Danio rerio

12 known processes

nod2

nucleotide-binding oligomerization domain containing 2

(Aliases: card15)

nod2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
defense response to other organism GO:0098542 33 0.416
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.360
Mouse
response to bacterium GO:0009617 58 0.331
regulation of defense response to virus by host GO:0050691 1 0.325
sialylation GO:0097503 4 0.241
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.232
Mouse
response to other organism GO:0051707 97 0.175
response to stress GO:0006950 263 0.166
immune effector process GO:0002252 23 0.144
Mouse
response to dsrna GO:0043331 7 0.126
Mouse
positive regulation of jnk cascade GO:0046330 3 0.125
Mouse
larval development GO:0002164 2 0.119
defense response to bacterium GO:0042742 22 0.119
positive regulation of innate immune response GO:0045089 8 0.117
Mouse
regulation of autophagy GO:0010506 3 0.112
ganglioside metabolic process GO:0001573 3 0.107
positive regulation of epithelial cell proliferation GO:0050679 1 0.103
Mouse
positive regulation of defense response to virus by host GO:0002230 0 0.102
erk1 and erk2 cascade GO:0070371 4 0.098
Mouse
membrane lipid biosynthetic process GO:0046467 2 0.096
response to biotic stimulus GO:0009607 97 0.088
eye photoreceptor cell development GO:0042462 30 0.087
nitrogen compound metabolic process GO:0006807 319 0.085
Mouse
sensory perception of chemical stimulus GO:0007606 3 0.084
dicarboxylic acid transport GO:0006835 1 0.081
interferon beta production GO:0032608 1 0.080
type i interferon production GO:0032606 2 0.080
defense response GO:0006952 47 0.079
cognition GO:0050890 1 0.071
response to external biotic stimulus GO:0043207 97 0.070
cellular biosynthetic process GO:0044249 286 0.068
Mouse
heterocycle metabolic process GO:0046483 290 0.068
Mouse
biosynthetic process GO:0009058 294 0.068
Mouse
heterocycle biosynthetic process GO:0018130 215 0.064
Mouse
macromolecule glycosylation GO:0043413 9 0.064
purine nucleoside monophosphate catabolic process GO:0009128 4 0.062
regulation of interferon beta production GO:0032648 1 0.060
tissue remodeling GO:0048771 4 0.058
positive regulation of cell cycle GO:0045787 3 0.057
cell surface receptor signaling pathway GO:0007166 325 0.056
Mouse
regulation of cytokine production GO:0001817 3 0.054
Mouse
regulation of cellular amine metabolic process GO:0033238 0 0.054
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.054
lipid metabolic process GO:0006629 52 0.054
Mouse
regulation of macromolecule biosynthetic process GO:0010556 225 0.053
Mouse
positive regulation of cellular metabolic process GO:0031325 94 0.052
Mouse
single organism metabolic process GO:0044710 217 0.051
Mouse
protein modification process GO:0036211 100 0.049
Mouse
organic cyclic compound metabolic process GO:1901360 301 0.049
Mouse
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.048
Mouse
response to external stimulus GO:0009605 264 0.047
aging GO:0007568 2 0.045
mitochondrion organization GO:0007005 4 0.044
protein metabolic process GO:0019538 183 0.043
Mouse
glycosylation GO:0070085 11 0.043
amine metabolic process GO:0009308 2 0.041
stem cell maintenance GO:0019827 4 0.040
multicellular organism growth GO:0035264 4 0.039
cellular macromolecule biosynthetic process GO:0034645 224 0.039
Mouse
regulation of epithelial cell proliferation GO:0050678 3 0.038
Mouse
regulation of gene expression GO:0010468 265 0.038
Mouse
nucleic acid metabolic process GO:0090304 244 0.038
Mouse
cellular amine metabolic process GO:0044106 2 0.038
negative regulation of protein kinase activity GO:0006469 4 0.038
negative regulation of cytokine production GO:0001818 1 0.038
Mouse
negative regulation of protein phosphorylation GO:0001933 4 0.037
regulation of multicellular organism growth GO:0040014 4 0.036
organonitrogen compound biosynthetic process GO:1901566 47 0.036
Mouse
hemopoiesis GO:0030097 183 0.036
regulation of cellular ketone metabolic process GO:0010565 7 0.035
regulation of ph GO:0006885 3 0.034
photoreceptor cell development GO:0042461 40 0.034
establishment of protein localization to organelle GO:0072594 4 0.034
response to wounding GO:0009611 116 0.033
Mouse
response to organic substance GO:0010033 153 0.033
Mouse
autophagy GO:0006914 4 0.033
cellular response to stress GO:0033554 62 0.033
Mouse
response to corticosteroid GO:0031960 1 0.032
response to drug GO:0042493 3 0.031
leukocyte differentiation GO:0002521 25 0.031
detection of chemical stimulus GO:0009593 4 0.031
regulation of erk1 and erk2 cascade GO:0070372 4 0.031
Mouse
regulation of signal transduction GO:0009966 225 0.030
Mouse
response to xenobiotic stimulus GO:0009410 45 0.030
single organism carbohydrate metabolic process GO:0044723 12 0.030
response to alkaloid GO:0043279 2 0.029
mononuclear cell proliferation GO:0032943 1 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.029
peptidyl serine phosphorylation GO:0018105 1 0.029
positive regulation of cytokine production GO:0001819 2 0.029
Mouse
phagocytosis GO:0006909 3 0.029
Mouse
establishment of localization GO:0051234 244 0.029
Mouse
regulation of striated muscle contraction GO:0006942 2 0.029
regulation of inflammatory response GO:0050727 2 0.028
Mouse
positive regulation of transport GO:0051050 2 0.028
Mouse
regulation of cellular amino acid metabolic process GO:0006521 0 0.028
response to molecule of bacterial origin GO:0002237 14 0.028
Mouse
cellular response to chemical stimulus GO:0070887 157 0.028
Mouse
macromolecule modification GO:0043412 111 0.027
Mouse
positive regulation of cellular component biogenesis GO:0044089 3 0.027
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.027
Mouse
long chain fatty acid transport GO:0015909 1 0.026
estrogen metabolic process GO:0008210 2 0.026
regulation of protein polymerization GO:0032271 2 0.026
cellular response to biotic stimulus GO:0071216 3 0.026
Mouse
stem cell proliferation GO:0072089 4 0.026
carboxylic acid transport GO:0046942 8 0.025
cellular aromatic compound metabolic process GO:0006725 295 0.025
Mouse
anterior posterior pattern specification GO:0009952 152 0.025
regulation of multicellular organismal process GO:0051239 277 0.025
Mouse
germ line stem cell division GO:0042078 1 0.025
regulation of cell communication GO:0010646 232 0.024
Mouse
compound eye development GO:0048749 2 0.024
cellular ketone metabolic process GO:0042180 11 0.024
multi organism process GO:0051704 134 0.024
positive regulation of secretion by cell GO:1903532 1 0.024
Mouse
protein targeting to nucleus GO:0044744 3 0.024
cellular response to extracellular stimulus GO:0031668 2 0.024
regulation of glial cell differentiation GO:0045685 4 0.024
liver development GO:0001889 96 0.023
erythrocyte homeostasis GO:0034101 55 0.023
oxoacid metabolic process GO:0043436 31 0.023
cellular response to oxygen levels GO:0071453 1 0.023
enzyme linked receptor protein signaling pathway GO:0007167 106 0.023
maintenance of location GO:0051235 4 0.023
oocyte maturation GO:0001556 4 0.023
carboxylic acid metabolic process GO:0019752 22 0.023
internal protein amino acid acetylation GO:0006475 2 0.022
negative regulation of growth rate GO:0045967 1 0.022
regulation of gtpase activity GO:0043087 2 0.022
positive regulation of cell activation GO:0050867 1 0.022
hormone metabolic process GO:0042445 19 0.022
regulation of rac protein signal transduction GO:0035020 1 0.022
macromolecule biosynthetic process GO:0009059 227 0.022
Mouse
amino acid transport GO:0006865 2 0.022
regulation of biological quality GO:0065008 263 0.022
polarized epithelial cell differentiation GO:0030859 4 0.022
organic acid metabolic process GO:0006082 31 0.022
vasculogenesis GO:0001570 41 0.022
positive regulation of cellular amine metabolic process GO:0033240 0 0.021
hematopoietic or lymphoid organ development GO:0048534 191 0.021
cellular protein modification process GO:0006464 100 0.021
Mouse
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.021
regulation of biosynthetic process GO:0009889 250 0.021
Mouse
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.020
Mouse
cell cycle g2 m phase transition GO:0044839 4 0.020
opioid receptor signaling pathway GO:0038003 3 0.020
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.020
Mouse
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.020
Mouse
transmission of nerve impulse GO:0019226 19 0.020
organonitrogen compound metabolic process GO:1901564 74 0.020
Mouse
regulation of dna replication GO:0006275 3 0.020
response to endogenous stimulus GO:0009719 83 0.020
Mouse
cellular amino acid metabolic process GO:0006520 7 0.020
positive regulation of biological process GO:0048518 253 0.020
Mouse
vasculature development GO:0001944 278 0.020
guanosine containing compound metabolic process GO:1901068 4 0.020
nucleobase containing compound biosynthetic process GO:0034654 205 0.020
Mouse
renal tubule morphogenesis GO:0061333 1 0.020
heart process GO:0003015 71 0.020
positive regulation of protein kinase b signaling GO:0051897 1 0.020
organelle organization GO:0006996 227 0.020
cellular response to organic substance GO:0071310 105 0.019
Mouse
phosphate containing compound metabolic process GO:0006796 108 0.019
Mouse
regulation of purine nucleotide catabolic process GO:0033121 2 0.019
foregut morphogenesis GO:0007440 4 0.019
peptide metabolic process GO:0006518 1 0.019
Mouse
response to virus GO:0009615 21 0.019
morphogenesis of an epithelium GO:0002009 333 0.019
stem cell fate commitment GO:0048865 1 0.019
cytokine metabolic process GO:0042107 1 0.019
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.019
cellular protein metabolic process GO:0044267 129 0.019
Mouse
rho protein signal transduction GO:0007266 5 0.019
eye photoreceptor cell differentiation GO:0001754 45 0.019
positive regulation of apoptotic signaling pathway GO:2001235 1 0.019
positive regulation of dna metabolic process GO:0051054 1 0.019
positive regulation of lipid metabolic process GO:0045834 1 0.019
Mouse
positive regulation of endothelial cell differentiation GO:0045603 2 0.019
sphingolipid biosynthetic process GO:0030148 2 0.019
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.019
regulation of protein transport GO:0051223 3 0.018
Mouse
septum transversum development GO:0003343 4 0.018
response to chemical GO:0042221 320 0.018
Mouse
cell aging GO:0007569 2 0.018
myeloid cell differentiation GO:0030099 86 0.018
nerve development GO:0021675 45 0.017
single organism nuclear import GO:1902593 3 0.017
cellular response to lipopolysaccharide GO:0071222 3 0.017
production of molecular mediator of immune response GO:0002440 2 0.017
Mouse
regulation of endopeptidase activity GO:0052548 23 0.017
regulation of skeletal muscle tissue development GO:0048641 4 0.017
nephron epithelium morphogenesis GO:0072088 1 0.017
nucleocytoplasmic transport GO:0006913 4 0.017
smad protein complex assembly GO:0007183 1 0.017
regulation of nucleoside metabolic process GO:0009118 2 0.017
regulation of protein metabolic process GO:0051246 56 0.017
Mouse
guanosine containing compound catabolic process GO:1901069 2 0.017
regulation of skeletal muscle fiber development GO:0048742 2 0.017
ph reduction GO:0045851 1 0.017
spliceosomal complex assembly GO:0000245 1 0.016
regulation of cellular biosynthetic process GO:0031326 245 0.016
Mouse
muscle organ development GO:0007517 101 0.016
somatic stem cell maintenance GO:0035019 1 0.016
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.016
myotube cell development GO:0014904 35 0.016
regulation of mrna processing GO:0050684 3 0.016
cellular response to molecule of bacterial origin GO:0071219 3 0.016
Mouse
b cell activation GO:0042113 2 0.016
transport GO:0006810 220 0.016
Mouse
peptidyl serine modification GO:0018209 2 0.016
cellular response to external stimulus GO:0071496 2 0.016
regulation of cell activation GO:0050865 1 0.016
regulation of protein complex assembly GO:0043254 3 0.016
neuron development GO:0048666 262 0.016
regulation of nitrogen compound metabolic process GO:0051171 251 0.016
Mouse
negative regulation of kinase activity GO:0033673 4 0.016
regulation of mapk cascade GO:0043408 14 0.016
Mouse
positive regulation of stem cell proliferation GO:2000648 1 0.016
regulation of nucleotide catabolic process GO:0030811 2 0.016
blood vessel development GO:0001568 246 0.016
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.015
carbohydrate biosynthetic process GO:0016051 1 0.015
germ line stem cell maintenance GO:0030718 2 0.015
chordate embryonic development GO:0043009 271 0.015
organic substance biosynthetic process GO:1901576 289 0.015
Mouse
regulation of metabolic process GO:0019222 359 0.015
Mouse
morphogenesis of an epithelial fold GO:0060571 1 0.015
positive regulation of map kinase activity GO:0043406 3 0.015
Mouse
ribonucleoside monophosphate catabolic process GO:0009158 4 0.015
negative regulation of type i interferon production GO:0032480 1 0.015
xenobiotic metabolic process GO:0006805 4 0.015
negative regulation of biological process GO:0048519 304 0.015
Mouse
nephron tubule morphogenesis GO:0072078 1 0.015
muscle fiber development GO:0048747 52 0.015
carbohydrate derivative biosynthetic process GO:1901137 43 0.015
protein acylation GO:0043543 3 0.015
g2 m transition of mitotic cell cycle GO:0000086 4 0.015
g1 s transition of mitotic cell cycle GO:0000082 1 0.015
positive regulation of epithelial cell differentiation GO:0030858 2 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.015
cellular component biogenesis GO:0044085 178 0.014
stem cell division GO:0017145 1 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.014
response to exogenous dsrna GO:0043330 6 0.014
Mouse
signal transduction GO:0007165 455 0.014
Mouse
mapk cascade GO:0000165 18 0.014
Mouse
response to uv GO:0009411 3 0.014
positive regulation of chromatin modification GO:1903310 1 0.014
regulation of binding GO:0051098 3 0.014
single organism biosynthetic process GO:0044711 71 0.014
i kappab kinase nf kappab signaling GO:0007249 4 0.014
Mouse
regulation of cell development GO:0060284 100 0.014
response to vitamin GO:0033273 3 0.014
tissue regeneration GO:0042246 74 0.014
negative regulation of epithelial cell migration GO:0010633 1 0.014
cellular nitrogen compound metabolic process GO:0034641 290 0.014
Mouse
regulation of signaling GO:0023051 235 0.014
Mouse
regulation of protein ubiquitination GO:0031396 3 0.014
Mouse
regulation of response to biotic stimulus GO:0002831 2 0.014
Mouse
locomotion GO:0040011 313 0.014
Mouse
olfactory placode development GO:0071698 12 0.014
gene expression GO:0010467 252 0.014
Mouse
gtp catabolic process GO:0006184 2 0.014
gtp metabolic process GO:0046039 4 0.014
lymphocyte proliferation GO:0046651 1 0.014
single organism organelle organization GO:1902589 199 0.014
positive regulation of neuron death GO:1901216 1 0.013
regulation of calcium ion transport GO:0051924 2 0.013
regulation of endothelial cell differentiation GO:0045601 3 0.013
positive regulation of stress activated mapk cascade GO:0032874 3 0.013
Mouse
nucleic acid transport GO:0050657 2 0.013
epithelial tube morphogenesis GO:0060562 148 0.013
b cell mediated immunity GO:0019724 3 0.013
Mouse
embryo development ending in birth or egg hatching GO:0009792 271 0.013
striated muscle tissue development GO:0014706 110 0.013
myeloid cell development GO:0061515 32 0.013
negative regulation of immune response GO:0050777 2 0.013
Mouse
positive regulation of translation GO:0045727 1 0.013
regulation of developmental process GO:0050793 247 0.013
heart morphogenesis GO:0003007 156 0.013
cellular response to hypoxia GO:0071456 1 0.013
nuclear transport GO:0051169 4 0.013
synaptic transmission cholinergic GO:0007271 4 0.013
male meiosis GO:0007140 2 0.013
atp catabolic process GO:0006200 4 0.013
response to ketone GO:1901654 1 0.013
pronephros development GO:0048793 69 0.013
protein secretion GO:0009306 1 0.013
Mouse
regulation of response to stimulus GO:0048583 269 0.013
Mouse
positive regulation of chromosome organization GO:2001252 1 0.013
skeletal system development GO:0001501 181 0.013
mechanoreceptor differentiation GO:0042490 37 0.013
eye development GO:0001654 277 0.013
endocardium morphogenesis GO:0003160 4 0.013
angiogenesis GO:0001525 158 0.013
regulation of mitochondrion organization GO:0010821 1 0.012
negative regulation of multicellular organismal process GO:0051241 69 0.012
Mouse
regulation of rho protein signal transduction GO:0035023 2 0.012
positive regulation of cellular process GO:0048522 201 0.012
Mouse
extrinsic apoptotic signaling pathway GO:0097191 3 0.012
muscle tissue development GO:0060537 110 0.012
regulation of oligodendrocyte differentiation GO:0048713 1 0.012
phosphatidylinositol mediated signaling GO:0048015 2 0.012
cellular macromolecule metabolic process GO:0044260 391 0.012
Mouse
immune system development GO:0002520 191 0.012
protein import GO:0017038 3 0.012
neuroblast fate commitment GO:0014017 1 0.012
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.012
Mouse
phosphorylation GO:0016310 69 0.012
Mouse
response to abiotic stimulus GO:0009628 122 0.012
negative regulation of cellular process GO:0048523 283 0.012
Mouse
regulation of metal ion transport GO:0010959 4 0.012
response to glucocorticoid GO:0051384 1 0.012
small molecule metabolic process GO:0044281 77 0.012
membrane invagination GO:0010324 1 0.012
ceramide biosynthetic process GO:0046513 1 0.012
glial cell fate determination GO:0007403 1 0.012
neuroblast differentiation GO:0014016 1 0.012
astrocyte differentiation GO:0048708 1 0.012
reactive oxygen species biosynthetic process GO:1903409 1 0.012
negative regulation of molecular function GO:0044092 23 0.012
Mouse
response to nutrient GO:0007584 3 0.012
membrane lipid metabolic process GO:0006643 10 0.012
nephron morphogenesis GO:0072028 2 0.011
actin filament polymerization GO:0030041 2 0.011
somatic cell dna recombination GO:0016444 1 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
Mouse
regulation of gtp catabolic process GO:0033124 2 0.011
glycolipid biosynthetic process GO:0009247 1 0.011
appendage morphogenesis GO:0035107 56 0.011
regulation of establishment of protein localization GO:0070201 4 0.011
Mouse
regulation of protein localization to nucleus GO:1900180 2 0.011
blood vessel morphogenesis GO:0048514 216 0.011
cytoskeleton dependent cytokinesis GO:0061640 3 0.011
cellular response to growth factor stimulus GO:0071363 39 0.011
osteoclast differentiation GO:0030316 1 0.011
negative regulation of signaling GO:0023057 96 0.011
Mouse
protein import into nucleus GO:0006606 3 0.011
cellular response to nutrient levels GO:0031669 2 0.011
protein phosphorylation GO:0006468 47 0.011
Mouse
keratinocyte differentiation GO:0030216 0 0.011
internal peptidyl lysine acetylation GO:0018393 2 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.011
protein localization to nucleus GO:0034504 3 0.011
sex determination GO:0007530 1 0.011
exocytosis GO:0006887 1 0.011
regulation of leukocyte differentiation GO:1902105 5 0.011
transcription dna templated GO:0006351 181 0.011
Mouse
regulation of intracellular protein transport GO:0033157 3 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
exocrine pancreas development GO:0031017 28 0.011
apoptotic process involved in development GO:1902742 2 0.011
embryonic limb morphogenesis GO:0030326 2 0.011
defense response to gram positive bacterium GO:0050830 6 0.011
Mouse
regulation of jun kinase activity GO:0043506 3 0.011
positive regulation of multicellular organismal process GO:0051240 52 0.011
Mouse
regulation of cytokine biosynthetic process GO:0042035 1 0.011
cellular component movement GO:0006928 335 0.011
Mouse
water soluble vitamin metabolic process GO:0006767 1 0.011
positive regulation of carbohydrate metabolic process GO:0045913 1 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 20 0.010
fatty acid transport GO:0015908 1 0.010
regulation of multicellular organismal development GO:2000026 223 0.010
regulation of stem cell proliferation GO:0072091 2 0.010
regulation of cardiac muscle contraction GO:0055117 2 0.010
hormone biosynthetic process GO:0042446 3 0.010
regulation of photoreceptor cell differentiation GO:0046532 2 0.010
organ regeneration GO:0031100 1 0.010
intracellular signal transduction GO:0035556 85 0.010
Mouse
cellular response to starvation GO:0009267 1 0.010
regulation of cytoplasmic transport GO:1903649 4 0.010
glial cell proliferation GO:0014009 4 0.010
immune system process GO:0002376 241 0.010
Mouse
modulation by virus of host morphology or physiology GO:0019048 1 0.010
epithelial cell morphogenesis GO:0003382 2 0.010
nucleoside monophosphate catabolic process GO:0009125 4 0.010
actin filament based process GO:0030029 64 0.010
homeostasis of number of cells GO:0048872 62 0.010
regulation of mesenchymal cell proliferation GO:0010464 1 0.010

nod2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.024
disease of anatomical entity DOID:7 0 0.020
inherited metabolic disorder DOID:655 0 0.018
musculoskeletal system disease DOID:17 0 0.016
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
lysosomal storage disease DOID:3211 0 0.014
myopathy DOID:423 0 0.011
muscular disease DOID:0080000 0 0.011
heart disease DOID:114 0 0.011
cardiomyopathy DOID:0050700 0 0.011
cardiovascular system disease DOID:1287 0 0.011
muscle tissue disease DOID:66 0 0.011