Danio rerio

60 known processes

top2b

topoisomerase (DNA) II beta

(Aliases: si:dkey-98n4.1,im:7138121,wu:fc38e02)

top2b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuron development GO:0048666 262 0.620
cell migration GO:0016477 237 0.515
Mouse
larval development GO:0002164 2 0.507
Worm
signal transduction GO:0007165 455 0.381
response to external stimulus GO:0009605 264 0.348
regulation of response to stimulus GO:0048583 269 0.304
camera type eye development GO:0043010 222 0.302
cell part morphogenesis GO:0032990 246 0.279
embryonic organ morphogenesis GO:0048562 274 0.255
chemotaxis GO:0006935 104 0.251
cell surface receptor signaling pathway GO:0007166 325 0.245
cell morphogenesis involved in differentiation GO:0000904 195 0.217
nucleobase containing compound metabolic process GO:0006139 274 0.195
Human Fly
cellular macromolecule metabolic process GO:0044260 391 0.188
Human Fly
generation of neurons GO:0048699 385 0.185
cellular component movement GO:0006928 335 0.180
cell motility GO:0048870 244 0.173
Mouse
cell cycle GO:0007049 93 0.169
Fly
cell projection morphogenesis GO:0048858 244 0.165
regulation of neuron differentiation GO:0045664 56 0.156
regulation of cellular biosynthetic process GO:0031326 245 0.149
Fly
cell projection organization GO:0030030 284 0.145
morphogenesis of an epithelium GO:0002009 333 0.143
taxis GO:0042330 109 0.135
neuron projection guidance GO:0097485 86 0.128
transport GO:0006810 220 0.128
Worm
localization of cell GO:0051674 244 0.127
Mouse
neuron differentiation GO:0030182 353 0.124
response to chemical GO:0042221 320 0.123
angiogenesis GO:0001525 158 0.121
nitrogen compound metabolic process GO:0006807 319 0.119
Human Fly
growth GO:0040007 174 0.116
regulation of metabolic process GO:0019222 359 0.114
Worm Fly
axon guidance GO:0007411 86 0.112
regulation of developmental process GO:0050793 247 0.109
regulation of signal transduction GO:0009966 225 0.106
protein localization to nucleus GO:0034504 3 0.105
maintenance of location GO:0051235 4 0.104
neuron projection development GO:0031175 180 0.098
regulation of reproductive process GO:2000241 4 0.098
mitotic nuclear division GO:0007067 18 0.097
Fly
cellular component morphogenesis GO:0032989 336 0.095
mitotic cell cycle GO:0000278 64 0.095
Fly
phosphorus metabolic process GO:0006793 109 0.093
Human Fly
nucleocytoplasmic transport GO:0006913 4 0.091
extrinsic apoptotic signaling pathway GO:0097191 3 0.090
negative regulation of biological process GO:0048519 304 0.089
Worm Fly
nuclear transport GO:0051169 4 0.088
eye development GO:0001654 277 0.087
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.084
single organism nuclear import GO:1902593 3 0.083
response to stress GO:0006950 263 0.081
Fly
axon development GO:0061564 166 0.081
blood vessel morphogenesis GO:0048514 216 0.079
tube morphogenesis GO:0035239 349 0.079
multicellular organism growth GO:0035264 4 0.077
embryonic organ development GO:0048568 381 0.076
developmental growth GO:0048589 166 0.076
aging GO:0007568 2 0.075
regulation of primary metabolic process GO:0080090 311 0.074
Fly
gene expression GO:0010467 252 0.074
Worm Fly
single organism localization GO:1902578 225 0.073
positive regulation of transport GO:0051050 2 0.073
sensory organ morphogenesis GO:0090596 200 0.073
nuclear import GO:0051170 3 0.073
phagocytosis GO:0006909 3 0.072
brain development GO:0007420 293 0.071
Mouse
establishment of localization in cell GO:0051649 77 0.069
Fly
head development GO:0060322 303 0.069
Mouse
cellular nitrogen compound metabolic process GO:0034641 290 0.068
Human Fly
ameboidal type cell migration GO:0001667 143 0.068
sensory organ development GO:0007423 393 0.068
digestive system development GO:0055123 289 0.067
nucleic acid metabolic process GO:0090304 244 0.067
Human Fly
chordate embryonic development GO:0043009 271 0.067
organic substance biosynthetic process GO:1901576 289 0.067
Fly
central nervous system development GO:0007417 387 0.067
Mouse
convergent extension GO:0060026 118 0.066
regulation of circadian rhythm GO:0042752 4 0.066
protein import GO:0017038 3 0.065
single organism transport GO:0044765 206 0.065
neuron projection morphogenesis GO:0048812 161 0.064
regulation of multicellular organismal process GO:0051239 277 0.064
cellular macromolecule biosynthetic process GO:0034645 224 0.064
Fly
cognition GO:0050890 1 0.063
establishment of protein localization to organelle GO:0072594 4 0.063
regulation of nucleotide catabolic process GO:0030811 2 0.062
heterocycle metabolic process GO:0046483 290 0.062
Human Fly
eye morphogenesis GO:0048592 144 0.060
positive regulation of biological process GO:0048518 253 0.059
digestive tract development GO:0048565 265 0.058
protein targeting to nucleus GO:0044744 3 0.057
skeletal system development GO:0001501 181 0.057
lateral line system development GO:0048925 76 0.057
embryo development ending in birth or egg hatching GO:0009792 271 0.056
Worm
urogenital system development GO:0001655 97 0.056
positive regulation of cell adhesion GO:0045785 1 0.056
mitotic cell cycle process GO:1903047 48 0.056
Fly
guanosine containing compound metabolic process GO:1901068 4 0.055
vasculature development GO:0001944 278 0.055
regulation of nucleoside metabolic process GO:0009118 2 0.053
cellular component assembly GO:0022607 170 0.053
establishment of localization GO:0051234 244 0.053
Worm Fly
enzyme linked receptor protein signaling pathway GO:0007167 106 0.052
cellular nitrogen compound biosynthetic process GO:0044271 218 0.051
Fly
cell morphogenesis GO:0000902 289 0.051
positive regulation of secretion GO:0051047 1 0.050
cellular response to stress GO:0033554 62 0.049
Fly
negative regulation of synapse assembly GO:0051964 2 0.049
meiotic nuclear division GO:0007126 4 0.048
single organism cellular localization GO:1902580 46 0.047
heart development GO:0007507 313 0.047
regulation of cell communication GO:0010646 232 0.047
positive regulation of cellular component biogenesis GO:0044089 3 0.047
organonitrogen compound metabolic process GO:1901564 74 0.047
Human Fly
biosynthetic process GO:0009058 294 0.046
Fly
wnt signaling pathway GO:0016055 80 0.046
ion transport GO:0006811 114 0.046
cellular component biogenesis GO:0044085 178 0.046
negative regulation of response to stimulus GO:0048585 104 0.045
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 4 0.044
guanosine containing compound catabolic process GO:1901069 2 0.044
organic cyclic compound biosynthetic process GO:1901362 223 0.043
Fly
peptidyl serine phosphorylation GO:0018105 1 0.043
system process GO:0003008 185 0.041
cellular biosynthetic process GO:0044249 286 0.041
Fly
response to axon injury GO:0048678 14 0.041
regulation of transcription dna templated GO:0006355 213 0.040
Fly
canonical wnt signaling pathway GO:0060070 48 0.040
protein import into nucleus GO:0006606 3 0.040
cell growth GO:0016049 57 0.040
entrainment of circadian clock GO:0009649 2 0.040
positive regulation of signal transduction GO:0009967 56 0.040
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.040
regulation of organelle assembly GO:1902115 4 0.040
gtp catabolic process GO:0006184 2 0.039
regulation of multicellular organism growth GO:0040014 4 0.039
blood vessel development GO:0001568 246 0.039
retina development in camera type eye GO:0060041 146 0.038
female sex differentiation GO:0046660 4 0.038
heterocycle biosynthetic process GO:0018130 215 0.038
Fly
gtp metabolic process GO:0046039 4 0.038
regulation of nucleic acid templated transcription GO:1903506 213 0.037
Fly
positive regulation of secretion by cell GO:1903532 1 0.037
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.037
establishment of epithelial cell polarity GO:0090162 2 0.037
regulation of organ growth GO:0046620 3 0.036
organic cyclic compound metabolic process GO:1901360 301 0.036
Human Fly
optomotor response GO:0071632 1 0.036
negative regulation of cellular process GO:0048523 283 0.036
Fly
organelle organization GO:0006996 227 0.036
Fly
regulation of synapse organization GO:0050807 3 0.036
regulation of protein targeting GO:1903533 2 0.035
regulation of cell substrate adhesion GO:0010810 1 0.035
intracellular signal transduction GO:0035556 85 0.035
cellular amine metabolic process GO:0044106 2 0.035
cellular aromatic compound metabolic process GO:0006725 295 0.035
Human Fly
cell substrate junction assembly GO:0007044 2 0.035
single organism organelle organization GO:1902589 199 0.034
Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.034
Fly
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.034
Fly
cell matrix adhesion GO:0007160 4 0.034
adherens junction assembly GO:0034333 1 0.034
cell cycle process GO:0022402 53 0.034
Fly
synaptic target recognition GO:0008039 1 0.033
negative regulation of macromolecule metabolic process GO:0010605 76 0.033
Worm Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.033
Fly
positive regulation of cellular catabolic process GO:0031331 3 0.033
developmental growth involved in morphogenesis GO:0060560 86 0.033
regulation of protein transport GO:0051223 3 0.032
circadian rhythm GO:0007623 19 0.032
positive regulation of catabolic process GO:0009896 4 0.032
single organism metabolic process GO:0044710 217 0.032
Human Fly
death GO:0016265 121 0.032
regulation of purine nucleotide catabolic process GO:0033121 2 0.031
regulation of growth GO:0040008 42 0.031
regulation of establishment of protein localization GO:0070201 4 0.031
actomyosin structure organization GO:0031032 53 0.031
regulation of axonogenesis GO:0050770 32 0.031
response to organic substance GO:0010033 153 0.031
stem cell proliferation GO:0072089 4 0.031
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.030
negative regulation of protein transport GO:0051224 3 0.030
development of primary female sexual characteristics GO:0046545 4 0.030
immune system process GO:0002376 241 0.030
cell substrate adherens junction assembly GO:0007045 1 0.030
transmembrane transport GO:0055085 120 0.030
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.029
Fly
hair cell differentiation GO:0035315 32 0.029
regulation of synapse assembly GO:0051963 3 0.029
cell death GO:0008219 121 0.029
digestive tract morphogenesis GO:0048546 231 0.028
cell adhesion GO:0007155 40 0.028
regulation of signaling GO:0023051 235 0.028
muscle cell migration GO:0014812 4 0.028
gastrulation GO:0007369 208 0.028
cytoskeleton organization GO:0007010 96 0.028
Fly
dendrite guidance GO:0070983 0 0.027
regulation of protein import into nucleus GO:0042306 2 0.027
protein secretion GO:0009306 1 0.027
hematopoietic or lymphoid organ development GO:0048534 191 0.027
regulation of cellular component organization GO:0051128 86 0.027
protein complex localization GO:0031503 1 0.027
negative regulation of protein phosphorylation GO:0001933 4 0.027
mononuclear cell proliferation GO:0032943 1 0.027
cytokinesis GO:0000910 3 0.027
macromolecule biosynthetic process GO:0009059 227 0.027
Fly
locomotor rhythm GO:0045475 3 0.026
locomotion GO:0040011 313 0.026
apoptotic process GO:0006915 116 0.026
multi organism process GO:0051704 134 0.026
regulation of jak stat cascade GO:0046425 3 0.026
regulation of gtp catabolic process GO:0033124 2 0.025
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.025
positive regulation of cellular process GO:0048522 201 0.025
cell cycle g1 s phase transition GO:0044843 1 0.025
establishment or maintenance of cell polarity GO:0007163 29 0.025
regulation of stem cell proliferation GO:0072091 2 0.025
positive regulation of jak stat cascade GO:0046427 2 0.025
establishment of melanosome localization GO:0032401 19 0.025
amine metabolic process GO:0009308 2 0.025
epiboly GO:0090504 41 0.025
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.024
Fly
negative regulation of cytoplasmic transport GO:1903650 2 0.024
protein metabolic process GO:0019538 183 0.024
regulation of wnt signaling pathway GO:0030111 53 0.024
cell fate commitment GO:0045165 99 0.024
phosphate containing compound metabolic process GO:0006796 108 0.024
Human Fly
peptidyl serine modification GO:0018209 2 0.024
cellular response to oxygen levels GO:0071453 1 0.024
nucleoside monophosphate catabolic process GO:0009125 4 0.024
Human Fly
nuclear division GO:0000280 23 0.023
Fly
regulation of cytokine production GO:0001817 3 0.023
regulation of multicellular organismal development GO:2000026 223 0.023
cell substrate adhesion GO:0031589 4 0.023
negative regulation of cell communication GO:0010648 96 0.022
regulation of localization GO:0032879 104 0.022
embryonic heart tube development GO:0035050 133 0.022
regulation of calcium ion transport GO:0051924 2 0.022
developmental cell growth GO:0048588 52 0.022
macromolecule localization GO:0033036 54 0.022
axonogenesis GO:0007409 152 0.022
transcription from rna polymerase ii promoter GO:0006366 80 0.022
microtubule organizing center organization GO:0031023 1 0.021
female gonad development GO:0008585 4 0.021
sexual reproduction GO:0019953 36 0.021
cell migration involved in gastrulation GO:0042074 79 0.021
neuromuscular synaptic transmission GO:0007274 2 0.021
skeletal system morphogenesis GO:0048705 102 0.021
negative regulation of reproductive process GO:2000242 3 0.021
programmed cell death GO:0012501 119 0.021
carbohydrate derivative metabolic process GO:1901135 61 0.021
Human Fly
organelle assembly GO:0070925 110 0.021
regulation of protein localization to nucleus GO:1900180 2 0.021
retina layer formation GO:0010842 24 0.020
synaptic growth at neuromuscular junction GO:0051124 2 0.020
embryonic cranial skeleton morphogenesis GO:0048701 90 0.020
response to ketone GO:1901654 1 0.020
regulation of cellular amine metabolic process GO:0033238 0 0.020
regulation of cytoplasmic transport GO:1903649 4 0.020
positive regulation of dna metabolic process GO:0051054 1 0.020
double strand break repair GO:0006302 3 0.020
regulation of gtpase activity GO:0043087 2 0.020
macromolecule modification GO:0043412 111 0.020
homeostatic process GO:0042592 142 0.020
regulation of intracellular protein transport GO:0033157 3 0.020
cellular response to chemical stimulus GO:0070887 157 0.020
negative regulation of intracellular protein transport GO:0090317 3 0.019
regulation of cell morphogenesis GO:0022604 42 0.019
neurological system process GO:0050877 62 0.019
determination of left right symmetry GO:0007368 179 0.019
pronephros development GO:0048793 69 0.019
kidney development GO:0001822 92 0.019
cellular carbohydrate metabolic process GO:0044262 4 0.019
fertilization GO:0009566 3 0.019
regulation of cell shape GO:0008360 1 0.019
epithelial tube morphogenesis GO:0060562 148 0.019
negative regulation of signaling GO:0023057 96 0.019
action potential GO:0001508 19 0.019
leukocyte differentiation GO:0002521 25 0.019
regulation of locomotion GO:0040012 55 0.019
lymphocyte proliferation GO:0046651 1 0.019
embryonic eye morphogenesis GO:0048048 30 0.018
regulation of transporter activity GO:0032409 2 0.018
regulation of synaptic plasticity GO:0048167 1 0.018
positive regulation of nucleotide catabolic process GO:0030813 1 0.018
rna metabolic process GO:0016070 219 0.018
Fly
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.018
stem cell division GO:0017145 1 0.018
cell proliferation GO:0008283 80 0.018
neural retina development GO:0003407 49 0.018
embryonic skeletal system development GO:0048706 97 0.018
positive regulation of nucleoside metabolic process GO:0045979 1 0.018
regulation of dna replication GO:0006275 3 0.018
cellular response to hypoxia GO:0071456 1 0.018
regulation of cell matrix adhesion GO:0001952 1 0.018
establishment of organelle localization GO:0051656 45 0.018
Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.018
lipid storage GO:0019915 1 0.018
regulation of metal ion transport GO:0010959 4 0.018
cellular response to nutrient levels GO:0031669 2 0.018
cellular protein metabolic process GO:0044267 129 0.017
response to abiotic stimulus GO:0009628 122 0.017
organic acid metabolic process GO:0006082 31 0.017
cellular response to decreased oxygen levels GO:0036294 1 0.017
polarized epithelial cell differentiation GO:0030859 4 0.017
cellular protein catabolic process GO:0044257 4 0.017
cytoskeleton dependent cytokinesis GO:0061640 3 0.017
regulation of cell activation GO:0050865 1 0.017
negative regulation of biosynthetic process GO:0009890 55 0.017
Fly
multicellular organismal reproductive process GO:0048609 35 0.017
positive regulation of response to stimulus GO:0048584 80 0.017
myeloid cell homeostasis GO:0002262 56 0.017
regionalization GO:0003002 274 0.016
myeloid cell differentiation GO:0030099 86 0.016
negative regulation of kinase activity GO:0033673 4 0.016
reproductive process GO:0022414 40 0.016
ovulation cycle GO:0042698 2 0.016
cellular response to organic substance GO:0071310 105 0.016
regulation of cellular ketone metabolic process GO:0010565 7 0.016
rna 3 end processing GO:0031123 2 0.016
central nervous system neuron differentiation GO:0021953 74 0.016
positive regulation of exocytosis GO:0045921 1 0.016
regulation of membrane potential GO:0042391 23 0.016
regulation of nucleocytoplasmic transport GO:0046822 2 0.016
embryonic viscerocranium morphogenesis GO:0048703 52 0.016
single fertilization GO:0007338 3 0.016
positive regulation of cell activation GO:0050867 1 0.016
organelle fission GO:0048285 23 0.016
Fly
rhythmic process GO:0048511 21 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.016
response to drug GO:0042493 3 0.016
regulation of organelle organization GO:0033043 29 0.016
cell projection assembly GO:0030031 64 0.016
multi organism reproductive process GO:0044703 36 0.016
chemosensory behavior GO:0007635 1 0.015
establishment of pigment granule localization GO:0051905 22 0.015
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
hemopoiesis GO:0030097 183 0.015
cellular amino acid metabolic process GO:0006520 7 0.015
gland development GO:0048732 143 0.015
embryonic skeletal system morphogenesis GO:0048704 93 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.015
convergent extension involved in organogenesis GO:0060029 10 0.015
adherens junction organization GO:0034332 4 0.015
small molecule metabolic process GO:0044281 77 0.015
Human Fly
proteasomal protein catabolic process GO:0010498 2 0.015
oxoacid metabolic process GO:0043436 31 0.015
protein localization GO:0008104 40 0.015
regulation of biological quality GO:0065008 263 0.015
regulation of binding GO:0051098 3 0.015
centrosome organization GO:0051297 1 0.015
organic substance transport GO:0071702 58 0.015
cellular response to unfolded protein GO:0034620 2 0.015
neuroblast proliferation GO:0007405 2 0.015
regulation of anatomical structure morphogenesis GO:0022603 130 0.015
forebrain cell migration GO:0021885 1 0.015
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.015
i kappab kinase nf kappab signaling GO:0007249 4 0.015
g protein coupled receptor signaling pathway GO:0007186 74 0.015
negative regulation of dna metabolic process GO:0051053 4 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
ear development GO:0043583 127 0.014
convergent extension involved in gastrulation GO:0060027 71 0.014
autophagy GO:0006914 4 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
mechanoreceptor differentiation GO:0042490 37 0.014
actin filament based process GO:0030029 64 0.014
ribosome biogenesis GO:0042254 9 0.014
developmental process involved in reproduction GO:0003006 27 0.014
retinal ganglion cell axon guidance GO:0031290 35 0.014
somatic muscle development GO:0007525 4 0.014
positive regulation of cell cycle GO:0045787 3 0.014
organelle localization GO:0051640 49 0.014
Fly
negative regulation of mapk cascade GO:0043409 4 0.014
metal ion homeostasis GO:0055065 26 0.014
regulation of receptor mediated endocytosis GO:0048259 4 0.014
regulation of protein ubiquitination GO:0031396 3 0.014
cranial nerve development GO:0021545 42 0.014
forebrain development GO:0030900 96 0.014
Mouse
muscle cell differentiation GO:0042692 139 0.014
axon extension GO:0048675 45 0.014
compound eye development GO:0048749 2 0.014
regulation of neurogenesis GO:0050767 87 0.013
tissue regeneration GO:0042246 74 0.013
regulation of hydrolase activity GO:0051336 28 0.013
brain morphogenesis GO:0048854 18 0.013
spermatid development GO:0007286 2 0.013
regulation of cell growth GO:0001558 29 0.013
response to nicotine GO:0035094 2 0.013
immune system development GO:0002520 191 0.013
phosphorylation GO:0016310 69 0.013
ovulation cycle process GO:0022602 2 0.013
cellular response to lipopolysaccharide GO:0071222 3 0.013
aromatic compound biosynthetic process GO:0019438 217 0.013
Fly
extracellular structure organization GO:0043062 27 0.013
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.013
leukocyte proliferation GO:0070661 1 0.013
negative regulation of intracellular transport GO:0032387 3 0.013
regulation of meiotic cell cycle GO:0051445 1 0.013
regulation of cellular metabolic process GO:0031323 320 0.013
Fly
multicellular organism reproduction GO:0032504 35 0.013
spermatid differentiation GO:0048515 2 0.013
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.013
regulation of cell differentiation GO:0045595 142 0.013
exocytosis GO:0006887 1 0.013
er nucleus signaling pathway GO:0006984 2 0.013
rna polyadenylation GO:0043631 2 0.012
olfactory lobe development GO:0021988 4 0.012
regulation of rna metabolic process GO:0051252 224 0.012
Fly
peripheral nervous system neuron differentiation GO:0048934 28 0.012
nerve development GO:0021675 45 0.012
cell division GO:0051301 20 0.012
positive regulation of protein complex assembly GO:0031334 2 0.012
cellular response to external stimulus GO:0071496 2 0.012
regulation of protein catabolic process GO:0042176 1 0.012
negative regulation of multi organism process GO:0043901 3 0.012
neuron fate determination GO:0048664 2 0.012
nuclear migration GO:0007097 3 0.012
cartilage condensation GO:0001502 3 0.012
olfactory bulb development GO:0021772 4 0.012
negative regulation of defense response GO:0031348 2 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
regulation of developmental growth GO:0048638 38 0.012
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.012
interspecies interaction between organisms GO:0044419 4 0.012
embryonic skeletal joint development GO:0072498 3 0.012
regulation of nervous system development GO:0051960 90 0.012
glucose homeostasis GO:0042593 1 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
regulation of canonical wnt signaling pathway GO:0060828 34 0.012
regulation of transmembrane transporter activity GO:0022898 2 0.012
energy reserve metabolic process GO:0006112 2 0.012
axon midline choice point recognition GO:0016199 4 0.012
regulation of dna metabolic process GO:0051052 11 0.012
macromolecular complex disassembly GO:0032984 1 0.012
cellular response to starvation GO:0009267 1 0.011
lamellipodium organization GO:0097581 1 0.011
regulation of axon extension GO:0030516 24 0.011
regulation of cell cycle GO:0051726 52 0.011
Fly
heart morphogenesis GO:0003007 156 0.011
ribonucleoprotein complex biogenesis GO:0022613 13 0.011
negative regulation of epithelial cell proliferation GO:0050680 1 0.011
regulation of proteolysis GO:0030162 24 0.011
dna biosynthetic process GO:0071897 3 0.011
pancreas development GO:0031016 84 0.011
neuron projection extension GO:1990138 45 0.011
peripheral nervous system neuron development GO:0048935 22 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.011
nuclear export GO:0051168 1 0.011
developmental programmed cell death GO:0010623 4 0.011
endosomal transport GO:0016197 2 0.011
regulation of macromolecule metabolic process GO:0060255 317 0.011
Worm Fly
negative regulation of apoptotic process GO:0043066 55 0.011
cellular protein localization GO:0034613 20 0.011
cell type specific apoptotic process GO:0097285 22 0.011
positive regulation of cell substrate adhesion GO:0010811 1 0.011
positive regulation of cell communication GO:0010647 56 0.011
microtubule cytoskeleton organization GO:0000226 33 0.011
Fly
pancreatic d cell differentiation GO:0003311 2 0.011
cellular ketone metabolic process GO:0042180 11 0.011
mesenchymal cell proliferation GO:0010463 1 0.011
negative regulation of protein import into nucleus GO:0042308 2 0.011
regulation of ion transmembrane transporter activity GO:0032412 2 0.011
positive regulation of multi organism process GO:0043902 3 0.011
cellular chemical homeostasis GO:0055082 17 0.011
regulation of production of molecular mediator of immune response GO:0002700 1 0.011
cytokinetic process GO:0032506 2 0.011
regulation of cellular component size GO:0032535 30 0.011
meiotic chromosome segregation GO:0045132 3 0.011
rna processing GO:0006396 25 0.011
gliogenesis GO:0042063 45 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.011
protein dephosphorylation GO:0006470 3 0.011
regulation of cytoskeleton organization GO:0051493 11 0.011
peptide transport GO:0015833 1 0.011
multi organism cellular process GO:0044764 2 0.010
mrna 3 end processing GO:0031124 2 0.010
regulation of cell death GO:0010941 103 0.010
negative regulation of wnt signaling pathway GO:0030178 30 0.010
regulation of macromolecule biosynthetic process GO:0010556 225 0.010
Fly
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.010
negative regulation of map kinase activity GO:0043407 2 0.010
cellular response to extracellular stimulus GO:0031668 2 0.010
regulation of biosynthetic process GO:0009889 250 0.010
Fly
g1 s transition of mitotic cell cycle GO:0000082 1 0.010
response to hydrogen peroxide GO:0042542 3 0.010
secondary metabolic process GO:0019748 3 0.010
viral process GO:0016032 1 0.010
response to topologically incorrect protein GO:0035966 2 0.010
single organism reproductive process GO:0044702 40 0.010
regulation of cell motility GO:2000145 46 0.010

top2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.031
nervous system disease DOID:863 0 0.021
sensory system disease DOID:0050155 0 0.014
eye and adnexa disease DOID:1492 0 0.014
disease of metabolism DOID:0014667 0 0.014