Danio rerio

0 known processes

arhgef1

rho guanine nucleotide exchange factor (GEF) 1

(Aliases: zgc:158261,cb473)

arhgef1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell projection organization GO:0030030 284 0.211
protein polymerization GO:0051258 4 0.173
larval development GO:0002164 2 0.148
neuron development GO:0048666 262 0.141
blood vessel development GO:0001568 246 0.134
response to stress GO:0006950 263 0.123
cortical cytoskeleton organization GO:0030865 1 0.109
neuron differentiation GO:0030182 353 0.107
localization of cell GO:0051674 244 0.103
adherens junction organization GO:0034332 4 0.102
endosomal transport GO:0016197 2 0.097
compound eye development GO:0048749 2 0.091
cell motility GO:0048870 244 0.085
single organism organelle organization GO:1902589 199 0.083
hemopoiesis GO:0030097 183 0.083
cortical actin cytoskeleton organization GO:0030866 1 0.082
cellular component movement GO:0006928 335 0.080
regulation of biological quality GO:0065008 263 0.078
head development GO:0060322 303 0.071
immune system development GO:0002520 191 0.069
regulation of nitrogen compound metabolic process GO:0051171 251 0.068
lipid storage GO:0019915 1 0.065
positive regulation of biological process GO:0048518 253 0.065
eye development GO:0001654 277 0.064
response to chemical GO:0042221 320 0.064
regulation of metabolic process GO:0019222 359 0.062
central nervous system development GO:0007417 387 0.061
signal transduction GO:0007165 455 0.061
morphogenesis of an epithelium GO:0002009 333 0.059
cell migration GO:0016477 237 0.058
maintenance of location GO:0051235 4 0.058
vasculature development GO:0001944 278 0.056
purine nucleoside monophosphate catabolic process GO:0009128 4 0.053
aging GO:0007568 2 0.053
cellular nitrogen compound metabolic process GO:0034641 290 0.052
phagocytosis GO:0006909 3 0.052
multicellular organism growth GO:0035264 4 0.051
regulation of macromolecule metabolic process GO:0060255 317 0.048
atp catabolic process GO:0006200 4 0.048
cell part morphogenesis GO:0032990 246 0.048
nucleic acid metabolic process GO:0090304 244 0.046
positive regulation of cellular catabolic process GO:0031331 3 0.046
cellular protein metabolic process GO:0044267 129 0.044
response to external stimulus GO:0009605 264 0.044
macromolecular complex disassembly GO:0032984 1 0.042
small molecule metabolic process GO:0044281 77 0.042
protein metabolic process GO:0019538 183 0.042
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.042
cell morphogenesis involved in differentiation GO:0000904 195 0.041
generation of neurons GO:0048699 385 0.041
brain development GO:0007420 293 0.041
cellular component disassembly GO:0022411 1 0.040
nucleobase containing compound metabolic process GO:0006139 274 0.040
cytoskeleton organization GO:0007010 96 0.040
regulation of intracellular protein transport GO:0033157 3 0.040
cellular macromolecule metabolic process GO:0044260 391 0.039
organonitrogen compound metabolic process GO:1901564 74 0.039
carboxylic acid metabolic process GO:0019752 22 0.039
homeostasis of number of cells GO:0048872 62 0.038
heterocycle metabolic process GO:0046483 290 0.038
gtp catabolic process GO:0006184 2 0.037
regulation of synapse assembly GO:0051963 3 0.037
positive regulation of catabolic process GO:0009896 4 0.037
adult behavior GO:0030534 2 0.037
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.036
ribonucleoside monophosphate catabolic process GO:0009158 4 0.036
protein targeting to nucleus GO:0044744 3 0.036
microtubule depolymerization GO:0007019 1 0.036
ribonucleotide metabolic process GO:0009259 27 0.035
nitrogen compound metabolic process GO:0006807 319 0.035
negative regulation of biological process GO:0048519 304 0.035
phosphate containing compound metabolic process GO:0006796 108 0.034
regulation of protein transport GO:0051223 3 0.034
gtp metabolic process GO:0046039 4 0.034
erythrocyte differentiation GO:0030218 54 0.034
single organism metabolic process GO:0044710 217 0.033
positive regulation of transport GO:0051050 2 0.033
guanosine containing compound metabolic process GO:1901068 4 0.033
regulation of primary metabolic process GO:0080090 311 0.033
striated muscle tissue development GO:0014706 110 0.032
single organism nuclear import GO:1902593 3 0.032
regulation of synapse organization GO:0050807 3 0.032
heart development GO:0007507 313 0.032
cellular protein modification process GO:0006464 100 0.031
regulation of developmental process GO:0050793 247 0.031
embryo development ending in birth or egg hatching GO:0009792 271 0.030
macromolecular complex subunit organization GO:0043933 74 0.030
single organism localization GO:1902578 225 0.030
macromolecule modification GO:0043412 111 0.030
regulation of cellular amine metabolic process GO:0033238 0 0.030
regulation of anatomical structure morphogenesis GO:0022603 130 0.029
protein acetylation GO:0006473 2 0.029
regulation of protein complex disassembly GO:0043244 1 0.029
protein complex disassembly GO:0043241 1 0.029
erk1 and erk2 cascade GO:0070371 4 0.029
regulation of autophagy GO:0010506 3 0.029
regulation of multicellular organismal process GO:0051239 277 0.028
regulation of protein complex assembly GO:0043254 3 0.028
negative regulation of protein phosphorylation GO:0001933 4 0.028
cellular biosynthetic process GO:0044249 286 0.027
cell projection morphogenesis GO:0048858 244 0.027
regulation of protein polymerization GO:0032271 2 0.027
somatic muscle development GO:0007525 4 0.027
growth GO:0040007 174 0.027
organophosphate metabolic process GO:0019637 37 0.027
tube morphogenesis GO:0035239 349 0.027
actin cytoskeleton organization GO:0030036 63 0.027
regulation of erk1 and erk2 cascade GO:0070372 4 0.027
regulation of cytoplasmic transport GO:1903649 4 0.027
ribose phosphate metabolic process GO:0019693 27 0.027
regulation of nucleocytoplasmic transport GO:0046822 2 0.026
regulation of multicellular organismal development GO:2000026 223 0.026
response to uv GO:0009411 3 0.026
organic substance biosynthetic process GO:1901576 289 0.026
regulation of purine nucleotide catabolic process GO:0033121 2 0.026
regulation of dna templated transcription in response to stress GO:0043620 0 0.026
regulation of reproductive process GO:2000241 4 0.026
autophagy GO:0006914 4 0.026
neuron projection development GO:0031175 180 0.026
internal protein amino acid acetylation GO:0006475 2 0.025
hematopoietic or lymphoid organ development GO:0048534 191 0.025
guanosine containing compound catabolic process GO:1901069 2 0.025
nucleotide metabolic process GO:0009117 28 0.025
angiogenesis GO:0001525 158 0.025
erythrocyte homeostasis GO:0034101 55 0.025
neuron projection regeneration GO:0031102 16 0.025
positive regulation of cellular component biogenesis GO:0044089 3 0.025
adherens junction assembly GO:0034333 1 0.025
peptidyl serine phosphorylation GO:0018105 1 0.025
myoblast fusion GO:0007520 10 0.025
cellular component biogenesis GO:0044085 178 0.025
regulation of protein depolymerization GO:1901879 1 0.024
protein localization to plasma membrane GO:0072659 1 0.024
actin polymerization or depolymerization GO:0008154 2 0.024
cellular component assembly GO:0022607 170 0.024
regulation of biosynthetic process GO:0009889 250 0.024
regulation of establishment of protein localization GO:0070201 4 0.023
cellular response to chemical stimulus GO:0070887 157 0.023
small gtpase mediated signal transduction GO:0007264 8 0.023
positive regulation of protein polymerization GO:0032273 2 0.023
cellular protein complex assembly GO:0043623 19 0.023
cellular macromolecular complex assembly GO:0034622 24 0.023
regulation of myotube differentiation GO:0010830 2 0.023
immune system process GO:0002376 241 0.023
microtubule based process GO:0007017 60 0.023
regulation of nucleoside metabolic process GO:0009118 2 0.023
aromatic compound biosynthetic process GO:0019438 217 0.023
carboxylic acid catabolic process GO:0046395 3 0.022
amine metabolic process GO:0009308 2 0.022
negative regulation of metabolic process GO:0009892 86 0.022
nucleoside monophosphate catabolic process GO:0009125 4 0.022
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.022
cell morphogenesis GO:0000902 289 0.022
sensory organ development GO:0007423 393 0.022
cellular localization GO:0051641 97 0.022
vasculogenesis GO:0001570 41 0.022
protein depolymerization GO:0051261 1 0.022
regulation of gtpase activity GO:0043087 2 0.022
regulation of natural killer cell mediated immunity GO:0002715 1 0.022
septum transversum development GO:0003343 4 0.022
angioblast cell migration involved in selective angioblast sprouting GO:0035475 4 0.021
nuclear transport GO:0051169 4 0.021
nucleobase containing small molecule metabolic process GO:0055086 32 0.021
organic acid metabolic process GO:0006082 31 0.021
modification dependent protein catabolic process GO:0019941 3 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.021
regulation of cell motility GO:2000145 46 0.021
intracellular signal transduction GO:0035556 85 0.021
organic cyclic compound metabolic process GO:1901360 301 0.021
regulation of gtp catabolic process GO:0033124 2 0.021
cellular component morphogenesis GO:0032989 336 0.020
neuron neuron synaptic transmission GO:0007270 1 0.020
macromolecule biosynthetic process GO:0009059 227 0.020
regulation of signal transduction GO:0009966 225 0.020
regulation of cell differentiation GO:0045595 142 0.020
cellular response to nutrient levels GO:0031669 2 0.020
protein import into nucleus GO:0006606 3 0.020
cell fate commitment GO:0045165 99 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.020
endothelial cell development GO:0001885 12 0.020
protein localization to nucleus GO:0034504 3 0.020
positive regulation of gtp catabolic process GO:0033126 1 0.020
embryonic heart tube development GO:0035050 133 0.020
regulation of cell shape GO:0008360 1 0.020
ras protein signal transduction GO:0007265 7 0.020
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.020
myotube differentiation GO:0014902 45 0.020
regulation of cellular amino acid metabolic process GO:0006521 0 0.020
blood vessel morphogenesis GO:0048514 216 0.019
regulation of cell activation GO:0050865 1 0.019
negative regulation of cellular process GO:0048523 283 0.019
membrane invagination GO:0010324 1 0.019
organelle organization GO:0006996 227 0.019
regulation of locomotion GO:0040012 55 0.019
oxoacid metabolic process GO:0043436 31 0.019
regulation of cellular metabolic process GO:0031323 320 0.019
protein import GO:0017038 3 0.019
establishment of protein localization to organelle GO:0072594 4 0.019
regulation of nucleotide catabolic process GO:0030811 2 0.018
cellular macromolecule biosynthetic process GO:0034645 224 0.018
cellular response to methanol GO:0071405 4 0.018
establishment of localization GO:0051234 244 0.018
system process GO:0003008 185 0.018
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.018
sulfur compound biosynthetic process GO:0044272 9 0.018
axon regeneration GO:0031103 14 0.018
muscle structure development GO:0061061 196 0.018
transport GO:0006810 220 0.018
cell surface receptor signaling pathway GO:0007166 325 0.018
muscle cell differentiation GO:0042692 139 0.018
cell death GO:0008219 121 0.018
response to organic substance GO:0010033 153 0.017
response to amino acid GO:0043200 2 0.017
regulation of cell projection assembly GO:0060491 4 0.017
regulation of response to extracellular stimulus GO:0032104 1 0.017
regulation of response to stimulus GO:0048583 269 0.017
cellular carbohydrate metabolic process GO:0044262 4 0.017
heart morphogenesis GO:0003007 156 0.017
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.017
negative regulation of ras protein signal transduction GO:0046580 1 0.017
convergent extension GO:0060026 118 0.017
regulation of cellular component organization GO:0051128 86 0.017
mitotic cell cycle process GO:1903047 48 0.017
regulation of protein import into nucleus GO:0042306 2 0.017
regulation of binding GO:0051098 3 0.017
regulation of inflammatory response GO:0050727 2 0.017
cellular response to oxygen levels GO:0071453 1 0.017
regulation of cytokine production GO:0001817 3 0.016
positive regulation of cellular amine metabolic process GO:0033240 0 0.016
positive regulation of gtpase activity GO:0043547 1 0.016
protein phosphorylation GO:0006468 47 0.016
cellular amino acid metabolic process GO:0006520 7 0.016
nucleocytoplasmic transport GO:0006913 4 0.016
protein dephosphorylation GO:0006470 3 0.016
multi organism cellular process GO:0044764 2 0.016
inositol lipid mediated signaling GO:0048017 2 0.016
cellular protein catabolic process GO:0044257 4 0.016
pole plasm assembly GO:0007315 4 0.016
neuroblast proliferation GO:0007405 2 0.016
proteasomal protein catabolic process GO:0010498 2 0.016
epithelial cell morphogenesis GO:0003382 2 0.016
cellular protein complex disassembly GO:0043624 1 0.016
transcription dna templated GO:0006351 181 0.016
positive regulation of cell adhesion GO:0045785 1 0.015
stem cell maintenance GO:0019827 4 0.015
response to nutrient GO:0007584 3 0.015
regulation of metal ion transport GO:0010959 4 0.015
embryonic hemopoiesis GO:0035162 53 0.015
nucleic acid templated transcription GO:0097659 181 0.015
cytokinesis GO:0000910 3 0.015
establishment of endothelial barrier GO:0061028 3 0.015
regulation of intracellular signal transduction GO:1902531 57 0.015
phosphorus metabolic process GO:0006793 109 0.015
nucleoside phosphate metabolic process GO:0006753 28 0.015
cardiac muscle tissue morphogenesis GO:0055008 7 0.015
protein acylation GO:0043543 3 0.015
phagocytosis engulfment GO:0006911 1 0.015
locomotion GO:0040011 313 0.015
cellular aromatic compound metabolic process GO:0006725 295 0.015
receptor recycling GO:0001881 4 0.015
establishment of protein localization to plasma membrane GO:0090002 1 0.015
positive regulation of protein complex assembly GO:0031334 2 0.015
epithelial tube morphogenesis GO:0060562 148 0.015
cell substrate junction assembly GO:0007044 2 0.015
regulation of dendrite development GO:0050773 3 0.015
digestive tract development GO:0048565 265 0.014
response to drug GO:0042493 3 0.014
regulation of microtubule cytoskeleton organization GO:0070507 3 0.014
rna biosynthetic process GO:0032774 181 0.014
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.014
g protein coupled receptor signaling pathway GO:0007186 74 0.014
intracellular receptor signaling pathway GO:0030522 30 0.014
proepicardium development GO:0003342 4 0.014
regulation of cellular biosynthetic process GO:0031326 245 0.014
myeloid cell differentiation GO:0030099 86 0.014
negative regulation of macromolecule metabolic process GO:0010605 76 0.014
positive regulation of secretion GO:0051047 1 0.014
meiotic nuclear division GO:0007126 4 0.014
homeostatic process GO:0042592 142 0.014
regulation of localization GO:0032879 104 0.014
ubiquitin dependent protein catabolic process GO:0006511 3 0.014
rna localization GO:0006403 4 0.014
positive regulation of metabolic process GO:0009893 108 0.014
cellular response to stress GO:0033554 62 0.014
nucleobase containing compound biosynthetic process GO:0034654 205 0.014
positive regulation of cell cycle GO:0045787 3 0.014
peptidyl threonine phosphorylation GO:0018107 1 0.014
regulation of protein catabolic process GO:0042176 1 0.014
syncytium formation by plasma membrane fusion GO:0000768 12 0.013
organelle localization GO:0051640 49 0.013
positive regulation of nucleotide catabolic process GO:0030813 1 0.013
cellular response to decreased oxygen levels GO:0036294 1 0.013
enzyme linked receptor protein signaling pathway GO:0007167 106 0.013
establishment of mitotic spindle localization GO:0040001 12 0.013
peptidyl serine modification GO:0018209 2 0.013
natural killer cell mediated immunity GO:0002228 1 0.013
ventricular cardiac muscle tissue development GO:0003229 3 0.013
single organism transport GO:0044765 206 0.013
negative regulation of reproductive process GO:2000242 3 0.013
negative regulation of dna metabolic process GO:0051053 4 0.013
single organism cell adhesion GO:0098602 29 0.013
cellular ketone metabolic process GO:0042180 11 0.013
cellular nitrogen compound biosynthetic process GO:0044271 218 0.013
regulation of transcription dna templated GO:0006355 213 0.013
modification dependent macromolecule catabolic process GO:0043632 3 0.013
cell substrate adhesion GO:0031589 4 0.013
protein complex assembly GO:0006461 30 0.013
regulation of macromolecule biosynthetic process GO:0010556 225 0.013
syncytium formation GO:0006949 12 0.013
synaptic transmission cholinergic GO:0007271 4 0.013
regulation of oligodendrocyte differentiation GO:0048713 1 0.013
cellular response to extracellular stimulus GO:0031668 2 0.013
circulatory system process GO:0003013 87 0.012
neuron projection morphogenesis GO:0048812 161 0.012
response to wounding GO:0009611 116 0.012
regulation of sequestering of calcium ion GO:0051282 4 0.012
cell cycle GO:0007049 93 0.012
protein localization GO:0008104 40 0.012
response to endogenous stimulus GO:0009719 83 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
microtubule polymerization GO:0046785 2 0.012
mitochondrion organization GO:0007005 4 0.012
peptidyl lysine acetylation GO:0018394 2 0.012
peptidyl threonine modification GO:0018210 1 0.012
regulation of purine nucleotide metabolic process GO:1900542 17 0.012
actin filament based process GO:0030029 64 0.012
digestive system development GO:0055123 289 0.012
regulation of receptor mediated endocytosis GO:0048259 4 0.012
purine ribonucleotide metabolic process GO:0009150 27 0.012
muscle organ development GO:0007517 101 0.012
myeloid cell homeostasis GO:0002262 56 0.012
positive regulation of nucleoside metabolic process GO:0045979 1 0.012
purine nucleotide metabolic process GO:0006163 27 0.012
nuclear export GO:0051168 1 0.012
regulation of stem cell proliferation GO:0072091 2 0.012
negative regulation of muscle cell differentiation GO:0051148 1 0.012
response to corticosteroid GO:0031960 1 0.012
locomotor rhythm GO:0045475 3 0.012
neurotransmitter transport GO:0006836 2 0.012
protein modification process GO:0036211 100 0.012
central nervous system neuron axonogenesis GO:0021955 18 0.012
regulation of signaling GO:0023051 235 0.012
axon development GO:0061564 166 0.012
synaptic growth at neuromuscular junction GO:0051124 2 0.012
establishment of synaptic vesicle localization GO:0097480 1 0.012
biological adhesion GO:0022610 40 0.011
negative regulation of chemotaxis GO:0050922 4 0.011
regulation of carbohydrate metabolic process GO:0006109 4 0.011
rho protein signal transduction GO:0007266 5 0.011
striated muscle cell differentiation GO:0051146 129 0.011
calcium mediated signaling GO:0019722 2 0.011
cellular response to external stimulus GO:0071496 2 0.011
cellular catabolic process GO:0044248 27 0.011
calcium ion dependent exocytosis GO:0017156 1 0.011
muscle cell development GO:0055001 115 0.011
cellular response to hypoxia GO:0071456 1 0.011
cellular amine metabolic process GO:0044106 2 0.011
long chain fatty acid metabolic process GO:0001676 1 0.011
microtubule cytoskeleton organization GO:0000226 33 0.011
regulation of programmed cell death GO:0043067 101 0.011
morphogenesis of an epithelial sheet GO:0002011 49 0.011
regulation of microtubule polymerization or depolymerization GO:0031110 3 0.011
regulation of cell projection organization GO:0031344 44 0.011
negative regulation of defense response GO:0031348 2 0.011
developmental growth GO:0048589 166 0.011
internal peptidyl lysine acetylation GO:0018393 2 0.011
regulation of multicellular organism growth GO:0040014 4 0.011
positive regulation of translation GO:0045727 1 0.011
regulation of protein targeting GO:1903533 2 0.011
regulation of cardiac muscle tissue development GO:0055024 1 0.011
regulation of skeletal muscle fiber development GO:0048742 2 0.011
post embryonic organ development GO:0048569 4 0.010
regulation of cell communication GO:0010646 232 0.010
maternal determination of anterior posterior axis embryo GO:0008358 4 0.010
phagosome maturation GO:0090382 1 0.010
b cell activation GO:0042113 2 0.010
primary neural tube formation GO:0014020 1 0.010
stem cell division GO:0017145 1 0.010
carbohydrate homeostasis GO:0033500 1 0.010
cognition GO:0050890 1 0.010
g1 s transition of mitotic cell cycle GO:0000082 1 0.010
response to organic cyclic compound GO:0014070 51 0.010
ameboidal type cell migration GO:0001667 143 0.010
cellular response to radiation GO:0071478 4 0.010
axon cargo transport GO:0008088 2 0.010
negative regulation of cellular catabolic process GO:0031330 3 0.010
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.010
response to alkaloid GO:0043279 2 0.010
cellular macromolecule localization GO:0070727 21 0.010
regulation of tube size GO:0035150 2 0.010
regulation of phosphorus metabolic process GO:0051174 43 0.010
response to inorganic substance GO:0010035 38 0.010
negative regulation of multi organism process GO:0043901 3 0.010

arhgef1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.018
disease of anatomical entity DOID:7 0 0.015
nervous system disease DOID:863 0 0.015
cardiovascular system disease DOID:1287 0 0.012
disease of cellular proliferation DOID:14566 0 0.011