Danio rerio

18 known processes

lnx2b

ligand of numb-protein X 2b

(Aliases: id:ibd3184,lnxL,MGC85925,MGC162185,zgc:85925)

lnx2b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
digestive system development GO:0055123 289 0.356
epithelial tube morphogenesis GO:0060562 148 0.354
tube morphogenesis GO:0035239 349 0.325
embryonic organ morphogenesis GO:0048562 274 0.288
kidney development GO:0001822 92 0.257
regulation of macromolecule biosynthetic process GO:0010556 225 0.226
locomotion GO:0040011 313 0.225
heart development GO:0007507 313 0.211
regionalization GO:0003002 274 0.206
regulation of gene expression GO:0010468 265 0.203
cell projection organization GO:0030030 284 0.169
cell motility GO:0048870 244 0.166
cell migration GO:0016477 237 0.156
specification of symmetry GO:0009799 204 0.140
cilium morphogenesis GO:0060271 85 0.136
nephron morphogenesis GO:0072028 2 0.132
microtubule based movement GO:0007018 33 0.123
cellular component movement GO:0006928 335 0.119
determination of bilateral symmetry GO:0009855 204 0.110
digestive tract morphogenesis GO:0048546 231 0.104
regulation of biosynthetic process GO:0009889 250 0.102
determination of left right symmetry GO:0007368 179 0.097
regulation of signaling GO:0023051 235 0.096
Fly
single organism reproductive process GO:0044702 40 0.094
morphogenesis of an epithelium GO:0002009 333 0.085
nephron epithelium morphogenesis GO:0072088 1 0.083
regulation of rna metabolic process GO:0051252 224 0.083
cell part morphogenesis GO:0032990 246 0.082
cilium assembly GO:0042384 58 0.080
single organism organelle organization GO:1902589 199 0.080
kupffer s vesicle development GO:0070121 50 0.079
sensory organ development GO:0007423 393 0.077
bmp signaling pathway GO:0030509 52 0.077
cellular component assembly GO:0022607 170 0.073
cilium organization GO:0044782 71 0.072
urogenital system development GO:0001655 97 0.069
central nervous system development GO:0007417 387 0.069
determination of left right asymmetry in nervous system GO:0035545 4 0.067
nitrogen compound metabolic process GO:0006807 319 0.066
regulation of cellular biosynthetic process GO:0031326 245 0.066
cell projection morphogenesis GO:0048858 244 0.062
nuclear export GO:0051168 1 0.058
regulation of multicellular organismal development GO:2000026 223 0.057
regulation of epithelial cell proliferation GO:0050678 3 0.057
gastrulation with mouth forming second GO:0001702 44 0.055
regulation of wnt signaling pathway planar cell polarity pathway GO:2000095 2 0.054
cell projection assembly GO:0030031 64 0.054
melanosome transport GO:0032402 19 0.054
embryonic heart tube morphogenesis GO:0003143 108 0.053
macromolecule biosynthetic process GO:0009059 227 0.053
transcription dna templated GO:0006351 181 0.052
aromatic compound biosynthetic process GO:0019438 217 0.052
rna metabolic process GO:0016070 219 0.052
determination of left right asymmetry in diencephalon GO:0035462 4 0.051
anterior posterior pattern specification GO:0009952 152 0.050
cell morphogenesis GO:0000902 289 0.048
cellular response to chemical stimulus GO:0070887 157 0.047
renal tubule morphogenesis GO:0061333 1 0.047
nucleobase containing compound biosynthetic process GO:0034654 205 0.046
negative regulation of biological process GO:0048519 304 0.046
digestive tract development GO:0048565 265 0.045
regulation of fibroblast growth factor receptor signaling pathway GO:0040036 20 0.044
regulation of cardiac muscle tissue development GO:0055024 1 0.043
left right pattern formation GO:0060972 19 0.042
cell adhesion GO:0007155 40 0.042
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.042
regulation of establishment of planar polarity GO:0090175 4 0.040
regulation of metal ion transport GO:0010959 4 0.040
cellular carbohydrate metabolic process GO:0044262 4 0.039
embryonic heart tube development GO:0035050 133 0.039
biosynthetic process GO:0009058 294 0.039
maintenance of location GO:0051235 4 0.039
heart jogging GO:0003146 40 0.036
axis elongation GO:0003401 31 0.036
female meiotic division GO:0007143 2 0.036
cellular component morphogenesis GO:0032989 336 0.036
cellular macromolecule metabolic process GO:0044260 391 0.035
localization of cell GO:0051674 244 0.034
glucocorticoid biosynthetic process GO:0006704 1 0.034
response to organic substance GO:0010033 153 0.034
system process GO:0003008 185 0.034
Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.033
response to growth factor GO:0070848 39 0.033
hormone biosynthetic process GO:0042446 3 0.033
cytoskeleton dependent intracellular transport GO:0030705 10 0.033
regulation of primary metabolic process GO:0080090 311 0.033
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules GO:0007157 2 0.032
brain development GO:0007420 293 0.032
regulation of cellular metabolic process GO:0031323 320 0.031
segmentation GO:0035282 97 0.031
centrosome duplication GO:0051298 1 0.030
larval development GO:0002164 2 0.030
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.030
centrosome cycle GO:0007098 1 0.029
ameboidal type cell migration GO:0001667 143 0.029
organelle organization GO:0006996 227 0.029
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.029
growth GO:0040007 174 0.028
negative regulation of stem cell differentiation GO:2000737 2 0.028
regulation of rna biosynthetic process GO:2001141 213 0.028
regulation of transcription dna templated GO:0006355 213 0.028
post golgi vesicle mediated transport GO:0006892 1 0.028
glucose homeostasis GO:0042593 1 0.028
sensory perception GO:0007600 39 0.027
Fly
head development GO:0060322 303 0.027
response to chemical GO:0042221 320 0.027
regulation of establishment of protein localization GO:0070201 4 0.027
negative regulation of epithelial cell proliferation GO:0050680 1 0.027
striated muscle tissue development GO:0014706 110 0.027
peptidyl serine modification GO:0018209 2 0.027
transcription from rna polymerase ii promoter GO:0006366 80 0.027
nucleobase containing compound metabolic process GO:0006139 274 0.027
cellular component biogenesis GO:0044085 178 0.027
nephron tubule morphogenesis GO:0072078 1 0.027
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.026
cell migration involved in gastrulation GO:0042074 79 0.026
glycoprotein metabolic process GO:0009100 23 0.026
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.026
gastrulation GO:0007369 208 0.026
organic cyclic compound metabolic process GO:1901360 301 0.025
aging GO:0007568 2 0.025
regulation of nitrogen compound metabolic process GO:0051171 251 0.025
extrinsic apoptotic signaling pathway GO:0097191 3 0.025
response to stress GO:0006950 263 0.025
wnt signaling pathway planar cell polarity pathway GO:0060071 4 0.025
microtubule organizing center organization GO:0031023 1 0.024
nucleic acid metabolic process GO:0090304 244 0.024
cellular nitrogen compound metabolic process GO:0034641 290 0.024
regulation of cellular amine metabolic process GO:0033238 0 0.024
signal transduction GO:0007165 455 0.024
Fly
multicellular organism growth GO:0035264 4 0.024
heterocycle biosynthetic process GO:0018130 215 0.024
alcohol biosynthetic process GO:0046165 2 0.023
negative regulation of multicellular organismal process GO:0051241 69 0.023
chordate embryonic development GO:0043009 271 0.023
embryonic organ development GO:0048568 381 0.022
organic substance biosynthetic process GO:1901576 289 0.022
multi organism process GO:0051704 134 0.022
mesenchyme development GO:0060485 127 0.022
nucleic acid templated transcription GO:0097659 181 0.022
ovulation cycle GO:0042698 2 0.022
cardiac atrium development GO:0003230 4 0.022
regulation of developmental process GO:0050793 247 0.022
biological adhesion GO:0022610 40 0.022
gene expression GO:0010467 252 0.022
regulation of heart growth GO:0060420 2 0.021
blood vessel development GO:0001568 246 0.021
establishment of protein localization to plasma membrane GO:0090002 1 0.021
enzyme linked receptor protein signaling pathway GO:0007167 106 0.021
sulfur compound metabolic process GO:0006790 13 0.021
embryo development ending in birth or egg hatching GO:0009792 271 0.020
regulation of nucleic acid templated transcription GO:1903506 213 0.020
golgi vesicle transport GO:0048193 3 0.020
death GO:0016265 121 0.020
tube formation GO:0035148 25 0.020
negative regulation of cell communication GO:0010648 96 0.020
rna biosynthetic process GO:0032774 181 0.020
determination of heart left right asymmetry GO:0061371 117 0.019
regulation of programmed cell death GO:0043067 101 0.019
cellular response to growth factor stimulus GO:0071363 39 0.019
cell cell signaling GO:0007267 52 0.019
regulation of macromolecule metabolic process GO:0060255 317 0.019
regulation of response to stimulus GO:0048583 269 0.019
Fly
regulation of metabolic process GO:0019222 359 0.019
negative regulation of cellular process GO:0048523 283 0.019
regulation of ectodermal cell fate specification GO:0042665 2 0.019
heart looping GO:0001947 94 0.018
branching morphogenesis of an epithelial tube GO:0048754 15 0.018
erk1 and erk2 cascade GO:0070371 4 0.018
cell substrate adhesion GO:0031589 4 0.018
regulation of receptor activity GO:0010469 2 0.018
organelle assembly GO:0070925 110 0.018
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 2 0.018
epithelial cell morphogenesis GO:0003382 2 0.018
megakaryocyte differentiation GO:0030219 1 0.018
regulation of transmembrane transporter activity GO:0022898 2 0.017
protein localization to plasma membrane GO:0072659 1 0.017
protein homooligomerization GO:0051260 3 0.017
negative regulation of apoptotic process GO:0043066 55 0.017
ectodermal cell fate specification GO:0001715 2 0.017
regulation of neural precursor cell proliferation GO:2000177 3 0.017
positive regulation of translation GO:0045727 1 0.017
cell migration involved in mesendoderm migration GO:0090134 2 0.017
regulation of nodal signaling pathway GO:1900107 4 0.017
regulation of cytokine production GO:0001817 3 0.017
specification of axis polarity GO:0065001 4 0.017
monovalent inorganic cation transport GO:0015672 42 0.017
reproductive process GO:0022414 40 0.017
ectoderm formation GO:0001705 2 0.016
mitotic cell cycle embryonic GO:0045448 2 0.016
centrosome organization GO:0051297 1 0.016
camera type eye development GO:0043010 222 0.016
cellular response to organic substance GO:0071310 105 0.016
negative regulation of wnt signaling pathway GO:0030178 30 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.016
stem cell maintenance GO:0019827 4 0.016
vasculature development GO:0001944 278 0.016
cellular macromolecule biosynthetic process GO:0034645 224 0.016
transmission of nerve impulse GO:0019226 19 0.016
organic acid metabolic process GO:0006082 31 0.016
apoptotic process involved in development GO:1902742 2 0.016
eye development GO:0001654 277 0.016
oxoacid metabolic process GO:0043436 31 0.016
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.015
regulation of alcohol biosynthetic process GO:1902930 1 0.015
cellular response to drug GO:0035690 1 0.015
cellular biosynthetic process GO:0044249 286 0.015
gtp metabolic process GO:0046039 4 0.015
tube closure GO:0060606 1 0.015
positive regulation of blood circulation GO:1903524 2 0.015
cellular modified amino acid metabolic process GO:0006575 3 0.015
macromolecule localization GO:0033036 54 0.015
cellular transition metal ion homeostasis GO:0046916 3 0.015
morphogenesis of an epithelial sheet GO:0002011 49 0.015
positive regulation of muscle organ development GO:0048636 1 0.014
establishment of cell polarity involved in gastrulation cell migration GO:0003379 2 0.014
zinc ion homeostasis GO:0055069 1 0.014
retina morphogenesis in camera type eye GO:0060042 79 0.014
regulation of transporter activity GO:0032409 2 0.014
positive regulation of striated muscle tissue development GO:0045844 1 0.014
negative regulation of gastrulation GO:2000542 11 0.014
blood vessel morphogenesis GO:0048514 216 0.014
proteasomal protein catabolic process GO:0010498 2 0.014
negative regulation of developmental process GO:0051093 65 0.013
macromolecular complex assembly GO:0065003 35 0.013
negative regulation of gene expression GO:0010629 65 0.013
positive regulation of cell adhesion GO:0045785 1 0.013
anatomical structure arrangement GO:0048532 2 0.013
ovarian follicle development GO:0001541 2 0.013
axial mesoderm formation GO:0048320 4 0.013
muscle tissue development GO:0060537 110 0.013
apoptotic process GO:0006915 116 0.013
gamete generation GO:0007276 33 0.013
cell matrix adhesion GO:0007160 4 0.013
regulation of ion transmembrane transporter activity GO:0032412 2 0.013
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.013
response to endogenous stimulus GO:0009719 83 0.013
regulation of wnt signaling pathway GO:0030111 53 0.013
eye morphogenesis GO:0048592 144 0.013
appendage morphogenesis GO:0035107 56 0.013
gland development GO:0048732 143 0.012
regulation of cardiac muscle cell differentiation GO:2000725 1 0.012
meiosis ii GO:0007135 1 0.012
endocardial cushion formation GO:0003272 2 0.012
peptide metabolic process GO:0006518 1 0.012
programmed cell death GO:0012501 119 0.012
regulation of cellular response to oxidative stress GO:1900407 2 0.012
oocyte maturation GO:0001556 4 0.012
cellular amino acid metabolic process GO:0006520 7 0.012
negative regulation of mesodermal cell fate specification GO:0042662 3 0.012
cell death GO:0008219 121 0.012
protein stabilization GO:0050821 2 0.012
nucleocytoplasmic transport GO:0006913 4 0.012
morphogenesis of a branching epithelium GO:0061138 16 0.012
regulation of multicellular organismal process GO:0051239 277 0.012
response to other organism GO:0051707 97 0.012
axis specification GO:0009798 43 0.012
regulation of cell communication GO:0010646 232 0.012
Fly
cellular protein catabolic process GO:0044257 4 0.012
positive regulation of biological process GO:0048518 253 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
heart contraction GO:0060047 71 0.012
developmental growth involved in morphogenesis GO:0060560 86 0.012
glucose import GO:0046323 2 0.012
intestinal cholesterol absorption GO:0030299 2 0.011
regulation of embryonic development GO:0045995 47 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
female sex differentiation GO:0046660 4 0.011
cellular localization GO:0051641 97 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.011
primary neural tube formation GO:0014020 1 0.011
cell substrate junction assembly GO:0007044 2 0.011
regulation of oxidative stress induced cell death GO:1903201 2 0.011
mesenchymal cell development GO:0014031 78 0.011
cell surface receptor signaling pathway GO:0007166 325 0.011
Fly
regulation of wnt signaling pathway involved in digestive tract morphogenesis GO:2000056 2 0.011
carbohydrate homeostasis GO:0033500 1 0.011
regulation of mitotic cell cycle embryonic GO:0009794 2 0.011
developmental growth GO:0048589 166 0.011
spindle assembly involved in meiosis GO:0090306 1 0.011
angioblast cell differentiation GO:0035779 2 0.011
cellular nitrogen compound biosynthetic process GO:0044271 218 0.011
establishment of pigment granule localization GO:0051905 22 0.011
negative regulation of myeloid cell differentiation GO:0045638 1 0.011
regulation of ectoderm development GO:2000383 2 0.011
positive regulation of rna metabolic process GO:0051254 59 0.011
single organism transport GO:0044765 206 0.011
embryonic limb morphogenesis GO:0030326 2 0.011
negative regulation of cell adhesion GO:0007162 6 0.011
regulation of epithelial to mesenchymal transition GO:0010717 3 0.011
regulation of blood pressure GO:0008217 1 0.011
lipid storage GO:0019915 1 0.011
skeletal system morphogenesis GO:0048705 102 0.011
regulation of bone mineralization GO:0030500 2 0.011
maternal determination of anterior posterior axis embryo GO:0008358 4 0.011
synaptic vesicle recycling GO:0036465 1 0.011
odontogenesis of dentin containing tooth GO:0042475 1 0.011
negative regulation of myeloid leukocyte differentiation GO:0002762 1 0.011
smooth muscle contraction GO:0006939 2 0.010
specification of organ axis polarity GO:0010084 2 0.010
autophagy GO:0006914 4 0.010
hormone transport GO:0009914 2 0.010
regulation of apoptotic process GO:0042981 98 0.010
melanin biosynthetic process GO:0042438 1 0.010
regulation of glucose import GO:0046324 1 0.010
female gonad development GO:0008585 4 0.010
regulation of multicellular organism growth GO:0040014 4 0.010
epithelial tube formation GO:0072175 19 0.010
striated muscle cell differentiation GO:0051146 129 0.010
phagocytosis GO:0006909 3 0.010
regulation of gastrulation GO:0010470 24 0.010
endodermal digestive tract morphogenesis GO:0061031 2 0.010
response to dexamethasone GO:0071548 1 0.010
heart morphogenesis GO:0003007 156 0.010
negative regulation of cellular metabolic process GO:0031324 77 0.010

lnx2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.053
nervous system disease DOID:863 0 0.015
disease of metabolism DOID:0014667 0 0.013
motor neuron disease DOID:231 0 0.013
central nervous system disease DOID:331 0 0.013
amyotrophic lateral sclerosis DOID:332 0 0.013
neurodegenerative disease DOID:1289 0 0.013
lysosomal storage disease DOID:3211 0 0.013
inherited metabolic disorder DOID:655 0 0.013
musculoskeletal system disease DOID:17 0 0.011