Danio rerio

0 known processes

hmgcl

3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)

(Aliases: MGC56248,zgc:56248)

hmgcl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular nitrogen compound biosynthetic process GO:0044271 218 0.083
mitochondrion organization GO:0007005 4 0.079
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.060
cellular protein catabolic process GO:0044257 4 0.059
cellular macromolecule metabolic process GO:0044260 391 0.055
larval development GO:0002164 2 0.053
single organism organelle organization GO:1902589 199 0.051
cellular biosynthetic process GO:0044249 286 0.045
protein localization to plasma membrane GO:0072659 1 0.045
aging GO:0007568 2 0.039
response to drug GO:0042493 3 0.038
organic substance biosynthetic process GO:1901576 289 0.038
regulation of protein transport GO:0051223 3 0.035
cellular nitrogen compound metabolic process GO:0034641 290 0.035
macromolecule biosynthetic process GO:0009059 227 0.034
biosynthetic process GO:0009058 294 0.033
regulation of establishment of protein localization GO:0070201 4 0.033
maintenance of location GO:0051235 4 0.033
membrane fusion GO:0061025 2 0.032
organelle fusion GO:0048284 3 0.032
ubiquitin dependent protein catabolic process GO:0006511 3 0.031
heterocycle metabolic process GO:0046483 290 0.031
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.031
eye development GO:0001654 277 0.029
homeostatic process GO:0042592 142 0.029
organelle organization GO:0006996 227 0.029
nucleobase containing compound biosynthetic process GO:0034654 205 0.029
immune system process GO:0002376 241 0.029
rna metabolic process GO:0016070 219 0.028
compound eye development GO:0048749 2 0.027
carboxylic acid metabolic process GO:0019752 22 0.026
cellular amino acid metabolic process GO:0006520 7 0.026
protein import GO:0017038 3 0.026
nitrogen compound metabolic process GO:0006807 319 0.026
proteasomal protein catabolic process GO:0010498 2 0.025
stem cell maintenance GO:0019827 4 0.025
protein polyubiquitination GO:0000209 4 0.024
lipid storage GO:0019915 1 0.024
regulation of protein ubiquitination GO:0031396 3 0.024
exocytosis GO:0006887 1 0.023
negative regulation of protein phosphorylation GO:0001933 4 0.023
immune system development GO:0002520 191 0.023
regulation of multicellular organism growth GO:0040014 4 0.023
nucleic acid metabolic process GO:0090304 244 0.023
cellular component biogenesis GO:0044085 178 0.023
response to stress GO:0006950 263 0.022
positive regulation of cellular catabolic process GO:0031331 3 0.022
heterocycle biosynthetic process GO:0018130 215 0.022
mitochondrial transport GO:0006839 2 0.022
myeloid cell differentiation GO:0030099 86 0.022
cellular modified amino acid metabolic process GO:0006575 3 0.022
hemopoiesis GO:0030097 183 0.021
oxoacid metabolic process GO:0043436 31 0.021
organelle assembly GO:0070925 110 0.021
cellular macromolecule biosynthetic process GO:0034645 224 0.021
positive regulation of catabolic process GO:0009896 4 0.021
modification dependent macromolecule catabolic process GO:0043632 3 0.021
nucleocytoplasmic transport GO:0006913 4 0.021
regulation of protein catabolic process GO:0042176 1 0.021
endosomal transport GO:0016197 2 0.021
guanosine containing compound catabolic process GO:1901069 2 0.021
central nervous system development GO:0007417 387 0.020
regulation of biological quality GO:0065008 263 0.020
small molecule metabolic process GO:0044281 77 0.020
single organism membrane fusion GO:0044801 2 0.020
positive regulation of transport GO:0051050 2 0.020
gene expression GO:0010467 252 0.020
hematopoietic or lymphoid organ development GO:0048534 191 0.020
myeloid cell homeostasis GO:0002262 56 0.020
sensory organ development GO:0007423 393 0.020
rna localization GO:0006403 4 0.019
cellular ketone metabolic process GO:0042180 11 0.019
cytoskeleton organization GO:0007010 96 0.019
erythrocyte differentiation GO:0030218 54 0.019
multicellular organism growth GO:0035264 4 0.019
response to chemical GO:0042221 320 0.019
regulation of intracellular protein transport GO:0033157 3 0.019
heart development GO:0007507 313 0.019
regulation of protein localization to plasma membrane GO:1903076 1 0.018
nucleobase containing compound metabolic process GO:0006139 274 0.018
adherens junction organization GO:0034332 4 0.018
modification dependent protein catabolic process GO:0019941 3 0.018
regulation of oocyte development GO:0060281 3 0.018
response to abiotic stimulus GO:0009628 122 0.018
gtp metabolic process GO:0046039 4 0.018
single organism metabolic process GO:0044710 217 0.018
nuclear transport GO:0051169 4 0.018
transmembrane transport GO:0055085 120 0.018
cellular component assembly involved in morphogenesis GO:0010927 107 0.017
muscle structure development GO:0061061 196 0.017
cellular component assembly GO:0022607 170 0.017
guanosine containing compound metabolic process GO:1901068 4 0.017
homeostasis of number of cells GO:0048872 62 0.017
amine metabolic process GO:0009308 2 0.017
synaptic growth at neuromuscular junction GO:0051124 2 0.017
regulation of synapse organization GO:0050807 3 0.017
cellular response to external stimulus GO:0071496 2 0.017
pole plasm assembly GO:0007315 4 0.016
organonitrogen compound metabolic process GO:1901564 74 0.016
cellular response to starvation GO:0009267 1 0.016
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
cellular component movement GO:0006928 335 0.016
gtp catabolic process GO:0006184 2 0.016
regulation of gtpase activity GO:0043087 2 0.016
rna biosynthetic process GO:0032774 181 0.016
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
establishment of protein localization to organelle GO:0072594 4 0.016
embryonic organ morphogenesis GO:0048562 274 0.016
striated muscle cell differentiation GO:0051146 129 0.016
regulation of cellular ketone metabolic process GO:0010565 7 0.016
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.016
aromatic compound biosynthetic process GO:0019438 217 0.015
actin cytoskeleton organization GO:0030036 63 0.015
regulation of cytoplasmic transport GO:1903649 4 0.015
embryonic organ development GO:0048568 381 0.015
regulation of cellular amine metabolic process GO:0033238 0 0.015
alpha amino acid metabolic process GO:1901605 3 0.015
establishment of protein localization to plasma membrane GO:0090002 1 0.015
nucleic acid templated transcription GO:0097659 181 0.015
response to glucocorticoid GO:0051384 1 0.015
regulation of nucleotide catabolic process GO:0030811 2 0.015
regulation of tube size GO:0035150 2 0.015
organic acid metabolic process GO:0006082 31 0.015
response to nutrient GO:0007584 3 0.015
single organism localization GO:1902578 225 0.014
cellular response to nutrient levels GO:0031669 2 0.014
regulation of biosynthetic process GO:0009889 250 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.014
response to corticosteroid GO:0031960 1 0.014
signal transduction GO:0007165 455 0.014
regulation of mrna processing GO:0050684 3 0.014
head development GO:0060322 303 0.014
hepaticobiliary system development GO:0061008 98 0.014
establishment of localization GO:0051234 244 0.014
macromolecule modification GO:0043412 111 0.013
regulation of synapse assembly GO:0051963 3 0.013
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.013
cell substrate adhesion GO:0031589 4 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
single organism transport GO:0044765 206 0.013
regulation of protein complex assembly GO:0043254 3 0.013
regulation of localization GO:0032879 104 0.013
autophagy GO:0006914 4 0.013
negative regulation of kinase activity GO:0033673 4 0.013
regulation of gene expression GO:0010468 265 0.013
regulation of reproductive process GO:2000241 4 0.013
regulation of macromolecule metabolic process GO:0060255 317 0.013
regulation of rna biosynthetic process GO:2001141 213 0.013
i kappab kinase nf kappab signaling GO:0007249 4 0.013
regulation of cell activation GO:0050865 1 0.013
transcription dna templated GO:0006351 181 0.012
stem cell division GO:0017145 1 0.012
meiosis i GO:0007127 1 0.012
response to external stimulus GO:0009605 264 0.012
regulation of developmental process GO:0050793 247 0.012
protein metabolic process GO:0019538 183 0.012
cellular aromatic compound metabolic process GO:0006725 295 0.012
regulation of primary metabolic process GO:0080090 311 0.012
regulation of metabolic process GO:0019222 359 0.012
negative regulation of map kinase activity GO:0043407 2 0.012
regulation of rna metabolic process GO:0051252 224 0.012
regulation of hormone secretion GO:0046883 2 0.012
protein targeting to nucleus GO:0044744 3 0.012
positive regulation of secretion by cell GO:1903532 1 0.012
response to monosaccharide GO:0034284 3 0.012
embryo development ending in birth or egg hatching GO:0009792 271 0.012
regulation of protein import into nucleus GO:0042306 2 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.012
catechol containing compound metabolic process GO:0009712 2 0.011
cytokinesis GO:0000910 3 0.011
sensory organ morphogenesis GO:0090596 200 0.011
regulation of binding GO:0051098 3 0.011
centrosome cycle GO:0007098 1 0.011
protein k48 linked ubiquitination GO:0070936 1 0.011
adult behavior GO:0030534 2 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.011
muscle cell differentiation GO:0042692 139 0.011
brain development GO:0007420 293 0.011
positive regulation of cellular component biogenesis GO:0044089 3 0.011
skeletal system morphogenesis GO:0048705 102 0.011
regulation of cellular biosynthetic process GO:0031326 245 0.011
protein homooligomerization GO:0051260 3 0.011
locomotion GO:0040011 313 0.011
organic cyclic compound metabolic process GO:1901360 301 0.011
energy reserve metabolic process GO:0006112 2 0.011
meiotic cell cycle process GO:1903046 3 0.011
spindle assembly GO:0051225 2 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
cellular component disassembly GO:0022411 1 0.011
female sex differentiation GO:0046660 4 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
cellular amine metabolic process GO:0044106 2 0.011
regulation of nucleoside metabolic process GO:0009118 2 0.011
regulation of cellular metabolic process GO:0031323 320 0.011
cytoskeleton dependent cytokinesis GO:0061640 3 0.011
regulation of carbohydrate metabolic process GO:0006109 4 0.011
regulation of transcription dna templated GO:0006355 213 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.011
response to uv GO:0009411 3 0.011
positive regulation of cell cycle GO:0045787 3 0.011
muscle cell development GO:0055001 115 0.011
regulation of blood pressure GO:0008217 1 0.011
camera type eye development GO:0043010 222 0.011
muscle tissue development GO:0060537 110 0.011
germ line stem cell maintenance GO:0030718 2 0.010
peptide transport GO:0015833 1 0.010
golgi vesicle transport GO:0048193 3 0.010
negative regulation of synapse assembly GO:0051964 2 0.010
cell morphogenesis GO:0000902 289 0.010
single organism nuclear import GO:1902593 3 0.010
negative regulation of multi organism process GO:0043901 3 0.010
glial cell migration GO:0008347 3 0.010
carbohydrate biosynthetic process GO:0016051 1 0.010
ribonucleoside monophosphate catabolic process GO:0009158 4 0.010
regulation of organ growth GO:0046620 3 0.010
cell surface receptor signaling pathway GO:0007166 325 0.010
nucleobase containing compound transport GO:0015931 2 0.010
morphogenesis of an epithelium GO:0002009 333 0.010
germ line stem cell division GO:0042078 1 0.010
positive regulation of nucleotide catabolic process GO:0030813 1 0.010
nuclear import GO:0051170 3 0.010
regulation of protein localization to nucleus GO:1900180 2 0.010
positive regulation of cytokine production GO:0001819 2 0.010
ion transport GO:0006811 114 0.010
female gonad development GO:0008585 4 0.010
renal tubule morphogenesis GO:0061333 1 0.010
regulation of gtp catabolic process GO:0033124 2 0.010

hmgcl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.025
inherited metabolic disorder DOID:655 0 0.025
mitochondrial metabolism disease DOID:700 0 0.018
disease of cellular proliferation DOID:14566 0 0.015
cancer DOID:162 0 0.014
organ system cancer DOID:0050686 0 0.014
disease of anatomical entity DOID:7 0 0.014