Danio rerio

52 known processes

mxtx2

mix-type homeobox gene 2

(Aliases: MGC136526,mtx2,zgc:136526)

mxtx2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
spemann organizer formation GO:0060061 10 0.826
endoderm development GO:0007492 49 0.456
embryonic organ morphogenesis GO:0048562 274 0.295
gall bladder development GO:0061010 1 0.234
somitogenesis GO:0001756 87 0.223
regulation of nitrogen compound metabolic process GO:0051171 251 0.223
Mouse
aromatic compound biosynthetic process GO:0019438 217 0.196
Mouse
nucleic acid metabolic process GO:0090304 244 0.193
Mouse
digestive system development GO:0055123 289 0.185
gland development GO:0048732 143 0.185
regulation of gene expression GO:0010468 265 0.179
Mouse
cell motility GO:0048870 244 0.179
camera type eye development GO:0043010 222 0.166
cellular component movement GO:0006928 335 0.161
response to chemical GO:0042221 320 0.159
localization of cell GO:0051674 244 0.155
regulation of cell size GO:0008361 29 0.155
negative regulation of gastrulation GO:2000542 11 0.154
regulation of locomotion GO:0040012 55 0.150
determination of left right asymmetry in nervous system GO:0035545 4 0.146
head development GO:0060322 303 0.144
negative regulation of mesodermal cell fate specification GO:0042662 3 0.143
regulation of rna metabolic process GO:0051252 224 0.142
Mouse
cellular nitrogen compound metabolic process GO:0034641 290 0.139
Mouse
positive regulation of response to stimulus GO:0048584 80 0.138
cellular aromatic compound metabolic process GO:0006725 295 0.133
Mouse
embryonic eye morphogenesis GO:0048048 30 0.131
cellular nitrogen compound biosynthetic process GO:0044271 218 0.131
Mouse
single organism localization GO:1902578 225 0.129
embryonic organ development GO:0048568 381 0.128
eye morphogenesis GO:0048592 144 0.126
ion transport GO:0006811 114 0.124
regulation of macromolecule biosynthetic process GO:0010556 225 0.123
Mouse
somite development GO:0061053 96 0.118
segmentation GO:0035282 97 0.117
embryo development ending in birth or egg hatching GO:0009792 271 0.117
regulation of cellular component movement GO:0051270 55 0.115
cellular macromolecule metabolic process GO:0044260 391 0.115
Mouse
blood vessel development GO:0001568 246 0.115
tube morphogenesis GO:0035239 349 0.114
embryonic camera type eye formation GO:0060900 10 0.112
regulation of localization GO:0032879 104 0.112
endocrine system development GO:0035270 65 0.111
heart morphogenesis GO:0003007 156 0.110
diencephalon development GO:0021536 58 0.109
eye development GO:0001654 277 0.108
vasculature development GO:0001944 278 0.105
multicellular organism growth GO:0035264 4 0.105
endoderm formation GO:0001706 29 0.105
regulation of cellular metabolic process GO:0031323 320 0.102
Mouse
positive regulation of signaling GO:0023056 56 0.100
macromolecule biosynthetic process GO:0009059 227 0.097
Mouse
cation transport GO:0006812 81 0.094
embryonic camera type eye development GO:0031076 29 0.094
negative regulation of oocyte development GO:0060283 2 0.093
brain development GO:0007420 293 0.092
determination of dorsal ventral asymmetry GO:0048262 34 0.089
regeneration GO:0031099 91 0.088
cell growth GO:0016049 57 0.086
positive regulation of cellular metabolic process GO:0031325 94 0.085
Mouse
spemann organizer formation at the embryonic shield GO:0060063 2 0.084
locomotion GO:0040011 313 0.084
regulation of response to stimulus GO:0048583 269 0.082
cellular response to starvation GO:0009267 1 0.082
central nervous system development GO:0007417 387 0.080
dorsal ventral pattern formation GO:0009953 125 0.079
nitrogen compound metabolic process GO:0006807 319 0.077
Mouse
lipid oxidation GO:0034440 1 0.075
chordate embryonic development GO:0043009 271 0.073
cellular biosynthetic process GO:0044249 286 0.073
Mouse
optic placode formation GO:0001743 4 0.070
formation of primary germ layer GO:0001704 62 0.069
axonogenesis GO:0007409 152 0.069
gene expression GO:0010467 252 0.068
Mouse
regulation of cell motility GO:2000145 46 0.068
determination of dorsal identity GO:0048263 13 0.066
appendage development GO:0048736 80 0.063
axial mesoderm formation GO:0048320 4 0.063
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.062
Mouse
notochord development GO:0030903 54 0.061
regulation of reactive oxygen species metabolic process GO:2000377 2 0.061
regulation of macromolecule metabolic process GO:0060255 317 0.060
Mouse
regulation of reproductive process GO:2000241 4 0.060
taxis GO:0042330 109 0.060
xenobiotic metabolic process GO:0006805 4 0.060
maintenance of location GO:0051235 4 0.059
regulation of anterior head development GO:2000742 2 0.057
gastrulation GO:0007369 208 0.056
positive regulation of biological process GO:0048518 253 0.056
Mouse
regulation of endodermal cell fate specification GO:0042663 15 0.055
cell migration GO:0016477 237 0.055
regulation of biosynthetic process GO:0009889 250 0.055
Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.055
protein targeting to nucleus GO:0044744 3 0.055
chemotaxis GO:0006935 104 0.055
neuron development GO:0048666 262 0.055
embryonic heart tube development GO:0035050 133 0.054
pectoral fin morphogenesis GO:0035138 29 0.053
oocyte maturation GO:0001556 4 0.052
embryonic camera type eye morphogenesis GO:0048596 19 0.052
aging GO:0007568 2 0.052
determination of bilateral symmetry GO:0009855 204 0.052
cell projection organization GO:0030030 284 0.051
hepatocyte proliferation GO:0072574 2 0.051
nucleobase containing compound metabolic process GO:0006139 274 0.051
Mouse
energy reserve metabolic process GO:0006112 2 0.051
anterior posterior pattern specification GO:0009952 152 0.050
striated muscle tissue development GO:0014706 110 0.050
cellular response to chemical stimulus GO:0070887 157 0.050
cellular macromolecule biosynthetic process GO:0034645 224 0.049
Mouse
pigmentation GO:0043473 85 0.049
pectoral fin development GO:0033339 50 0.049
gamete generation GO:0007276 33 0.049
regulation of nucleotide catabolic process GO:0030811 2 0.049
single organism transport GO:0044765 206 0.048
regionalization GO:0003002 274 0.048
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.047
cell fate specification GO:0001708 68 0.046
sensory organ development GO:0007423 393 0.045
larval development GO:0002164 2 0.044
positive regulation of cellular process GO:0048522 201 0.044
Mouse
neuron projection development GO:0031175 180 0.043
developmental induction GO:0031128 10 0.043
optic placode formation involved in camera type eye formation GO:0046619 3 0.043
convergent extension involved in organogenesis GO:0060029 10 0.043
hepaticobiliary system development GO:0061008 98 0.042
ameboidal type cell migration GO:0001667 143 0.042
cell part morphogenesis GO:0032990 246 0.042
biosynthetic process GO:0009058 294 0.042
Mouse
positive regulation of cellular catabolic process GO:0031331 3 0.042
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.041
regulation of primary metabolic process GO:0080090 311 0.041
Mouse
nucleic acid templated transcription GO:0097659 181 0.041
Mouse
determination of left right symmetry GO:0007368 179 0.040
metal ion transport GO:0030001 58 0.040
connective tissue development GO:0061448 99 0.040
regulation of developmental process GO:0050793 247 0.040
Mouse
kupffer s vesicle development GO:0070121 50 0.040
female sex differentiation GO:0046660 4 0.038
digestive tract morphogenesis GO:0048546 231 0.038
regulation of circadian sleep wake cycle GO:0042749 1 0.038
neuron differentiation GO:0030182 353 0.037
regulation of multicellular organismal development GO:2000026 223 0.037
Mouse
adenohypophysis development GO:0021984 15 0.036
positive regulation of rna biosynthetic process GO:1902680 57 0.036
Mouse
positive regulation of cell communication GO:0010647 56 0.036
transcription dna templated GO:0006351 181 0.035
Mouse
response to external stimulus GO:0009605 264 0.035
organic substance biosynthetic process GO:1901576 289 0.035
Mouse
transport GO:0006810 220 0.035
regulation of cell migration GO:0030334 40 0.035
generation of neurons GO:0048699 385 0.035
regulation of nucleocytoplasmic transport GO:0046822 2 0.035
fin development GO:0033333 77 0.034
endodermal cell fate specification GO:0001714 17 0.034
neuron projection guidance GO:0097485 86 0.034
heart development GO:0007507 313 0.033
Mouse
regulation of wnt signaling pathway calcium modulating pathway GO:0008591 3 0.033
liver development GO:0001889 96 0.032
regulation of establishment of protein localization GO:0070201 4 0.032
regulation of embryonic development GO:0045995 47 0.032
lytic vacuole organization GO:0080171 1 0.032
pathway restricted smad protein phosphorylation GO:0060389 1 0.031
axon extension GO:0048675 45 0.031
determination of left right asymmetry in diencephalon GO:0035462 4 0.031
rna biosynthetic process GO:0032774 181 0.031
Mouse
cell cell signaling GO:0007267 52 0.031
sensory epithelium regeneration GO:0070654 14 0.031
positive regulation of cellular biosynthetic process GO:0031328 68 0.031
Mouse
regulation of protein targeting GO:1903533 2 0.030
establishment of localization GO:0051234 244 0.030
rna metabolic process GO:0016070 219 0.030
Mouse
thrombocyte differentiation GO:0002574 4 0.030
regulation of protein metabolic process GO:0051246 56 0.030
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.030
Mouse
response to abiotic stimulus GO:0009628 122 0.029
heterocycle metabolic process GO:0046483 290 0.029
Mouse
muscle cell differentiation GO:0042692 139 0.029
axon guidance GO:0007411 86 0.029
neural crest cell migration GO:0001755 42 0.029
lipid storage GO:0019915 1 0.029
fin morphogenesis GO:0033334 53 0.029
regulation of signaling GO:0023051 235 0.029
cellular response to nutrient levels GO:0031669 2 0.028
positive regulation of macromolecule metabolic process GO:0010604 93 0.028
Mouse
positive regulation of catabolic process GO:0009896 4 0.028
regulation of biological quality GO:0065008 263 0.027
system process GO:0003008 185 0.027
retina morphogenesis in camera type eye GO:0060042 79 0.027
regulation of oocyte development GO:0060281 3 0.027
endodermal digestive tract morphogenesis GO:0061031 2 0.027
regulation of tube size GO:0035150 2 0.027
sensory system development GO:0048880 76 0.027
tissue regeneration GO:0042246 74 0.027
regulation of wnt signaling pathway involved in digestive tract morphogenesis GO:2000056 2 0.027
anterior head development GO:0097065 2 0.026
cellular response to extracellular stimulus GO:0031668 2 0.026
mesenchymal cell development GO:0014031 78 0.026
mesenchymal cell differentiation GO:0048762 87 0.026
nucleocytoplasmic transport GO:0006913 4 0.025
multicellular organismal reproductive process GO:0048609 35 0.025
regulation of multicellular organism growth GO:0040014 4 0.025
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.025
regulation of cellular biosynthetic process GO:0031326 245 0.025
Mouse
phagocytosis GO:0006909 3 0.025
protein import GO:0017038 3 0.024
axon development GO:0061564 166 0.024
regulation of metabolic process GO:0019222 359 0.024
Mouse
endodermal cell fate determination GO:0007493 2 0.024
regulation of response to external stimulus GO:0032101 31 0.023
fin regeneration GO:0031101 51 0.023
response to temperature stimulus GO:0009266 15 0.023
regulation of gastrulation GO:0010470 24 0.023
membrane invagination GO:0010324 1 0.023
modification dependent protein catabolic process GO:0019941 3 0.023
negative regulation of cell fate specification GO:0009996 11 0.023
gene silencing by rna GO:0031047 4 0.022
endodermal cell differentiation GO:0035987 19 0.022
Mouse
cell proliferation GO:0008283 80 0.022
camera type eye morphogenesis GO:0048593 108 0.022
regulation of gtpase activity GO:0043087 2 0.022
multi organism process GO:0051704 134 0.022
growth GO:0040007 174 0.022
homeostatic process GO:0042592 142 0.021
cell fate commitment GO:0045165 99 0.021
response to wounding GO:0009611 116 0.021
regulation of purine nucleotide catabolic process GO:0033121 2 0.021
regulation of metal ion transport GO:0010959 4 0.021
regulation of intracellular protein transport GO:0033157 3 0.021
regulation of cellular protein metabolic process GO:0032268 52 0.021
bmp signaling pathway involved in determination of left right symmetry GO:0003154 14 0.021
spinal cord anterior posterior patterning GO:0021512 1 0.021
regulation of rna biosynthetic process GO:2001141 213 0.021
Mouse
regulation of anatomical structure morphogenesis GO:0022603 130 0.021
circadian sleep wake cycle sleep GO:0050802 1 0.021
germ cell development GO:0007281 22 0.021
neural crest cell development GO:0014032 62 0.021
regulation of protein complex assembly GO:0043254 3 0.020
regulation of cytoplasmic transport GO:1903649 4 0.020
negative regulation of endodermal cell differentiation GO:1903225 8 0.020
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.020
pancreas development GO:0031016 84 0.020
sleep GO:0030431 1 0.020
regulation of protein transport GO:0051223 3 0.020
mesenchyme development GO:0060485 127 0.019
canonical wnt signaling pathway GO:0060070 48 0.019
negative regulation of intracellular protein transport GO:0090317 3 0.019
peptide transport GO:0015833 1 0.019
response to cadmium ion GO:0046686 14 0.019
regulation of cell fate commitment GO:0010453 22 0.019
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.019
endodermal cell fate commitment GO:0001711 18 0.019
wound healing GO:0042060 90 0.019
blood vessel morphogenesis GO:0048514 216 0.018
embryonic appendage morphogenesis GO:0035113 30 0.018
forebrain development GO:0030900 96 0.018
cell projection morphogenesis GO:0048858 244 0.018
negative regulation of nuclear division GO:0051784 3 0.018
chondrocyte intercalation involved in growth plate cartilage morphogenesis GO:0003428 1 0.018
protein import into nucleus GO:0006606 3 0.018
negative regulation of protein complex assembly GO:0031333 1 0.018
regulation of wnt signaling pathway involved in dorsal ventral axis specification GO:2000053 5 0.018
developmental growth involved in morphogenesis GO:0060560 86 0.018
optomotor response GO:0071632 1 0.017
embryonic pattern specification GO:0009880 44 0.017
oogenesis GO:0048477 14 0.017
regulation of skeletal muscle tissue development GO:0048641 4 0.017
reproductive process GO:0022414 40 0.017
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway GO:0022002 1 0.017
regulation of microtubule cytoskeleton organization GO:0070507 3 0.017
negative regulation of cell fate commitment GO:0010454 13 0.017
enzyme linked receptor protein signaling pathway GO:0007167 106 0.017
photoreceptor cell differentiation GO:0046530 55 0.017
regulation of cell fate specification GO:0042659 20 0.017
regulation of axon extension GO:0030516 24 0.017
heterocycle biosynthetic process GO:0018130 215 0.016
Mouse
bone remodeling GO:0046849 2 0.016
ovulation cycle GO:0042698 2 0.016
retina development in camera type eye GO:0060041 146 0.016
proteasomal protein catabolic process GO:0010498 2 0.016
developmental maturation GO:0021700 34 0.016
negative regulation of catabolic process GO:0009895 3 0.016
regulation of cell growth GO:0001558 29 0.016
cell morphogenesis GO:0000902 289 0.016
regulation of phosphorus metabolic process GO:0051174 43 0.016
embryonic heart tube left right pattern formation GO:0060971 5 0.015
female gamete generation GO:0007292 14 0.015
ectodermal placode development GO:0071696 37 0.015
pole plasm assembly GO:0007315 4 0.015
cartilage development GO:0051216 96 0.015
eye photoreceptor cell differentiation GO:0001754 45 0.015
single organism metabolic process GO:0044710 217 0.015
regulation of behavior GO:0050795 24 0.015
cellular response to growth factor stimulus GO:0071363 39 0.015
specification of organ identity GO:0010092 2 0.015
neural plate regionalization GO:0060897 10 0.015
locus ceruleus development GO:0021703 3 0.014
epithelial tube morphogenesis GO:0060562 148 0.014
chemosensory behavior GO:0007635 1 0.014
convergent extension GO:0060026 118 0.014
regulation of endodermal cell differentiation GO:1903224 15 0.014
notochord morphogenesis GO:0048570 17 0.014
regulation of phosphate metabolic process GO:0019220 43 0.014
regulation of blood vessel size GO:0050880 2 0.014
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.014
positive regulation of biosynthetic process GO:0009891 68 0.014
Mouse
determination of heart left right asymmetry GO:0061371 117 0.014
cytoskeleton organization GO:0007010 96 0.014
release of sequestered calcium ion into cytosol GO:0051209 3 0.014
positive regulation of translation GO:0045727 1 0.013
vacuolar transport GO:0007034 2 0.013
positive regulation of transport GO:0051050 2 0.013
appendage morphogenesis GO:0035107 56 0.013
wnt signaling pathway GO:0016055 80 0.013
regulation of cellular component size GO:0032535 30 0.013
response to external biotic stimulus GO:0043207 97 0.013
otic placode formation GO:0043049 23 0.013
bmp signaling pathway GO:0030509 52 0.013
embryonic neurocranium morphogenesis GO:0048702 15 0.013
protein metabolic process GO:0019538 183 0.013
wnt signaling pathway involved in digestive tract morphogenesis GO:0044333 4 0.013
long chain fatty acid transport GO:0015909 1 0.013
regulation of wnt signaling pathway GO:0030111 53 0.013
immune system development GO:0002520 191 0.013
Mouse
hormone secretion GO:0046879 2 0.013
response to stress GO:0006950 263 0.013
regulation of developmental growth GO:0048638 38 0.013
signal transduction GO:0007165 455 0.013
regulation of cytokine production GO:0001817 3 0.013
cellular protein catabolic process GO:0044257 4 0.013
single organism nuclear import GO:1902593 3 0.013
positive regulation of metabolic process GO:0009893 108 0.013
Mouse
negative regulation of behavior GO:0048521 6 0.012
heart jogging GO:0003146 40 0.012
negative regulation of mitosis GO:0045839 3 0.012
positive regulation of signal transduction GO:0009967 56 0.012
cellular component morphogenesis GO:0032989 336 0.012
development of primary female sexual characteristics GO:0046545 4 0.012
somite specification GO:0001757 12 0.012
tissue remodeling GO:0048771 4 0.012
regulation of mrna catabolic process GO:0061013 3 0.012
negative regulation of cellular catabolic process GO:0031330 3 0.012
rna stabilization GO:0043489 4 0.012
muscle tissue development GO:0060537 110 0.012
embryonic heart tube morphogenesis GO:0003143 108 0.012
establishment of protein localization to organelle GO:0072594 4 0.012
ion transmembrane transport GO:0034220 91 0.012
negative regulation of protein phosphorylation GO:0001933 4 0.012
fatty acid transport GO:0015908 1 0.012
cellular response to external stimulus GO:0071496 2 0.012
single organism reproductive process GO:0044702 40 0.012
hepatic duct development GO:0061011 2 0.012
ectodermal placode morphogenesis GO:0071697 32 0.012
regulation of nucleotide metabolic process GO:0006140 17 0.012
epithelial cell proliferation involved in liver morphogenesis GO:0072575 2 0.012
cell migration involved in gastrulation GO:0042074 79 0.012
blood circulation GO:0008015 87 0.012
negative regulation of hormone secretion GO:0046888 2 0.011
morphogenesis of an epithelium GO:0002009 333 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.011
Mouse
negative regulation of multi organism process GO:0043901 3 0.011
negative regulation of endodermal cell fate specification GO:0042664 8 0.011
organism emergence from protective structure GO:0071684 4 0.011
cellular response to oxygen levels GO:0071453 1 0.011
embryonic pectoral fin morphogenesis GO:0035118 24 0.011
cellular response to fibroblast growth factor stimulus GO:0044344 22 0.011
gtp catabolic process GO:0006184 2 0.011
organic cyclic compound metabolic process GO:1901360 301 0.011
Mouse
regulation of cell differentiation GO:0045595 142 0.011
Mouse
mitotic cell cycle process GO:1903047 48 0.011
membrane repolarization GO:0086009 2 0.011
response to bacterium GO:0009617 58 0.011
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.011
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.011
regulation of bmp signaling pathway GO:0030510 39 0.011
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.011
regulation of nucleic acid templated transcription GO:1903506 213 0.011
Mouse
single organism organelle organization GO:1902589 199 0.011
behavior GO:0007610 74 0.011
protein localization to nucleus GO:0034504 3 0.011
negative regulation of response to external stimulus GO:0032102 9 0.010
negative regulation of metabolic process GO:0009892 86 0.010
anion transport GO:0006820 38 0.010
oocyte anterior posterior axis specification GO:0007314 4 0.010
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.010
regulation of circadian rhythm GO:0042752 4 0.010
organic cyclic compound biosynthetic process GO:1901362 223 0.010
Mouse
regulation of bone remodeling GO:0046850 2 0.010
rostrocaudal neural tube patterning GO:0021903 29 0.010
cellular localization GO:0051641 97 0.010
regulation of protein catabolic process GO:0042176 1 0.010
axial mesodermal cell fate specification GO:0048327 3 0.010
regulation of mrna stability GO:0043488 4 0.010
response to biotic stimulus GO:0009607 97 0.010
cardioblast migration GO:0003260 7 0.010

mxtx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of mental health DOID:150 0 0.013
developmental disorder of mental health DOID:0060037 0 0.013