Danio rerio

0 known processes

huwe1

HECT, UBA and WWE domain containing 1

(Aliases: si:dkey-242a8.2)

huwe1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.214
regulation of macromolecule metabolic process GO:0060255 317 0.196
regulation of biological quality GO:0065008 263 0.155
regulation of cellular component organization GO:0051128 86 0.149
rna 3 end processing GO:0031123 2 0.136
meiotic nuclear division GO:0007126 4 0.125
larval development GO:0002164 2 0.117
negative regulation of biological process GO:0048519 304 0.103
organic cyclic compound metabolic process GO:1901360 301 0.101
cellular nitrogen compound metabolic process GO:0034641 290 0.096
regulation of nucleocytoplasmic transport GO:0046822 2 0.096
gtp catabolic process GO:0006184 2 0.086
positive regulation of cellular catabolic process GO:0031331 3 0.086
regulation of cell shape GO:0008360 1 0.083
gene expression GO:0010467 252 0.081
positive regulation of transport GO:0051050 2 0.078
organelle organization GO:0006996 227 0.077
embryo development ending in birth or egg hatching GO:0009792 271 0.075
regulation of signal transduction GO:0009966 225 0.075
regulation of dendrite development GO:0050773 3 0.069
guanosine containing compound metabolic process GO:1901068 4 0.069
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.068
cell migration GO:0016477 237 0.065
regulation of gene expression GO:0010468 265 0.064
regulation of response to stimulus GO:0048583 269 0.064
regulation of epithelial cell proliferation GO:0050678 3 0.064
regulation of synapse organization GO:0050807 3 0.062
regulation of nucleotide catabolic process GO:0030811 2 0.057
localization of cell GO:0051674 244 0.056
regulation of protein complex assembly GO:0043254 3 0.055
regulation of cell morphogenesis GO:0022604 42 0.054
immune system process GO:0002376 241 0.054
regulation of cytoplasmic transport GO:1903649 4 0.052
regulation of intracellular protein transport GO:0033157 3 0.050
gtp metabolic process GO:0046039 4 0.049
regulation of synapse assembly GO:0051963 3 0.048
multi organism process GO:0051704 134 0.048
protein import GO:0017038 3 0.048
single organism transport GO:0044765 206 0.046
pronuclear migration GO:0035046 1 0.046
peptide transport GO:0015833 1 0.045
cellular component disassembly GO:0022411 1 0.044
rho protein signal transduction GO:0007266 5 0.044
single organism localization GO:1902578 225 0.044
neuroblast proliferation GO:0007405 2 0.044
nuclear transport GO:0051169 4 0.044
erk1 and erk2 cascade GO:0070371 4 0.043
regulation of cell projection organization GO:0031344 44 0.042
synaptic growth at neuromuscular junction GO:0051124 2 0.042
establishment of localization GO:0051234 244 0.042
regulation of mrna processing GO:0050684 3 0.041
negative regulation of chromosome organization GO:2001251 1 0.041
regulation of establishment of protein localization GO:0070201 4 0.041
negative regulation of mrna metabolic process GO:1903312 3 0.041
response to stress GO:0006950 263 0.041
cellular component movement GO:0006928 335 0.041
regulation of multicellular organismal process GO:0051239 277 0.040
macromolecular complex subunit organization GO:0043933 74 0.040
rna polyadenylation GO:0043631 2 0.039
locomotion GO:0040011 313 0.039
purine nucleoside monophosphate catabolic process GO:0009128 4 0.037
organonitrogen compound metabolic process GO:1901564 74 0.036
response to external stimulus GO:0009605 264 0.036
negative regulation of protein complex assembly GO:0031333 1 0.035
cell motility GO:0048870 244 0.035
regulation of nucleoside metabolic process GO:0009118 2 0.035
proteasomal protein catabolic process GO:0010498 2 0.034
nucleobase containing compound metabolic process GO:0006139 274 0.034
single organism nuclear import GO:1902593 3 0.034
positive regulation of catabolic process GO:0009896 4 0.034
negative regulation of dna metabolic process GO:0051053 4 0.033
spermatid development GO:0007286 2 0.033
regulation of chromatin organization GO:1902275 5 0.033
transport GO:0006810 220 0.033
actin filament based process GO:0030029 64 0.032
establishment of protein localization to organelle GO:0072594 4 0.032
defense response GO:0006952 47 0.032
heterocycle metabolic process GO:0046483 290 0.032
regulation of purine nucleotide catabolic process GO:0033121 2 0.031
signal transduction GO:0007165 455 0.031
organic substance biosynthetic process GO:1901576 289 0.031
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.031
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.030
hormone secretion GO:0046879 2 0.030
guanosine containing compound catabolic process GO:1901069 2 0.030
regulation of metal ion transport GO:0010959 4 0.030
cellular response to organic substance GO:0071310 105 0.029
regulation of gene silencing GO:0060968 1 0.029
regulation of protein import into nucleus GO:0042306 2 0.029
neuron differentiation GO:0030182 353 0.029
rna localization GO:0006403 4 0.029
embryonic organ development GO:0048568 381 0.028
regulation of protein transport GO:0051223 3 0.028
regulation of gtp catabolic process GO:0033124 2 0.028
determination of bilateral symmetry GO:0009855 204 0.028
response to chemical GO:0042221 320 0.027
cellular macromolecule metabolic process GO:0044260 391 0.027
organism emergence from protective structure GO:0071684 4 0.027
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.027
protein depolymerization GO:0051261 1 0.027
epithelial tube morphogenesis GO:0060562 148 0.027
cellular protein catabolic process GO:0044257 4 0.026
regulation of response to stress GO:0080134 36 0.026
negative regulation of defense response GO:0031348 2 0.026
regulation of cellular protein catabolic process GO:1903362 1 0.026
cellular component maintenance GO:0043954 3 0.026
phosphorus metabolic process GO:0006793 109 0.026
regulation of protein targeting GO:1903533 2 0.025
carbohydrate homeostasis GO:0033500 1 0.025
regulation of erk1 and erk2 cascade GO:0070372 4 0.025
aging GO:0007568 2 0.025
spermatid differentiation GO:0048515 2 0.025
regulation of localization GO:0032879 104 0.025
determination of left right symmetry GO:0007368 179 0.025
negative regulation of cellular catabolic process GO:0031330 3 0.025
cellular response to chemical stimulus GO:0070887 157 0.025
single organism metabolic process GO:0044710 217 0.025
modification dependent macromolecule catabolic process GO:0043632 3 0.024
regulation of mrna catabolic process GO:0061013 3 0.024
response to organic substance GO:0010033 153 0.024
transcription from rna polymerase ii promoter GO:0006366 80 0.024
nitrogen compound metabolic process GO:0006807 319 0.024
biosynthetic process GO:0009058 294 0.024
membrane invagination GO:0010324 1 0.024
mrna metabolic process GO:0016071 20 0.023
transmission of nerve impulse GO:0019226 19 0.023
regulation of anatomical structure morphogenesis GO:0022603 130 0.023
negative regulation of macromolecule metabolic process GO:0010605 76 0.023
regulation of protein ubiquitination GO:0031396 3 0.023
regulation of dendrite morphogenesis GO:0048814 3 0.023
negative regulation of synapse assembly GO:0051964 2 0.022
locomotor rhythm GO:0045475 3 0.022
negative regulation of reproductive process GO:2000242 3 0.022
regulation of protein catabolic process GO:0042176 1 0.022
regulation of response to cytokine stimulus GO:0060759 3 0.022
fertilization GO:0009566 3 0.022
eye development GO:0001654 277 0.022
multicellular organismal signaling GO:0035637 22 0.022
positive regulation of epithelial cell proliferation GO:0050679 1 0.022
stem cell division GO:0017145 1 0.022
macromolecular complex disassembly GO:0032984 1 0.022
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.022
nucleoside monophosphate catabolic process GO:0009125 4 0.022
response to carbohydrate GO:0009743 3 0.022
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.022
regulation of nitrogen compound metabolic process GO:0051171 251 0.021
regulation of rho protein signal transduction GO:0035023 2 0.021
negative regulation of cellular process GO:0048523 283 0.021
positive regulation of gtp catabolic process GO:0033126 1 0.021
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.021
neuroblast differentiation GO:0014016 1 0.021
cytoskeleton organization GO:0007010 96 0.021
regulation of signaling GO:0023051 235 0.021
ubiquitin dependent protein catabolic process GO:0006511 3 0.020
embryonic heart tube development GO:0035050 133 0.020
regulation of multicellular organismal development GO:2000026 223 0.020
negative regulation of cellular metabolic process GO:0031324 77 0.020
atp catabolic process GO:0006200 4 0.020
protein stabilization GO:0050821 2 0.020
negative regulation of response to cytokine stimulus GO:0060761 2 0.019
cellular macromolecular complex assembly GO:0034622 24 0.019
negative regulation of catabolic process GO:0009895 3 0.019
developmental growth GO:0048589 166 0.019
embryonic organ morphogenesis GO:0048562 274 0.019
negative regulation of chromatin modification GO:1903309 1 0.019
modification dependent protein catabolic process GO:0019941 3 0.019
sensory organ development GO:0007423 393 0.019
cellular response to extracellular stimulus GO:0031668 2 0.019
cell morphogenesis GO:0000902 289 0.019
positive regulation of myeloid cell differentiation GO:0045639 2 0.019
protein localization to nucleus GO:0034504 3 0.019
positive regulation of cellular process GO:0048522 201 0.018
negative regulation of histone modification GO:0031057 1 0.018
cellular component biogenesis GO:0044085 178 0.018
regulation of gtpase activity GO:0043087 2 0.018
regulation of reproductive process GO:2000241 4 0.018
protein complex assembly GO:0006461 30 0.018
multicellular organism growth GO:0035264 4 0.018
camera type eye development GO:0043010 222 0.018
synapse organization GO:0050808 21 0.018
cellular response to nutrient levels GO:0031669 2 0.018
nucleocytoplasmic transport GO:0006913 4 0.018
meiotic cell cycle process GO:1903046 3 0.018
nuclear division GO:0000280 23 0.017
specification of symmetry GO:0009799 204 0.017
cellular protein metabolic process GO:0044267 129 0.017
negative regulation of metabolic process GO:0009892 86 0.017
protein complex subunit organization GO:0071822 46 0.017
calcium ion import GO:0070509 4 0.017
tissue migration GO:0090130 37 0.017
regulation of ras gtpase activity GO:0032318 2 0.017
regulation of catalytic activity GO:0050790 55 0.017
positive regulation of jnk cascade GO:0046330 3 0.017
negative regulation of epithelial cell proliferation GO:0050680 1 0.017
regulation of cellular protein metabolic process GO:0032268 52 0.017
small molecule metabolic process GO:0044281 77 0.017
protein polymerization GO:0051258 4 0.017
gamete generation GO:0007276 33 0.017
actin cytoskeleton organization GO:0030036 63 0.017
nuclear import GO:0051170 3 0.016
immune response GO:0006955 28 0.016
heterocycle catabolic process GO:0046700 15 0.016
protein complex disassembly GO:0043241 1 0.016
negative regulation of cellular component organization GO:0051129 16 0.016
intracellular signal transduction GO:0035556 85 0.016
positive regulation of cell activation GO:0050867 1 0.016
regulation of protein complex disassembly GO:0043244 1 0.016
growth GO:0040007 174 0.016
cellular catabolic process GO:0044248 27 0.016
regulation of defense response GO:0031347 14 0.016
positive regulation of biological process GO:0048518 253 0.016
regulation of transport GO:0051049 45 0.016
single organism organelle organization GO:1902589 199 0.016
regulation of striated muscle contraction GO:0006942 2 0.016
regulation of cellular metabolic process GO:0031323 320 0.016
negative regulation of mapk cascade GO:0043409 4 0.016
actin polymerization or depolymerization GO:0008154 2 0.016
macromolecule biosynthetic process GO:0009059 227 0.016
heart looping GO:0001947 94 0.016
heart development GO:0007507 313 0.016
positive regulation of cellular component biogenesis GO:0044089 3 0.016
regulation of cytokine mediated signaling pathway GO:0001959 3 0.016
regulation of developmental process GO:0050793 247 0.016
response to bacterium GO:0009617 58 0.016
cytokinesis GO:0000910 3 0.016
cellular component assembly GO:0022607 170 0.016
developmental growth involved in morphogenesis GO:0060560 86 0.016
determination of heart left right asymmetry GO:0061371 117 0.016
stem cell fate commitment GO:0048865 1 0.016
retina development in camera type eye GO:0060041 146 0.015
regulation of rna metabolic process GO:0051252 224 0.015
purine nucleotide metabolic process GO:0006163 27 0.015
head development GO:0060322 303 0.015
positive regulation of response to stimulus GO:0048584 80 0.015
antimicrobial humoral response GO:0019730 2 0.015
development of primary female sexual characteristics GO:0046545 4 0.015
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.015
mrna 3 end processing GO:0031124 2 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.015
neuron projection development GO:0031175 180 0.015
protein localization to plasma membrane GO:0072659 1 0.015
brain development GO:0007420 293 0.015
oogenesis GO:0048477 14 0.015
carbohydrate derivative metabolic process GO:1901135 61 0.015
macromolecular complex assembly GO:0065003 35 0.015
regulation of protein localization to nucleus GO:1900180 2 0.015
positive regulation of apoptotic process GO:0043065 29 0.015
cellular response to starvation GO:0009267 1 0.015
positive regulation of nucleoside metabolic process GO:0045979 1 0.015
response to uv GO:0009411 3 0.015
axonal defasciculation GO:0007414 2 0.015
maintenance of location GO:0051235 4 0.014
embryonic heart tube morphogenesis GO:0003143 108 0.014
heart morphogenesis GO:0003007 156 0.014
lateral inhibition GO:0046331 1 0.014
neuron projection extension GO:1990138 45 0.014
protein metabolic process GO:0019538 183 0.014
mitotic cell cycle GO:0000278 64 0.014
ribose phosphate metabolic process GO:0019693 27 0.014
intracellular mrna localization GO:0008298 1 0.014
cellular amide metabolic process GO:0043603 4 0.014
negative regulation of mitosis GO:0045839 3 0.014
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.014
cell cycle g1 s phase transition GO:0044843 1 0.014
digestive system development GO:0055123 289 0.014
regulation of immune system process GO:0002682 34 0.014
regulation of postsynaptic membrane potential GO:0060078 1 0.014
central nervous system neuron differentiation GO:0021953 74 0.014
branchiomotor neuron axon guidance GO:0021785 1 0.014
protein import into nucleus GO:0006606 3 0.014
stem cell proliferation GO:0072089 4 0.014
immune system development GO:0002520 191 0.014
single organism cellular localization GO:1902580 46 0.014
peptidyl tyrosine dephosphorylation GO:0035335 1 0.014
epithelial cell differentiation GO:0030855 116 0.013
regulation of primary metabolic process GO:0080090 311 0.013
protein localization GO:0008104 40 0.013
regulation of myelination GO:0031641 1 0.013
mrna polyadenylation GO:0006378 2 0.013
cellular nitrogen compound biosynthetic process GO:0044271 218 0.013
cellular protein complex disassembly GO:0043624 1 0.013
establishment of organelle localization GO:0051656 45 0.013
enzyme linked receptor protein signaling pathway GO:0007167 106 0.013
morphogenesis of an epithelium GO:0002009 333 0.013
spliceosomal complex assembly GO:0000245 1 0.013
response to other organism GO:0051707 97 0.013
cellular aromatic compound metabolic process GO:0006725 295 0.013
positive regulation of nervous system development GO:0051962 25 0.013
programmed cell death GO:0012501 119 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.013
single organism behavior GO:0044708 24 0.013
cellular response to external stimulus GO:0071496 2 0.013
cellular response to stress GO:0033554 62 0.013
regulation of multicellular organism growth GO:0040014 4 0.013
cellular biosynthetic process GO:0044249 286 0.013
actin filament polymerization GO:0030041 2 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.012
forebrain cell migration GO:0021885 1 0.012
nucleobase containing compound transport GO:0015931 2 0.012
homeostatic process GO:0042592 142 0.012
positive regulation of apoptotic signaling pathway GO:2001235 1 0.012
organic substance transport GO:0071702 58 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
protein complex biogenesis GO:0070271 30 0.012
cell division GO:0051301 20 0.012
regulation of neurogenesis GO:0050767 87 0.012
developmental process involved in reproduction GO:0003006 27 0.012
ribonucleotide metabolic process GO:0009259 27 0.012
negative regulation of rna splicing GO:0033119 1 0.012
negative regulation of neuron projection regeneration GO:0070571 4 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.012
action potential GO:0001508 19 0.012
lamellipodium organization GO:0097581 1 0.012
muscle cell differentiation GO:0042692 139 0.012
regulation of cytokine production GO:0001817 3 0.012
positive regulation of mrna processing GO:0050685 1 0.012
p38mapk cascade GO:0038066 1 0.012
generation of neurons GO:0048699 385 0.011
positive regulation of secretion by cell GO:1903532 1 0.011
regulation of wound healing GO:0061041 2 0.011
negative regulation of multi organism process GO:0043901 3 0.011
central nervous system development GO:0007417 387 0.011
lymphocyte proliferation GO:0046651 1 0.011
regulation of axon regeneration GO:0048679 7 0.011
regulation of cell activation GO:0050865 1 0.011
adherens junction organization GO:0034332 4 0.011
response to hexose GO:0009746 3 0.011
protein targeting to nucleus GO:0044744 3 0.011
regulation of transmembrane transport GO:0034762 18 0.011
cell cycle GO:0007049 93 0.011
reproductive process GO:0022414 40 0.011
leukocyte proliferation GO:0070661 1 0.011
production of molecular mediator of immune response GO:0002440 2 0.011
rna metabolic process GO:0016070 219 0.011
aromatic compound biosynthetic process GO:0019438 217 0.011
multi organism reproductive process GO:0044703 36 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.010
muscle fiber development GO:0048747 52 0.010
pancreas development GO:0031016 84 0.010
positive regulation of mrna metabolic process GO:1903313 2 0.010
negative regulation of rna metabolic process GO:0051253 48 0.010
purine ribonucleotide metabolic process GO:0009150 27 0.010
transmembrane transport GO:0055085 120 0.010
defense response to other organism GO:0098542 33 0.010
adult behavior GO:0030534 2 0.010
rna transport GO:0050658 2 0.010
locomotory behavior GO:0007626 34 0.010
positive regulation of gtpase activity GO:0043547 1 0.010

huwe1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.021
disease of cellular proliferation DOID:14566 0 0.021
organ system cancer DOID:0050686 0 0.021
reproductive organ cancer DOID:193 0 0.011