Danio rerio

33 known processes

mdm2

transformed 3T3 cell double minute 2 homolog (mouse)

(Aliases: zgc:109834,MGC192439,MGC109834,MGC113866)

mdm2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitochondrion morphogenesis GO:0070584 2 0.437
cellular protein catabolic process GO:0044257 4 0.422
Human
regulation of macromolecule metabolic process GO:0060255 317 0.317
Human
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.305
extrinsic apoptotic signaling pathway GO:0097191 3 0.303
regulation of metabolic process GO:0019222 359 0.299
Human
regulation of response to stimulus GO:0048583 269 0.273
Human
organic cyclic compound metabolic process GO:1901360 301 0.234
Human
positive regulation of response to stimulus GO:0048584 80 0.222
single organism metabolic process GO:0044710 217 0.219
response to organic substance GO:0010033 153 0.214
cellular protein metabolic process GO:0044267 129 0.210
Human Mouse
modulation by virus of host morphology or physiology GO:0019048 1 0.206
regulation of cellular metabolic process GO:0031323 320 0.203
Human
positive regulation of cell cycle GO:0045787 3 0.202
Human Mouse
regulation of protein complex assembly GO:0043254 3 0.196
regulation of reactive oxygen species metabolic process GO:2000377 2 0.187
negative regulation of cellular process GO:0048523 283 0.185
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.184
immune system process GO:0002376 241 0.182
larval development GO:0002164 2 0.176
cell part morphogenesis GO:0032990 246 0.175
response to amino acid GO:0043200 2 0.174
proteolysis GO:0006508 38 0.172
Human
regulation of signaling GO:0023051 235 0.171
Human
regulation of cysteine type endopeptidase activity GO:2000116 21 0.169
negative regulation of protein maturation GO:1903318 10 0.165
positive regulation of cell killing GO:0031343 2 0.163
regulation of signal transduction GO:0009966 225 0.162
Human
regulation of protein metabolic process GO:0051246 56 0.162
Human
signal transduction GO:0007165 455 0.155
Human
programmed cell death GO:0012501 119 0.147
response to cadmium ion GO:0046686 14 0.147
cellular component assembly GO:0022607 170 0.146
Human
cellular response to external stimulus GO:0071496 2 0.146
modification dependent protein catabolic process GO:0019941 3 0.144
Human
positive regulation of biological process GO:0048518 253 0.141
Human Mouse
regulation of glucose transport GO:0010827 1 0.138
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.136
Human
hematopoietic or lymphoid organ development GO:0048534 191 0.136
regulation of glucose import GO:0046324 1 0.134
regulation of cell killing GO:0031341 2 0.132
negative regulation of protein phosphorylation GO:0001933 4 0.130
positive regulation of stress activated mapk cascade GO:0032874 3 0.129
meiotic nuclear division GO:0007126 4 0.127
regulation of endopeptidase activity GO:0052548 23 0.126
response to stress GO:0006950 263 0.124
Human
positive regulation of cellular process GO:0048522 201 0.124
Human Mouse
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.124
response to chemical GO:0042221 320 0.123
Human
protein targeting to nucleus GO:0044744 3 0.122
positive regulation of apoptotic process GO:0043065 29 0.120
single organism nuclear import GO:1902593 3 0.119
regulation of protein catabolic process GO:0042176 1 0.117
Human
positive regulation of cellular component biogenesis GO:0044089 3 0.116
cell projection morphogenesis GO:0048858 244 0.116
death GO:0016265 121 0.115
biosynthetic process GO:0009058 294 0.113
Human
negative regulation of response to stimulus GO:0048585 104 0.110
Human
mitochondrion organization GO:0007005 4 0.110
response to abiotic stimulus GO:0009628 122 0.109
glucose import GO:0046323 2 0.107
nucleocytoplasmic transport GO:0006913 4 0.107
nuclear transport GO:0051169 4 0.105
immune system development GO:0002520 191 0.105
regulation of cell death GO:0010941 103 0.105
chordate embryonic development GO:0043009 271 0.104
positive regulation of protein complex assembly GO:0031334 2 0.103
cell surface receptor signaling pathway GO:0007166 325 0.103
regulation of peptidase activity GO:0052547 23 0.103
establishment of protein localization to organelle GO:0072594 4 0.100
macromolecule modification GO:0043412 111 0.100
Human Mouse
organelle organization GO:0006996 227 0.100
organic substance catabolic process GO:1901575 28 0.098
Human Mouse
regulation of proteolysis GO:0030162 24 0.098
Human
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.097
cellular response to stress GO:0033554 62 0.096
Human
cellular response to organic substance GO:0071310 105 0.095
zymogen activation GO:0031638 3 0.095
cellular response to chemical stimulus GO:0070887 157 0.095
Human
protein import GO:0017038 3 0.094
gene expression GO:0010467 252 0.091
Human
negative regulation of protein kinase activity GO:0006469 4 0.091
cell killing GO:0001906 2 0.091
protein metabolic process GO:0019538 183 0.090
Human Mouse
nuclear import GO:0051170 3 0.090
regulation of biological quality GO:0065008 263 0.089
Human
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.089
Human
response to antibiotic GO:0046677 1 0.088
Human
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.088
Human
p38mapk cascade GO:0038066 1 0.087
protein localization to nucleus GO:0034504 3 0.087
Human
regulation of molecular function GO:0065009 70 0.085
regulation of primary metabolic process GO:0080090 311 0.085
Human
sensory organ development GO:0007423 393 0.084
multi organism process GO:0051704 134 0.084
cytokinesis GO:0000910 3 0.084
heart development GO:0007507 313 0.082
cellular aromatic compound metabolic process GO:0006725 295 0.082
Human
single organism organelle organization GO:1902589 199 0.081
negative regulation of peptidase activity GO:0010466 10 0.080
ubiquitin dependent protein catabolic process GO:0006511 3 0.080
Human
maintenance of location GO:0051235 4 0.080
fertilization GO:0009566 3 0.080
vasculature development GO:0001944 278 0.079
regulation of protein targeting GO:1903533 2 0.079
regulation of cell communication GO:0010646 232 0.078
Human
regulation of catalytic activity GO:0050790 55 0.078
negative regulation of biological process GO:0048519 304 0.076
single organism transport GO:0044765 206 0.076
phosphorus metabolic process GO:0006793 109 0.076
positive regulation of macromolecule metabolic process GO:0010604 93 0.076
Human
embryo development ending in birth or egg hatching GO:0009792 271 0.072
positive regulation of apoptotic signaling pathway GO:2001235 1 0.072
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 20 0.072
positive regulation of cell communication GO:0010647 56 0.072
cellular macromolecule metabolic process GO:0044260 391 0.071
Human Mouse
stem cell proliferation GO:0072089 4 0.070
cellular component disassembly GO:0022411 1 0.070
cellular response to extracellular stimulus GO:0031668 2 0.070
aging GO:0007568 2 0.068
neuron projection morphogenesis GO:0048812 161 0.068
response to growth factor GO:0070848 39 0.068
response to metal ion GO:0010038 34 0.067
positive regulation of dna metabolic process GO:0051054 1 0.067
gland development GO:0048732 143 0.067
regionalization GO:0003002 274 0.067
protein import into nucleus GO:0006606 3 0.067
positive regulation of jnk cascade GO:0046330 3 0.066
cellular nitrogen compound metabolic process GO:0034641 290 0.066
Human
killing of cells in other organism involved in symbiotic interaction GO:0051883 1 0.066
response to external stimulus GO:0009605 264 0.066
regulation of protein import into nucleus GO:0042306 2 0.065
signal transduction in absence of ligand GO:0038034 1 0.063
cell cycle GO:0007049 93 0.062
positive regulation of cell death GO:0010942 29 0.062
cellular response to nutrient levels GO:0031669 2 0.062
single organism localization GO:1902578 225 0.062
killing of cells of other organism GO:0031640 1 0.061
cellular protein modification process GO:0006464 100 0.061
Human Mouse
regulation of protein localization to nucleus GO:1900180 2 0.061
negative regulation of catabolic process GO:0009895 3 0.061
response to hydrogen peroxide GO:0042542 3 0.060
embryonic limb morphogenesis GO:0030326 2 0.060
regulation of intracellular signal transduction GO:1902531 57 0.059
Human
positive regulation of transport GO:0051050 2 0.058
disruption of cells of other organism GO:0044364 1 0.058
myeloid cell differentiation GO:0030099 86 0.058
interaction with host GO:0051701 4 0.058
negative regulation of signal transduction GO:0009968 94 0.058
Human
regulation of rna biosynthetic process GO:2001141 213 0.058
Human
protein complex biogenesis GO:0070271 30 0.057
Human
head development GO:0060322 303 0.057
regulation of wound healing GO:0061041 2 0.057
cellular amine metabolic process GO:0044106 2 0.057
cellular response to starvation GO:0009267 1 0.057
rna biosynthetic process GO:0032774 181 0.057
Human
digestive tract development GO:0048565 265 0.056
response to external biotic stimulus GO:0043207 97 0.056
protein modification process GO:0036211 100 0.056
Human Mouse
regulation of response to stress GO:0080134 36 0.056
Human
phosphorylation GO:0016310 69 0.056
neuroblast proliferation GO:0007405 2 0.056
positive regulation of neuron apoptotic process GO:0043525 1 0.055
cellular response to endogenous stimulus GO:0071495 68 0.055
phosphate containing compound metabolic process GO:0006796 108 0.054
regulation of establishment of protein localization GO:0070201 4 0.054
phagocytosis GO:0006909 3 0.054
positive regulation of catabolic process GO:0009896 4 0.054
Human
regulation of cellular amine metabolic process GO:0033238 0 0.053
organonitrogen compound metabolic process GO:1901564 74 0.053
regulation of meiotic cell cycle GO:0051445 1 0.053
mitochondrial transport GO:0006839 2 0.053
cell morphogenesis GO:0000902 289 0.052
membrane fusion GO:0061025 2 0.052
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 4 0.052
tube morphogenesis GO:0035239 349 0.052
locomotor rhythm GO:0045475 3 0.051
response to organic cyclic compound GO:0014070 51 0.051
cellular amino acid metabolic process GO:0006520 7 0.050
amine metabolic process GO:0009308 2 0.050
regulation of cell cycle GO:0051726 52 0.050
apoptotic process GO:0006915 116 0.050
cellular biosynthetic process GO:0044249 286 0.050
Human
regulation of cytoplasmic transport GO:1903649 4 0.049
gtp catabolic process GO:0006184 2 0.049
determination of bilateral symmetry GO:0009855 204 0.049
regulation of organelle organization GO:0033043 29 0.049
transport GO:0006810 220 0.049
single organism membrane fusion GO:0044801 2 0.048
cellular component biogenesis GO:0044085 178 0.048
Human
neuron differentiation GO:0030182 353 0.048
regulation of cellular protein metabolic process GO:0032268 52 0.048
Human
negative regulation of cell death GO:0060548 60 0.048
regulation of epithelial cell proliferation GO:0050678 3 0.048
tissue remodeling GO:0048771 4 0.047
multicellular organismal macromolecule metabolic process GO:0044259 2 0.047
cellular ketone metabolic process GO:0042180 11 0.046
regulation of nucleocytoplasmic transport GO:0046822 2 0.046
response to carbohydrate GO:0009743 3 0.046
multi organism cellular process GO:0044764 2 0.046
negative regulation of macromolecule metabolic process GO:0010605 76 0.046
Human
cellular response to biotic stimulus GO:0071216 3 0.045
regulation of rna metabolic process GO:0051252 224 0.045
Human
positive regulation of signal transduction GO:0009967 56 0.045
cellular component morphogenesis GO:0032989 336 0.045
cellular response to hormone stimulus GO:0032870 39 0.045
negative regulation of signaling GO:0023057 96 0.044
Human
peptidyl serine phosphorylation GO:0018105 1 0.044
regulation of hydrolase activity GO:0051336 28 0.044
appendage development GO:0048736 80 0.044
cellular component movement GO:0006928 335 0.043
negative regulation of mitosis GO:0045839 3 0.043
response to alkaloid GO:0043279 2 0.043
regulation of intracellular protein transport GO:0033157 3 0.043
segmentation GO:0035282 97 0.043
rna localization GO:0006403 4 0.042
generation of neurons GO:0048699 385 0.042
response to other organism GO:0051707 97 0.042
organelle fusion GO:0048284 3 0.042
determination of left right symmetry GO:0007368 179 0.042
centrosome cycle GO:0007098 1 0.041
protein complex localization GO:0031503 1 0.041
homeostatic process GO:0042592 142 0.041
macromolecular complex subunit organization GO:0043933 74 0.041
Human
aromatic compound biosynthetic process GO:0019438 217 0.041
Human
digestive system development GO:0055123 289 0.041
cellular localization GO:0051641 97 0.040
Human
positive regulation of chromatin modification GO:1903310 1 0.040
nucleic acid metabolic process GO:0090304 244 0.040
Human
positive regulation of neuron death GO:1901216 1 0.040
post embryonic morphogenesis GO:0009886 4 0.040
positive regulation of signaling GO:0023056 56 0.039
morphogenesis of an epithelium GO:0002009 333 0.039
development of primary female sexual characteristics GO:0046545 4 0.039
nitrogen compound metabolic process GO:0006807 319 0.039
Human
cellular response to radiation GO:0071478 4 0.039
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.039
Human
regulation of protein maturation GO:1903317 10 0.039
spindle assembly GO:0051225 2 0.038
brain development GO:0007420 293 0.038
embryonic organ development GO:0048568 381 0.038
regulation of phosphorus metabolic process GO:0051174 43 0.038
rna metabolic process GO:0016070 219 0.038
Human
localization of cell GO:0051674 244 0.038
stem cell division GO:0017145 1 0.038
regulation of transport GO:0051049 45 0.037
regulation of apoptotic process GO:0042981 98 0.037
axonogenesis GO:0007409 152 0.037
odontogenesis of dentin containing tooth GO:0042475 1 0.037
epithelial tube morphogenesis GO:0060562 148 0.036
microtubule organizing center organization GO:0031023 1 0.036
locomotion GO:0040011 313 0.036
regulation of multicellular organismal development GO:2000026 223 0.036
negative regulation of kinase activity GO:0033673 4 0.036
response to endogenous stimulus GO:0009719 83 0.036
positive regulation of chromosome organization GO:2001252 1 0.035
centrosome organization GO:0051297 1 0.035
regulation of protein transport GO:0051223 3 0.035
regulation of cellular ketone metabolic process GO:0010565 7 0.035
response to oxidative stress GO:0006979 11 0.035
regulation of anatomical structure morphogenesis GO:0022603 130 0.035
regulation of cellular amino acid metabolic process GO:0006521 0 0.035
modification dependent macromolecule catabolic process GO:0043632 3 0.035
Human
regulation of cellular component organization GO:0051128 86 0.035
regulation of p38mapk cascade GO:1900744 1 0.035
embryonic organ morphogenesis GO:0048562 274 0.035
pigmentation GO:0043473 85 0.035
nucleobase containing compound metabolic process GO:0006139 274 0.035
Human
negative regulation of catalytic activity GO:0043086 21 0.034
collagen metabolic process GO:0032963 2 0.034
lipid storage GO:0019915 1 0.034
cell matrix adhesion GO:0007160 4 0.034
mitotic cell cycle GO:0000278 64 0.034
Human Mouse
circadian sleep wake cycle process GO:0022410 2 0.034
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.033
growth GO:0040007 174 0.033
neuron development GO:0048666 262 0.033
dorsal ventral pattern formation GO:0009953 125 0.033
reactive oxygen species metabolic process GO:0072593 6 0.033
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.033
activation of mapkkk activity GO:0000185 1 0.033
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 7 0.033
protein homooligomerization GO:0051260 3 0.032
carboxylic acid metabolic process GO:0019752 22 0.032
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.032
response to topologically incorrect protein GO:0035966 2 0.032
positive regulation of catalytic activity GO:0043085 25 0.032
regulation of organ growth GO:0046620 3 0.032
cell death GO:0008219 121 0.032
regulation of binding GO:0051098 3 0.032
negative regulation of epithelial cell proliferation GO:0050680 1 0.032
hepaticobiliary system development GO:0061008 98 0.032
viral process GO:0016032 1 0.031
response to glucocorticoid GO:0051384 1 0.031
embryonic appendage morphogenesis GO:0035113 30 0.031
response to mechanical stimulus GO:0009612 24 0.031
negative regulation of proteolysis GO:0045861 10 0.031
regulation of cytokine production GO:0001817 3 0.031
response to uv GO:0009411 3 0.031
synaptic growth at neuromuscular junction GO:0051124 2 0.031
transcription from rna polymerase ii promoter GO:0006366 80 0.030
Human
cell cycle process GO:0022402 53 0.030
regulation of mitochondrion organization GO:0010821 1 0.030
multicellular organism growth GO:0035264 4 0.030
negative regulation of cytoplasmic transport GO:1903650 2 0.030
nucleobase containing compound biosynthetic process GO:0034654 205 0.030
Human
positive regulation of programmed cell death GO:0043068 29 0.030
erythrocyte homeostasis GO:0034101 55 0.030
modification of morphology or physiology of other organism GO:0035821 4 0.030
appendage morphogenesis GO:0035107 56 0.030
guanosine containing compound metabolic process GO:1901068 4 0.030
neuron projection development GO:0031175 180 0.029
cell motility GO:0048870 244 0.029
negative regulation of metabolic process GO:0009892 86 0.029
Human
response to inorganic substance GO:0010035 38 0.029
regulation of localization GO:0032879 104 0.029
cell growth GO:0016049 57 0.029
mitotic cell cycle process GO:1903047 48 0.029
Human Mouse
female gonad development GO:0008585 4 0.029
circadian sleep wake cycle sleep GO:0050802 1 0.029
cellular response to estrogen stimulus GO:0071391 24 0.029
regulation of stem cell differentiation GO:2000736 4 0.029
antimicrobial humoral response GO:0019730 2 0.029
sleep GO:0030431 1 0.029
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.029
response to wounding GO:0009611 116 0.029
positive regulation of cellular metabolic process GO:0031325 94 0.028
Human
protein maturation GO:0051604 12 0.028
cellular response to lipid GO:0071396 39 0.028
somitogenesis GO:0001756 87 0.028
post embryonic organ development GO:0048569 4 0.028
cellular response to molecule of bacterial origin GO:0071219 3 0.028
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.028
response to methylmercury GO:0051597 11 0.028
apoptotic signaling pathway GO:0097190 23 0.028
intracellular signal transduction GO:0035556 85 0.028
Human
gtp metabolic process GO:0046039 4 0.028
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.028
response to oxygen containing compound GO:1901700 55 0.028
positive regulation of cellular catabolic process GO:0031331 3 0.028
Human
cell proliferation GO:0008283 80 0.028
regulation of programmed cell death GO:0043067 101 0.027
liver development GO:0001889 96 0.027
oxoacid metabolic process GO:0043436 31 0.027
transcription dna templated GO:0006351 181 0.027
Human
regulation of dendrite development GO:0050773 3 0.027
organic acid metabolic process GO:0006082 31 0.027
regulation of nitrogen compound metabolic process GO:0051171 251 0.027
Human
circadian sleep wake cycle GO:0042745 2 0.027
negative regulation of phosphate metabolic process GO:0045936 13 0.027
multicellular organismal metabolic process GO:0044236 2 0.027
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 10 0.027
heterocycle metabolic process GO:0046483 290 0.027
Human
neurotransmitter transport GO:0006836 2 0.027
protein processing GO:0016485 12 0.027
apoptotic process involved in development GO:1902742 2 0.026
positive regulation of molecular function GO:0044093 33 0.026
cell projection organization GO:0030030 284 0.026
cell migration GO:0016477 237 0.026
regulation of phosphate metabolic process GO:0019220 43 0.026
cellular carbohydrate metabolic process GO:0044262 4 0.026
female sex differentiation GO:0046660 4 0.026
negative regulation of nuclear division GO:0051784 3 0.026
regulation of nucleic acid templated transcription GO:1903506 213 0.026
Human
regulation of phosphorylation GO:0042325 26 0.026
protein complex subunit organization GO:0071822 46 0.025
Human
guanosine containing compound catabolic process GO:1901069 2 0.025
cellular response to growth factor stimulus GO:0071363 39 0.025
negative regulation of cell communication GO:0010648 96 0.025
Human
regulation of metal ion transport GO:0010959 4 0.025
axon development GO:0061564 166 0.025
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.025
cell substrate adhesion GO:0031589 4 0.025
regulation of reproductive process GO:2000241 4 0.025
i kappab kinase nf kappab signaling GO:0007249 4 0.025
negative regulation of protein transport GO:0051224 3 0.025
interspecies interaction between organisms GO:0044419 4 0.025
hemopoiesis GO:0030097 183 0.024
cellular response to reactive oxygen species GO:0034614 2 0.024
regulation of cell differentiation GO:0045595 142 0.024
astrocyte differentiation GO:0048708 1 0.024
regulation of cellular response to oxidative stress GO:1900407 2 0.024
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.024
response to glucose GO:0009749 3 0.024
mesenchyme development GO:0060485 127 0.024
protein phosphorylation GO:0006468 47 0.024
negative regulation of endopeptidase activity GO:0010951 10 0.024
positive regulation of metabolic process GO:0009893 108 0.024
Human
positive regulation of multi organism process GO:0043902 3 0.024
regulation of developmental process GO:0050793 247 0.024
regulation of cellular protein catabolic process GO:1903362 1 0.024
Human
macromolecule biosynthetic process GO:0009059 227 0.024
Human
response to steroid hormone GO:0048545 35 0.024
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 3 0.023
multicellular organismal homeostasis GO:0048871 29 0.023
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.023
cell morphogenesis involved in differentiation GO:0000904 195 0.023
macromolecular complex disassembly GO:0032984 1 0.023
myeloid cell homeostasis GO:0002262 56 0.023
specification of symmetry GO:0009799 204 0.023
regulation of carbohydrate metabolic process GO:0006109 4 0.023
positive regulation of cell division GO:0051781 2 0.022
stem cell development GO:0048864 82 0.022
digestive tract morphogenesis GO:0048546 231 0.022
protein complex disassembly GO:0043241 1 0.022
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.022
Human
negative regulation of protein metabolic process GO:0051248 16 0.022
negative regulation of protein processing GO:0010955 10 0.022
regulation of myotube differentiation GO:0010830 2 0.022
regulation of nucleotide catabolic process GO:0030811 2 0.022
regulation of nervous system development GO:0051960 90 0.022
response to hexose GO:0009746 3 0.021
regulation of response to oxidative stress GO:1902882 2 0.021
establishment of localization GO:0051234 244 0.021
Human
negative regulation of molecular function GO:0044092 23 0.021
rhythmic process GO:0048511 21 0.021
defense response to fungus GO:0050832 2 0.021
protein localization to plasma membrane GO:0072659 1 0.021
regulation of macromolecule biosynthetic process GO:0010556 225 0.021
Human
hatching gland development GO:0048785 3 0.021
developmental process involved in reproduction GO:0003006 27 0.021
er nucleus signaling pathway GO:0006984 2 0.021
blood vessel development GO:0001568 246 0.021
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.021
negative regulation of cellular catabolic process GO:0031330 3 0.020
mitotic cell cycle checkpoint GO:0007093 5 0.020
Human
developmental growth GO:0048589 166 0.020
cell death in response to oxidative stress GO:0036473 2 0.020
cellular response to organic cyclic compound GO:0071407 38 0.020
regulation of circadian sleep wake cycle GO:0042749 1 0.020
central nervous system development GO:0007417 387 0.020
regulation of protein processing GO:0070613 10 0.020
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.020
axon guidance GO:0007411 86 0.020
blood vessel morphogenesis GO:0048514 216 0.020
protein polymerization GO:0051258 4 0.020
protein localization GO:0008104 40 0.020
Human
response to corticosteroid GO:0031960 1 0.020
apoptotic process involved in morphogenesis GO:0060561 2 0.020
positive regulation of gtpase activity GO:0043547 1 0.020
germ cell development GO:0007281 22 0.020
fin development GO:0033333 77 0.019
system process GO:0003008 185 0.019
response to drug GO:0042493 3 0.019
regulation of dna replication GO:0006275 3 0.019
response to monosaccharide GO:0034284 3 0.019
regulation of cell development GO:0060284 100 0.019
negative regulation of protein complex assembly GO:0031333 1 0.019
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.019
phagocytosis engulfment GO:0006911 1 0.019
skin development GO:0043588 54 0.019
developmental programmed cell death GO:0010623 4 0.019
response to decreased oxygen levels GO:0036293 25 0.019
Human
microtubule based process GO:0007017 60 0.019
actin filament based process GO:0030029 64 0.019
nucleic acid templated transcription GO:0097659 181 0.018
Human
cellular response to oxygen containing compound GO:1901701 20 0.018
cellular response to light stimulus GO:0071482 4 0.018
regulation of cellular biosynthetic process GO:0031326 245 0.018
Human
eye development GO:0001654 277 0.018
regulation of transcription dna templated GO:0006355 213 0.018
Human
compound eye development GO:0048749 2 0.018
proteasomal protein catabolic process GO:0010498 2 0.018
Human
regulation of inflammatory response GO:0050727 2 0.018
b cell activation GO:0042113 2 0.018
endoplasmic reticulum unfolded protein response GO:0030968 2 0.018
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.018
pathway restricted smad protein phosphorylation GO:0060389 1 0.018
positive regulation of immune effector process GO:0002699 3 0.018
single organism intracellular transport GO:1902582 25 0.018
response to cold GO:0009409 4 0.018
somite development GO:0061053 96 0.017
regulation of cell shape GO:0008360 1 0.017
cilium morphogenesis GO:0060271 85 0.017
organic substance biosynthetic process GO:1901576 289 0.017
Human
angiogenesis GO:0001525 158 0.017
negative regulation of cellular metabolic process GO:0031324 77 0.017
Human
post embryonic organ morphogenesis GO:0048563 1 0.017
enzyme linked receptor protein signaling pathway GO:0007167 106 0.017
negative regulation of tor signaling GO:0032007 2 0.017
embryonic heart tube development GO:0035050 133 0.017
positive regulation of cytoskeleton organization GO:0051495 3 0.017
membrane organization GO:0061024 21 0.017
nitric oxide biosynthetic process GO:0006809 2 0.017

mdm2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.074
disease of cellular proliferation DOID:14566 0 0.074
organ system cancer DOID:0050686 0 0.074
gastrointestinal system cancer DOID:3119 0 0.062
disease of metabolism DOID:0014667 0 0.058
lysosomal storage disease DOID:3211 0 0.058
inherited metabolic disorder DOID:655 0 0.058
colon carcinoma DOID:1520 0 0.047
large intestine cancer DOID:5672 0 0.047
colon cancer DOID:219 0 0.047
intestinal cancer DOID:10155 0 0.047
colorectal cancer DOID:9256 0 0.047
disease of anatomical entity DOID:7 0 0.044
immune system disease DOID:2914 0 0.020