Danio rerio

68 known processes

pik3cd

phosphoinositide-3-kinase, catalytic, delta polypeptide

(Aliases: zgc:63473,MGC63473)

pik3cd biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.159
Worm Fly
aging GO:0007568 2 0.072
Worm
signal transduction GO:0007165 455 0.056
Mouse Fly
regulation of cell shape GO:0008360 1 0.054
maintenance of location GO:0051235 4 0.049
regulation of multicellular organismal process GO:0051239 277 0.045
regulation of developmental process GO:0050793 247 0.044
regulation of anatomical structure morphogenesis GO:0022603 130 0.043
regulation of metabolic process GO:0019222 359 0.042
Fly
neuron differentiation GO:0030182 353 0.042
regulation of cellular metabolic process GO:0031323 320 0.042
Fly
negative regulation of cellular process GO:0048523 283 0.042
Fly
regulation of biological quality GO:0065008 263 0.041
phagocytosis GO:0006909 3 0.040
single organism membrane fusion GO:0044801 2 0.040
cell morphogenesis GO:0000902 289 0.037
lipid storage GO:0019915 1 0.037
cellular component morphogenesis GO:0032989 336 0.037
regulation of multicellular organism growth GO:0040014 4 0.035
Fly
regulation of multicellular organismal development GO:2000026 223 0.035
positive regulation of cellular component biogenesis GO:0044089 3 0.035
tube morphogenesis GO:0035239 349 0.035
positive regulation of biological process GO:0048518 253 0.035
Fly
embryonic organ development GO:0048568 381 0.034
cellular macromolecule metabolic process GO:0044260 391 0.034
Fly
generation of neurons GO:0048699 385 0.033
regulation of biosynthetic process GO:0009889 250 0.033
Fly
positive regulation of transport GO:0051050 2 0.033
cellular nitrogen compound metabolic process GO:0034641 290 0.032
single organism nuclear import GO:1902593 3 0.032
cognition GO:0050890 1 0.032
Worm
gtp metabolic process GO:0046039 4 0.032
cell part morphogenesis GO:0032990 246 0.032
regulation of protein complex assembly GO:0043254 3 0.032
regulation of establishment of protein localization GO:0070201 4 0.032
establishment of protein localization to organelle GO:0072594 4 0.031
response to chemical GO:0042221 320 0.031
Worm
nucleocytoplasmic transport GO:0006913 4 0.031
positive regulation of cellular process GO:0048522 201 0.031
Fly
multicellular organism growth GO:0035264 4 0.030
Fly
nucleobase containing compound metabolic process GO:0006139 274 0.029
response to stress GO:0006950 263 0.028
Worm Fly
protein metabolic process GO:0019538 183 0.028
Fly
regulation of protein transport GO:0051223 3 0.028
membrane fusion GO:0061025 2 0.027
nitrogen compound metabolic process GO:0006807 319 0.027
regulation of cellular amine metabolic process GO:0033238 0 0.027
i kappab kinase nf kappab signaling GO:0007249 4 0.027
single organism metabolic process GO:0044710 217 0.027
Fly
protein localization to nucleus GO:0034504 3 0.027
amine metabolic process GO:0009308 2 0.026
protein secretion GO:0009306 1 0.026
cellular amine metabolic process GO:0044106 2 0.026
regulation of cytokine production GO:0001817 3 0.026
cytokinesis GO:0000910 3 0.026
cell surface receptor signaling pathway GO:0007166 325 0.026
Mouse Fly
organelle fusion GO:0048284 3 0.026
gastrulation GO:0007369 208 0.026
response to carbohydrate GO:0009743 3 0.026
guanosine containing compound metabolic process GO:1901068 4 0.025
organic cyclic compound metabolic process GO:1901360 301 0.025
leukocyte proliferation GO:0070661 1 0.025
protein import into nucleus GO:0006606 3 0.025
modification dependent macromolecule catabolic process GO:0043632 3 0.025
nuclear transport GO:0051169 4 0.025
establishment of localization GO:0051234 244 0.025
exocytosis GO:0006887 1 0.025
single organism transport GO:0044765 206 0.025
gtp catabolic process GO:0006184 2 0.024
growth GO:0040007 174 0.024
negative regulation of biological process GO:0048519 304 0.024
Fly
central nervous system development GO:0007417 387 0.024
regulation of cell differentiation GO:0045595 142 0.024
cellular response to external stimulus GO:0071496 2 0.024
Fly
regulation of reproductive process GO:2000241 4 0.024
regulation of sequestering of calcium ion GO:0051282 4 0.024
nuclear import GO:0051170 3 0.024
cellular ketone metabolic process GO:0042180 11 0.024
biosynthetic process GO:0009058 294 0.023
Fly
ubiquitin dependent protein catabolic process GO:0006511 3 0.023
regulation of cellular amino acid metabolic process GO:0006521 0 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.023
cellular component disassembly GO:0022411 1 0.023
positive regulation of protein complex assembly GO:0031334 2 0.023
cellular component movement GO:0006928 335 0.023
cytoskeleton dependent cytokinesis GO:0061640 3 0.022
embryonic organ morphogenesis GO:0048562 274 0.022
positive regulation of cell cycle GO:0045787 3 0.022
transport GO:0006810 220 0.022
rna metabolic process GO:0016070 219 0.022
negative regulation of protein kinase activity GO:0006469 4 0.022
cation transport GO:0006812 81 0.022
regulation of nitrogen compound metabolic process GO:0051171 251 0.022
guanosine containing compound catabolic process GO:1901069 2 0.022
tissue remodeling GO:0048771 4 0.022
regulation of gene expression GO:0010468 265 0.022
Fly
adult behavior GO:0030534 2 0.022
autophagy GO:0006914 4 0.022
Fly
cellular macromolecule biosynthetic process GO:0034645 224 0.022
Fly
heterocycle biosynthetic process GO:0018130 215 0.022
embryo development ending in birth or egg hatching GO:0009792 271 0.022
Worm Fly
protein targeting to nucleus GO:0044744 3 0.022
single organism organelle organization GO:1902589 199 0.022
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.022
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.021
regulation of protein targeting GO:1903533 2 0.021
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.021
locomotion GO:0040011 313 0.021
Worm
cellular aromatic compound metabolic process GO:0006725 295 0.021
regulation of cellular ketone metabolic process GO:0010565 7 0.021
digestive tract morphogenesis GO:0048546 231 0.021
organelle organization GO:0006996 227 0.021
positive regulation of catabolic process GO:0009896 4 0.021
negative regulation of metabolic process GO:0009892 86 0.021
Fly
neuron development GO:0048666 262 0.021
regulation of cell activation GO:0050865 1 0.021
morphogenesis of an epithelium GO:0002009 333 0.021
stem cell proliferation GO:0072089 4 0.021
regulation of intracellular protein transport GO:0033157 3 0.021
negative regulation of kinase activity GO:0033673 4 0.021
macromolecule biosynthetic process GO:0009059 227 0.021
Fly
single organism localization GO:1902578 225 0.020
synaptic growth at neuromuscular junction GO:0051124 2 0.020
Fly
negative regulation of protein phosphorylation GO:0001933 4 0.020
small molecule metabolic process GO:0044281 77 0.020
regulation of cytoplasmic transport GO:1903649 4 0.020
cell projection organization GO:0030030 284 0.020
carboxylic acid metabolic process GO:0019752 22 0.020
regulation of synapse assembly GO:0051963 3 0.020
regulation of dna replication GO:0006275 3 0.020
mitochondrion organization GO:0007005 4 0.020
oxoacid metabolic process GO:0043436 31 0.020
neuron neuron synaptic transmission GO:0007270 1 0.020
endosomal transport GO:0016197 2 0.020
peptidyl serine phosphorylation GO:0018105 1 0.020
double strand break repair GO:0006302 3 0.020
organic acid metabolic process GO:0006082 31 0.020
cellular protein catabolic process GO:0044257 4 0.020
regulation of dendrite development GO:0050773 3 0.020
Fly
positive regulation of stress activated mapk cascade GO:0032874 3 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.020
cell projection morphogenesis GO:0048858 244 0.019
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.019
protein polymerization GO:0051258 4 0.019
g1 s transition of mitotic cell cycle GO:0000082 1 0.019
regulation of macromolecule biosynthetic process GO:0010556 225 0.019
Fly
positive regulation of jnk cascade GO:0046330 3 0.019
b cell activation GO:0042113 2 0.019
Mouse
regulation of macromolecule metabolic process GO:0060255 317 0.019
Fly
digestive tract development GO:0048565 265 0.019
system process GO:0003008 185 0.019
Worm
regulation of neurotransmitter transport GO:0051588 1 0.019
response to glucose GO:0009749 3 0.019
cellular nitrogen compound biosynthetic process GO:0044271 218 0.019
peptide transport GO:0015833 1 0.018
regulation of nucleocytoplasmic transport GO:0046822 2 0.018
heterocycle metabolic process GO:0046483 290 0.018
organonitrogen compound metabolic process GO:1901564 74 0.018
regulation of response to stimulus GO:0048583 269 0.018
Worm Fly
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
ion transport GO:0006811 114 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
organic substance biosynthetic process GO:1901576 289 0.018
Fly
proteasomal protein catabolic process GO:0010498 2 0.018
aromatic compound biosynthetic process GO:0019438 217 0.018
positive regulation of cell activation GO:0050867 1 0.018
convergent extension GO:0060026 118 0.018
developmental growth GO:0048589 166 0.018
regulation of binding GO:0051098 3 0.018
regulation of stem cell differentiation GO:2000736 4 0.018
regulation of nucleoside metabolic process GO:0009118 2 0.018
skeletal system development GO:0001501 181 0.018
protein acetylation GO:0006473 2 0.017
regulation of cellular biosynthetic process GO:0031326 245 0.017
Fly
heart development GO:0007507 313 0.017
nucleic acid metabolic process GO:0090304 244 0.017
positive regulation of cellular catabolic process GO:0031331 3 0.017
cellular biosynthetic process GO:0044249 286 0.017
Fly
neuron projection morphogenesis GO:0048812 161 0.017
production of molecular mediator of immune response GO:0002440 2 0.017
meiotic nuclear division GO:0007126 4 0.017
hepaticobiliary system development GO:0061008 98 0.017
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.017
positive regulation of secretion GO:0051047 1 0.017
cell morphogenesis involved in differentiation GO:0000904 195 0.017
multi organism process GO:0051704 134 0.017
Fly
modification dependent protein catabolic process GO:0019941 3 0.017
axonogenesis GO:0007409 152 0.017
response to hexose GO:0009746 3 0.017
inner ear development GO:0048839 126 0.016
organic substance transport GO:0071702 58 0.016
protein localization to plasma membrane GO:0072659 1 0.016
sensory perception of chemical stimulus GO:0007606 3 0.016
macromolecular complex disassembly GO:0032984 1 0.016
rna localization GO:0006403 4 0.016
stem cell maintenance GO:0019827 4 0.016
cellular protein modification process GO:0006464 100 0.016
nucleic acid templated transcription GO:0097659 181 0.016
regulation of tube size GO:0035150 2 0.016
regulation of primary metabolic process GO:0080090 311 0.016
Fly
cellular component assembly GO:0022607 170 0.016
Fly
protein complex disassembly GO:0043241 1 0.016
rna biosynthetic process GO:0032774 181 0.016
regulation of nucleotide catabolic process GO:0030811 2 0.016
cell cycle g1 s phase transition GO:0044843 1 0.016
regulation of autophagy GO:0010506 3 0.016
Fly
regulation of gtp catabolic process GO:0033124 2 0.016
regulation of embryonic development GO:0045995 47 0.016
phosphate containing compound metabolic process GO:0006796 108 0.016
Fly
sensory organ development GO:0007423 393 0.016
regulation of cell communication GO:0010646 232 0.016
Fly
protein import GO:0017038 3 0.016
positive regulation of cytoskeleton organization GO:0051495 3 0.016
gene expression GO:0010467 252 0.016
Fly
cellular response to extracellular stimulus GO:0031668 2 0.015
Fly
synaptic vesicle transport GO:0048489 1 0.015
regionalization GO:0003002 274 0.015
regulation of gtpase activity GO:0043087 2 0.015
axon development GO:0061564 166 0.015
meiotic cell cycle process GO:1903046 3 0.015
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.015
head development GO:0060322 303 0.015
cellular protein metabolic process GO:0044267 129 0.015
Fly
cellular amino acid metabolic process GO:0006520 7 0.015
defense response GO:0006952 47 0.015
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.015
Fly
brain development GO:0007420 293 0.015
sequestering of calcium ion GO:0051208 3 0.015
blood circulation GO:0008015 87 0.015
chemosensory behavior GO:0007635 1 0.015
extrinsic apoptotic signaling pathway GO:0097191 3 0.015
protein acylation GO:0043543 3 0.015
regulation of synapse organization GO:0050807 3 0.015
Fly
liver development GO:0001889 96 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.015
regulation of signaling GO:0023051 235 0.015
Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.015
phagocytosis engulfment GO:0006911 1 0.015
positive regulation of map kinase activity GO:0043406 3 0.015
peptidyl lysine acetylation GO:0018394 2 0.015
mononuclear cell proliferation GO:0032943 1 0.014
regulation of protein import into nucleus GO:0042306 2 0.014
neuroblast proliferation GO:0007405 2 0.014
synaptic transmission cholinergic GO:0007271 4 0.014
blood vessel development GO:0001568 246 0.014
neurotransmitter transport GO:0006836 2 0.014
localization of cell GO:0051674 244 0.014
negative regulation of signal transduction GO:0009968 94 0.014
Fly
lymphocyte proliferation GO:0046651 1 0.014
cellular response to nutrient levels GO:0031669 2 0.014
Fly
histone h3 k4 methylation GO:0051568 2 0.014
regulation of calcium ion transport GO:0051924 2 0.014
regulation of meiotic cell cycle GO:0051445 1 0.014
regulation of nucleic acid templated transcription GO:1903506 213 0.014
regulation of neurotransmitter secretion GO:0046928 1 0.014
digestive system development GO:0055123 289 0.014
response to monosaccharide GO:0034284 3 0.014
sequestering of metal ion GO:0051238 3 0.014
regulation of neurogenesis GO:0050767 87 0.014
regulation of cell development GO:0060284 100 0.014
internal peptidyl lysine acetylation GO:0018393 2 0.014
cell death GO:0008219 121 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.014
multicellular organismal metabolic process GO:0044236 2 0.014
homeostatic process GO:0042592 142 0.014
Mouse
regulation of metal ion transport GO:0010959 4 0.014
response to corticosteroid GO:0031960 1 0.014
chordate embryonic development GO:0043009 271 0.014
phosphorus metabolic process GO:0006793 109 0.013
Fly
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.013
regulation of mrna processing GO:0050684 3 0.013
peptidyl serine modification GO:0018209 2 0.013
internal protein amino acid acetylation GO:0006475 2 0.013
superoxide metabolic process GO:0006801 2 0.013
cellular response to chemical stimulus GO:0070887 157 0.013
positive regulation of cell adhesion GO:0045785 1 0.013
regulation of signal transduction GO:0009966 225 0.013
Fly
activation of mapk activity GO:0000187 3 0.013
neurotransmitter secretion GO:0007269 2 0.013
actin polymerization or depolymerization GO:0008154 2 0.013
alternative mrna splicing via spliceosome GO:0000380 1 0.013
intracellular signal transduction GO:0035556 85 0.013
positive regulation of secretion by cell GO:1903532 1 0.013
macromolecule modification GO:0043412 111 0.013
nuclear export GO:0051168 1 0.013
carbohydrate homeostasis GO:0033500 1 0.013
single fertilization GO:0007338 3 0.013
membrane invagination GO:0010324 1 0.013
regulation of synaptic plasticity GO:0048167 1 0.013
Fly
response to nutrient GO:0007584 3 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.013
actin filament polymerization GO:0030041 2 0.013
microtubule organizing center organization GO:0031023 1 0.013
organism emergence from protective structure GO:0071684 4 0.013
negative regulation of gene expression GO:0010629 65 0.012
negative regulation of cytokine production GO:0001818 1 0.012
vasculature development GO:0001944 278 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.012
nucleobase containing compound biosynthetic process GO:0034654 205 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.012
spermatid development GO:0007286 2 0.012
regulation of protein polymerization GO:0032271 2 0.012
stem cell division GO:0017145 1 0.012
regulation of neural precursor cell proliferation GO:2000177 3 0.012
neuromuscular synaptic transmission GO:0007274 2 0.012
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.012
immune system process GO:0002376 241 0.012
Mouse
inositol lipid mediated signaling GO:0048017 2 0.012
transcription dna templated GO:0006351 181 0.012
positive regulation of cytokine production GO:0001819 2 0.012
muscle cell differentiation GO:0042692 139 0.012
regulation of dendrite morphogenesis GO:0048814 3 0.012
regulation of blood vessel size GO:0050880 2 0.012
regulation of organelle assembly GO:1902115 4 0.012
cell migration GO:0016477 237 0.012
ear development GO:0043583 127 0.012
wound healing GO:0042060 90 0.012
establishment of synaptic vesicle localization GO:0097480 1 0.012
regulation of rna metabolic process GO:0051252 224 0.012
positive regulation of immune effector process GO:0002699 3 0.012
cell substrate adhesion GO:0031589 4 0.012
cell growth GO:0016049 57 0.012
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
regulation of cellular component organization GO:0051128 86 0.012
death GO:0016265 121 0.012
response to drug GO:0042493 3 0.012
negative regulation of multicellular organismal process GO:0051241 69 0.012
glucose homeostasis GO:0042593 1 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.012
synaptic vesicle localization GO:0097479 1 0.012
immune system development GO:0002520 191 0.012
mitochondrial transport GO:0006839 2 0.012
regulation of muscle contraction GO:0006937 3 0.012
cellular carbohydrate metabolic process GO:0044262 4 0.012
release of sequestered calcium ion into cytosol GO:0051209 3 0.011
response to external stimulus GO:0009605 264 0.011
Worm Fly
cardiac atrium morphogenesis GO:0003209 2 0.011
regulation of exocytosis GO:0017157 1 0.011
neuron projection development GO:0031175 180 0.011
protein modification process GO:0036211 100 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
muscle structure development GO:0061061 196 0.011
taxis GO:0042330 109 0.011
Worm
cellular localization GO:0051641 97 0.011
interspecies interaction between organisms GO:0044419 4 0.011
hematopoietic or lymphoid organ development GO:0048534 191 0.011
establishment of localization in cell GO:0051649 77 0.011
cellular response to oxygen levels GO:0071453 1 0.011
cellular response to molecule of bacterial origin GO:0071219 3 0.011
regulation of cell substrate adhesion GO:0010810 1 0.011
regulation of wound healing GO:0061041 2 0.011
protein depolymerization GO:0051261 1 0.011
compound eye development GO:0048749 2 0.011
striated muscle cell differentiation GO:0051146 129 0.011
ear morphogenesis GO:0042471 64 0.011
cortical cytoskeleton organization GO:0030865 1 0.011
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
Fly
regulation of protein catabolic process GO:0042176 1 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
lateral inhibition GO:0046331 1 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
Fly
cell cycle arrest GO:0007050 1 0.011
protein polyubiquitination GO:0000209 4 0.011
regulation of molecular function GO:0065009 70 0.011
erk1 and erk2 cascade GO:0070371 4 0.011
regulation of inflammatory response GO:0050727 2 0.011
cortical actin cytoskeleton organization GO:0030866 1 0.011
small gtpase mediated signal transduction GO:0007264 8 0.011
heart process GO:0003015 71 0.011
ion transmembrane transport GO:0034220 91 0.011
response to organic substance GO:0010033 153 0.011
protein dephosphorylation GO:0006470 3 0.011
b cell differentiation GO:0030183 1 0.011
regulation of erk1 and erk2 cascade GO:0070372 4 0.011
nucleoside monophosphate catabolic process GO:0009125 4 0.011
circulatory system process GO:0003013 87 0.011
programmed cell death GO:0012501 119 0.011
apoptotic process GO:0006915 116 0.011
fatty acid transport GO:0015908 1 0.011
hormone secretion GO:0046879 2 0.011
negative regulation of mapk cascade GO:0043409 4 0.011
ras protein signal transduction GO:0007265 7 0.011
pancreas development GO:0031016 84 0.011
cytoskeleton organization GO:0007010 96 0.011
cell motility GO:0048870 244 0.011
regulation of microtubule cytoskeleton organization GO:0070507 3 0.010
spermatid differentiation GO:0048515 2 0.010
phosphatidylinositol mediated signaling GO:0048015 2 0.010
bone remodeling GO:0046849 2 0.010
mitotic dna integrity checkpoint GO:0044774 4 0.010
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.010
regulation of nervous system development GO:0051960 90 0.010
cytoplasm organization GO:0007028 4 0.010
negative regulation of cell communication GO:0010648 96 0.010
Fly
regulation of cell morphogenesis GO:0022604 42 0.010
regulation of protein complex disassembly GO:0043244 1 0.010
response to wounding GO:0009611 116 0.010
negative regulation of catabolic process GO:0009895 3 0.010
Fly
cellular response to biotic stimulus GO:0071216 3 0.010
fertilization GO:0009566 3 0.010
transmembrane transport GO:0055085 120 0.010
regulation of transcription dna templated GO:0006355 213 0.010
multicellular organismal response to stress GO:0033555 2 0.010
metal ion transport GO:0030001 58 0.010
protein stabilization GO:0050821 2 0.010
positive regulation of exocytosis GO:0045921 1 0.010
positive regulation of gtpase activity GO:0043547 1 0.010
dna templated transcription elongation GO:0006354 3 0.010
developmental growth involved in morphogenesis GO:0060560 86 0.010
positive regulation of nucleotide catabolic process GO:0030813 1 0.010
lateral line development GO:0048882 66 0.010
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.010
dorsal ventral pattern formation GO:0009953 125 0.010
regulation of receptor activity GO:0010469 2 0.010
negative regulation of dna metabolic process GO:0051053 4 0.010
cytosolic calcium ion transport GO:0060401 3 0.010

pik3cd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.059
immune system disease DOID:2914 0 0.019
cancer DOID:162 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
nervous system disease DOID:863 0 0.016
musculoskeletal system disease DOID:17 0 0.013
organ system cancer DOID:0050686 0 0.013
disease of metabolism DOID:0014667 0 0.011