Danio rerio

24 known processes

shox2

short stature homeobox 2

(Aliases: zgc:65884,MGC65884,zgc:77344)

shox2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
central nervous system development GO:0007417 387 0.395
neuron differentiation GO:0030182 353 0.207
eye development GO:0001654 277 0.188
generation of neurons GO:0048699 385 0.163
regulation of developmental process GO:0050793 247 0.140
head development GO:0060322 303 0.117
brain development GO:0007420 293 0.114
cellular macromolecule metabolic process GO:0044260 391 0.096
heterocycle biosynthetic process GO:0018130 215 0.094
regulation of multicellular organismal process GO:0051239 277 0.091
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.088
larval development GO:0002164 2 0.087
camera type eye development GO:0043010 222 0.087
neuron development GO:0048666 262 0.085
cell projection organization GO:0030030 284 0.077
cell part morphogenesis GO:0032990 246 0.075
organic substance biosynthetic process GO:1901576 289 0.072
morphogenesis of an epithelium GO:0002009 333 0.071
embryonic organ development GO:0048568 381 0.070
aging GO:0007568 2 0.070
negative regulation of biological process GO:0048519 304 0.069
regulation of cell differentiation GO:0045595 142 0.068
regulation of neuron projection development GO:0010975 40 0.068
neuron projection development GO:0031175 180 0.067
response to chemical GO:0042221 320 0.067
axonogenesis GO:0007409 152 0.064
hindbrain development GO:0030902 91 0.063
cellular component morphogenesis GO:0032989 336 0.060
multicellular organism growth GO:0035264 4 0.060
biosynthetic process GO:0009058 294 0.059
regulation of nitrogen compound metabolic process GO:0051171 251 0.059
sensory organ development GO:0007423 393 0.059
cellular nitrogen compound biosynthetic process GO:0044271 218 0.058
embryonic organ morphogenesis GO:0048562 274 0.056
specification of symmetry GO:0009799 204 0.055
cartilage development GO:0051216 96 0.054
cell projection morphogenesis GO:0048858 244 0.054
regulation of rna metabolic process GO:0051252 224 0.053
neuron projection morphogenesis GO:0048812 161 0.053
regulation of neuron differentiation GO:0045664 56 0.053
regulation of transcription dna templated GO:0006355 213 0.050
regulation of neurogenesis GO:0050767 87 0.049
positive regulation of cellular process GO:0048522 201 0.049
macromolecule biosynthetic process GO:0009059 227 0.048
regulation of signaling GO:0023051 235 0.048
regulation of macromolecule metabolic process GO:0060255 317 0.047
rna biosynthetic process GO:0032774 181 0.047
cellular macromolecule biosynthetic process GO:0034645 224 0.046
rna metabolic process GO:0016070 219 0.046
developmental growth involved in morphogenesis GO:0060560 86 0.046
determination of bilateral symmetry GO:0009855 204 0.045
regulation of cell development GO:0060284 100 0.045
nitrogen compound metabolic process GO:0006807 319 0.044
tissue remodeling GO:0048771 4 0.044
negative regulation of cellular process GO:0048523 283 0.044
regulation of nervous system development GO:0051960 90 0.043
organic cyclic compound biosynthetic process GO:1901362 223 0.043
determination of left right symmetry GO:0007368 179 0.043
regulation of nucleic acid templated transcription GO:1903506 213 0.041
axon development GO:0061564 166 0.041
forebrain development GO:0030900 96 0.041
transcription dna templated GO:0006351 181 0.040
nucleic acid templated transcription GO:0097659 181 0.040
neuron projection extension GO:1990138 45 0.039
regulation of macromolecule biosynthetic process GO:0010556 225 0.039
axon guidance GO:0007411 86 0.039
cellular component movement GO:0006928 335 0.039
cell morphogenesis involved in differentiation GO:0000904 195 0.038
nucleobase containing compound biosynthetic process GO:0034654 205 0.038
skeletal system development GO:0001501 181 0.038
central nervous system neuron differentiation GO:0021953 74 0.038
regulation of metabolic process GO:0019222 359 0.037
cellular biosynthetic process GO:0044249 286 0.037
aromatic compound biosynthetic process GO:0019438 217 0.037
axon extension GO:0048675 45 0.037
heterocycle metabolic process GO:0046483 290 0.037
regulation of gene expression GO:0010468 265 0.037
negative regulation of developmental process GO:0051093 65 0.037
retina development in camera type eye GO:0060041 146 0.036
hepaticobiliary system development GO:0061008 98 0.036
regulation of cellular biosynthetic process GO:0031326 245 0.035
signal transduction GO:0007165 455 0.035
sensory organ morphogenesis GO:0090596 200 0.035
regulation of anatomical structure morphogenesis GO:0022603 130 0.035
regulation of primary metabolic process GO:0080090 311 0.034
skin development GO:0043588 54 0.034
nucleobase containing compound metabolic process GO:0006139 274 0.034
endocrine system development GO:0035270 65 0.034
organic cyclic compound metabolic process GO:1901360 301 0.034
growth GO:0040007 174 0.034
cellular amine metabolic process GO:0044106 2 0.034
developmental cell growth GO:0048588 52 0.033
cell substrate adhesion GO:0031589 4 0.033
ear development GO:0043583 127 0.033
positive regulation of biological process GO:0048518 253 0.032
response to external stimulus GO:0009605 264 0.032
positive regulation of transport GO:0051050 2 0.032
inner ear morphogenesis GO:0042472 63 0.032
connective tissue development GO:0061448 99 0.032
hematopoietic or lymphoid organ development GO:0048534 191 0.031
cell morphogenesis GO:0000902 289 0.031
localization of cell GO:0051674 244 0.031
amine metabolic process GO:0009308 2 0.031
heart development GO:0007507 313 0.031
regulation of cellular metabolic process GO:0031323 320 0.031
vasculature development GO:0001944 278 0.031
immune system process GO:0002376 241 0.031
regulation of signal transduction GO:0009966 225 0.031
regulation of multicellular organismal development GO:2000026 223 0.030
regulation of biosynthetic process GO:0009889 250 0.030
regulation of synapse assembly GO:0051963 3 0.030
maintenance of location GO:0051235 4 0.030
regulation of axonogenesis GO:0050770 32 0.030
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.029
nucleic acid metabolic process GO:0090304 244 0.029
sensory system development GO:0048880 76 0.029
immune system development GO:0002520 191 0.029
camera type eye morphogenesis GO:0048593 108 0.028
ectodermal placode morphogenesis GO:0071697 32 0.028
homeostatic process GO:0042592 142 0.028
retina morphogenesis in camera type eye GO:0060042 79 0.028
tube morphogenesis GO:0035239 349 0.028
alternative mrna splicing via spliceosome GO:0000380 1 0.028
gland development GO:0048732 143 0.028
regulation of synapse organization GO:0050807 3 0.028
cell surface receptor signaling pathway GO:0007166 325 0.027
liver development GO:0001889 96 0.027
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.027
regulation of reproductive process GO:2000241 4 0.027
regionalization GO:0003002 274 0.027
chordate embryonic development GO:0043009 271 0.027
regulation of cell communication GO:0010646 232 0.027
regulation of cellular amino acid metabolic process GO:0006521 0 0.027
appendage development GO:0048736 80 0.027
dorsal ventral pattern formation GO:0009953 125 0.026
metencephalon development GO:0022037 27 0.026
cellular response to xenobiotic stimulus GO:0071466 35 0.026
inner ear development GO:0048839 126 0.026
locomotion GO:0040011 313 0.026
regulation of cellular ketone metabolic process GO:0010565 7 0.025
single organism metabolic process GO:0044710 217 0.025
cell motility GO:0048870 244 0.024
somatic stem cell maintenance GO:0035019 1 0.024
negative regulation of multicellular organismal process GO:0051241 69 0.024
cell fate commitment GO:0045165 99 0.024
eye morphogenesis GO:0048592 144 0.024
developmental growth GO:0048589 166 0.024
gene expression GO:0010467 252 0.024
cell growth GO:0016049 57 0.024
female gonad development GO:0008585 4 0.024
regulation of response to stimulus GO:0048583 269 0.024
regulation of cellular amine metabolic process GO:0033238 0 0.023
cellular aromatic compound metabolic process GO:0006725 295 0.023
chemotaxis GO:0006935 104 0.023
rhombomere 5 development GO:0021571 4 0.023
meiotic nuclear division GO:0007126 4 0.023
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.023
stem cell maintenance GO:0019827 4 0.023
regulation of axon extension GO:0030516 24 0.023
angiogenesis GO:0001525 158 0.022
otolith development GO:0048840 32 0.022
hemopoiesis GO:0030097 183 0.022
cellular nitrogen compound metabolic process GO:0034641 290 0.022
regulation of mrna splicing via spliceosome GO:0048024 3 0.021
response to stress GO:0006950 263 0.021
embryo development ending in birth or egg hatching GO:0009792 271 0.021
transcription from rna polymerase ii promoter GO:0006366 80 0.021
regulation of rna biosynthetic process GO:2001141 213 0.021
anterior posterior pattern specification GO:0009952 152 0.021
oxoacid metabolic process GO:0043436 31 0.021
protein localization to plasma membrane GO:0072659 1 0.021
regulation of cell morphogenesis GO:0022604 42 0.021
neuron projection guidance GO:0097485 86 0.021
diencephalon development GO:0021536 58 0.021
blood vessel development GO:0001568 246 0.021
regulation of tissue remodeling GO:0034103 2 0.021
positive regulation of cellular component biogenesis GO:0044089 3 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.020
kupffer s vesicle development GO:0070121 50 0.020
midbrain development GO:0030901 28 0.020
establishment of protein localization to plasma membrane GO:0090002 1 0.020
ectodermal placode development GO:0071696 37 0.019
regulation of biological quality GO:0065008 263 0.019
digestive tract development GO:0048565 265 0.019
organic acid metabolic process GO:0006082 31 0.019
cilium morphogenesis GO:0060271 85 0.019
nuclear export GO:0051168 1 0.019
phagocytosis GO:0006909 3 0.019
regulation of mrna processing GO:0050684 3 0.019
regulation of cell projection organization GO:0031344 44 0.019
regulation of ph GO:0006885 3 0.019
regulation of cellular component organization GO:0051128 86 0.019
positive regulation of macromolecule metabolic process GO:0010604 93 0.019
carboxylic acid metabolic process GO:0019752 22 0.018
behavior GO:0007610 74 0.018
membrane fusion GO:0061025 2 0.018
cellular ketone metabolic process GO:0042180 11 0.018
cellular response to nutrient levels GO:0031669 2 0.018
neuron fate specification GO:0048665 20 0.018
digestive system development GO:0055123 289 0.018
otic vesicle development GO:0071599 42 0.018
regulation of tube size GO:0035150 2 0.018
organonitrogen compound metabolic process GO:1901564 74 0.018
synaptic transmission cholinergic GO:0007271 4 0.018
establishment of localization GO:0051234 244 0.018
adult behavior GO:0030534 2 0.018
stem cell differentiation GO:0048863 117 0.018
cellular amide metabolic process GO:0043603 4 0.018
stem cell division GO:0017145 1 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
synaptic growth at neuromuscular junction GO:0051124 2 0.017
notochord development GO:0030903 54 0.017
taxis GO:0042330 109 0.017
single organism transport GO:0044765 206 0.017
cellular response to starvation GO:0009267 1 0.017
cellular response to external stimulus GO:0071496 2 0.017
single organism localization GO:1902578 225 0.017
negative regulation of cell differentiation GO:0045596 46 0.017
cellular response to extracellular stimulus GO:0031668 2 0.017
regulation of blood vessel size GO:0050880 2 0.017
regulation of dendrite development GO:0050773 3 0.017
response to xenobiotic stimulus GO:0009410 45 0.017
oocyte maturation GO:0001556 4 0.016
peripheral nervous system development GO:0007422 55 0.016
pectoral fin development GO:0033339 50 0.016
cell migration GO:0016477 237 0.016
response to monosaccharide GO:0034284 3 0.016
neuron fate commitment GO:0048663 26 0.016
female sex differentiation GO:0046660 4 0.016
fin development GO:0033333 77 0.016
cellular component assembly GO:0022607 170 0.016
lipid storage GO:0019915 1 0.016
cell aging GO:0007569 2 0.016
stem cell fate commitment GO:0048865 1 0.015
germ line stem cell maintenance GO:0030718 2 0.015
negative chemotaxis GO:0050919 1 0.015
response to carbohydrate GO:0009743 3 0.015
nuclear transport GO:0051169 4 0.015
protein metabolic process GO:0019538 183 0.015
negative regulation of neurogenesis GO:0050768 20 0.015
central nervous system neuron axonogenesis GO:0021955 18 0.015
cellular carbohydrate metabolic process GO:0044262 4 0.015
regulation of protein complex assembly GO:0043254 3 0.015
heart morphogenesis GO:0003007 156 0.015
fibroblast growth factor receptor signaling pathway GO:0008543 22 0.015
regulation of wnt signaling pathway GO:0030111 53 0.015
system process GO:0003008 185 0.015
lipid homeostasis GO:0055088 3 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.015
embryonic limb morphogenesis GO:0030326 2 0.015
lateral line development GO:0048882 66 0.015
response to vitamin GO:0033273 3 0.015
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.015
regulation of protein localization to plasma membrane GO:1903076 1 0.015
response to uv GO:0009411 3 0.015
regulation of sequestering of calcium ion GO:0051282 4 0.014
negative regulation of nervous system development GO:0051961 22 0.014
lateral line system development GO:0048925 76 0.014
pancreas development GO:0031016 84 0.014
regulation of binding GO:0051098 3 0.014
regulation of cell motility GO:2000145 46 0.014
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.014
cellular component biogenesis GO:0044085 178 0.014
epithelial tube morphogenesis GO:0060562 148 0.014
response to wounding GO:0009611 116 0.014
regulation of bone remodeling GO:0046850 2 0.014
small molecule metabolic process GO:0044281 77 0.014
positive regulation of cell cycle GO:0045787 3 0.014
positive regulation of catabolic process GO:0009896 4 0.014
regulation of extent of cell growth GO:0061387 29 0.014
spinal cord development GO:0021510 46 0.014
regulation of multicellular organism growth GO:0040014 4 0.014
positive regulation of biosynthetic process GO:0009891 68 0.014
carbohydrate homeostasis GO:0033500 1 0.014
positive regulation of metabolic process GO:0009893 108 0.014
neurotransmitter transport GO:0006836 2 0.014
regulation of establishment of protein localization GO:0070201 4 0.014
cellular amino acid metabolic process GO:0006520 7 0.014
enzyme linked receptor protein signaling pathway GO:0007167 106 0.014
response to hexose GO:0009746 3 0.014
embryonic skeletal system development GO:0048706 97 0.014
epidermis development GO:0008544 48 0.013
cellular response to chemical stimulus GO:0070887 157 0.013
embryonic heart tube development GO:0035050 133 0.013
embryonic skeletal system morphogenesis GO:0048704 93 0.013
regulation of ion transmembrane transporter activity GO:0032412 2 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.013
cell death GO:0008219 121 0.013
mesenchyme development GO:0060485 127 0.013
erk1 and erk2 cascade GO:0070371 4 0.013
negative regulation of protein kinase activity GO:0006469 4 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.013
otic vesicle formation GO:0030916 27 0.013
gastrulation GO:0007369 208 0.013
development of primary female sexual characteristics GO:0046545 4 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.013
negative regulation of signal transduction GO:0009968 94 0.013
b cell activation GO:0042113 2 0.013
cell proliferation GO:0008283 80 0.013
mitochondrion organization GO:0007005 4 0.013
transport GO:0006810 220 0.013
rhombomere 6 development GO:0021572 4 0.012
embryonic cranial skeleton morphogenesis GO:0048701 90 0.012
wound healing GO:0042060 90 0.012
positive regulation of cellular catabolic process GO:0031331 3 0.012
apoptotic process GO:0006915 116 0.012
mechanosensory lateral line system development GO:0048881 49 0.012
death GO:0016265 121 0.012
negative regulation of sequestering of calcium ion GO:0051283 4 0.012
regulation of cellular component movement GO:0051270 55 0.012
regulation of transmembrane transporter activity GO:0022898 2 0.012
organelle organization GO:0006996 227 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
oligodendrocyte differentiation GO:0048709 23 0.012
negative regulation of cell communication GO:0010648 96 0.012
cell fate specification GO:0001708 68 0.012
negative regulation of apoptotic process GO:0043066 55 0.012
release of sequestered calcium ion into cytosol GO:0051209 3 0.012
positive regulation of gene expression GO:0010628 71 0.012
mitotic cytokinesis GO:0000281 3 0.012
single organism organelle organization GO:1902589 199 0.012
negative regulation of protein phosphorylation GO:0001933 4 0.012
programmed cell death GO:0012501 119 0.012
response to nutrient GO:0007584 3 0.012
protein acylation GO:0043543 3 0.012
otic placode formation GO:0043049 23 0.012
positive regulation of protein polymerization GO:0032273 2 0.012
cellular response to fibroblast growth factor stimulus GO:0044344 22 0.012
regulation of cell migration GO:0030334 40 0.012
establishment of protein localization to organelle GO:0072594 4 0.012
stem cell proliferation GO:0072089 4 0.011
regulation of meiotic cell cycle GO:0051445 1 0.011
negative regulation of kinase activity GO:0033673 4 0.011
regulation of muscle contraction GO:0006937 3 0.011
peptidyl serine modification GO:0018209 2 0.011
regulation of cell activation GO:0050865 1 0.011
convergent extension GO:0060026 118 0.011
mitotic dna integrity checkpoint GO:0044774 4 0.011
cytoskeleton dependent cytokinesis GO:0061640 3 0.011
digestive tract morphogenesis GO:0048546 231 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.011
regulation of transporter activity GO:0032409 2 0.011
response to drug GO:0042493 3 0.011
nerve development GO:0021675 45 0.011
ribonucleoside monophosphate catabolic process GO:0009158 4 0.011
embryonic pattern specification GO:0009880 44 0.011
cellular response to stress GO:0033554 62 0.011
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.011
protein targeting to membrane GO:0006612 1 0.011
regulation of endothelial cell proliferation GO:0001936 1 0.011
response to hydrogen peroxide GO:0042542 3 0.011
pectoral fin morphogenesis GO:0035138 29 0.011
regulation of cell growth GO:0001558 29 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
bone remodeling GO:0046849 2 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
single organism membrane fusion GO:0044801 2 0.011
stem cell development GO:0048864 82 0.011
regulation of cell size GO:0008361 29 0.011
negative regulation of map kinase activity GO:0043407 2 0.011
sequestering of metal ion GO:0051238 3 0.011
negative regulation of cell development GO:0010721 26 0.011
gtp catabolic process GO:0006184 2 0.011
regulation of cell shape GO:0008360 1 0.011
positive regulation of nucleic acid templated transcription GO:1903508 57 0.011
atp catabolic process GO:0006200 4 0.011
neurotransmitter secretion GO:0007269 2 0.011
response to organic substance GO:0010033 153 0.010
protein polymerization GO:0051258 4 0.010
chemosensory behavior GO:0007635 1 0.010
peptide metabolic process GO:0006518 1 0.010
guanosine containing compound catabolic process GO:1901069 2 0.010
spermatid development GO:0007286 2 0.010
negative regulation of metabolic process GO:0009892 86 0.010
cranial nerve development GO:0021545 42 0.010
embryonic skeletal joint morphogenesis GO:0060272 3 0.010
positive regulation of transcription dna templated GO:0045893 57 0.010
response to glucocorticoid GO:0051384 1 0.010
amyloid precursor protein metabolic process GO:0042982 1 0.010
response to glucose GO:0009749 3 0.010
wnt signaling pathway GO:0016055 80 0.010
positive regulation of cellular metabolic process GO:0031325 94 0.010
ear morphogenesis GO:0042471 64 0.010
regulation of locomotion GO:0040012 55 0.010
central nervous system neuron development GO:0021954 29 0.010
protein import GO:0017038 3 0.010
posterior lateral line system development GO:0048915 46 0.010
negative regulation of signaling GO:0023057 96 0.010
regulation of cytokine production GO:0001817 3 0.010
sequestering of calcium ion GO:0051208 3 0.010
negative regulation of cell projection organization GO:0031345 9 0.010
otic vesicle morphogenesis GO:0071600 34 0.010
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.010
multi organism process GO:0051704 134 0.010

shox2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.044
cancer DOID:162 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
disease of metabolism DOID:0014667 0 0.025
organ system cancer DOID:0050686 0 0.020
musculoskeletal system disease DOID:17 0 0.018
nervous system disease DOID:863 0 0.015
immune system disease DOID:2914 0 0.012