Danio rerio

77 known processes

chuk

conserved helix-loop-helix ubiquitous kinase

(Aliases: zgc:56539,ikk1,MGC56539)

chuk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
aromatic compound biosynthetic process GO:0019438 217 0.603
Human
modification dependent macromolecule catabolic process GO:0043632 3 0.474
negative regulation of cellular process GO:0048523 283 0.457
modification dependent protein catabolic process GO:0019941 3 0.426
cellular nitrogen compound metabolic process GO:0034641 290 0.419
Human Fly
nucleic acid metabolic process GO:0090304 244 0.416
Human
ubiquitin dependent protein catabolic process GO:0006511 3 0.412
negative regulation of biological process GO:0048519 304 0.395
rna metabolic process GO:0016070 219 0.379
Human
regulation of cellular metabolic process GO:0031323 320 0.324
Human Fly
larval development GO:0002164 2 0.316
cellular aromatic compound metabolic process GO:0006725 295 0.304
Human
regulation of defense response GO:0031347 14 0.301
Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.296
Human
proteasomal protein catabolic process GO:0010498 2 0.286
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.267
nucleobase containing compound metabolic process GO:0006139 274 0.267
Human
regionalization GO:0003002 274 0.265
cell surface receptor signaling pathway GO:0007166 325 0.256
regulation of signal transduction GO:0009966 225 0.248
regulation of metabolic process GO:0019222 359 0.231
Human Fly
response to external stimulus GO:0009605 264 0.230
Fly
cellular macromolecule metabolic process GO:0044260 391 0.228
Human Mouse Fly
meiosis i GO:0007127 1 0.220
signal transduction GO:0007165 455 0.210
heterocycle biosynthetic process GO:0018130 215 0.205
Human
gene expression GO:0010467 252 0.202
Human
heart development GO:0007507 313 0.202
organic cyclic compound metabolic process GO:1901360 301 0.198
Human
erythrocyte homeostasis GO:0034101 55 0.189
cellular macromolecule biosynthetic process GO:0034645 224 0.186
Human
nitrogen compound metabolic process GO:0006807 319 0.185
Human Fly
biosynthetic process GO:0009058 294 0.184
Human Fly
regulation of cell death GO:0010941 103 0.183
digestive tract development GO:0048565 265 0.180
regulation of cellular biosynthetic process GO:0031326 245 0.167
Human Fly
cellular protein catabolic process GO:0044257 4 0.162
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.161
Human
negative regulation of response to stimulus GO:0048585 104 0.161
regulation of response to stimulus GO:0048583 269 0.160
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.149
Human
regulation of biological quality GO:0065008 263 0.146
Mouse
response to abiotic stimulus GO:0009628 122 0.142
morphogenesis of an epithelium GO:0002009 333 0.142
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.140
regulation of gene expression GO:0010468 265 0.138
Human
regulation of cell shape GO:0008360 1 0.136
nuclear transport GO:0051169 4 0.131
heterocycle metabolic process GO:0046483 290 0.128
Human
response to external biotic stimulus GO:0043207 97 0.128
Fly
regulation of macromolecule metabolic process GO:0060255 317 0.127
Human
regulation of rna metabolic process GO:0051252 224 0.127
Human
protein metabolic process GO:0019538 183 0.125
Human Mouse Fly
peptidyl serine phosphorylation GO:0018105 1 0.125
Fly
cytokinetic process GO:0032506 2 0.124
sensory organ morphogenesis GO:0090596 200 0.117
somitogenesis GO:0001756 87 0.114
organic substance biosynthetic process GO:1901576 289 0.113
Human Fly
rna biosynthetic process GO:0032774 181 0.109
Human
response to chemical GO:0042221 320 0.109
Human
regulation of biosynthetic process GO:0009889 250 0.109
Human Fly
anterior posterior pattern specification GO:0009952 152 0.101
i kappab kinase nf kappab signaling GO:0007249 4 0.101
regulation of primary metabolic process GO:0080090 311 0.096
Human
nucleobase containing compound biosynthetic process GO:0034654 205 0.094
Human
macromolecule biosynthetic process GO:0009059 227 0.094
Human
regulation of cell communication GO:0010646 232 0.094
cell morphogenesis GO:0000902 289 0.092
programmed cell death GO:0012501 119 0.090
hindbrain development GO:0030902 91 0.088
positive regulation of cellular process GO:0048522 201 0.084
Human Mouse Fly
cellular macromolecule catabolic process GO:0044265 12 0.082
digestive tract morphogenesis GO:0048546 231 0.082
sensory organ development GO:0007423 393 0.081
morphogenesis of an epithelial sheet GO:0002011 49 0.079
organic cyclic compound biosynthetic process GO:1901362 223 0.077
Human
transcription from rna polymerase ii promoter GO:0006366 80 0.077
Human
regulation of mrna splicing via spliceosome GO:0048024 3 0.076
blood vessel development GO:0001568 246 0.074
cellular component morphogenesis GO:0032989 336 0.074
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.073
cell migration GO:0016477 237 0.068
apoptotic process GO:0006915 116 0.067
muscle cell differentiation GO:0042692 139 0.064
organic substance catabolic process GO:1901575 28 0.064
Fly
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.064
developmental growth GO:0048589 166 0.064
sequestering of metal ion GO:0051238 3 0.063
somite development GO:0061053 96 0.062
regulation of protein catabolic process GO:0042176 1 0.062
homeostatic process GO:0042592 142 0.061
single organism metabolic process GO:0044710 217 0.058
negative regulation of signal transduction GO:0009968 94 0.057
regulation of nucleocytoplasmic transport GO:0046822 2 0.056
central nervous system development GO:0007417 387 0.056
rna modification GO:0009451 2 0.056
peptidyl serine modification GO:0018209 2 0.056
Fly
regulation of developmental process GO:0050793 247 0.055
meiotic nuclear division GO:0007126 4 0.054
cell adhesion GO:0007155 40 0.054
protein modification process GO:0036211 100 0.054
Human Mouse Fly
single organism organelle organization GO:1902589 199 0.053
regulation of signaling GO:0023051 235 0.053
cellular protein modification process GO:0006464 100 0.053
Human Mouse Fly
cellular component movement GO:0006928 335 0.052
intracellular signal transduction GO:0035556 85 0.052
homeostasis of number of cells GO:0048872 62 0.051
negative regulation of apoptotic process GO:0043066 55 0.050
regulation of rna biosynthetic process GO:2001141 213 0.050
Human
dna biosynthetic process GO:0071897 3 0.049
negative regulation of cell communication GO:0010648 96 0.049
establishment of protein localization to organelle GO:0072594 4 0.049
gastrulation with mouth forming second GO:0001702 44 0.048
regulation of transcription dna templated GO:0006355 213 0.047
Human
ameboidal type cell migration GO:0001667 143 0.047
regulation of apoptotic process GO:0042981 98 0.047
response to salt stress GO:0009651 10 0.046
nucleic acid templated transcription GO:0097659 181 0.046
Human
positive regulation of biological process GO:0048518 253 0.045
Human Mouse Fly
protein import GO:0017038 3 0.045
cell cycle g1 s phase transition GO:0044843 1 0.045
immune system process GO:0002376 241 0.044
Mouse Fly
regulation of multicellular organism growth GO:0040014 4 0.044
nik nf kappab signaling GO:0038061 1 0.044
cellular protein metabolic process GO:0044267 129 0.043
Human Mouse Fly
tube morphogenesis GO:0035239 349 0.043
death GO:0016265 121 0.042
oxoacid metabolic process GO:0043436 31 0.042
cellular response to stress GO:0033554 62 0.042
regulation of programmed cell death GO:0043067 101 0.042
alternative mrna splicing via spliceosome GO:0000380 1 0.042
specification of symmetry GO:0009799 204 0.041
cell proliferation GO:0008283 80 0.041
Mouse
nucleocytoplasmic transport GO:0006913 4 0.041
regulation of mrna stability GO:0043488 4 0.040
negative regulation of sequestering of calcium ion GO:0051283 4 0.040
maintenance of location GO:0051235 4 0.039
enzyme linked receptor protein signaling pathway GO:0007167 106 0.038
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.038
metencephalon development GO:0022037 27 0.038
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.038
skeletal muscle organ development GO:0060538 78 0.037
erythrocyte differentiation GO:0030218 54 0.037
cellular biosynthetic process GO:0044249 286 0.037
Human Fly
negative regulation of cell death GO:0060548 60 0.036
cell death GO:0008219 121 0.036
regulation of mrna processing GO:0050684 3 0.035
muscle organ development GO:0007517 101 0.035
growth GO:0040007 174 0.035
locomotion GO:0040011 313 0.035
regulation of cell proliferation GO:0042127 37 0.035
microtubule cytoskeleton organization GO:0000226 33 0.035
striated muscle tissue development GO:0014706 110 0.034
regulation of cytokine production GO:0001817 3 0.034
axonogenesis GO:0007409 152 0.034
multicellular organism growth GO:0035264 4 0.034
transcription dna templated GO:0006351 181 0.034
Human
establishment of localization GO:0051234 244 0.034
Mouse
cytoskeleton organization GO:0007010 96 0.034
camera type eye morphogenesis GO:0048593 108 0.034
ear development GO:0043583 127 0.034
response to uv GO:0009411 3 0.033
telomere organization GO:0032200 1 0.033
negative regulation of protein phosphorylation GO:0001933 4 0.032
regulation of cellular protein metabolic process GO:0032268 52 0.032
organonitrogen compound metabolic process GO:1901564 74 0.032
Fly
histone modification GO:0016570 20 0.032
eye development GO:0001654 277 0.032
epiboly GO:0090504 41 0.032
single organism nuclear import GO:1902593 3 0.031
single organism localization GO:1902578 225 0.031
Mouse
positive regulation of transport GO:0051050 2 0.030
developmental growth involved in morphogenesis GO:0060560 86 0.030
embryonic organ morphogenesis GO:0048562 274 0.030
positive regulation of catabolic process GO:0009896 4 0.029
organelle organization GO:0006996 227 0.029
regulation of intracellular protein transport GO:0033157 3 0.029
protein localization to nucleus GO:0034504 3 0.029
heart morphogenesis GO:0003007 156 0.028
cellular nitrogen compound biosynthetic process GO:0044271 218 0.027
Human Fly
embryonic skeletal system development GO:0048706 97 0.027
positive regulation of biosynthetic process GO:0009891 68 0.027
Human Fly
myeloid cell homeostasis GO:0002262 56 0.027
regulation of macromolecule biosynthetic process GO:0010556 225 0.027
Human
cellular response to oxygen levels GO:0071453 1 0.027
transport GO:0006810 220 0.027
Mouse
macromolecule modification GO:0043412 111 0.027
Human Mouse Fly
regulation of neuron differentiation GO:0045664 56 0.026
regulation of protein ubiquitination GO:0031396 3 0.026
rna splicing GO:0008380 16 0.026
retina morphogenesis in camera type eye GO:0060042 79 0.025
response to stress GO:0006950 263 0.025
Fly
mitochondrion organization GO:0007005 4 0.024
connective tissue development GO:0061448 99 0.024
nuclear import GO:0051170 3 0.024
skeletal system morphogenesis GO:0048705 102 0.024
stem cell division GO:0017145 1 0.024
double strand break repair via homologous recombination GO:0000724 1 0.024
negative regulation of signaling GO:0023057 96 0.024
regulation of multicellular organismal process GO:0051239 277 0.024
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.024
regulation of anatomical structure morphogenesis GO:0022603 130 0.024
organelle fission GO:0048285 23 0.023
angiogenesis GO:0001525 158 0.023
cortical cytoskeleton organization GO:0030865 1 0.023
embryonic organ development GO:0048568 381 0.023
purine nucleoside monophosphate catabolic process GO:0009128 4 0.023
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.023
convergent extension GO:0060026 118 0.023
cellular response to light stimulus GO:0071482 4 0.023
compound eye development GO:0048749 2 0.023
g1 s transition of mitotic cell cycle GO:0000082 1 0.023
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.023
Human
positive regulation of cytokine production GO:0001819 2 0.022
recombinational repair GO:0000725 1 0.022
unidimensional cell growth GO:0009826 5 0.022
regulation of cardiac muscle tissue development GO:0055024 1 0.021
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 1 0.021
protein import into nucleus GO:0006606 3 0.021
cell projection morphogenesis GO:0048858 244 0.021
positive regulation of cellular catabolic process GO:0031331 3 0.021
extracellular structure organization GO:0043062 27 0.021
protein polyubiquitination GO:0000209 4 0.021
response to light stimulus GO:0009416 46 0.020
posttranscriptional regulation of gene expression GO:0010608 14 0.020
negative regulation of defense response GO:0031348 2 0.020
striated muscle cell differentiation GO:0051146 129 0.020
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 8 0.020
positive regulation of protein complex assembly GO:0031334 2 0.020
response to other organism GO:0051707 97 0.020
Fly
small molecule metabolic process GO:0044281 77 0.020
regulation of nucleoside metabolic process GO:0009118 2 0.020
regulation of protein import into nucleus GO:0042306 2 0.020
regulation of response to biotic stimulus GO:0002831 2 0.020
Fly
regulation of cellular protein catabolic process GO:1903362 1 0.020
cell migration involved in gastrulation GO:0042074 79 0.019
centrosome organization GO:0051297 1 0.019
multi organism process GO:0051704 134 0.019
Fly
cell cycle GO:0007049 93 0.018
cerebellum development GO:0021549 17 0.018
cell motility GO:0048870 244 0.018
telomere maintenance GO:0000723 1 0.018
aging GO:0007568 2 0.018
head development GO:0060322 303 0.018
thermosensory behavior GO:0040040 1 0.018
rna stabilization GO:0043489 4 0.018
atp synthesis coupled electron transport GO:0042773 1 0.018
response to radiation GO:0009314 51 0.018
cation transport GO:0006812 81 0.018
gastrulation GO:0007369 208 0.018
nucleic acid transport GO:0050657 2 0.018
centrosome cycle GO:0007098 1 0.018
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.018
embryonic limb morphogenesis GO:0030326 2 0.018
cellular amino acid metabolic process GO:0006520 7 0.018
taxis GO:0042330 109 0.017
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.017
synaptic growth at neuromuscular junction GO:0051124 2 0.017
muscle structure development GO:0061061 196 0.017
cellular response to chemical stimulus GO:0070887 157 0.017
Human
intrinsic apoptotic signaling pathway GO:0097193 20 0.017
protein k48 linked ubiquitination GO:0070936 1 0.017
regulation of nitrogen compound metabolic process GO:0051171 251 0.017
Human Fly
carbohydrate biosynthetic process GO:0016051 1 0.017
er to golgi vesicle mediated transport GO:0006888 1 0.017
response to organic substance GO:0010033 153 0.017
Human
immune response GO:0006955 28 0.017
Fly
chromosome organization involved in meiosis GO:0070192 1 0.016
regulation of growth GO:0040008 42 0.016
regulation of protein metabolic process GO:0051246 56 0.016
regulation of tube size GO:0035150 2 0.016
calcium ion transport into cytosol GO:0060402 3 0.016
regulation of nucleotide catabolic process GO:0030811 2 0.016
negative regulation of programmed cell death GO:0043069 58 0.016
regulation of protein targeting GO:1903533 2 0.016
immune system development GO:0002520 191 0.016
Mouse
response to endogenous stimulus GO:0009719 83 0.016
atp catabolic process GO:0006200 4 0.016
regulation of response to stress GO:0080134 36 0.016
Fly
blood vessel morphogenesis GO:0048514 216 0.016
cellular response to dna damage stimulus GO:0006974 24 0.016
inner ear development GO:0048839 126 0.016
negative regulation of intracellular signal transduction GO:1902532 22 0.016
homologous chromosome segregation GO:0045143 1 0.016
protein modification by small protein conjugation or removal GO:0070647 14 0.016
cellular response to growth factor stimulus GO:0071363 39 0.016
regulation of cell size GO:0008361 29 0.016
neuron projection morphogenesis GO:0048812 161 0.016
carboxylic acid metabolic process GO:0019752 22 0.015
regulation of dendrite development GO:0050773 3 0.015
regulation of metal ion transport GO:0010959 4 0.015
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.015
fertilization GO:0009566 3 0.015
chemosensory behavior GO:0007635 1 0.015
regulation of developmental growth GO:0048638 38 0.015
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.015
cellular amino acid biosynthetic process GO:0008652 2 0.015
cellular carbohydrate metabolic process GO:0044262 4 0.015
ribosomal small subunit biogenesis GO:0042274 2 0.015
chordate embryonic development GO:0043009 271 0.015
negative regulation of chemotaxis GO:0050922 4 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.015
cell projection organization GO:0030030 284 0.015
cytokinesis GO:0000910 3 0.015
axis specification GO:0009798 43 0.015
g protein coupled receptor signaling pathway GO:0007186 74 0.015
mrna splicing via spliceosome GO:0000398 10 0.015
sequestering of calcium ion GO:0051208 3 0.015
tissue remodeling GO:0048771 4 0.015
meiotic cell cycle process GO:1903046 3 0.015
innate immune response GO:0045087 13 0.015
Fly
cell death in response to oxidative stress GO:0036473 2 0.015
spindle assembly GO:0051225 2 0.014
axon guidance GO:0007411 86 0.014
ion homeostasis GO:0050801 41 0.014
hemopoiesis GO:0030097 183 0.014
Mouse
skeletal muscle tissue development GO:0007519 67 0.014
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.014
multicellular organismal reproductive process GO:0048609 35 0.014
b cell activation GO:0042113 2 0.014
regulation of phosphate metabolic process GO:0019220 43 0.014
negative regulation of cytokine production GO:0001818 1 0.014
endocrine process GO:0050886 2 0.014
proteolysis GO:0006508 38 0.014
negative regulation of catabolic process GO:0009895 3 0.014
neural tube patterning GO:0021532 33 0.013
segmentation GO:0035282 97 0.013
sulfur compound biosynthetic process GO:0044272 9 0.013
rna localization GO:0006403 4 0.013
organonitrogen compound biosynthetic process GO:1901566 47 0.013
Fly
neuroblast proliferation GO:0007405 2 0.013
gtp metabolic process GO:0046039 4 0.013
reactive oxygen species biosynthetic process GO:1903409 1 0.013
cellular amine metabolic process GO:0044106 2 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
negative regulation of apoptotic signaling pathway GO:2001234 10 0.013
entrainment of circadian clock by photoperiod GO:0043153 1 0.013
actin filament based movement GO:0030048 1 0.013
biological adhesion GO:0022610 40 0.013
organic acid metabolic process GO:0006082 31 0.013
cellular response to lipid GO:0071396 39 0.013
cellular response to starvation GO:0009267 1 0.013
stem cell proliferation GO:0072089 4 0.013
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9 0.013
cellular response to decreased oxygen levels GO:0036294 1 0.012
myeloid cell development GO:0061515 32 0.012
amine metabolic process GO:0009308 2 0.012
double strand break repair GO:0006302 3 0.012
response to xenobiotic stimulus GO:0009410 45 0.012
regulation of circadian rhythm GO:0042752 4 0.012
regulation of reactive oxygen species metabolic process GO:2000377 2 0.012
apoptotic signaling pathway GO:0097190 23 0.012
regulation of stem cell proliferation GO:0072091 2 0.012
cell part morphogenesis GO:0032990 246 0.012
axon development GO:0061564 166 0.012
cellular response to topologically incorrect protein GO:0035967 2 0.012
establishment of apical basal cell polarity GO:0035089 2 0.012
microtubule based process GO:0007017 60 0.012
negative regulation of metabolic process GO:0009892 86 0.012
phosphorylation GO:0016310 69 0.012
Human Mouse Fly
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
regulation of insulin like growth factor receptor signaling pathway GO:0043567 1 0.012
signal transduction by p53 class mediator GO:0072331 13 0.012
cell morphogenesis involved in differentiation GO:0000904 195 0.012
macromolecule localization GO:0033036 54 0.012
embryonic cranial skeleton morphogenesis GO:0048701 90 0.012
regulation of innate immune response GO:0045088 11 0.012
Fly
specification of organ identity GO:0010092 2 0.012
cellular response to hypoxia GO:0071456 1 0.012
female meiotic division GO:0007143 2 0.012
spindle assembly involved in meiosis GO:0090306 1 0.011
cell substrate adhesion GO:0031589 4 0.011
g2 dna damage checkpoint GO:0031572 3 0.011
internal peptidyl lysine acetylation GO:0018393 2 0.011
mucopolysaccharide metabolic process GO:1903510 2 0.011
ribonucleoside monophosphate catabolic process GO:0009158 4 0.011
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.011
organelle assembly GO:0070925 110 0.011
positive regulation of striated muscle tissue development GO:0045844 1 0.011
mononuclear cell proliferation GO:0032943 1 0.011
macromolecular complex subunit organization GO:0043933 74 0.011
regulation of cellular ketone metabolic process GO:0010565 7 0.011
multi organism reproductive process GO:0044703 36 0.011
digestive system development GO:0055123 289 0.011
neuron differentiation GO:0030182 353 0.011
negative regulation of protein kinase activity GO:0006469 4 0.011
regulation of neural precursor cell proliferation GO:2000177 3 0.011
microtubule organizing center organization GO:0031023 1 0.011
negative regulation of response to cytokine stimulus GO:0060761 2 0.011
cellular response to radiation GO:0071478 4 0.011
cell cycle process GO:0022402 53 0.011
regulation of cytoplasmic transport GO:1903649 4 0.010
lipid storage GO:0019915 1 0.010
cellular component disassembly GO:0022411 1 0.010
toll like receptor signaling pathway GO:0002224 4 0.010
hematopoietic or lymphoid organ development GO:0048534 191 0.010
Mouse
positive regulation of muscle cell differentiation GO:0051149 1 0.010
reciprocal dna recombination GO:0035825 1 0.010
wnt signaling pathway GO:0016055 80 0.010
phototransduction visible light GO:0007603 2 0.010
peptidyl amino acid modification GO:0018193 16 0.010
Fly
forebrain development GO:0030900 96 0.010
cellular response to vascular endothelial growth factor stimulus GO:0035924 3 0.010
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.010
mrna processing GO:0006397 14 0.010
developmental programmed cell death GO:0010623 4 0.010
retina development in camera type eye GO:0060041 146 0.010
positive regulation of blood circulation GO:1903524 2 0.010

chuk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
sensory system disease DOID:0050155 0 0.021
eye and adnexa disease DOID:1492 0 0.021
nervous system disease DOID:863 0 0.021
disease of metabolism DOID:0014667 0 0.011
mitochondrial metabolism disease DOID:700 0 0.011
inherited metabolic disorder DOID:655 0 0.011
central nervous system disease DOID:331 0 0.010
neurodegenerative disease DOID:1289 0 0.010