Danio rerio

0 known processes

rhpn2

rhophilin, Rho GTPase binding protein 2

(Aliases: wu:fa26b12,cb668,wu:fk87d04,zgc:55960,MGC55960,sb:cb668)

rhpn2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular macromolecule metabolic process GO:0044260 391 0.401
heterocycle metabolic process GO:0046483 290 0.200
aromatic compound biosynthetic process GO:0019438 217 0.178
cellular aromatic compound metabolic process GO:0006725 295 0.163
aging GO:0007568 2 0.147
adherens junction organization GO:0034332 4 0.115
larval development GO:0002164 2 0.110
organelle organization GO:0006996 227 0.105
morphogenesis of an epithelium GO:0002009 333 0.097
hemopoiesis GO:0030097 183 0.096
vasculature development GO:0001944 278 0.093
heart development GO:0007507 313 0.093
organic cyclic compound biosynthetic process GO:1901362 223 0.091
cellular nitrogen compound metabolic process GO:0034641 290 0.090
neuron differentiation GO:0030182 353 0.089
nitrogen compound metabolic process GO:0006807 319 0.088
biosynthetic process GO:0009058 294 0.086
regulation of rna biosynthetic process GO:2001141 213 0.081
muscle structure development GO:0061061 196 0.079
negative regulation of biological process GO:0048519 304 0.077
transport GO:0006810 220 0.075
gene expression GO:0010467 252 0.073
positive regulation of cell adhesion GO:0045785 1 0.068
protein localization to plasma membrane GO:0072659 1 0.068
photoreceptor cell differentiation GO:0046530 55 0.067
regulation of transport GO:0051049 45 0.067
regulation of axonogenesis GO:0050770 32 0.067
maternal determination of anterior posterior axis embryo GO:0008358 4 0.067
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.064
hematopoietic or lymphoid organ development GO:0048534 191 0.063
macromolecule biosynthetic process GO:0009059 227 0.063
cellular component movement GO:0006928 335 0.061
regulation of transcription dna templated GO:0006355 213 0.061
negative regulation of ras protein signal transduction GO:0046580 1 0.061
cortical cytoskeleton organization GO:0030865 1 0.058
negative regulation of cellular process GO:0048523 283 0.057
heterocycle biosynthetic process GO:0018130 215 0.057
regulation of nitrogen compound metabolic process GO:0051171 251 0.057
embryo development ending in birth or egg hatching GO:0009792 271 0.056
phosphorus metabolic process GO:0006793 109 0.056
morphogenesis of an epithelial sheet GO:0002011 49 0.054
regulation of rna metabolic process GO:0051252 224 0.054
cellular nitrogen compound biosynthetic process GO:0044271 218 0.054
single organism metabolic process GO:0044710 217 0.053
germ line stem cell division GO:0042078 1 0.053
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.052
regulation of synapse assembly GO:0051963 3 0.052
central nervous system development GO:0007417 387 0.051
medulla oblongata development GO:0021550 4 0.050
single organism intracellular transport GO:1902582 25 0.050
biological adhesion GO:0022610 40 0.050
nucleic acid templated transcription GO:0097659 181 0.049
actin filament based process GO:0030029 64 0.049
regulation of gene expression GO:0010468 265 0.049
regulation of cell development GO:0060284 100 0.049
golgi vesicle transport GO:0048193 3 0.048
digestive system development GO:0055123 289 0.048
cellular component biogenesis GO:0044085 178 0.047
positive regulation of transport GO:0051050 2 0.046
regulation of multicellular organismal process GO:0051239 277 0.046
intracellular transport GO:0046907 32 0.045
rna metabolic process GO:0016070 219 0.045
meiotic nuclear division GO:0007126 4 0.044
brain development GO:0007420 293 0.044
regulation of developmental process GO:0050793 247 0.043
regulation of cellular biosynthetic process GO:0031326 245 0.043
regulation of cell shape GO:0008360 1 0.043
cardiac muscle tissue development GO:0048738 48 0.043
long chain fatty acid biosynthetic process GO:0042759 1 0.042
positive regulation of biological process GO:0048518 253 0.042
single organism localization GO:1902578 225 0.042
regulation of photoreceptor cell differentiation GO:0046532 2 0.041
single organism membrane fusion GO:0044801 2 0.041
regulation of signal transduction GO:0009966 225 0.041
cell migration GO:0016477 237 0.041
positive regulation of cellular component biogenesis GO:0044089 3 0.041
oocyte anterior posterior axis specification GO:0007314 4 0.041
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.040
stem cell division GO:0017145 1 0.040
retina development in camera type eye GO:0060041 146 0.040
camera type eye development GO:0043010 222 0.040
positive regulation of cell cycle GO:0045787 3 0.039
regulation of establishment of protein localization to plasma membrane GO:0090003 1 0.039
cortical actin cytoskeleton organization GO:0030866 1 0.039
cellular macromolecule biosynthetic process GO:0034645 224 0.038
maintenance of location GO:0051235 4 0.038
retina morphogenesis in camera type eye GO:0060042 79 0.038
regulation of multicellular organism growth GO:0040014 4 0.038
cellular amine metabolic process GO:0044106 2 0.038
protein localization to nucleus GO:0034504 3 0.038
synaptic growth at neuromuscular junction GO:0051124 2 0.038
regulation of cell size GO:0008361 29 0.038
regulation of establishment of protein localization GO:0070201 4 0.037
generation of neurons GO:0048699 385 0.037
single organism transport GO:0044765 206 0.037
signal transduction GO:0007165 455 0.037
cognition GO:0050890 1 0.036
segmentation GO:0035282 97 0.036
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.036
blood vessel development GO:0001568 246 0.036
autophagy GO:0006914 4 0.035
epidermis development GO:0008544 48 0.035
regulation of cell matrix adhesion GO:0001952 1 0.035
protein metabolic process GO:0019538 183 0.035
angiogenesis GO:0001525 158 0.035
fatty acid elongation GO:0030497 1 0.035
chordate embryonic development GO:0043009 271 0.035
response to chemical GO:0042221 320 0.034
regulation of cellular metabolic process GO:0031323 320 0.034
regulation of protein transport GO:0051223 3 0.034
immune system process GO:0002376 241 0.033
lipid metabolic process GO:0006629 52 0.033
pigment granule transport GO:0051904 19 0.033
localization of cell GO:0051674 244 0.033
rna biosynthetic process GO:0032774 181 0.033
muscle tissue development GO:0060537 110 0.033
actin filament based movement GO:0030048 1 0.032
establishment or maintenance of apical basal cell polarity GO:0035088 12 0.032
nucleobase containing compound biosynthetic process GO:0034654 205 0.032
organic cyclic compound metabolic process GO:1901360 301 0.032
phosphate containing compound metabolic process GO:0006796 108 0.032
system process GO:0003008 185 0.031
regulation of anatomical structure morphogenesis GO:0022603 130 0.031
regulation of cellular amine metabolic process GO:0033238 0 0.031
adherens junction maintenance GO:0034334 2 0.031
eye development GO:0001654 277 0.031
regulation of cell communication GO:0010646 232 0.031
axonogenesis GO:0007409 152 0.031
negative regulation of metabolic process GO:0009892 86 0.031
striated muscle cell differentiation GO:0051146 129 0.031
very long chain fatty acid biosynthetic process GO:0042761 4 0.030
specification of symmetry GO:0009799 204 0.030
regulation of synapse organization GO:0050807 3 0.030
cytokinesis GO:0000910 3 0.030
cell junction maintenance GO:0034331 2 0.030
establishment or maintenance of bipolar cell polarity GO:0061245 12 0.030
regulation of nucleic acid templated transcription GO:1903506 213 0.030
cellular component morphogenesis GO:0032989 336 0.029
nucleic acid metabolic process GO:0090304 244 0.029
establishment of protein localization to plasma membrane GO:0090002 1 0.029
tube morphogenesis GO:0035239 349 0.029
establishment of synaptic vesicle localization GO:0097480 1 0.029
nuclear transport GO:0051169 4 0.029
actin polymerization or depolymerization GO:0008154 2 0.029
determination of left right symmetry GO:0007368 179 0.029
very long chain fatty acid metabolic process GO:0000038 4 0.028
intracellular signal transduction GO:0035556 85 0.028
muscle cell differentiation GO:0042692 139 0.028
cell part morphogenesis GO:0032990 246 0.028
female sex differentiation GO:0046660 4 0.028
nucleobase containing compound metabolic process GO:0006139 274 0.028
regulation of neurogenesis GO:0050767 87 0.028
meiotic cell cycle process GO:1903046 3 0.028
apical junction assembly GO:0043297 1 0.028
cellular component assembly GO:0022607 170 0.028
regulation of synaptic plasticity GO:0048167 1 0.028
cytokinetic process GO:0032506 2 0.027
establishment or maintenance of polarity of embryonic epithelium GO:0016332 2 0.027
regulation of macromolecule metabolic process GO:0060255 317 0.027
cell morphogenesis GO:0000902 289 0.027
multicellular organism growth GO:0035264 4 0.027
regulation of circadian rhythm GO:0042752 4 0.027
developmental growth GO:0048589 166 0.027
embryonic heart tube development GO:0035050 133 0.027
neurological system process GO:0050877 62 0.027
regulation of macromolecule biosynthetic process GO:0010556 225 0.026
epithelial tube morphogenesis GO:0060562 148 0.026
synaptic vesicle endocytosis GO:0048488 1 0.026
camera type eye morphogenesis GO:0048593 108 0.026
lipid storage GO:0019915 1 0.026
regulation of skeletal muscle fiber development GO:0048742 2 0.025
cellular component maintenance GO:0043954 3 0.025
establishment or maintenance of cell polarity GO:0007163 29 0.025
cell growth GO:0016049 57 0.025
immune system development GO:0002520 191 0.025
regulation of cell growth GO:0001558 29 0.025
phagocytosis GO:0006909 3 0.025
regulation of localization GO:0032879 104 0.025
transcription dna templated GO:0006351 181 0.025
amine metabolic process GO:0009308 2 0.025
response to growth factor GO:0070848 39 0.025
hormone biosynthetic process GO:0042446 3 0.025
determination of bilateral symmetry GO:0009855 204 0.025
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.024
nucleocytoplasmic transport GO:0006913 4 0.024
regulation of neuron differentiation GO:0045664 56 0.024
response to organic substance GO:0010033 153 0.024
regulation of cell morphogenesis GO:0022604 42 0.024
cellular response to growth factor stimulus GO:0071363 39 0.024
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.024
regulation of reproductive process GO:2000241 4 0.024
carboxylic acid metabolic process GO:0019752 22 0.024
cell substrate adhesion GO:0031589 4 0.024
protein complex disassembly GO:0043241 1 0.023
regulation of protein complex assembly GO:0043254 3 0.023
cytoskeleton dependent cytokinesis GO:0061640 3 0.023
primary neural tube formation GO:0014020 1 0.023
cell morphogenesis involved in differentiation GO:0000904 195 0.023
regulation of cellular amino acid metabolic process GO:0006521 0 0.023
nuclear import GO:0051170 3 0.023
skin development GO:0043588 54 0.023
guanosine containing compound metabolic process GO:1901068 4 0.023
cell projection organization GO:0030030 284 0.022
regulation of nervous system development GO:0051960 90 0.022
organelle assembly GO:0070925 110 0.022
regulation of cell substrate adhesion GO:0010810 1 0.022
germ line stem cell maintenance GO:0030718 2 0.022
stem cell maintenance GO:0019827 4 0.022
oxoacid metabolic process GO:0043436 31 0.022
regulation of dendrite development GO:0050773 3 0.022
carbohydrate transport GO:0008643 13 0.022
negative regulation of cell communication GO:0010648 96 0.022
negative regulation of response to stimulus GO:0048585 104 0.022
long chain fatty acid metabolic process GO:0001676 1 0.022
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.022
striated muscle tissue development GO:0014706 110 0.022
regulation of developmental growth GO:0048638 38 0.022
single organism cellular localization GO:1902580 46 0.021
regulation of muscle contraction GO:0006937 3 0.021
liver development GO:0001889 96 0.021
protein polymerization GO:0051258 4 0.021
regulation of circadian sleep wake cycle GO:0042749 1 0.021
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.021
cellular biosynthetic process GO:0044249 286 0.021
heart morphogenesis GO:0003007 156 0.021
cell cycle GO:0007049 93 0.021
protein import into nucleus GO:0006606 3 0.021
regulation of anatomical structure size GO:0090066 33 0.020
negative regulation of signal transduction GO:0009968 94 0.020
macromolecule localization GO:0033036 54 0.020
digestive tract morphogenesis GO:0048546 231 0.020
cell adhesion GO:0007155 40 0.020
cellular response to organic substance GO:0071310 105 0.020
dna biosynthetic process GO:0071897 3 0.020
regulation of blood pressure GO:0008217 1 0.020
cellular response to chemical stimulus GO:0070887 157 0.020
cellular amino acid metabolic process GO:0006520 7 0.020
peptidyl serine phosphorylation GO:0018105 1 0.020
regulation of cell differentiation GO:0045595 142 0.020
organonitrogen compound metabolic process GO:1901564 74 0.020
pigmentation GO:0043473 85 0.020
digestive tract development GO:0048565 265 0.020
regulation of apoptotic process GO:0042981 98 0.020
kupffer s vesicle development GO:0070121 50 0.020
neuron development GO:0048666 262 0.019
regulation of biosynthetic process GO:0009889 250 0.019
negative regulation of gene expression GO:0010629 65 0.019
neuroblast proliferation GO:0007405 2 0.019
gastrulation GO:0007369 208 0.019
transcription from rna polymerase ii promoter GO:0006366 80 0.019
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.019
stem cell proliferation GO:0072089 4 0.019
regulation of biological quality GO:0065008 263 0.019
regulation of response to stimulus GO:0048583 269 0.019
positive regulation of cell division GO:0051781 2 0.019
establishment of protein localization to organelle GO:0072594 4 0.019
protein import GO:0017038 3 0.019
circadian sleep wake cycle GO:0042745 2 0.019
cellular component disassembly GO:0022411 1 0.019
cellular carbohydrate metabolic process GO:0044262 4 0.019
muscle organ development GO:0007517 101 0.019
ventricular cardiac muscle tissue development GO:0003229 3 0.018
membrane lipid biosynthetic process GO:0046467 2 0.018
homeostatic process GO:0042592 142 0.018
hormone transport GO:0009914 2 0.018
protein localization GO:0008104 40 0.018
response to drug GO:0042493 3 0.018
cell projection morphogenesis GO:0048858 244 0.018
cell matrix adhesion GO:0007160 4 0.018
cellular ketone metabolic process GO:0042180 11 0.018
mesodermal cell migration GO:0008078 12 0.018
gtp catabolic process GO:0006184 2 0.018
embryonic organ development GO:0048568 381 0.018
protein phosphorylation GO:0006468 47 0.018
regulation of wnt signaling pathway GO:0030111 53 0.018
cellular response to endogenous stimulus GO:0071495 68 0.018
androgen metabolic process GO:0008209 2 0.018
epithelial cell morphogenesis GO:0003382 2 0.018
regulation of signaling GO:0023051 235 0.018
rna localization GO:0006403 4 0.018
regulation of organelle organization GO:0033043 29 0.018
regulation of multicellular organismal development GO:2000026 223 0.018
synaptic vesicle recycling GO:0036465 1 0.018
organic acid metabolic process GO:0006082 31 0.017
regulation of oocyte development GO:0060281 3 0.017
regulation of cell projection organization GO:0031344 44 0.017
positive regulation of muscle organ development GO:0048636 1 0.017
neuron projection extension GO:1990138 45 0.017
cell motility GO:0048870 244 0.017
intracellular mrna localization GO:0008298 1 0.017
gtp metabolic process GO:0046039 4 0.017
post golgi vesicle mediated transport GO:0006892 1 0.017
small molecule metabolic process GO:0044281 77 0.017
cell surface receptor signaling pathway GO:0007166 325 0.017
regulation of cellular component movement GO:0051270 55 0.017
positive regulation of response to stimulus GO:0048584 80 0.017
locomotion GO:0040011 313 0.017
pigment cell differentiation GO:0050931 38 0.017
negative regulation of multicellular organismal process GO:0051241 69 0.016
sensory organ morphogenesis GO:0090596 200 0.016
establishment of localization GO:0051234 244 0.016
regulation of ph GO:0006885 3 0.016
cellular response to starvation GO:0009267 1 0.016
muscle cell development GO:0055001 115 0.016
regulation of cellular component size GO:0032535 30 0.016
organelle localization GO:0051640 49 0.016
regulation of glucose import GO:0046324 1 0.016
regulation of stem cell differentiation GO:2000736 4 0.016
regionalization GO:0003002 274 0.016
inner ear development GO:0048839 126 0.016
s adenosylmethionine metabolic process GO:0046500 1 0.016
meiotic chromosome segregation GO:0045132 3 0.016
negative regulation of cellular metabolic process GO:0031324 77 0.016
ameboidal type cell migration GO:0001667 143 0.016
death GO:0016265 121 0.016
response to stress GO:0006950 263 0.015
regulation of cellular ketone metabolic process GO:0010565 7 0.015
guanosine containing compound catabolic process GO:1901069 2 0.015
regulation of nucleocytoplasmic transport GO:0046822 2 0.015
response to ketone GO:1901654 1 0.015
small gtpase mediated signal transduction GO:0007264 8 0.015
sensory organ development GO:0007423 393 0.015
directional locomotion GO:0033058 1 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
regulation of primary metabolic process GO:0080090 311 0.015
negative regulation of developmental process GO:0051093 65 0.015
actin mediated cell contraction GO:0070252 1 0.015
glucose import GO:0046323 2 0.015
regulation of cytoplasmic transport GO:1903649 4 0.015
response to external biotic stimulus GO:0043207 97 0.015
carbohydrate derivative metabolic process GO:1901135 61 0.014
positive regulation of cytoskeleton organization GO:0051495 3 0.014
sleep GO:0030431 1 0.014
tube closure GO:0060606 1 0.014
regulation of cytoskeleton organization GO:0051493 11 0.014
fatty acid elongation unsaturated fatty acid GO:0019368 1 0.014
regulation of protein localization to plasma membrane GO:1903076 1 0.014
embryonic heart tube morphogenesis GO:0003143 108 0.014
cell cell junction organization GO:0045216 10 0.014
cellular protein modification process GO:0006464 100 0.014
regulation of protein catabolic process GO:0042176 1 0.014
protein stabilization GO:0050821 2 0.014
action potential GO:0001508 19 0.014
hepaticobiliary system development GO:0061008 98 0.014
cell death GO:0008219 121 0.014
regulation of intracellular protein transport GO:0033157 3 0.013
membrane fusion GO:0061025 2 0.013
ras protein signal transduction GO:0007265 7 0.013
establishment of localization in cell GO:0051649 77 0.013
dopamine metabolic process GO:0042417 2 0.013
adult behavior GO:0030534 2 0.013
gland development GO:0048732 143 0.013
kidney development GO:0001822 92 0.013
pole plasm assembly GO:0007315 4 0.013
regulation of metabolic process GO:0019222 359 0.013
epithelial cell differentiation GO:0030855 116 0.013
cation transport GO:0006812 81 0.013
interspecies interaction between organisms GO:0044419 4 0.013
neuron projection morphogenesis GO:0048812 161 0.013
cytoskeleton organization GO:0007010 96 0.013
cellular protein complex disassembly GO:0043624 1 0.013
establishment of melanosome localization GO:0032401 19 0.013
microtubule polymerization or depolymerization GO:0031109 3 0.013
embryonic organ morphogenesis GO:0048562 274 0.013
neuron projection development GO:0031175 180 0.013
endocrine hormone secretion GO:0060986 2 0.012
regulation of protein localization to nucleus GO:1900180 2 0.012
microtubule organizing center organization GO:0031023 1 0.012
regulation of growth GO:0040008 42 0.012
pronephros development GO:0048793 69 0.012
cell division GO:0051301 20 0.012
regulation of organ growth GO:0046620 3 0.012
protein depolymerization GO:0051261 1 0.012
positive regulation of secretion by cell GO:1903532 1 0.012
embryonic skeletal joint development GO:0072498 3 0.012
response to external stimulus GO:0009605 264 0.012
membrane invagination GO:0010324 1 0.012
single organism biosynthetic process GO:0044711 71 0.012
regulation of protein complex disassembly GO:0043244 1 0.012
blood vessel morphogenesis GO:0048514 216 0.012
microtubule cytoskeleton organization GO:0000226 33 0.012
multicellular organismal signaling GO:0035637 22 0.012
positive regulation of cellular process GO:0048522 201 0.012
positive regulation of cell killing GO:0031343 2 0.012
organic substance biosynthetic process GO:1901576 289 0.011
taxis GO:0042330 109 0.011
embryonic hemopoiesis GO:0035162 53 0.011
actin filament bundle assembly GO:0051017 6 0.011
protein acetylation GO:0006473 2 0.011
axon extension GO:0048675 45 0.011
positive regulation of signaling GO:0023056 56 0.011
circulatory system process GO:0003013 87 0.011
metal ion transport GO:0030001 58 0.011
heart looping GO:0001947 94 0.011
protein complex biogenesis GO:0070271 30 0.011
regulation of ion transmembrane transporter activity GO:0032412 2 0.011
epithelial tube formation GO:0072175 19 0.011
eye morphogenesis GO:0048592 144 0.011
positive regulation of apoptotic signaling pathway GO:2001235 1 0.011
positive regulation of signal transduction GO:0009967 56 0.011
regulation of binding GO:0051098 3 0.011
regulation of glucose transport GO:0010827 1 0.011
somite development GO:0061053 96 0.011
regulation of cellular response to growth factor stimulus GO:0090287 35 0.011
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.011
urogenital system development GO:0001655 97 0.011
protein targeting to nucleus GO:0044744 3 0.011
spermatid development GO:0007286 2 0.011
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.011
regulation of receptor mediated endocytosis GO:0048259 4 0.011
striated muscle cell development GO:0055002 108 0.011
regulation of epithelial to mesenchymal transition GO:0010717 3 0.011
regulation of response to nutrient levels GO:0032107 1 0.011
positive regulation of epithelial cell migration GO:0010634 2 0.010
regulation of axon extension GO:0030516 24 0.010
regulation of skeletal muscle tissue development GO:0048641 4 0.010
neural nucleus development GO:0048857 15 0.010
cellular protein catabolic process GO:0044257 4 0.010
positive regulation of multi organism process GO:0043902 3 0.010
cardiocyte differentiation GO:0035051 44 0.010
developmental cell growth GO:0048588 52 0.010
tissue migration GO:0090130 37 0.010
response to food GO:0032094 1 0.010
determination of heart left right asymmetry GO:0061371 117 0.010
regulation of embryonic development GO:0045995 47 0.010
regulation of cell maturation GO:1903429 1 0.010
internal peptidyl lysine acetylation GO:0018393 2 0.010
regulation of cell adhesion GO:0030155 15 0.010
hair cell differentiation GO:0035315 32 0.010
cell substrate junction assembly GO:0007044 2 0.010
positive regulation of cellular amine metabolic process GO:0033240 0 0.010
internal protein amino acid acetylation GO:0006475 2 0.010
neural tube development GO:0021915 62 0.010
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.010
cellular response to external stimulus GO:0071496 2 0.010
nuclear export GO:0051168 1 0.010
regulation of hormone secretion GO:0046883 2 0.010
anterior posterior pattern specification GO:0009952 152 0.010

rhpn2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.043
disease of cellular proliferation DOID:14566 0 0.043
organ system cancer DOID:0050686 0 0.043
x linked disease DOID:0050735 0 0.016
disease of anatomical entity DOID:7 0 0.014
cardiovascular system disease DOID:1287 0 0.014