Danio rerio

0 known processes

hint2

histidine triad nucleotide binding protein 2

(Aliases: MGC163082,si:dkey-87i10.2,zgc:163082)

hint2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
inner ear development GO:0048839 126 0.287
transmembrane transport GO:0055085 120 0.235
ear development GO:0043583 127 0.218
sensory organ development GO:0007423 393 0.166
response to external stimulus GO:0009605 264 0.164
semicircular canal development GO:0060872 24 0.125
cytosolic calcium ion transport GO:0060401 3 0.083
regulation of cell projection assembly GO:0060491 4 0.079
larval development GO:0002164 2 0.076
organelle organization GO:0006996 227 0.074
vasculature development GO:0001944 278 0.072
mitochondrion organization GO:0007005 4 0.071
positive regulation of transport GO:0051050 2 0.068
positive regulation of secretion GO:0051047 1 0.067
actin polymerization or depolymerization GO:0008154 2 0.064
regulation of reactive oxygen species metabolic process GO:2000377 2 0.064
positive regulation of biological process GO:0048518 253 0.063
regulation of synaptic plasticity GO:0048167 1 0.061
aging GO:0007568 2 0.058
angiogenesis GO:0001525 158 0.056
regulation of guanylate cyclase activity GO:0031282 6 0.055
central nervous system development GO:0007417 387 0.055
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.055
cellular response to toxic substance GO:0097237 1 0.052
hydrogen peroxide metabolic process GO:0042743 2 0.050
positive regulation of protein polymerization GO:0032273 2 0.050
cell projection organization GO:0030030 284 0.049
maintenance of location GO:0051235 4 0.048
biosynthetic process GO:0009058 294 0.047
multicellular organism growth GO:0035264 4 0.047
amine metabolic process GO:0009308 2 0.047
positive regulation of cgmp biosynthetic process GO:0030828 6 0.046
establishment of localization GO:0051234 244 0.046
regulation of protein ubiquitination GO:0031396 3 0.043
somite development GO:0061053 96 0.043
cellular transition metal ion homeostasis GO:0046916 3 0.043
regulation of multicellular organism growth GO:0040014 4 0.043
taste bud formation GO:0061195 3 0.042
single organism transport GO:0044765 206 0.041
g protein coupled receptor signaling pathway GO:0007186 74 0.041
cognition GO:0050890 1 0.040
sensory organ morphogenesis GO:0090596 200 0.039
regulation of reproductive process GO:2000241 4 0.039
single organism localization GO:1902578 225 0.039
skeletal muscle organ development GO:0060538 78 0.039
embryonic organ development GO:0048568 381 0.039
phototransduction visible light GO:0007603 2 0.039
negative regulation of kinase activity GO:0033673 4 0.039
negative regulation of biological process GO:0048519 304 0.038
head development GO:0060322 303 0.038
regulation of cellular amino acid metabolic process GO:0006521 0 0.037
positive regulation of muscle tissue development GO:1901863 1 0.037
developmental programmed cell death GO:0010623 4 0.036
regulation of response to oxidative stress GO:1902882 2 0.036
regulation of cgmp biosynthetic process GO:0030826 6 0.035
cellular amino acid metabolic process GO:0006520 7 0.035
oocyte maturation GO:0001556 4 0.034
regulation of cellular amine metabolic process GO:0033238 0 0.034
cellular response to light stimulus GO:0071482 4 0.034
heart morphogenesis GO:0003007 156 0.033
positive regulation of striated muscle tissue development GO:0045844 1 0.032
heart development GO:0007507 313 0.032
positive regulation of blood circulation GO:1903524 2 0.032
organic acid metabolic process GO:0006082 31 0.032
cellular ketone metabolic process GO:0042180 11 0.032
embryonic heart tube morphogenesis GO:0003143 108 0.032
rhodopsin mediated signaling pathway GO:0016056 1 0.032
positive regulation of muscle organ development GO:0048636 1 0.032
tube morphogenesis GO:0035239 349 0.031
cellular component movement GO:0006928 335 0.031
single organism metabolic process GO:0044710 217 0.030
regulation of protein complex assembly GO:0043254 3 0.030
cellular macromolecule metabolic process GO:0044260 391 0.030
actin filament polymerization GO:0030041 2 0.030
intramembranous ossification GO:0001957 3 0.030
cellular localization GO:0051641 97 0.030
carboxylic acid metabolic process GO:0019752 22 0.030
positive regulation of cellular amine metabolic process GO:0033240 0 0.030
locomotion GO:0040011 313 0.029
embryonic organ morphogenesis GO:0048562 274 0.029
regulation of muscle contraction GO:0006937 3 0.029
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.029
cellular response to chemical stimulus GO:0070887 157 0.029
phototransduction GO:0007602 2 0.029
monoamine transport GO:0015844 1 0.029
signal transduction GO:0007165 455 0.028
system process GO:0003008 185 0.028
regulation of metal ion transport GO:0010959 4 0.027
chordate embryonic development GO:0043009 271 0.027
protein polymerization GO:0051258 4 0.027
cellular protein catabolic process GO:0044257 4 0.027
striated muscle cell differentiation GO:0051146 129 0.027
cellular response to decreased oxygen levels GO:0036294 1 0.027
cellular component biogenesis GO:0044085 178 0.027
transport GO:0006810 220 0.027
cellular response to radiation GO:0071478 4 0.027
blood vessel morphogenesis GO:0048514 216 0.026
cellular component morphogenesis GO:0032989 336 0.026
single organism organelle organization GO:1902589 199 0.026
blood vessel development GO:0001568 246 0.026
regulation of protein polymerization GO:0032271 2 0.026
adult behavior GO:0030534 2 0.026
determination of bilateral symmetry GO:0009855 204 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.025
locus ceruleus development GO:0021703 3 0.025
erk1 and erk2 cascade GO:0070371 4 0.025
organic substance biosynthetic process GO:1901576 289 0.025
heart process GO:0003015 71 0.025
negative regulation of protein phosphorylation GO:0001933 4 0.025
positive regulation of cellular component biogenesis GO:0044089 3 0.024
regulation of filopodium assembly GO:0051489 2 0.024
long chain fatty acid transport GO:0015909 1 0.024
ion transport GO:0006811 114 0.024
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.024
positive regulation of cellular process GO:0048522 201 0.024
direct ossification GO:0036072 3 0.024
regulation of sodium ion transport GO:0002028 2 0.023
cell death in response to oxidative stress GO:0036473 2 0.023
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.023
regulation of blood pressure GO:0008217 1 0.023
regulation of localization GO:0032879 104 0.022
sequestering of metal ion GO:0051238 3 0.022
regulation of cellular response to oxidative stress GO:1900407 2 0.022
cgmp metabolic process GO:0046068 7 0.022
ribonucleoside monophosphate catabolic process GO:0009158 4 0.022
heart contraction GO:0060047 71 0.022
hindbrain formation GO:0021576 3 0.022
cation transmembrane transport GO:0098655 65 0.022
autophagy GO:0006914 4 0.022
nucleobase containing compound biosynthetic process GO:0034654 205 0.022
small molecule metabolic process GO:0044281 77 0.021
macromolecular complex subunit organization GO:0043933 74 0.021
regulation of blood vessel size GO:0050880 2 0.021
brain development GO:0007420 293 0.021
response to drug GO:0042493 3 0.021
positive regulation of secretion by cell GO:1903532 1 0.021
establishment of localization in cell GO:0051649 77 0.021
limb bud formation GO:0060174 2 0.021
calcium ion transmembrane transport GO:0070588 13 0.021
inner ear morphogenesis GO:0042472 63 0.021
circulatory system process GO:0003013 87 0.021
organonitrogen compound metabolic process GO:1901564 74 0.021
regulation of receptor mediated endocytosis GO:0048259 4 0.020
regulation of signaling GO:0023051 235 0.020
cellular response to external stimulus GO:0071496 2 0.020
regulation of gene expression GO:0010468 265 0.020
establishment of synaptic vesicle localization GO:0097480 1 0.020
protein complex biogenesis GO:0070271 30 0.020
intracellular signal transduction GO:0035556 85 0.019
specification of symmetry GO:0009799 204 0.019
determination of left right symmetry GO:0007368 179 0.019
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.019
neurotransmitter transport GO:0006836 2 0.019
regulation of cellular ketone metabolic process GO:0010565 7 0.019
cell morphogenesis involved in differentiation GO:0000904 195 0.019
negative regulation of developmental process GO:0051093 65 0.019
cellular respiration GO:0045333 3 0.019
neuron neuron synaptic transmission GO:0007270 1 0.018
heart looping GO:0001947 94 0.018
regulation of transporter activity GO:0032409 2 0.018
regulation of ion transmembrane transporter activity GO:0032412 2 0.018
positive regulation of protein complex assembly GO:0031334 2 0.018
oxidation reduction process GO:0055114 41 0.018
regulation of cellular metabolic process GO:0031323 320 0.018
smooth muscle contraction GO:0006939 2 0.018
porphyrin containing compound metabolic process GO:0006778 10 0.017
actin filament based movement GO:0030048 1 0.017
stem cell maintenance GO:0019827 4 0.017
cardiac muscle cell differentiation GO:0055007 30 0.017
regulation of hydrogen peroxide metabolic process GO:0010310 1 0.017
negative regulation of cellular process GO:0048523 283 0.017
regulation of oxidative stress induced cell death GO:1903201 2 0.017
cellular component disassembly GO:0022411 1 0.017
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 2 0.017
protein heterooligomerization GO:0051291 1 0.017
regulation of neurotransmitter secretion GO:0046928 1 0.016
rhombomere 6 development GO:0021572 4 0.016
synaptic vesicle transport GO:0048489 1 0.016
response to vitamin GO:0033273 3 0.016
regulation of skeletal muscle tissue development GO:0048641 4 0.016
regulation of calcium ion transport GO:0051924 2 0.016
cell morphogenesis GO:0000902 289 0.016
regulation of receptor internalization GO:0002090 2 0.016
anterior posterior pattern specification GO:0009952 152 0.016
skeletal muscle tissue development GO:0007519 67 0.016
negative regulation of map kinase activity GO:0043407 2 0.016
regulation of fatty acid metabolic process GO:0019217 1 0.016
organelle fusion GO:0048284 3 0.016
negative regulation of mapk cascade GO:0043409 4 0.016
negative regulation of epithelial cell proliferation GO:0050680 1 0.016
lipid homeostasis GO:0055088 3 0.016
generation of neurons GO:0048699 385 0.016
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.016
determination of heart left right asymmetry GO:0061371 117 0.016
embryo development ending in birth or egg hatching GO:0009792 271 0.016
semicircular canal formation GO:0060876 4 0.016
microtubule depolymerization GO:0007019 1 0.016
peptidyl serine phosphorylation GO:0018105 1 0.015
inorganic cation transmembrane transport GO:0098662 50 0.015
tissue remodeling GO:0048771 4 0.015
regulation of biological quality GO:0065008 263 0.015
specification of axis polarity GO:0065001 4 0.015
regulation of multicellular organismal process GO:0051239 277 0.015
response to carbohydrate GO:0009743 3 0.015
regulation of endothelial cell proliferation GO:0001936 1 0.015
sensory perception GO:0007600 39 0.015
regulation of cell communication GO:0010646 232 0.015
muscle contraction GO:0006936 18 0.015
nitrogen compound metabolic process GO:0006807 319 0.015
response to monosaccharide GO:0034284 3 0.015
regulation of binding GO:0051098 3 0.015
regulation of transmembrane transporter activity GO:0022898 2 0.015
meiotic chromosome segregation GO:0045132 3 0.015
positive regulation of skeletal muscle tissue development GO:0048643 1 0.015
astrocyte differentiation GO:0048708 1 0.015
positive regulation of exocytosis GO:0045921 1 0.015
neurotransmitter secretion GO:0007269 2 0.015
small molecule catabolic process GO:0044282 3 0.015
kupffer s vesicle development GO:0070121 50 0.014
regulation of release of sequestered calcium ion into cytosol GO:0051279 1 0.014
spermatid development GO:0007286 2 0.014
regulation of tube size GO:0035150 2 0.014
macromolecule biosynthetic process GO:0009059 227 0.014
cellular component assembly GO:0022607 170 0.014
protein import GO:0017038 3 0.014
organic cyclic compound metabolic process GO:1901360 301 0.014
olfactory lobe development GO:0021988 4 0.014
renal system process GO:0003014 14 0.014
meiotic cell cycle process GO:1903046 3 0.014
establishment of protein localization to organelle GO:0072594 4 0.014
protein metabolic process GO:0019538 183 0.014
regulation of metabolic process GO:0019222 359 0.014
mitotic dna integrity checkpoint GO:0044774 4 0.014
positive regulation of cell cycle GO:0045787 3 0.014
regulation of macromolecule metabolic process GO:0060255 317 0.014
cellular response to nutrient levels GO:0031669 2 0.014
regulation of meiotic cell cycle GO:0051445 1 0.014
growth GO:0040007 174 0.014
spermatid differentiation GO:0048515 2 0.014
receptor internalization GO:0031623 2 0.014
multi organism process GO:0051704 134 0.014
regulation of nucleotide biosynthetic process GO:0030808 15 0.013
response to food GO:0032094 1 0.013
regulation of bone remodeling GO:0046850 2 0.013
homeostasis of number of cells within a tissue GO:0048873 4 0.013
cellular amine metabolic process GO:0044106 2 0.013
meiotic nuclear division GO:0007126 4 0.013
compound eye development GO:0048749 2 0.013
regulation of neurotransmitter transport GO:0051588 1 0.013
regulation of developmental process GO:0050793 247 0.013
reactive oxygen species metabolic process GO:0072593 6 0.013
regulation of organelle assembly GO:1902115 4 0.013
mitochondrial transport GO:0006839 2 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.013
response to nutrient GO:0007584 3 0.013
reproduction GO:0000003 40 0.013
positive regulation of heart contraction GO:0045823 2 0.013
regulation of intracellular protein transport GO:0033157 3 0.013
cell projection morphogenesis GO:0048858 244 0.013
membrane hyperpolarization GO:0060081 1 0.013
light induced release of internally sequestered calcium ion GO:0008377 1 0.013
response to abiotic stimulus GO:0009628 122 0.013
insulin like growth factor receptor signaling pathway GO:0048009 4 0.013
negative regulation of intracellular transport GO:0032387 3 0.013
response to hexose GO:0009746 3 0.013
response to antibiotic GO:0046677 1 0.013
modification dependent protein catabolic process GO:0019941 3 0.013
regulation of protein transport GO:0051223 3 0.013
regulation of insulin like growth factor receptor signaling pathway GO:0043567 1 0.013
heterocycle metabolic process GO:0046483 290 0.013
regulation of cyclase activity GO:0031279 12 0.012
response to glucose GO:0009749 3 0.012
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.012
tetrapyrrole metabolic process GO:0033013 10 0.012
ion transmembrane transport GO:0034220 91 0.012
inner ear receptor cell differentiation GO:0060113 29 0.012
cellular biosynthetic process GO:0044249 286 0.012
synaptic vesicle localization GO:0097479 1 0.012
macromolecule modification GO:0043412 111 0.012
ear morphogenesis GO:0042471 64 0.012
negative regulation of blood circulation GO:1903523 2 0.012
photoreceptor cell fate specification GO:0043704 1 0.012
organonitrogen compound biosynthetic process GO:1901566 47 0.012
response to stress GO:0006950 263 0.012
cellular nitrogen compound metabolic process GO:0034641 290 0.012
cell aging GO:0007569 2 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
neurological system process GO:0050877 62 0.012
cgmp biosynthetic process GO:0006182 7 0.012
regulation of cytoplasmic transport GO:1903649 4 0.012
embryonic skeletal joint development GO:0072498 3 0.012
organic cyclic compound biosynthetic process GO:1901362 223 0.012
developmental growth GO:0048589 166 0.012
positive regulation of cellular catabolic process GO:0031331 3 0.012
embryonic limb morphogenesis GO:0030326 2 0.012
mesenchyme development GO:0060485 127 0.012
striated muscle cell development GO:0055002 108 0.012
lipid catabolic process GO:0016042 4 0.012
negative regulation of catabolic process GO:0009895 3 0.012
organelle localization GO:0051640 49 0.012
cell projection assembly GO:0030031 64 0.011
neuron differentiation GO:0030182 353 0.011
synaptic transmission cholinergic GO:0007271 4 0.011
chemosensory behavior GO:0007635 1 0.011
cell proliferation GO:0008283 80 0.011
death GO:0016265 121 0.011
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.011
neuron projection development GO:0031175 180 0.011
muscle structure development GO:0061061 196 0.011
protein stabilization GO:0050821 2 0.011
carbon dioxide transport GO:0015670 3 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.011
sequestering of calcium ion GO:0051208 3 0.011
inositol lipid mediated signaling GO:0048017 2 0.011
localization of cell GO:0051674 244 0.011
i kappab kinase nf kappab signaling GO:0007249 4 0.011
striated muscle tissue development GO:0014706 110 0.011
protein complex disassembly GO:0043241 1 0.011
single organism membrane fusion GO:0044801 2 0.011
chromosome organization involved in meiosis GO:0070192 1 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
cellular response to vascular endothelial growth factor stimulus GO:0035924 3 0.011
regulation of lyase activity GO:0051339 12 0.011
negative regulation of cellular catabolic process GO:0031330 3 0.011
cyclic nucleotide biosynthetic process GO:0009190 18 0.011
respiratory electron transport chain GO:0022904 2 0.011
cellular aldehyde metabolic process GO:0006081 4 0.011
gtp catabolic process GO:0006184 2 0.011
regulation of systemic arterial blood pressure GO:0003073 1 0.011
nuclear transport GO:0051169 4 0.011
ventricular cardiac muscle tissue development GO:0003229 3 0.011
cell part morphogenesis GO:0032990 246 0.011
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.011
actin filament based process GO:0030029 64 0.010
regulation of gastrulation GO:0010470 24 0.010
negative regulation of dna metabolic process GO:0051053 4 0.010
regulation of mitochondrion organization GO:0010821 1 0.010
regulation of blood circulation GO:1903522 32 0.010
regulation of carbohydrate biosynthetic process GO:0043255 1 0.010
single organism nuclear import GO:1902593 3 0.010
locomotor rhythm GO:0045475 3 0.010
sensory perception of chemical stimulus GO:0007606 3 0.010
fat soluble vitamin metabolic process GO:0006775 4 0.010
release of sequestered calcium ion into cytosol GO:0051209 3 0.010
muscle cell differentiation GO:0042692 139 0.010
morphogenesis of an epithelium GO:0002009 333 0.010
blood circulation GO:0008015 87 0.010
detection of external stimulus GO:0009581 24 0.010
negative regulation of signaling GO:0023057 96 0.010
regulation of epithelial cell proliferation GO:0050678 3 0.010
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 1 0.010
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.010
cell cell signaling GO:0007267 52 0.010
cellular response to hypoxia GO:0071456 1 0.010
sleep GO:0030431 1 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.010
regulation of tissue remodeling GO:0034103 2 0.010
development of primary female sexual characteristics GO:0046545 4 0.010

hint2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
parkinson s disease DOID:14330 0 0.094
synucleinopathy DOID:0050890 0 0.094
central nervous system disease DOID:331 0 0.094
disease of anatomical entity DOID:7 0 0.094
neurodegenerative disease DOID:1289 0 0.094
nervous system disease DOID:863 0 0.094
disease of metabolism DOID:0014667 0 0.051
inherited metabolic disorder DOID:655 0 0.051
myopathy DOID:423 0 0.013
muscular disease DOID:0080000 0 0.013
musculoskeletal system disease DOID:17 0 0.013
muscle tissue disease DOID:66 0 0.013