Danio rerio

13 known processes

bin1

bridging integrator 1

(Aliases: zgc:86701,cb57)

bin1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of biological quality GO:0065008 263 0.112
convergent extension involved in gastrulation GO:0060027 71 0.081
cellular component morphogenesis GO:0032989 336 0.074
adherens junction organization GO:0034332 4 0.070
single organism localization GO:1902578 225 0.064
establishment of localization GO:0051234 244 0.061
cell surface receptor signaling pathway GO:0007166 325 0.060
positive regulation of transport GO:0051050 2 0.053
regulation of molecular function GO:0065009 70 0.052
actin polymerization or depolymerization GO:0008154 2 0.050
homeostatic process GO:0042592 142 0.048
lipid storage GO:0019915 1 0.047
central nervous system development GO:0007417 387 0.047
Human
locomotion GO:0040011 313 0.045
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.043
cation transmembrane transport GO:0098655 65 0.043
negative regulation of signaling GO:0023057 96 0.043
regulation of synapse assembly GO:0051963 3 0.042
regulation of binding GO:0051098 3 0.041
regulation of cell communication GO:0010646 232 0.041
cellular component movement GO:0006928 335 0.041
gene expression GO:0010467 252 0.040
regulation of response to stimulus GO:0048583 269 0.040
signal transduction GO:0007165 455 0.040
cell migration GO:0016477 237 0.039
single organism transport GO:0044765 206 0.039
cellular component assembly involved in morphogenesis GO:0010927 107 0.039
response to chemical GO:0042221 320 0.038
aging GO:0007568 2 0.038
multicellular organismal metabolic process GO:0044236 2 0.038
regulation of multicellular organism growth GO:0040014 4 0.038
ion transmembrane transport GO:0034220 91 0.038
vasculature development GO:0001944 278 0.037
maintenance of location GO:0051235 4 0.037
negative regulation of cell communication GO:0010648 96 0.037
transport GO:0006810 220 0.036
regulation of primary metabolic process GO:0080090 311 0.034
lipid homeostasis GO:0055088 3 0.034
cellular carbohydrate metabolic process GO:0044262 4 0.034
response to fluid shear stress GO:0034405 2 0.034
localization of cell GO:0051674 244 0.033
regulation of establishment of protein localization GO:0070201 4 0.032
positive regulation of cellular component biogenesis GO:0044089 3 0.031
regulation of biomineral tissue development GO:0070167 2 0.031
negative regulation of protein complex assembly GO:0031333 1 0.031
regulation of epithelial cell proliferation GO:0050678 3 0.031
pericardium development GO:0060039 1 0.030
regulation of stem cell differentiation GO:2000736 4 0.030
stem cell proliferation GO:0072089 4 0.030
cell morphogenesis involved in differentiation GO:0000904 195 0.030
epithelium migration GO:0090132 25 0.028
regulation of nitrogen compound metabolic process GO:0051171 251 0.028
protein polymerization GO:0051258 4 0.028
regulation of nucleotide catabolic process GO:0030811 2 0.028
cell substrate adhesion GO:0031589 4 0.028
cell substrate junction assembly GO:0007044 2 0.028
tissue regeneration GO:0042246 74 0.028
regulation of metabolic process GO:0019222 359 0.027
cytoskeleton organization GO:0007010 96 0.027
transmembrane transport GO:0055085 120 0.027
cellular nitrogen compound biosynthetic process GO:0044271 218 0.026
ameboidal type cell migration GO:0001667 143 0.026
protein homooligomerization GO:0051260 3 0.025
g1 s transition of mitotic cell cycle GO:0000082 1 0.025
single organism organelle organization GO:1902589 199 0.025
cellular response to chemical stimulus GO:0070887 157 0.025
response to carbohydrate GO:0009743 3 0.025
protein complex disassembly GO:0043241 1 0.025
fin regeneration GO:0031101 51 0.024
regionalization GO:0003002 274 0.024
cell cycle g1 s phase transition GO:0044843 1 0.024
regulation of protein polymerization GO:0032271 2 0.024
cellular response to hormone stimulus GO:0032870 39 0.024
heart development GO:0007507 313 0.024
response to endogenous stimulus GO:0009719 83 0.024
response to organic substance GO:0010033 153 0.024
cellular ketone metabolic process GO:0042180 11 0.024
heart valve formation GO:0003188 4 0.023
regulation of cell projection assembly GO:0060491 4 0.023
macromolecule biosynthetic process GO:0009059 227 0.023
response to external stimulus GO:0009605 264 0.023
brain development GO:0007420 293 0.023
neuroblast proliferation GO:0007405 2 0.023
protein localization to plasma membrane GO:0072659 1 0.023
regulation of protein complex assembly GO:0043254 3 0.023
cell morphogenesis GO:0000902 289 0.023
single organism membrane organization GO:0044802 20 0.023
amino acid transport GO:0006865 2 0.023
aromatic compound biosynthetic process GO:0019438 217 0.023
protein complex biogenesis GO:0070271 30 0.023
regulation of signal transduction GO:0009966 225 0.022
regulation of neural precursor cell proliferation GO:2000177 3 0.022
response to hexose GO:0009746 3 0.022
positive regulation of map kinase activity GO:0043406 3 0.022
nitrogen compound metabolic process GO:0006807 319 0.022
enzyme linked receptor protein signaling pathway GO:0007167 106 0.022
ribonucleoside monophosphate catabolic process GO:0009158 4 0.022
chemical homeostasis GO:0048878 49 0.022
negative regulation of biological process GO:0048519 304 0.022
Human
negative regulation of synapse assembly GO:0051964 2 0.021
organelle organization GO:0006996 227 0.021
Fly
response to monosaccharide GO:0034284 3 0.021
response to biotic stimulus GO:0009607 97 0.021
cell matrix adhesion GO:0007160 4 0.021
organonitrogen compound metabolic process GO:1901564 74 0.021
cellular nitrogen compound metabolic process GO:0034641 290 0.021
regulation of protein transport GO:0051223 3 0.021
morphogenesis of an epithelium GO:0002009 333 0.021
protein localization to nucleus GO:0034504 3 0.021
regulation of cytokine production GO:0001817 3 0.021
membrane fusion GO:0061025 2 0.021
stem cell differentiation GO:0048863 117 0.021
larval development GO:0002164 2 0.021
positive regulation of catabolic process GO:0009896 4 0.021
regulation of synapse organization GO:0050807 3 0.021
regulation of signaling GO:0023051 235 0.020
female sex differentiation GO:0046660 4 0.020
sensory organ development GO:0007423 393 0.020
Fly
germ line stem cell maintenance GO:0030718 2 0.020
circadian sleep wake cycle sleep GO:0050802 1 0.020
regulation of cell shape GO:0008360 1 0.020
specification of symmetry GO:0009799 204 0.020
cellular macromolecule metabolic process GO:0044260 391 0.020
circadian sleep wake cycle GO:0042745 2 0.020
regulation of cellular amine metabolic process GO:0033238 0 0.020
determination of left right symmetry GO:0007368 179 0.020
circadian sleep wake cycle process GO:0022410 2 0.019
cell motility GO:0048870 244 0.019
negative regulation of signal transduction GO:0009968 94 0.019
organelle assembly GO:0070925 110 0.019
regulation of gene expression GO:0010468 265 0.019
ubiquitin dependent protein catabolic process GO:0006511 3 0.019
regulation of transporter activity GO:0032409 2 0.019
protein metabolic process GO:0019538 183 0.019
negative regulation of ras protein signal transduction GO:0046580 1 0.019
membrane lipid biosynthetic process GO:0046467 2 0.019
positive regulation of biological process GO:0048518 253 0.019
Human
cognition GO:0050890 1 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
leukocyte proliferation GO:0070661 1 0.019
forebrain cell migration GO:0021885 1 0.019
fatty acid transport GO:0015908 1 0.019
muscle structure development GO:0061061 196 0.019
Mouse
tissue migration GO:0090130 37 0.019
multicellular organism growth GO:0035264 4 0.018
somatic muscle development GO:0007525 4 0.018
oxoacid metabolic process GO:0043436 31 0.018
cellular biosynthetic process GO:0044249 286 0.018
cellular amine metabolic process GO:0044106 2 0.018
regulation of filopodium assembly GO:0051489 2 0.018
regulation of rna metabolic process GO:0051252 224 0.018
cell projection organization GO:0030030 284 0.018
positive regulation of cellular catabolic process GO:0031331 3 0.018
establishment of localization in cell GO:0051649 77 0.018
regulation of glucose import GO:0046324 1 0.018
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.018
nucleoside monophosphate catabolic process GO:0009125 4 0.018
ion transport GO:0006811 114 0.018
cellular component assembly GO:0022607 170 0.018
Human
adult behavior GO:0030534 2 0.018
regulation of carbohydrate metabolic process GO:0006109 4 0.018
medulla oblongata development GO:0021550 4 0.018
stem cell division GO:0017145 1 0.017
actin cytoskeleton organization GO:0030036 63 0.017
positive regulation of muscle cell differentiation GO:0051149 1 0.017
lymphocyte proliferation GO:0046651 1 0.017
digestive system development GO:0055123 289 0.017
convergent extension GO:0060026 118 0.017
lipid catabolic process GO:0016042 4 0.017
regulation of nucleoside metabolic process GO:0009118 2 0.017
nuclear transport GO:0051169 4 0.017
positive regulation of lipid metabolic process GO:0045834 1 0.017
organic substance biosynthetic process GO:1901576 289 0.017
cellular response to endogenous stimulus GO:0071495 68 0.017
single organism nuclear import GO:1902593 3 0.017
multi organism process GO:0051704 134 0.017
determination of bilateral symmetry GO:0009855 204 0.017
autophagy GO:0006914 4 0.017
blood vessel development GO:0001568 246 0.017
response to glucose GO:0009749 3 0.017
regulation of purine nucleotide catabolic process GO:0033121 2 0.017
cell projection assembly GO:0030031 64 0.017
single organism membrane fusion GO:0044801 2 0.017
development of primary female sexual characteristics GO:0046545 4 0.017
erythrocyte homeostasis GO:0034101 55 0.016
neuron differentiation GO:0030182 353 0.016
Human Fly
wound healing GO:0042060 90 0.016
muscle contraction GO:0006936 18 0.016
protein import into nucleus GO:0006606 3 0.016
regulation of organelle assembly GO:1902115 4 0.016
regulation of cardiac muscle tissue development GO:0055024 1 0.016
myeloid cell differentiation GO:0030099 86 0.016
response to glucocorticoid GO:0051384 1 0.016
response to corticosteroid GO:0031960 1 0.016
regulation of cellular component organization GO:0051128 86 0.016
regulation of protein binding GO:0043393 3 0.016
regulation of hormone secretion GO:0046883 2 0.016
striated muscle cell differentiation GO:0051146 129 0.016
regulation of cell differentiation GO:0045595 142 0.016
Human
regulation of transmembrane transporter activity GO:0022898 2 0.016
cellular response to starvation GO:0009267 1 0.016
negative regulation of protein phosphorylation GO:0001933 4 0.016
immune system development GO:0002520 191 0.016
regulation of dendrite development GO:0050773 3 0.016
regulation of cell matrix adhesion GO:0001952 1 0.016
single organism metabolic process GO:0044710 217 0.015
positive regulation of secretion by cell GO:1903532 1 0.015
regulation of cellular metabolic process GO:0031323 320 0.015
cellular component biogenesis GO:0044085 178 0.015
Human Fly
head development GO:0060322 303 0.015
extrinsic apoptotic signaling pathway GO:0097191 3 0.015
nuclear import GO:0051170 3 0.015
regulation of glucose transport GO:0010827 1 0.015
small molecule catabolic process GO:0044282 3 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.015
stem cell maintenance GO:0019827 4 0.015
cellular response to nutrient levels GO:0031669 2 0.015
spermatid differentiation GO:0048515 2 0.015
regulation of cell substrate adhesion GO:0010810 1 0.015
cellular response to extracellular stimulus GO:0031668 2 0.015
regulation of multicellular organismal development GO:2000026 223 0.015
Human
single organism cellular localization GO:1902580 46 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
cellular response to growth factor stimulus GO:0071363 39 0.015
actin filament based process GO:0030029 64 0.015
positive regulation of secretion GO:0051047 1 0.015
negative regulation of response to stimulus GO:0048585 104 0.015
macromolecular complex disassembly GO:0032984 1 0.015
cellular macromolecule biosynthetic process GO:0034645 224 0.015
regulation of localization GO:0032879 104 0.015
protein targeting to nucleus GO:0044744 3 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.015
positive regulation of gtp catabolic process GO:0033126 1 0.014
negative regulation of cellular process GO:0048523 283 0.014
Human
establishment of protein localization to plasma membrane GO:0090002 1 0.014
gastrulation GO:0007369 208 0.014
chordate embryonic development GO:0043009 271 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.014
regulation of macromolecule metabolic process GO:0060255 317 0.014
regulation of intracellular protein transport GO:0033157 3 0.014
guanosine containing compound metabolic process GO:1901068 4 0.014
heart morphogenesis GO:0003007 156 0.014
regulation of cellular biosynthetic process GO:0031326 245 0.014
plasma membrane repair GO:0001778 2 0.014
cellular response to organic substance GO:0071310 105 0.014
regulation of gtp catabolic process GO:0033124 2 0.014
regulation of circadian sleep wake cycle GO:0042749 1 0.014
actin filament polymerization GO:0030041 2 0.014
gtp metabolic process GO:0046039 4 0.014
carbohydrate biosynthetic process GO:0016051 1 0.014
mechanosensory behavior GO:0007638 2 0.014
synaptic growth at neuromuscular junction GO:0051124 2 0.013
regulation of tube size GO:0035150 2 0.013
glucose import GO:0046323 2 0.013
hemopoiesis GO:0030097 183 0.013
blood vessel morphogenesis GO:0048514 216 0.013
establishment of protein localization to organelle GO:0072594 4 0.013
amine metabolic process GO:0009308 2 0.013
skeletal system development GO:0001501 181 0.013
heart process GO:0003015 71 0.013
purine nucleoside monophosphate catabolic process GO:0009128 4 0.013
regulation of protein localization to nucleus GO:1900180 2 0.013
mesenchymal cell development GO:0014031 78 0.013
muscle cell differentiation GO:0042692 139 0.013
Mouse
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.013
embryo development ending in birth or egg hatching GO:0009792 271 0.013
organic cyclic compound metabolic process GO:1901360 301 0.013
cellular amino acid metabolic process GO:0006520 7 0.013
apical junction assembly GO:0043297 1 0.013
adherens junction assembly GO:0034333 1 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.013
cellular component disassembly GO:0022411 1 0.013
multicellular organismal macromolecule metabolic process GO:0044259 2 0.013
proteasomal protein catabolic process GO:0010498 2 0.013
energy reserve metabolic process GO:0006112 2 0.013
somitogenesis GO:0001756 87 0.013
regulation of gtpase activity GO:0043087 2 0.013
organic cyclic compound biosynthetic process GO:1901362 223 0.013
nucleobase containing compound biosynthetic process GO:0034654 205 0.012
regulation of metal ion transport GO:0010959 4 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.012
somite development GO:0061053 96 0.012
rna localization GO:0006403 4 0.012
carbohydrate derivative metabolic process GO:1901135 61 0.012
protein import GO:0017038 3 0.012
regulation of mrna processing GO:0050684 3 0.012
intracellular signal transduction GO:0035556 85 0.012
carboxylic acid metabolic process GO:0019752 22 0.012
cell cycle arrest GO:0007050 1 0.012
Human
muscle tissue development GO:0060537 110 0.012
stem cell development GO:0048864 82 0.012
negative regulation of epithelial cell proliferation GO:0050680 1 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
regulation of cell activation GO:0050865 1 0.012
positive regulation of signal transduction GO:0009967 56 0.012
myofibril assembly GO:0030239 48 0.012
digestive tract morphogenesis GO:0048546 231 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
guanosine containing compound catabolic process GO:1901069 2 0.012
growth GO:0040007 174 0.012
regulation of biosynthetic process GO:0009889 250 0.012
organic substance transport GO:0071702 58 0.012
long chain fatty acid transport GO:0015909 1 0.012
cell projection morphogenesis GO:0048858 244 0.012
peptide transport GO:0015833 1 0.012
regulation of blood vessel size GO:0050880 2 0.012
cellular localization GO:0051641 97 0.012
membrane organization GO:0061024 21 0.012
death GO:0016265 121 0.012
Human
immune system process GO:0002376 241 0.012
heart contraction GO:0060047 71 0.012
generation of neurons GO:0048699 385 0.012
Human Fly
monovalent inorganic cation transport GO:0015672 42 0.012
cellular response to oxygen levels GO:0071453 1 0.012
ceramide biosynthetic process GO:0046513 1 0.011
phosphorus metabolic process GO:0006793 109 0.011
sensory system development GO:0048880 76 0.011
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.011
striated muscle cell development GO:0055002 108 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.011
regulation of skeletal muscle fiber development GO:0048742 2 0.011
response to drug GO:0042493 3 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
heterocycle metabolic process GO:0046483 290 0.011
atp catabolic process GO:0006200 4 0.011
glucose homeostasis GO:0042593 1 0.011
regulation of cellular ketone metabolic process GO:0010565 7 0.011
immunoglobulin mediated immune response GO:0016064 3 0.011
regulation of protein catabolic process GO:0042176 1 0.011
response to growth factor GO:0070848 39 0.011
cellular response to external stimulus GO:0071496 2 0.011
negative regulation of chemotaxis GO:0050922 4 0.011
regulation of protein localization to plasma membrane GO:1903076 1 0.011
cellular protein catabolic process GO:0044257 4 0.011
dna templated transcription elongation GO:0006354 3 0.011
epithelial cell migration GO:0010631 25 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
negative regulation of cytokine production GO:0001818 1 0.011
organic acid metabolic process GO:0006082 31 0.011
neuron neuron synaptic transmission GO:0007270 1 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.011
centrosome organization GO:0051297 1 0.011
apoptotic process GO:0006915 116 0.011
Human
nitric oxide metabolic process GO:0046209 2 0.011
neuron development GO:0048666 262 0.011
Fly
catechol containing compound biosynthetic process GO:0009713 2 0.011
system process GO:0003008 185 0.011
cellular response to hypoxia GO:0071456 1 0.011
regulation of catalytic activity GO:0050790 55 0.011
embryonic pattern specification GO:0009880 44 0.011
muscle cell development GO:0055001 115 0.011
modulation by virus of host morphology or physiology GO:0019048 1 0.011
modification dependent protein catabolic process GO:0019941 3 0.011
regulation of ion transmembrane transporter activity GO:0032412 2 0.011
gtp catabolic process GO:0006184 2 0.011
negative regulation of translation GO:0017148 1 0.011
carbohydrate homeostasis GO:0033500 1 0.010
rna biosynthetic process GO:0032774 181 0.010
muscle organ development GO:0007517 101 0.010
signal transduction in absence of ligand GO:0038034 1 0.010
anterior posterior pattern specification GO:0009952 152 0.010
negative regulation of dna metabolic process GO:0051053 4 0.010
germ line stem cell division GO:0042078 1 0.010
regulation of transcription dna templated GO:0006355 213 0.010
spermatid development GO:0007286 2 0.010
regulation of myotube differentiation GO:0010830 2 0.010
actomyosin structure organization GO:0031032 53 0.010
muscle fiber development GO:0048747 52 0.010
regulation of developmental process GO:0050793 247 0.010
Human
regulation of receptor mediated endocytosis GO:0048259 4 0.010
hematopoietic or lymphoid organ development GO:0048534 191 0.010
establishment or maintenance of polarity of embryonic epithelium GO:0016332 2 0.010
lateral inhibition GO:0046331 1 0.010
smad protein complex assembly GO:0007183 1 0.010
protein heterooligomerization GO:0051291 1 0.010
positive regulation of muscle organ development GO:0048636 1 0.010
macromolecule localization GO:0033036 54 0.010
Fly
regulation of membrane potential GO:0042391 23 0.010
kidney development GO:0001822 92 0.010

bin1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
muscular disease DOID:0080000 0 0.047
Human
disease of anatomical entity DOID:7 0 0.047
Human
musculoskeletal system disease DOID:17 0 0.047
Human
disease of metabolism DOID:0014667 0 0.015
muscle tissue disease DOID:66 0 0.015
Human