Danio rerio

0 known processes

psmd4b

proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b

(Aliases: psmd4,wu:fc68c04,im:6912672,zgc:110247)

psmd4b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
modification dependent macromolecule catabolic process GO:0043632 3 0.853
Yeast Worm
cellular protein catabolic process GO:0044257 4 0.843
Yeast Worm
ubiquitin dependent protein catabolic process GO:0006511 3 0.775
Yeast Worm
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.690
Yeast Worm
modification dependent protein catabolic process GO:0019941 3 0.679
Yeast Worm
aging GO:0007568 2 0.601
Worm
cellular macromolecule metabolic process GO:0044260 391 0.450
Yeast Worm Fly
fertilization GO:0009566 3 0.443
single fertilization GO:0007338 3 0.401
regulation of meiotic cell cycle GO:0051445 1 0.388
larval development GO:0002164 2 0.359
Worm
protein polyubiquitination GO:0000209 4 0.346
regulation of metabolic process GO:0019222 359 0.334
Worm Fly
protein metabolic process GO:0019538 183 0.306
Yeast Worm Fly
cellular protein metabolic process GO:0044267 129 0.300
Yeast Worm Fly
meiotic nuclear division GO:0007126 4 0.245
meiotic cell cycle process GO:1903046 3 0.243
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.229
cellular component assembly GO:0022607 170 0.182
pronuclear migration GO:0035046 1 0.169
proteasomal protein catabolic process GO:0010498 2 0.154
organelle organization GO:0006996 227 0.147
meiotic chromosome segregation GO:0045132 3 0.135
cellular macromolecule catabolic process GO:0044265 12 0.133
Yeast Worm
establishment of localization GO:0051234 244 0.129
signal transduction GO:0007165 455 0.107
positive regulation of cellular component biogenesis GO:0044089 3 0.102
chromosome organization involved in meiosis GO:0070192 1 0.101
proteolysis GO:0006508 38 0.101
Yeast Worm Fly
cellular catabolic process GO:0044248 27 0.098
Yeast Worm
regulation of protein ubiquitination GO:0031396 3 0.098
Fly
catabolic process GO:0009056 32 0.096
Yeast Worm
regulation of biosynthetic process GO:0009889 250 0.096
positive regulation of biological process GO:0048518 253 0.096
cellular component biogenesis GO:0044085 178 0.095
single organism organelle organization GO:1902589 199 0.091
positive regulation of protein complex assembly GO:0031334 2 0.091
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.088
Fly
regulation of protein catabolic process GO:0042176 1 0.087
regulation of macromolecule metabolic process GO:0060255 317 0.087
Worm Fly
dna templated transcription initiation GO:0006352 1 0.087
cell morphogenesis GO:0000902 289 0.084
regulation of primary metabolic process GO:0080090 311 0.083
Fly
protein catabolic process GO:0030163 7 0.077
Yeast Worm
multicellular organism growth GO:0035264 4 0.077
protein secretion GO:0009306 1 0.076
transport GO:0006810 220 0.075
positive regulation of cell cycle GO:0045787 3 0.074
embryo development ending in birth or egg hatching GO:0009792 271 0.073
organic substance catabolic process GO:1901575 28 0.071
Yeast Worm
nitrogen compound metabolic process GO:0006807 319 0.070
positive regulation of metabolic process GO:0009893 108 0.068
regulation of protein complex assembly GO:0043254 3 0.068
response to organic substance GO:0010033 153 0.067
rna metabolic process GO:0016070 219 0.067
positive regulation of cellular metabolic process GO:0031325 94 0.066
macromolecule catabolic process GO:0009057 15 0.065
Yeast Worm
nucleobase containing compound metabolic process GO:0006139 274 0.065
nucleic acid metabolic process GO:0090304 244 0.065
positive regulation of cellular process GO:0048522 201 0.065
membrane fusion GO:0061025 2 0.064
cellular biosynthetic process GO:0044249 286 0.063
regulation of nitrogen compound metabolic process GO:0051171 251 0.063
protein complex assembly GO:0006461 30 0.063
cellular protein modification process GO:0006464 100 0.063
Fly
regulation of catalytic activity GO:0050790 55 0.063
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.061
protein k63 linked ubiquitination GO:0070534 2 0.061
negative regulation of biological process GO:0048519 304 0.061
Worm
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.061
ribonucleoside monophosphate catabolic process GO:0009158 4 0.059
response to stress GO:0006950 263 0.058
Fly
protein modification process GO:0036211 100 0.057
Fly
positive regulation of macromolecule metabolic process GO:0010604 93 0.056
regulation of establishment of protein localization GO:0070201 4 0.056
transcription dna templated GO:0006351 181 0.055
cellular nitrogen compound metabolic process GO:0034641 290 0.055
regulation of macromolecule biosynthetic process GO:0010556 225 0.054
regulation of cytoplasmic transport GO:1903649 4 0.054
regulation of response to stimulus GO:0048583 269 0.051
aromatic compound biosynthetic process GO:0019438 217 0.051
small molecule metabolic process GO:0044281 77 0.050
regulation of rna biosynthetic process GO:2001141 213 0.050
cytokinesis GO:0000910 3 0.049
organelle fusion GO:0048284 3 0.049
regulation of cell shape GO:0008360 1 0.049
nucleoside monophosphate catabolic process GO:0009125 4 0.048
cell projection morphogenesis GO:0048858 244 0.048
nucleic acid templated transcription GO:0097659 181 0.048
cellular response to extracellular stimulus GO:0031668 2 0.048
nucleobase containing compound biosynthetic process GO:0034654 205 0.047
cell proliferation GO:0008283 80 0.047
organic cyclic compound biosynthetic process GO:1901362 223 0.046
gene expression GO:0010467 252 0.045
Worm
single organism membrane fusion GO:0044801 2 0.044
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.044
macromolecular complex subunit organization GO:0043933 74 0.043
organic cyclic compound metabolic process GO:1901360 301 0.043
protein modification by small protein conjugation or removal GO:0070647 14 0.043
Fly
blood vessel development GO:0001568 246 0.043
heterocycle biosynthetic process GO:0018130 215 0.042
macromolecule modification GO:0043412 111 0.042
Fly
phagocytosis GO:0006909 3 0.042
generation of neurons GO:0048699 385 0.041
regulation of cellular biosynthetic process GO:0031326 245 0.040
pole plasm assembly GO:0007315 4 0.040
response to external stimulus GO:0009605 264 0.040
cellular aromatic compound metabolic process GO:0006725 295 0.039
macromolecular complex assembly GO:0065003 35 0.039
negative regulation of cellular process GO:0048523 283 0.039
cellular macromolecular complex assembly GO:0034622 24 0.039
maintenance of location GO:0051235 4 0.038
regulation of cell communication GO:0010646 232 0.038
response to abiotic stimulus GO:0009628 122 0.038
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.037
nuclear migration GO:0007097 3 0.037
regulation of cellular protein catabolic process GO:1903362 1 0.037
rna biosynthetic process GO:0032774 181 0.036
neuron projection morphogenesis GO:0048812 161 0.035
mitotic cell cycle process GO:1903047 48 0.035
regulation of developmental process GO:0050793 247 0.035
Worm
cell surface receptor signaling pathway GO:0007166 325 0.034
regulation of mitotic cell cycle GO:0007346 25 0.033
male meiosis GO:0007140 2 0.033
positive regulation of catabolic process GO:0009896 4 0.033
response to drug GO:0042493 3 0.033
cellular response to external stimulus GO:0071496 2 0.033
cellular macromolecule biosynthetic process GO:0034645 224 0.032
regulation of cellular metabolic process GO:0031323 320 0.032
Fly
regulation of nucleocytoplasmic transport GO:0046822 2 0.032
cellular protein complex assembly GO:0043623 19 0.032
cellular nitrogen compound biosynthetic process GO:0044271 218 0.032
protein polymerization GO:0051258 4 0.032
organelle assembly GO:0070925 110 0.032
negative regulation of response to stimulus GO:0048585 104 0.031
regulation of multicellular organismal process GO:0051239 277 0.031
Worm
response to wounding GO:0009611 116 0.031
single organism localization GO:1902578 225 0.030
positive regulation of transport GO:0051050 2 0.030
cell part morphogenesis GO:0032990 246 0.030
localization within membrane GO:0051668 1 0.030
gtp metabolic process GO:0046039 4 0.030
negative regulation of protein transport GO:0051224 3 0.029
oocyte anterior posterior axis specification GO:0007314 4 0.029
regulation of molecular function GO:0065009 70 0.029
positive regulation of cellular catabolic process GO:0031331 3 0.029
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.029
multi organism process GO:0051704 134 0.028
Worm
locomotion GO:0040011 313 0.028
vasculature development GO:0001944 278 0.028
meiosis ii GO:0007135 1 0.028
regulation of cell activation GO:0050865 1 0.028
autophagy GO:0006914 4 0.028
negative regulation of immune response GO:0050777 2 0.028
regulation of rna metabolic process GO:0051252 224 0.027
neuroblast proliferation GO:0007405 2 0.027
regulation of cellular component organization GO:0051128 86 0.027
organic substance transport GO:0071702 58 0.027
guanosine containing compound catabolic process GO:1901069 2 0.026
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.026
regulation of cellular protein metabolic process GO:0032268 52 0.026
Fly
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.026
cell cycle g2 m phase transition GO:0044839 4 0.026
cell projection organization GO:0030030 284 0.026
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.026
phosphate containing compound metabolic process GO:0006796 108 0.026
meiosis i GO:0007127 1 0.026
blood vessel morphogenesis GO:0048514 216 0.026
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.025
cortical cytoskeleton organization GO:0030865 1 0.024
regulation of response to stress GO:0080134 36 0.024
phosphorus metabolic process GO:0006793 109 0.024
response to chemical GO:0042221 320 0.024
double strand break repair GO:0006302 3 0.024
cellular response to nutrient levels GO:0031669 2 0.023
organelle localization GO:0051640 49 0.023
reproductive process GO:0022414 40 0.023
Worm
negative regulation of mitosis GO:0045839 3 0.023
regulation of signaling GO:0023051 235 0.023
negative regulation of cytoplasmic transport GO:1903650 2 0.023
gamete generation GO:0007276 33 0.023
Worm
macromolecule biosynthetic process GO:0009059 227 0.023
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.022
lipid storage GO:0019915 1 0.022
multi organism reproductive process GO:0044703 36 0.022
Worm
cytoplasm organization GO:0007028 4 0.022
neuron differentiation GO:0030182 353 0.022
cellular component morphogenesis GO:0032989 336 0.022
transcription from rna polymerase ii promoter GO:0006366 80 0.022
positive regulation of secretion by cell GO:1903532 1 0.022
establishment of organelle localization GO:0051656 45 0.022
single organism metabolic process GO:0044710 217 0.022
ribonucleotide metabolic process GO:0009259 27 0.021
synaptic growth at neuromuscular junction GO:0051124 2 0.021
nuclear transport GO:0051169 4 0.021
positive regulation of cell activation GO:0050867 1 0.021
nucleocytoplasmic transport GO:0006913 4 0.021
organelle fission GO:0048285 23 0.021
regulation of synapse assembly GO:0051963 3 0.021
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.021
regulation of biological quality GO:0065008 263 0.021
regulation of synapse organization GO:0050807 3 0.021
regulation of intracellular protein transport GO:0033157 3 0.021
sexual reproduction GO:0019953 36 0.021
Worm
regulation of proteolysis GO:0030162 24 0.021
programmed cell death GO:0012501 119 0.021
cellular response to stress GO:0033554 62 0.020
Fly
regulation of anatomical structure morphogenesis GO:0022603 130 0.020
regulation of protein transport GO:0051223 3 0.020
cell motility GO:0048870 244 0.020
positive regulation of secretion GO:0051047 1 0.020
double strand break repair via homologous recombination GO:0000724 1 0.020
regulation of multicellular organism growth GO:0040014 4 0.020
organonitrogen compound metabolic process GO:1901564 74 0.020
negative regulation of signaling GO:0023057 96 0.020
g2 m transition of mitotic cell cycle GO:0000086 4 0.020
regulation of inflammatory response GO:0050727 2 0.020
establishment of protein localization to organelle GO:0072594 4 0.019
positive regulation of transcription dna templated GO:0045893 57 0.019
regulation of endopeptidase activity GO:0052548 23 0.019
macromolecule localization GO:0033036 54 0.019
regulation of nucleoside metabolic process GO:0009118 2 0.019
stem cell differentiation GO:0048863 117 0.019
mitotic cell cycle GO:0000278 64 0.019
cell cycle GO:0007049 93 0.019
cell morphogenesis involved in differentiation GO:0000904 195 0.019
regulation of mitochondrion organization GO:0010821 1 0.019
heterocycle metabolic process GO:0046483 290 0.019
multicellular organism reproduction GO:0032504 35 0.018
Worm
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.018
ncrna catabolic process GO:0034661 1 0.018
regulation of mrna processing GO:0050684 3 0.018
response to temperature stimulus GO:0009266 15 0.018
regulation of transcription dna templated GO:0006355 213 0.018
chemotaxis GO:0006935 104 0.018
cellular response to starvation GO:0009267 1 0.018
organelle transport along microtubule GO:0072384 1 0.018
regionalization GO:0003002 274 0.018
purine nucleoside monophosphate catabolic process GO:0009128 4 0.018
establishment of localization in cell GO:0051649 77 0.017
regulation of mrna splicing via spliceosome GO:0048024 3 0.017
neuron projection development GO:0031175 180 0.017
positive regulation of cytoskeleton organization GO:0051495 3 0.017
localization of cell GO:0051674 244 0.017
regulation of protein import into nucleus GO:0042306 2 0.017
rna processing GO:0006396 25 0.017
regulation of response to oxidative stress GO:1902882 2 0.017
regulation of nucleic acid templated transcription GO:1903506 213 0.017
cell migration GO:0016477 237 0.017
purine nucleotide metabolic process GO:0006163 27 0.017
developmental growth GO:0048589 166 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.017
gtp catabolic process GO:0006184 2 0.017
i kappab kinase nf kappab signaling GO:0007249 4 0.016
positive regulation of gtp catabolic process GO:0033126 1 0.016
organic acid metabolic process GO:0006082 31 0.016
single organism transport GO:0044765 206 0.016
regulation of multicellular organismal development GO:2000026 223 0.016
Worm
tissue remodeling GO:0048771 4 0.016
neuron development GO:0048666 262 0.016
recombinational repair GO:0000725 1 0.016
positive regulation of protein metabolic process GO:0051247 23 0.016
negative regulation of metabolic process GO:0009892 86 0.016
Worm
regulation of binding GO:0051098 3 0.016
positive regulation of map kinase activity GO:0043406 3 0.016
defense response GO:0006952 47 0.015
reproduction GO:0000003 40 0.015
Worm
regulation of chromosome segregation GO:0051983 1 0.015
synaptic vesicle localization GO:0097479 1 0.015
regulation of carbohydrate metabolic process GO:0006109 4 0.015
regulation of response to external stimulus GO:0032101 31 0.015
axonogenesis GO:0007409 152 0.015
golgi vesicle transport GO:0048193 3 0.015
negative regulation of signal transduction GO:0009968 94 0.015
atp catabolic process GO:0006200 4 0.015
protein targeting to nucleus GO:0044744 3 0.015
regulation of dna templated transcription elongation GO:0032784 3 0.015
angiogenesis GO:0001525 158 0.015
regulation of cell projection assembly GO:0060491 4 0.015
chordate embryonic development GO:0043009 271 0.015
protein complex biogenesis GO:0070271 30 0.014
mitotic sister chromatid segregation GO:0000070 6 0.014
cellular component movement GO:0006928 335 0.014
hormone transport GO:0009914 2 0.014
regulation of purine nucleotide catabolic process GO:0033121 2 0.014
cellular response to chemical stimulus GO:0070887 157 0.014
cell cycle g1 s phase transition GO:0044843 1 0.014
negative regulation of synapse assembly GO:0051964 2 0.014
guanosine containing compound metabolic process GO:1901068 4 0.014
segmentation GO:0035282 97 0.014
dna biosynthetic process GO:0071897 3 0.014
growth GO:0040007 174 0.014
regulation of developmental growth GO:0048638 38 0.014
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.013
regulation of localization GO:0032879 104 0.013
biosynthetic process GO:0009058 294 0.013
regulation of nucleotide catabolic process GO:0030811 2 0.013
nucleotide metabolic process GO:0009117 28 0.013
female gamete generation GO:0007292 14 0.013
cortical actin cytoskeleton organization GO:0030866 1 0.013
positive regulation of gene expression GO:0010628 71 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.013
single organism nuclear import GO:1902593 3 0.013
protein localization to nucleus GO:0034504 3 0.013
adult behavior GO:0030534 2 0.013
mitotic dna damage checkpoint GO:0044773 4 0.013
cellular ketone metabolic process GO:0042180 11 0.013
regulation of membrane potential GO:0042391 23 0.013
negative regulation of apoptotic process GO:0043066 55 0.013
peptidyl serine phosphorylation GO:0018105 1 0.013
actin polymerization or depolymerization GO:0008154 2 0.013
cellular component disassembly GO:0022411 1 0.012
regulation of nuclear division GO:0051783 9 0.012
cellular response to organic substance GO:0071310 105 0.012
regulation of gene expression GO:0010468 265 0.012
Worm
regeneration GO:0031099 91 0.012
mitotic dna integrity checkpoint GO:0044774 4 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.012
regulation of filopodium assembly GO:0051489 2 0.012
wnt signaling pathway GO:0016055 80 0.012
positive regulation of signaling GO:0023056 56 0.012
apoptotic process involved in development GO:1902742 2 0.012
regulation of reproductive process GO:2000241 4 0.012
organic substance biosynthetic process GO:1901576 289 0.012
protein k48 linked ubiquitination GO:0070936 1 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.011
development of primary female sexual characteristics GO:0046545 4 0.011
regulation of locomotion GO:0040012 55 0.011
regulation of phosphorus metabolic process GO:0051174 43 0.011
carbohydrate biosynthetic process GO:0016051 1 0.011
maturation of ssu rrna GO:0030490 1 0.011
membrane invagination GO:0010324 1 0.011
regulation of stem cell differentiation GO:2000736 4 0.011
regulation of protein modification process GO:0031399 29 0.011
Fly
inflammatory response GO:0006954 8 0.011
regulation of peptidase activity GO:0052547 23 0.011
embryonic organ development GO:0048568 381 0.011
establishment of synaptic vesicle localization GO:0097480 1 0.011
golgi organization GO:0007030 1 0.011
macroautophagy GO:0016236 1 0.011
g1 s transition of mitotic cell cycle GO:0000082 1 0.011
carbohydrate homeostasis GO:0033500 1 0.011
protein localization to plasma membrane GO:0072659 1 0.011
regulation of hydrolase activity GO:0051336 28 0.011
positive regulation of proteolysis GO:0045862 10 0.011
positive regulation of notch signaling pathway GO:0045747 3 0.011
response to glucocorticoid GO:0051384 1 0.011
enzyme linked receptor protein signaling pathway GO:0007167 106 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
cellular response to dna damage stimulus GO:0006974 24 0.011
Fly
rna catabolic process GO:0006401 7 0.011
embryonic limb morphogenesis GO:0030326 2 0.011
lateral inhibition GO:0046331 1 0.011
germ cell development GO:0007281 22 0.011
regulation of protein metabolic process GO:0051246 56 0.010
Fly
cellular amino acid metabolic process GO:0006520 7 0.010
cell substrate adhesion GO:0031589 4 0.010
negative regulation of cellular metabolic process GO:0031324 77 0.010
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 1 0.010
cellular response to organic cyclic compound GO:0071407 38 0.010
negative regulation of defense response GO:0031348 2 0.010
compound eye development GO:0048749 2 0.010
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.010
cellular amine metabolic process GO:0044106 2 0.010
stem cell proliferation GO:0072089 4 0.010
protein import into nucleus GO:0006606 3 0.010
mitochondrion organization GO:0007005 4 0.010
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.010

psmd4b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.047
musculoskeletal system disease DOID:17 0 0.022
sensory system disease DOID:0050155 0 0.012
nervous system disease DOID:863 0 0.012
muscular disease DOID:0080000 0 0.010
muscle tissue disease DOID:66 0 0.010