:1902680 57 0.016
mitochondrion organization GO:0007005 4 0.016
cell aging GO:0007569 2 0.016
response to stress GO:0006950 263 0.016
posttranscriptional gene silencing GO:0016441 3 0.016
sex differentiation GO:0007548 5 0.016
response to oxygen levels GO:0070482 25 0.016
carbohydrate derivative metabolic process GO:1901135 61 0.016
regulation of cellular component organization GO:0051128 86 0.016
positive regulation of cell death GO:0010942 29 0.016
cellular response to hormone stimulus GO:0032870 39 0.016
negative regulation of cell communication GO:0010648 96 0.016
cellular macromolecular complex assembly GO:0034622 24 0.016
cellular response to reactive oxygen species GO:0034614 2 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.015
regulation of cell differentiation GO:0045595 142 0.015
reproductive structure development GO:0048608 5 0.015
organelle assembly GO:0070925 110 0.015
wound healing GO:0042060 90 0.015
cellular component assembly involved in morphogenesis GO:0010927 107 0.015
response to carbohydrate GO:0009743 3 0.014
negative regulation of protein kinase activity GO:0006469 4 0.014
production of molecular mediator of immune response GO:0002440 2 0.014
regulation of binding GO:0051098 3 0.014
immune system development GO:0002520 191 0.014
cellular response to oxygen levels GO:0071453 1 0.014
cell growth GO:0016049 57 0.014
regulation of developmental growth GO:0048638 38 0.014
regulation of cellular ketone metabolic process GO:0010565 7 0.014
single organism nuclear import GO:1902593 3 0.014
maintenance of dna repeat elements GO:0043570 2 0.014
maintenance of location GO:0051235 4 0.014
positive regulation of cell activation GO:0050867 1 0.014
leukocyte proliferation GO:0070661 1 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.014
cellular protein complex assembly GO:0043623 19 0.014
negative regulation of mrna metabolic process GO:1903312 3 0.013
phosphate containing compound metabolic process GO:0006796 108 0.013
negative regulation of kinase activity GO:0033673 4 0.013
negative regulation of molecular function GO:0044092 23 0.013
dna biosynthetic process GO:0071897 3 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.013
protein complex biogenesis GO:0070271 30 0.013
retina layer formation GO:0010842 24 0.013
response to vitamin GO:0033273 3 0.013
response to oxygen containing compound GO:1901700 55 0.013
alpha amino acid metabolic process GO:1901605 3 0.013
body morphogenesis GO:0010171 16 0.013
regulation of anatomical structure size GO:0090066 33 0.013
regulation of purine nucleotide catabolic process GO:0033121 2 0.013
camera type eye morphogenesis GO:0048593 108 0.013
stem cell differentiation GO:0048863 117 0.013
negative regulation of transcription dna templated GO:0045892 45 0.013
cell substrate adhesion GO:0031589 4 0.013
cellular response to stress GO:0033554 62 0.013
positive regulation of catabolic process GO:0009896 4 0.012
negative regulation of chromosome organization GO:2001251 1 0.012
spindle assembly involved in mitosis GO:0090307 1 0.012
response to ketone GO:1901654 1 0.012
negative regulation of chromatin modification GO:1903309 1 0.012
axonal defasciculation GO:0007414 2 0.012
muscle cell development GO:0055001 115 0.012
regulation of protein catabolic process GO:0042176 1 0.012
transcription from rna polymerase ii promoter GO:0006366 80 0.012
cellular response to estrogen stimulus GO:0071391 24 0.012
inositol lipid mediated signaling GO:0048017 2 0.012
embryonic heart tube morphogenesis GO:0003143 108 0.012
hemopoiesis GO:0030097 183 0.012
epithelial tube morphogenesis GO:0060562 148 0.011
embryonic heart tube development GO:0035050 133 0.011
cell cycle arrest GO:0007050 1 0.011
glucose homeostasis GO:0042593 1 0.011
regulation of cell shape GO:0008360 1 0.011
positive regulation of nucleoside metabolic process GO:0045979 1 0.011
embryonic organ development GO:0048568 381 0.011
morphogenesis of an epithelium GO:0002009 333 0.011
regulation of hydrolase activity GO:0051336 28 0.011
negative regulation of dna recombination GO:0045910 2 0.011
meiotic chromosome segregation GO:0045132 3 0.011
nuclear division GO:0000280 23 0.011
posttranscriptional regulation of gene expression GO:0010608 14 0.011
multicellular organismal reproductive process GO:0048609 35 0.011
cell fate commitment GO:0045165 99 0.011
positive regulation of histone modification GO:0031058 1 0.011
regulation of organelle assembly GO:1902115 4 0.011
regulation of phosphate metabolic process GO:0019220 43 0.011
epidermal cell differentiation GO:0009913 36 0.011
transmembrane transport GO:0055085 120 0.010
protein stabilization GO:0050821 2 0.010
intracellular transport GO:0046907 32 0.010
ribosomal small subunit assembly GO:0000028 1 0.010
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 20 0.010
cell cell recognition GO:0009988 1 0.010
developmental process involved in reproduction GO:0003006 27 0.010
positive regulation of cellular amine metabolic process GO:0033240 0 0.010
enzyme linked receptor protein signaling pathway GO:0007167 106 0.010
mononuclear cell proliferation GO:0032943 1 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.010
negative regulation of defense response GO:0031348 2 0.010
negative regulation of rna biosynthetic process GO:1902679 45 0.010
blood circulation GO:0008015 87 0.010

cad disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.065
nervous system disease DOID:863 0 0.026
disease of cellular proliferation DOID:14566 0 0.021
disease of metabolism DOID:0014667 0 0.015
sensory system disease DOID:0050155 0 0.013
cancer DOID:162 0 0.013
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011