Danio rerio

18 known processes

iclp1

invariant chain-like protein 1

(Aliases: wu:fb11f09,wu:fb13d06,wu:fk94e07,Iclp-1,wu:fb12a01)

iclp1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sensory system development GO:0048880 76 0.692
lateral line development GO:0048882 66 0.636
sensory organ development GO:0007423 393 0.527
inner ear development GO:0048839 126 0.505
cellular macromolecule metabolic process GO:0044260 391 0.157
immune system process GO:0002376 241 0.156
immune system development GO:0002520 191 0.152
embryonic organ development GO:0048568 381 0.108
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.107
cellular protein catabolic process GO:0044257 4 0.102
digestive tract morphogenesis GO:0048546 231 0.101
cellular ketone metabolic process GO:0042180 11 0.101
regulation of response to cytokine stimulus GO:0060759 3 0.081
tyrosine phosphorylation of stat protein GO:0007260 1 0.076
posterior lateral line system development GO:0048915 46 0.073
regulation of cytokine production GO:0001817 3 0.071
regulation of macromolecule metabolic process GO:0060255 317 0.068
multicellular organismal metabolic process GO:0044236 2 0.064
neuromast development GO:0048884 46 0.061
oxoacid metabolic process GO:0043436 31 0.061
locomotion GO:0040011 313 0.059
leukocyte differentiation GO:0002521 25 0.059
regulation of striated muscle contraction GO:0006942 2 0.057
response to external stimulus GO:0009605 264 0.054
lipid homeostasis GO:0055088 3 0.054
chemical homeostasis GO:0048878 49 0.052
positive regulation of myeloid cell differentiation GO:0045639 2 0.052
aging GO:0007568 2 0.051
retina morphogenesis in camera type eye GO:0060042 79 0.050
digestive tract development GO:0048565 265 0.049
ion transport GO:0006811 114 0.049
regulation of signal transduction GO:0009966 225 0.048
regulation of cellular amino acid metabolic process GO:0006521 0 0.048
tube morphogenesis GO:0035239 349 0.045
negative regulation of protein phosphorylation GO:0001933 4 0.045
renal tubule morphogenesis GO:0061333 1 0.045
larval development GO:0002164 2 0.045
regulation of cellular amine metabolic process GO:0033238 0 0.044
mechanosensory lateral line system development GO:0048881 49 0.043
camera type eye morphogenesis GO:0048593 108 0.042
camera type eye development GO:0043010 222 0.041
regulation of multicellular organismal process GO:0051239 277 0.041
localization of cell GO:0051674 244 0.041
cell surface receptor signaling pathway GO:0007166 325 0.041
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.040
regulation of metabolic process GO:0019222 359 0.039
collagen metabolic process GO:0032963 2 0.039
multi organism process GO:0051704 134 0.039
digestive system development GO:0055123 289 0.039
eye morphogenesis GO:0048592 144 0.038
regionalization GO:0003002 274 0.038
neurotransmitter secretion GO:0007269 2 0.038
response to wounding GO:0009611 116 0.038
stem cell proliferation GO:0072089 4 0.038
retina development in camera type eye GO:0060041 146 0.038
regulation of synapse organization GO:0050807 3 0.037
response to organic substance GO:0010033 153 0.037
cell death GO:0008219 121 0.036
ear development GO:0043583 127 0.036
actin mediated cell contraction GO:0070252 1 0.036
positive regulation of notch signaling pathway GO:0045747 3 0.036
regulation of protein transport GO:0051223 3 0.035
cellular carbohydrate metabolic process GO:0044262 4 0.035
amine metabolic process GO:0009308 2 0.035
organic acid metabolic process GO:0006082 31 0.035
outflow tract morphogenesis GO:0003151 1 0.035
embryonic skeletal system morphogenesis GO:0048704 93 0.035
regulation of cellular ketone metabolic process GO:0010565 7 0.034
regulation of multicellular organismal metabolic process GO:0044246 2 0.034
regulation of nitrogen compound metabolic process GO:0051171 251 0.034
regulation of cell activation GO:0050865 1 0.033
skin development GO:0043588 54 0.033
embryonic organ morphogenesis GO:0048562 274 0.032
skeletal system development GO:0001501 181 0.032
response to nutrient GO:0007584 3 0.032
extrinsic apoptotic signaling pathway GO:0097191 3 0.032
regulation of epithelial cell proliferation GO:0050678 3 0.032
proteasomal protein catabolic process GO:0010498 2 0.032
otic vesicle development GO:0071599 42 0.031
regulation of jak stat cascade GO:0046425 3 0.031
macromolecule modification GO:0043412 111 0.031
signal transduction GO:0007165 455 0.031
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.031
cellular amine metabolic process GO:0044106 2 0.031
macromolecule biosynthetic process GO:0009059 227 0.031
muscle cell migration GO:0014812 4 0.030
phosphorus metabolic process GO:0006793 109 0.030
protein secretion GO:0009306 1 0.030
phagocytosis GO:0006909 3 0.030
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 1 0.030
negative regulation of biological process GO:0048519 304 0.029
positive regulation of response to stimulus GO:0048584 80 0.029
liver development GO:0001889 96 0.029
cellular protein metabolic process GO:0044267 129 0.029
death GO:0016265 121 0.029
stem cell maintenance GO:0019827 4 0.028
astrocyte differentiation GO:0048708 1 0.028
cell migration involved in gastrulation GO:0042074 79 0.028
somitogenesis GO:0001756 87 0.028
positive regulation of transport GO:0051050 2 0.028
entrainment of circadian clock GO:0009649 2 0.028
regulation of primary metabolic process GO:0080090 311 0.027
protein metabolic process GO:0019538 183 0.027
heterocycle biosynthetic process GO:0018130 215 0.027
positive regulation of muscle cell differentiation GO:0051149 1 0.027
regulation of apoptotic process GO:0042981 98 0.027
single organism metabolic process GO:0044710 217 0.027
regulation of multicellular organism growth GO:0040014 4 0.027
cellular nitrogen compound metabolic process GO:0034641 290 0.026
dorsal ventral pattern formation GO:0009953 125 0.026
positive regulation of gliogenesis GO:0014015 2 0.026
homeostatic process GO:0042592 142 0.026
response to drug GO:0042493 3 0.026
regulation of glial cell differentiation GO:0045685 4 0.026
cellular amino acid metabolic process GO:0006520 7 0.026
regulation of synapse assembly GO:0051963 3 0.026
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.026
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.026
response to stress GO:0006950 263 0.026
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.026
biosynthetic process GO:0009058 294 0.026
regulation of cellular metabolic process GO:0031323 320 0.025
multicellular organism growth GO:0035264 4 0.024
positive regulation of epithelial cell differentiation GO:0030858 2 0.024
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.024
nephron morphogenesis GO:0072028 2 0.024
gastrulation GO:0007369 208 0.024
leukocyte proliferation GO:0070661 1 0.024
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.023
cation transmembrane transport GO:0098655 65 0.023
nuclear transport GO:0051169 4 0.023
lateral line system development GO:0048925 76 0.023
cellular aromatic compound metabolic process GO:0006725 295 0.023
apoptotic process GO:0006915 116 0.023
cellular component disassembly GO:0022411 1 0.023
posterior lateral line neuromast development GO:0048919 20 0.022
monocyte differentiation GO:0030224 2 0.022
morphogenesis of an epithelium GO:0002009 333 0.022
small molecule metabolic process GO:0044281 77 0.022
programmed cell death GO:0012501 119 0.022
regulation of programmed cell death GO:0043067 101 0.022
protein localization to nucleus GO:0034504 3 0.022
regulation of systemic arterial blood pressure GO:0003073 1 0.022
spermatid development GO:0007286 2 0.021
organelle organization GO:0006996 227 0.021
lateral inhibition GO:0046331 1 0.021
gene expression GO:0010467 252 0.021
regulation of muscle contraction GO:0006937 3 0.021
muscle contraction GO:0006936 18 0.021
epithelial cell differentiation GO:0030855 116 0.021
nephron tubule morphogenesis GO:0072078 1 0.021
regulation of gene expression GO:0010468 265 0.021
positive regulation of signaling GO:0023056 56 0.021
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.021
heart development GO:0007507 313 0.020
membrane invagination GO:0010324 1 0.020
regulation of response to stimulus GO:0048583 269 0.020
sensory perception of pain GO:0019233 1 0.020
regulation of multicellular organismal development GO:2000026 223 0.020
skeletal muscle organ development GO:0060538 78 0.020
regulation of mesenchymal cell proliferation GO:0010464 1 0.020
transcription dna templated GO:0006351 181 0.020
atp catabolic process GO:0006200 4 0.020
posterior lateral line neuromast hair cell differentiation GO:0048923 8 0.020
positive regulation of muscle organ development GO:0048636 1 0.019
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.019
peripheral nervous system neuron differentiation GO:0048934 28 0.019
production of molecular mediator of immune response GO:0002440 2 0.019
positive regulation of cellular amine metabolic process GO:0033240 0 0.019
regulation of cell shape GO:0008360 1 0.019
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.019
central nervous system neuron development GO:0021954 29 0.019
regulation of cell communication GO:0010646 232 0.019
directional locomotion GO:0033058 1 0.019
regulation of cellular biosynthetic process GO:0031326 245 0.019
nucleoside monophosphate catabolic process GO:0009125 4 0.019
positive regulation of secretion GO:0051047 1 0.019
mesenchyme development GO:0060485 127 0.019
cranial ganglion development GO:0061550 3 0.019
negative regulation of response to cytokine stimulus GO:0060761 2 0.019
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 1 0.018
regulation of heart growth GO:0060420 2 0.018
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.018
positive regulation of striated muscle cell differentiation GO:0051155 1 0.018
exocytosis GO:0006887 1 0.018
chordate embryonic development GO:0043009 271 0.018
central nervous system development GO:0007417 387 0.018
blood circulation GO:0008015 87 0.018
neuromast hair cell differentiation GO:0048886 12 0.018
positive regulation of catabolic process GO:0009896 4 0.018
glial cell migration GO:0008347 3 0.018
organic substance biosynthetic process GO:1901576 289 0.018
rna metabolic process GO:0016070 219 0.018
cellular protein modification process GO:0006464 100 0.018
angiogenesis GO:0001525 158 0.018
positive regulation of muscle tissue development GO:1901863 1 0.018
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.018
mitochondrion organization GO:0007005 4 0.018
negative regulation of chemotaxis GO:0050922 4 0.018
protein modification process GO:0036211 100 0.018
convergent extension GO:0060026 118 0.018
ameboidal type cell migration GO:0001667 143 0.018
regulation of transmembrane transporter activity GO:0022898 2 0.017
heart process GO:0003015 71 0.017
regulation of signaling GO:0023051 235 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.017
somatic muscle development GO:0007525 4 0.017
cell cell recognition GO:0009988 1 0.017
regulation of cell death GO:0010941 103 0.017
ribonucleoside monophosphate catabolic process GO:0009158 4 0.017
otic vesicle morphogenesis GO:0071600 34 0.017
regulation of biological quality GO:0065008 263 0.017
regulation of nucleoside metabolic process GO:0009118 2 0.017
regulation of blood pressure GO:0008217 1 0.017
tissue migration GO:0090130 37 0.017
regulation of nucleic acid templated transcription GO:1903506 213 0.017
nucleobase containing compound biosynthetic process GO:0034654 205 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
response to hexose GO:0009746 3 0.016
neurotransmitter transport GO:0006836 2 0.016
mononuclear cell proliferation GO:0032943 1 0.016
regulation of rna metabolic process GO:0051252 224 0.016
sensory organ morphogenesis GO:0090596 200 0.016
negative regulation of cytokine production GO:0001818 1 0.016
negative regulation of signal transduction GO:0009968 94 0.016
regulation of tube size GO:0035150 2 0.016
response to carbohydrate GO:0009743 3 0.016
regulation of binding GO:0051098 3 0.016
modification dependent macromolecule catabolic process GO:0043632 3 0.016
positive regulation of striated muscle tissue development GO:0045844 1 0.015
cellular response to organic substance GO:0071310 105 0.015
heterocycle metabolic process GO:0046483 290 0.015
positive regulation of map kinase activity GO:0043406 3 0.015
transcription from rna polymerase ii promoter GO:0006366 80 0.015
regulation of protein localization to nucleus GO:1900180 2 0.015
i kappab kinase nf kappab signaling GO:0007249 4 0.015
membrane repolarization GO:0086009 2 0.015
regulation of dna replication GO:0006275 3 0.015
nephron epithelium morphogenesis GO:0072088 1 0.015
regulation of cell development GO:0060284 100 0.015
negative regulation of programmed cell death GO:0043069 58 0.015
cellular response to chemical stimulus GO:0070887 157 0.015
pigment cell development GO:0070285 3 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
single organism membrane fusion GO:0044801 2 0.015
response to glucose GO:0009749 3 0.015
tissue remodeling GO:0048771 4 0.015
regulation of production of molecular mediator of immune response GO:0002700 1 0.014
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.014
positive regulation of cytokine production GO:0001819 2 0.014
peptidyl serine modification GO:0018209 2 0.014
regulation of skeletal muscle tissue development GO:0048641 4 0.014
positive regulation of signal transduction GO:0009967 56 0.014
aromatic compound biosynthetic process GO:0019438 217 0.014
nucleobase containing compound metabolic process GO:0006139 274 0.014
response to glucocorticoid GO:0051384 1 0.014
somite development GO:0061053 96 0.014
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.014
eye development GO:0001654 277 0.014
otolith development GO:0048840 32 0.014
negative regulation of apoptotic process GO:0043066 55 0.014
sequestering of metal ion GO:0051238 3 0.014
muscle organ development GO:0007517 101 0.014
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 1 0.014
regulation of cytoplasmic transport GO:1903649 4 0.014
regulation of establishment of protein localization GO:0070201 4 0.014
regulation of macromolecule biosynthetic process GO:0010556 225 0.014
positive regulation of apoptotic signaling pathway GO:2001235 1 0.014
positive regulation of biological process GO:0048518 253 0.014
positive regulation of cell adhesion GO:0045785 1 0.014
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.014
carbohydrate homeostasis GO:0033500 1 0.014
blood vessel development GO:0001568 246 0.014
cellular nitrogen compound biosynthetic process GO:0044271 218 0.014
cell proliferation GO:0008283 80 0.013
gland development GO:0048732 143 0.013
negative regulation of metabolic process GO:0009892 86 0.013
determination of heart left right asymmetry GO:0061371 117 0.013
multicellular organismal macromolecule metabolic process GO:0044259 2 0.013
positive regulation of cellular process GO:0048522 201 0.013
cellular response to lipopolysaccharide GO:0071222 3 0.013
tyrosine phosphorylation of stat3 protein GO:0042503 1 0.013
meiotic nuclear division GO:0007126 4 0.013
g1 s transition of mitotic cell cycle GO:0000082 1 0.013
regulation of cytokine mediated signaling pathway GO:0001959 3 0.013
protein stabilization GO:0050821 2 0.013
organic cyclic compound metabolic process GO:1901360 301 0.013
regulation of biosynthetic process GO:0009889 250 0.013
cellular response to retinoic acid GO:0071300 1 0.013
mesoderm formation GO:0001707 43 0.013
lymphocyte proliferation GO:0046651 1 0.013
carboxylic acid metabolic process GO:0019752 22 0.013
renal system development GO:0072001 94 0.013
macromolecular complex disassembly GO:0032984 1 0.013
response to chemical GO:0042221 320 0.013
spindle localization GO:0051653 12 0.013
negative regulation of epithelial cell proliferation GO:0050680 1 0.013
phagocytosis engulfment GO:0006911 1 0.013
head development GO:0060322 303 0.013
innate immune response GO:0045087 13 0.013
rna biosynthetic process GO:0032774 181 0.013
response to ketone GO:1901654 1 0.013
cell activation GO:0001775 16 0.013
embryo development ending in birth or egg hatching GO:0009792 271 0.013
intracellular signal transduction GO:0035556 85 0.013
regulation of stem cell differentiation GO:2000736 4 0.013
negative regulation of defense response GO:0031348 2 0.013
internal peptidyl lysine acetylation GO:0018393 2 0.013
centrosome organization GO:0051297 1 0.012
regulation of calcium ion transport GO:0051924 2 0.012
regulation of metal ion transport GO:0010959 4 0.012
epithelial tube morphogenesis GO:0060562 148 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.012
cellular component assembly involved in morphogenesis GO:0010927 107 0.012
gtp catabolic process GO:0006184 2 0.012
negative regulation of reproductive process GO:2000242 3 0.012
regulation of cell differentiation GO:0045595 142 0.012
regulation of blood vessel size GO:0050880 2 0.012
regulation of axon regeneration GO:0048679 7 0.012
single fertilization GO:0007338 3 0.012
muscle structure development GO:0061061 196 0.012
startle response GO:0001964 4 0.012
membrane fusion GO:0061025 2 0.012
negative regulation of myeloid cell differentiation GO:0045638 1 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.012
myeloid cell homeostasis GO:0002262 56 0.012
regulation of molecular function GO:0065009 70 0.012
somatic stem cell maintenance GO:0035019 1 0.012
positive regulation of immune effector process GO:0002699 3 0.012
action potential GO:0001508 19 0.012
erk1 and erk2 cascade GO:0070371 4 0.012
nitric oxide metabolic process GO:0046209 2 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.012
hemopoiesis GO:0030097 183 0.012
interspecies interaction between organisms GO:0044419 4 0.012
erythrocyte differentiation GO:0030218 54 0.012
mesoderm development GO:0007498 88 0.012
kidney development GO:0001822 92 0.012
negative regulation of map kinase activity GO:0043407 2 0.012
metal ion homeostasis GO:0055065 26 0.012
neuron differentiation GO:0030182 353 0.012
positive regulation of cell activation GO:0050867 1 0.012
protein polymerization GO:0051258 4 0.011
protein dephosphorylation GO:0006470 3 0.011
skeletal system morphogenesis GO:0048705 102 0.011
microtubule organizing center organization GO:0031023 1 0.011
inner ear morphogenesis GO:0042472 63 0.011
muscle tissue development GO:0060537 110 0.011
organelle localization GO:0051640 49 0.011
homeostasis of number of cells GO:0048872 62 0.011
protein complex disassembly GO:0043241 1 0.011
cellular component movement GO:0006928 335 0.011
nitrogen compound metabolic process GO:0006807 319 0.011
post embryonic organ development GO:0048569 4 0.011
regulation of inflammatory response GO:0050727 2 0.011
leukocyte activation GO:0045321 12 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
determination of left right asymmetry in nervous system GO:0035545 4 0.011
regulation of developmental process GO:0050793 247 0.011
regulation of protein complex assembly GO:0043254 3 0.011
positive regulation of protein polymerization GO:0032273 2 0.011
protein acylation GO:0043543 3 0.011
cell projection organization GO:0030030 284 0.011
renal filtration GO:0097205 10 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.011
embryonic cranial skeleton morphogenesis GO:0048701 90 0.011
muscle cell development GO:0055001 115 0.011
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.011
viral process GO:0016032 1 0.011
convergent extension involved in gastrulation GO:0060027 71 0.011
negative regulation of developmental process GO:0051093 65 0.011
cell proliferation involved in heart morphogenesis GO:0061323 2 0.011
endoderm development GO:0007492 49 0.011
calcium mediated signaling GO:0019722 2 0.011
regulation of gtpase activity GO:0043087 2 0.011
fin development GO:0033333 77 0.011
actin filament polymerization GO:0030041 2 0.011
regulation of meiotic cell cycle GO:0051445 1 0.011
regulation of response to stress GO:0080134 36 0.011
purine nucleoside monophosphate catabolic process GO:0009128 4 0.011
b cell mediated immunity GO:0019724 3 0.010
organelle fusion GO:0048284 3 0.010
response to antibiotic GO:0046677 1 0.010
smooth muscle contraction GO:0006939 2 0.010
regulation of cellular component organization GO:0051128 86 0.010
positive regulation of programmed cell death GO:0043068 29 0.010
anterior posterior pattern specification GO:0009952 152 0.010
toll like receptor signaling pathway GO:0002224 4 0.010
neuron development GO:0048666 262 0.010
positive regulation of cytoskeleton organization GO:0051495 3 0.010
direct ossification GO:0036072 3 0.010
mesoderm morphogenesis GO:0048332 51 0.010
negative regulation of neural precursor cell proliferation GO:2000178 1 0.010
epidermis development GO:0008544 48 0.010
protein import GO:0017038 3 0.010
proepicardium development GO:0003342 4 0.010
negative regulation of multi organism process GO:0043901 3 0.010
negative regulation of cellular metabolic process GO:0031324 77 0.010
sensory perception of chemical stimulus GO:0007606 3 0.010
maintenance of location GO:0051235 4 0.010
negative regulation of kinase activity GO:0033673 4 0.010
regulation of protein metabolic process GO:0051246 56 0.010
regulation of purine nucleotide catabolic process GO:0033121 2 0.010
multicellular organismal homeostasis GO:0048871 29 0.010
regeneration GO:0031099 91 0.010

iclp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.062
musculoskeletal system disease DOID:17 0 0.030
nervous system disease DOID:863 0 0.022
muscular disease DOID:0080000 0 0.017
muscle tissue disease DOID:66 0 0.017
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
sensory system disease DOID:0050155 0 0.015
heart disease DOID:114 0 0.014
cardiovascular system disease DOID:1287 0 0.014
myopathy DOID:423 0 0.013
cardiomyopathy DOID:0050700 0 0.013