Danio rerio

111 known processes

pax6a

paired box gene 6a

(Aliases: pax-a,paxzfa,wu:fc20e07,Pax6.1,pax[zf-a],pax6,zfpax-6b,cb280,zfpax-6a,fc20e07,PAXZF-A)

pax6a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
camera type eye development GO:0043010 222 0.997
oligodendrocyte cell fate specification GO:0021778 4 0.994
Mouse
abducens nucleus development GO:0021742 2 0.992
ventral spinal cord interneuron fate commitment GO:0060579 3 0.990
Mouse
forebrain midbrain boundary formation GO:0021905 1 0.989
Mouse
sensory organ morphogenesis GO:0090596 200 0.988
central nervous system development GO:0007417 387 0.985
forebrain neuron development GO:0021884 7 0.984
neuron differentiation GO:0030182 353 0.977
response to chemical GO:0042221 320 0.976
Mouse Rat
eye development GO:0001654 277 0.976
forebrain anterior posterior pattern specification GO:0021797 3 0.974
Mouse
regulation of gene expression GO:0010468 265 0.969
camera type eye morphogenesis GO:0048593 108 0.968
neuron fate determination GO:0048664 2 0.958
central nervous system neuron differentiation GO:0021953 74 0.958
Mouse
embryonic organ development GO:0048568 381 0.946
Mouse
cell proliferation in forebrain GO:0021846 3 0.942
Rat
transcription dna templated GO:0006351 181 0.935
cellular macromolecule biosynthetic process GO:0034645 224 0.919
embryonic skeletal system development GO:0048706 97 0.914
response to organic substance GO:0010033 153 0.910
Rat
cellular nitrogen compound biosynthetic process GO:0044271 218 0.909
embryonic cranial skeleton morphogenesis GO:0048701 90 0.902
cellular macromolecule metabolic process GO:0044260 391 0.901
organic cyclic compound metabolic process GO:1901360 301 0.896
brain development GO:0007420 293 0.895
sensory organ development GO:0007423 393 0.887
cell fate commitment GO:0045165 99 0.885
Mouse Rat Fly
spinal cord motor neuron cell fate specification GO:0021520 8 0.884
Mouse
regulation of macromolecule biosynthetic process GO:0010556 225 0.883
forebrain development GO:0030900 96 0.882
spinal cord motor neuron differentiation GO:0021522 26 0.871
Mouse
positive regulation of nervous system development GO:0051962 25 0.868
Mouse Rat
brain morphogenesis GO:0048854 18 0.857
Fly
nucleic acid metabolic process GO:0090304 244 0.857
regulation of primary metabolic process GO:0080090 311 0.856
nucleobase containing compound biosynthetic process GO:0034654 205 0.854
cellular biosynthetic process GO:0044249 286 0.853
stem cell fate determination GO:0048867 1 0.849
glial cell fate specification GO:0021780 4 0.849
Mouse
retinal cell programmed cell death GO:0046666 2 0.836
forebrain generation of neurons GO:0021872 14 0.835
Mouse
neuron fate commitment GO:0048663 26 0.834
Mouse Fly
negative regulation of neurogenesis GO:0050768 20 0.823
Mouse
neuron development GO:0048666 262 0.818
Mouse Rat
regulation of inner ear receptor cell differentiation GO:2000980 1 0.816
mesenchymal cell differentiation GO:0048762 87 0.814
Rat
cell projection morphogenesis GO:0048858 244 0.805
Mouse
rna biosynthetic process GO:0032774 181 0.794
diencephalon morphogenesis GO:0048852 5 0.791
positive regulation of rna biosynthetic process GO:1902680 57 0.783
ventral spinal cord development GO:0021517 35 0.781
Mouse
regulation of nucleic acid templated transcription GO:1903506 213 0.778
negative regulation of nervous system development GO:0051961 22 0.777
Mouse
regulation of neuron differentiation GO:0045664 56 0.774
Mouse Rat
negative regulation of neuron differentiation GO:0045665 10 0.769
Mouse
generation of neurons GO:0048699 385 0.761
head development GO:0060322 303 0.758
neuroblast fate commitment GO:0014017 1 0.756
regulation of rna biosynthetic process GO:2001141 213 0.751
embryonic organ morphogenesis GO:0048562 274 0.749
Mouse
negative regulation of cellular biosynthetic process GO:0031327 55 0.743
Mouse
nucleobase containing compound metabolic process GO:0006139 274 0.731
positive regulation of biological process GO:0048518 253 0.722
macromolecule biosynthetic process GO:0009059 227 0.720
heterocycle metabolic process GO:0046483 290 0.712
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.710
Human Zebrafish Mouse Rat
auditory receptor cell fate commitment GO:0009912 4 0.708
stem cell development GO:0048864 82 0.705
Rat
regulation of multicellular organismal process GO:0051239 277 0.699
Mouse Rat Fly
positive regulation of neural precursor cell proliferation GO:2000179 1 0.697
Mouse
chordate embryonic development GO:0043009 271 0.696
Mouse
retina layer formation GO:0010842 24 0.696
cellular response to organic substance GO:0071310 105 0.694
Rat
cell morphogenesis GO:0000902 289 0.694
Mouse
nitrogen compound metabolic process GO:0006807 319 0.687
inner ear receptor cell fate commitment GO:0060120 4 0.662
regulation of mechanoreceptor differentiation GO:0045631 1 0.653
photoreceptor cell fate commitment GO:0046552 1 0.653
Fly
cerebellar cortex development GO:0021695 5 0.644
axon development GO:0061564 166 0.642
Mouse
intracellular estrogen receptor signaling pathway GO:0030520 3 0.642
central nervous system neuron development GO:0021954 29 0.630
cell proliferation in hindbrain GO:0021534 4 0.623
photoreceptor cell fate specification GO:0043704 1 0.621
Fly
embryonic skeletal system morphogenesis GO:0048704 93 0.620
cell cell signaling GO:0007267 52 0.617
Rat
forebrain regionalization GO:0021871 4 0.616
Mouse
pancreatic a cell development GO:0003322 2 0.612
Human Mouse Rat
neuroblast fate determination GO:0007400 1 0.600
regionalization GO:0003002 274 0.598
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.585
hindbrain development GO:0030902 91 0.584
neurological system process GO:0050877 62 0.583
skeletal system morphogenesis GO:0048705 102 0.582
embryonic viscerocranium morphogenesis GO:0048703 52 0.579
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.558
positive regulation of cell fate specification GO:0042660 1 0.552
Rat
lens morphogenesis in camera type eye GO:0002089 7 0.551
Zebrafish
negative regulation of cellular process GO:0048523 283 0.551
Mouse
neuron projection morphogenesis GO:0048812 161 0.543
Mouse
positive regulation of cellular biosynthetic process GO:0031328 68 0.543
cell morphogenesis involved in differentiation GO:0000904 195 0.541
Mouse
negative regulation of cell development GO:0010721 26 0.535
Mouse
neuron fate specification GO:0048665 20 0.530
Mouse Fly
negative regulation of neural precursor cell proliferation GO:2000178 1 0.530
Mouse
posterior lateral line system development GO:0048915 46 0.529
negative regulation of chemotaxis GO:0050922 4 0.527
retinal pigment epithelium development GO:0003406 8 0.520
mechanoreceptor differentiation GO:0042490 37 0.520
dendrite guidance GO:0070983 0 0.518
cell part morphogenesis GO:0032990 246 0.515
Mouse
eye morphogenesis GO:0048592 144 0.512
motor neuron axon guidance GO:0008045 23 0.505
positive regulation of oligodendrocyte differentiation GO:0048714 1 0.504
regulation of metabolic process GO:0019222 359 0.503
forebrain neuron fate commitment GO:0021877 1 0.487
Mouse
specification of symmetry GO:0009799 204 0.487
astrocyte differentiation GO:0048708 1 0.486
Mouse Rat
retina morphogenesis in camera type eye GO:0060042 79 0.477
regulation of transcription dna templated GO:0006355 213 0.476
axon guidance GO:0007411 86 0.469
Mouse
specification of organ identity GO:0010092 2 0.455
iris morphogenesis GO:0061072 1 0.452
Human
regulation of neural precursor cell proliferation GO:2000177 3 0.436
Mouse
regulation of neurogenesis GO:0050767 87 0.436
Mouse Rat
peripheral nervous system development GO:0007422 55 0.434
heterocycle biosynthetic process GO:0018130 215 0.431
neuroblast differentiation GO:0014016 1 0.429
mesenchymal cell development GO:0014031 78 0.425
Rat
cellular response to chemical stimulus GO:0070887 157 0.415
Rat
regulation of developmental process GO:0050793 247 0.415
Mouse Rat Fly
regulation of axonogenesis GO:0050770 32 0.408
regulation of macromolecule metabolic process GO:0060255 317 0.407
regulation of cell development GO:0060284 100 0.404
Mouse Rat
positive regulation of glial cell differentiation GO:0045687 1 0.404
spinal cord oligodendrocyte cell fate specification GO:0021530 2 0.400
diencephalon development GO:0021536 58 0.400
Mouse
positive regulation of cellular process GO:0048522 201 0.399
stem cell fate commitment GO:0048865 1 0.398
regulation of cellular biosynthetic process GO:0031326 245 0.391
cellular aromatic compound metabolic process GO:0006725 295 0.388
glandular epithelial cell differentiation GO:0002067 9 0.384
Human Zebrafish Mouse Rat
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.380
Mouse
lens development in camera type eye GO:0002088 22 0.380
Zebrafish Mouse
regulation of biosynthetic process GO:0009889 250 0.375
anterior commissure morphogenesis GO:0021960 3 0.375
peripheral nervous system neuron differentiation GO:0048934 28 0.372
cell migration GO:0016477 237 0.371
Mouse Rat Fly
innervation GO:0060384 3 0.363
positive regulation of nucleic acid templated transcription GO:1903508 57 0.362
positive regulation of transcription dna templated GO:0045893 57 0.354
maintenance of location GO:0051235 4 0.351
oligodendrocyte development GO:0014003 7 0.347
cognition GO:0050890 1 0.345
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.341
lipid storage GO:0019915 1 0.340
rna metabolic process GO:0016070 219 0.339
single organism localization GO:1902578 225 0.334
Mouse Rat
cell surface receptor signaling pathway GO:0007166 325 0.334
Mouse Fly
positive regulation of transport GO:0051050 2 0.328
Rat
aromatic compound biosynthetic process GO:0019438 217 0.323
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.318
cellular component morphogenesis GO:0032989 336 0.316
Mouse
organelle organization GO:0006996 227 0.315
Mouse
response to oxygen containing compound GO:1901700 55 0.315
Rat
auditory receptor cell fate determination GO:0042668 2 0.313
adenohypophysis development GO:0021984 15 0.311
regulation of nitrogen compound metabolic process GO:0051171 251 0.308
chemotaxis GO:0006935 104 0.306
Mouse
regulation of cellular metabolic process GO:0031323 320 0.305
regulation of oligodendrocyte differentiation GO:0048713 1 0.301
regeneration GO:0031099 91 0.295
heart morphogenesis GO:0003007 156 0.290
vasculogenesis GO:0001570 41 0.289
central nervous system myelination GO:0022010 2 0.285
positive regulation of biosynthetic process GO:0009891 68 0.285
organic cyclic compound biosynthetic process GO:1901362 223 0.285
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.283
Mouse
mammillary body development GO:0021767 4 0.275
regulation of glial cell differentiation GO:0045685 4 0.274
heart development GO:0007507 313 0.271
neuron neuron synaptic transmission GO:0007270 1 0.268
regulation of multicellular organismal development GO:2000026 223 0.267
Mouse Rat
negative regulation of cell differentiation GO:0045596 46 0.260
Mouse
spinal cord association neuron differentiation GO:0021527 1 0.256
retinal ganglion cell axon guidance GO:0031290 35 0.255
neuron projection guidance GO:0097485 86 0.245
Mouse
organic substance biosynthetic process GO:1901576 289 0.241
morphogenesis of an epithelium GO:0002009 333 0.239
otic vesicle development GO:0071599 42 0.239
epithelial cell differentiation GO:0030855 116 0.237
Human Zebrafish Mouse Rat
nucleic acid templated transcription GO:0097659 181 0.229
rostrocaudal neural tube patterning GO:0021903 29 0.229
Mouse
positive regulation of cell cycle GO:0045787 3 0.229
positive regulation of signal transduction GO:0009967 56 0.227
ear morphogenesis GO:0042471 64 0.225
positive regulation of rna metabolic process GO:0051254 59 0.224
neuron migration GO:0001764 22 0.222
Mouse Rat
forebrain morphogenesis GO:0048853 6 0.220
gland development GO:0048732 143 0.220
Mouse
negative regulation of nucleic acid templated transcription GO:1903507 45 0.217
Mouse
gabaergic neuron differentiation GO:0097154 2 0.216
cellular component movement GO:0006928 335 0.213
Mouse Rat Fly
determination of bilateral symmetry GO:0009855 204 0.211
forebrain neuron differentiation GO:0021879 14 0.211
Mouse
larval development GO:0002164 2 0.206
positive regulation of gliogenesis GO:0014015 2 0.204
axonogenesis GO:0007409 152 0.203
Mouse
enzyme linked receptor protein signaling pathway GO:0007167 106 0.200
Fly
cell proliferation in midbrain GO:0033278 4 0.195
olfactory bulb development GO:0021772 4 0.195
Rat
neural tube patterning GO:0021532 33 0.193
Mouse
synaptic transmission GO:0007268 35 0.192
glial cell fate commitment GO:0021781 6 0.192
Mouse
post embryonic morphogenesis GO:0009886 4 0.191
positive regulation of neuron differentiation GO:0045666 12 0.190
determination of left right symmetry GO:0007368 179 0.188
forebrain cell migration GO:0021885 1 0.184
somatic motor neuron differentiation GO:0021523 5 0.183
Mouse
blood vessel development GO:0001568 246 0.183
Human
transport GO:0006810 220 0.181
Rat
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.180
Mouse
determination of pancreatic left right asymmetry GO:0035469 11 0.179
positive regulation of cell proliferation GO:0008284 15 0.177
regulation of cell differentiation GO:0045595 142 0.177
Mouse Rat
single organism behavior GO:0044708 24 0.177
Fly
neural tube development GO:0021915 62 0.174
Mouse
blood vessel morphogenesis GO:0048514 216 0.173
neural crest cell differentiation GO:0014033 72 0.171
Rat
peripheral nervous system neuron development GO:0048935 22 0.168
positive regulation of epithelial cell differentiation GO:0030858 2 0.167
Mouse
negative regulation of transcription dna templated GO:0045892 45 0.167
Mouse
positive regulation of macromolecule metabolic process GO:0010604 93 0.166
gene expression GO:0010467 252 0.165
protein metabolic process GO:0019538 183 0.163
Mouse Rat
negative regulation of rna metabolic process GO:0051253 48 0.163
Mouse
positive regulation of cell division GO:0051781 2 0.163
hindbrain morphogenesis GO:0021575 22 0.161
segmentation GO:0035282 97 0.159
optic cup morphogenesis involved in camera type eye development GO:0002072 7 0.157
positive regulation of gene expression GO:0010628 71 0.156
glial cell development GO:0021782 20 0.155
limbic system development GO:0021761 16 0.155
cardiac cell fate commitment GO:0060911 1 0.155
neural crest cell development GO:0014032 62 0.153
Rat
cardiocyte differentiation GO:0035051 44 0.152
regulation of neuron projection development GO:0010975 40 0.150
Rat
inner ear receptor cell differentiation GO:0060113 29 0.150
inner ear development GO:0048839 126 0.149
skeletal system development GO:0001501 181 0.147
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.145
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.142
neural precursor cell proliferation GO:0061351 20 0.141
Mouse Rat
dorsal ventral pattern formation GO:0009953 125 0.139
Mouse
cardiac muscle tissue development GO:0048738 48 0.138
mesoderm development GO:0007498 88 0.135
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.134
epithelial tube morphogenesis GO:0060562 148 0.131
cellular lipid catabolic process GO:0044242 3 0.131
anterior posterior pattern specification GO:0009952 152 0.130
pituitary gland development GO:0021983 16 0.130
Mouse
regulation of cell cycle GO:0051726 52 0.130
negative regulation of gliogenesis GO:0014014 1 0.130
endocardium formation GO:0060214 1 0.129
ventral spinal cord interneuron differentiation GO:0021514 12 0.129
Mouse
positive regulation of developmental process GO:0051094 50 0.129
Mouse Rat Fly
regulation of biological quality GO:0065008 263 0.128
Human Rat
endodermal digestive tract morphogenesis GO:0061031 2 0.127
heart looping GO:0001947 94 0.126
regulation of cell communication GO:0010646 232 0.126
Rat Fly
spinal cord development GO:0021510 46 0.124
Mouse Rat
hair cell differentiation GO:0035315 32 0.124
single organism transport GO:0044765 206 0.121
Rat
stem cell proliferation GO:0072089 4 0.120
Mouse
pancreatic d cell differentiation GO:0003311 2 0.119
Zebrafish
striated muscle cell differentiation GO:0051146 129 0.119
taxis GO:0042330 109 0.118
Mouse
negative regulation of signaling GO:0023057 96 0.118
primary neural tube formation GO:0014020 1 0.118
epidermal cell fate specification GO:0009957 4 0.117
pigmentation GO:0043473 85 0.116
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.115
Mouse
tube morphogenesis GO:0035239 349 0.115
pancreatic a cell differentiation GO:0003310 6 0.114
Human Zebrafish Mouse Rat
system process GO:0003008 185 0.114
somitogenesis GO:0001756 87 0.114
response to stress GO:0006950 263 0.112
Human
dendrite morphogenesis GO:0048813 5 0.112
photoreceptor cell differentiation GO:0046530 55 0.112
midbrain hindbrain boundary development GO:0030917 23 0.111
protein import into nucleus GO:0006606 3 0.110
cell fate specification involved in pattern specification GO:0060573 3 0.108
Mouse
negative regulation of biosynthetic process GO:0009890 55 0.108
Mouse
behavior GO:0007610 74 0.107
Fly
lateral line development GO:0048882 66 0.106
eye photoreceptor cell differentiation GO:0001754 45 0.105
neuroblast proliferation GO:0007405 2 0.105
Mouse
central nervous system neuron axonogenesis GO:0021955 18 0.103
embryonic camera type eye development GO:0031076 29 0.103
Mouse
otic vesicle formation GO:0030916 27 0.102
ensheathment of neurons GO:0007272 18 0.101
axon regeneration GO:0031103 14 0.100
growth GO:0040007 174 0.099
Fly
biosynthetic process GO:0009058 294 0.098
axonal fasciculation GO:0007413 11 0.098
aorta development GO:0035904 4 0.098
cellular protein metabolic process GO:0044267 129 0.098
Mouse
positive regulation of cell differentiation GO:0045597 30 0.096
Mouse Rat
wnt signaling pathway GO:0016055 80 0.096
negative regulation of metabolic process GO:0009892 86 0.095
Mouse
positive regulation of cell communication GO:0010647 56 0.094
Rat
regulation of protein metabolic process GO:0051246 56 0.093
Mouse
neural retina development GO:0003407 49 0.092
embryonic camera type eye morphogenesis GO:0048596 19 0.090
Mouse
taste bud formation GO:0061195 3 0.090
positive regulation of stem cell proliferation GO:2000648 1 0.089
Mouse
neuroepithelial cell differentiation GO:0060563 26 0.088
camera type eye photoreceptor cell differentiation GO:0060219 19 0.088
glial cell migration GO:0008347 3 0.087
Fly
regulation of photoreceptor cell differentiation GO:0046532 2 0.086
protein import GO:0017038 3 0.084
embryo development ending in birth or egg hatching GO:0009792 271 0.084
Mouse
regulation of programmed cell death GO:0043067 101 0.083
neural tube formation GO:0001841 16 0.083
positive regulation of neurogenesis GO:0050769 24 0.082
Mouse Rat
nuclear division GO:0000280 23 0.082
nucleocytoplasmic transport GO:0006913 4 0.082
negative regulation of developmental process GO:0051093 65 0.081
Mouse
artery morphogenesis GO:0048844 14 0.081
protein targeting to nucleus GO:0044744 3 0.080
glial cell fate determination GO:0007403 1 0.080
cell differentiation in spinal cord GO:0021515 40 0.079
Mouse
regulation of membrane potential GO:0042391 23 0.079
sensory system development GO:0048880 76 0.079
enteroendocrine cell differentiation GO:0035883 9 0.078
Human Zebrafish Mouse Rat
cellular response to prostaglandin stimulus GO:0071379 3 0.077
Rat
negative regulation of axon extension GO:0030517 7 0.077
atrial ventricular junction remodeling GO:0003294 2 0.077
mesodermal cell differentiation GO:0048333 21 0.077
negative regulation of cell projection organization GO:0031345 9 0.076
epithelial cell fate commitment GO:0072148 11 0.076
retina development in camera type eye GO:0060041 146 0.076
negative regulation of gene expression GO:0010629 65 0.074
Mouse
lipid catabolic process GO:0016042 4 0.074
embryonic heart tube morphogenesis GO:0003143 108 0.074
developmental programmed cell death GO:0010623 4 0.073
cellular nitrogen compound metabolic process GO:0034641 290 0.073
developmental growth GO:0048589 166 0.072
Fly
regulation of cell activation GO:0050865 1 0.071
adult behavior GO:0030534 2 0.071
Fly
spinal cord dorsal ventral patterning GO:0021513 5 0.071
Mouse
regulation of axon extension GO:0030516 24 0.071
cellular protein modification process GO:0006464 100 0.070
Mouse
phosphate containing compound metabolic process GO:0006796 108 0.070
Mouse
negative regulation of endothelial cell migration GO:0010596 1 0.069
multi organism process GO:0051704 134 0.069
single organism metabolic process GO:0044710 217 0.069
ear development GO:0043583 127 0.069
tube formation GO:0035148 25 0.067
regulation of dendrite development GO:0050773 3 0.066
regulation of neural retina development GO:0061074 2 0.066
regulation of cell proliferation GO:0042127 37 0.065
embryonic heart tube development GO:0035050 133 0.065
striated muscle tissue development GO:0014706 110 0.065
axon midline choice point recognition GO:0016199 4 0.064
response to external stimulus GO:0009605 264 0.064
Mouse
posterior lateral line nerve development GO:0048918 8 0.063
organelle fission GO:0048285 23 0.063
cerebellar granular layer development GO:0021681 3 0.063
central nervous system projection neuron axonogenesis GO:0021952 15 0.062
regulation of rna metabolic process GO:0051252 224 0.062
cardiac chamber formation GO:0003207 4 0.061
mesodermal cell fate specification GO:0007501 12 0.061
establishment of organelle localization GO:0051656 45 0.061
Mouse
positive regulation of multicellular organismal process GO:0051240 52 0.060
Mouse Rat Fly
central nervous system myelin formation GO:0032289 1 0.060
cell proliferation GO:0008283 80 0.060
neuromast development GO:0048884 46 0.060
signal transduction GO:0007165 455 0.060
Mouse Fly
ventricular system development GO:0021591 12 0.059
negative regulation of rna biosynthetic process GO:1902679 45 0.059
Mouse
muscle structure development GO:0061061 196 0.058
aging GO:0007568 2 0.058
endodermal cell fate determination GO:0007493 2 0.057
organelle localization GO:0051640 49 0.057
Mouse Rat
cell cell signaling involved in cell fate commitment GO:0045168 12 0.057
positive regulation of cell development GO:0010720 25 0.057
Mouse Rat
regulation of synaptic plasticity GO:0048167 1 0.057
determination of intestine left right asymmetry GO:0071908 2 0.056
patterning of lymph vessels GO:0060854 1 0.056
regulation of multicellular organism growth GO:0040014 4 0.056
Fly
canonical wnt signaling pathway GO:0060070 48 0.056
myelination GO:0042552 18 0.056
mitotic nuclear division GO:0007067 18 0.056
regulation of response to stimulus GO:0048583 269 0.055
Fly
nuclear transport GO:0051169 4 0.055
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.055
digestive system development GO:0055123 289 0.054
taste bud morphogenesis GO:0061194 3 0.053
hematopoietic or lymphoid organ development GO:0048534 191 0.053
nerve development GO:0021675 45 0.052
negative regulation of biological process GO:0048519 304 0.052
Mouse
stem cell differentiation GO:0048863 117 0.052
Rat
gliogenesis GO:0042063 45 0.051
Mouse Rat Fly
neuron projection development GO:0031175 180 0.051
Mouse Rat
gamete generation GO:0007276 33 0.051
heart formation GO:0060914 13 0.050
water homeostasis GO:0030104 4 0.050
floor plate development GO:0033504 15 0.050
chemosensory behavior GO:0007635 1 0.050
circulatory system process GO:0003013 87 0.048
regulation of signal transduction GO:0009966 225 0.047
Fly
positive regulation of response to stimulus GO:0048584 80 0.047
negative regulation of neuron projection development GO:0010977 9 0.047
tissue regeneration GO:0042246 74 0.047
response to hormone GO:0009725 48 0.047
Rat
single organism organelle organization GO:1902589 199 0.047
Mouse
sensory perception GO:0007600 39 0.046
sexual reproduction GO:0019953 36 0.046
pancreatic d cell development GO:0003324 1 0.046
regulation of locomotion GO:0040012 55 0.046
Mouse Rat
carboxylic acid catabolic process GO:0046395 3 0.046
skin development GO:0043588 54 0.046
Mouse
glial cell differentiation GO:0010001 42 0.045
Mouse Rat
developmental pigmentation GO:0048066 48 0.045
lymph vessel morphogenesis GO:0036303 25 0.044
oligodendrocyte differentiation GO:0048709 23 0.044
Mouse
stem cell division GO:0017145 1 0.044
epithelial cell development GO:0002064 42 0.044
Human Mouse Rat
negative regulation of axonogenesis GO:0050771 7 0.044
establishment of protein localization to organelle GO:0072594 4 0.043
reflex GO:0060004 2 0.043
brain segmentation GO:0035284 6 0.042
ventral spinal cord interneuron specification GO:0021521 3 0.042
Mouse
thalamus development GO:0021794 6 0.042
embryonic heart tube formation GO:0003144 1 0.042
lymphangiogenesis GO:0001946 25 0.041
homeostatic process GO:0042592 142 0.040
Human Rat
regulation of binding GO:0051098 3 0.040
epithelial tube formation GO:0072175 19 0.040
midbrain hindbrain boundary morphogenesis GO:0021555 5 0.040
auditory receptor cell development GO:0060117 8 0.040
neuromast hair cell differentiation GO:0048886 12 0.040
intracellular receptor signaling pathway GO:0030522 30 0.040
regulation of dendrite morphogenesis GO:0048814 3 0.040
determination of digestive tract left right asymmetry GO:0071907 10 0.040
establishment of localization in cell GO:0051649 77 0.039
Mouse Rat
negative regulation of epithelial cell migration GO:0010633 1 0.039
telencephalon development GO:0021537 14 0.039
Mouse Rat
regulation of establishment of protein localization GO:0070201 4 0.039
locomotion GO:0040011 313 0.038
Mouse Rat Fly
regulation of cardiac muscle tissue development GO:0055024 1 0.038
vasculature development GO:0001944 278 0.037
Human
pectoral fin morphogenesis GO:0035138 29 0.037
chemical homeostasis GO:0048878 49 0.037
Human Rat
regulation of neuron migration GO:2001222 2 0.037
Rat
neuron projection regeneration GO:0031102 16 0.037
positive regulation of neuron apoptotic process GO:0043525 1 0.037
cardiac muscle cell differentiation GO:0055007 30 0.036
response to abiotic stimulus GO:0009628 122 0.036
dna alkylation GO:0006305 8 0.035
response to wounding GO:0009611 116 0.035
Human
action potential GO:0001508 19 0.035
multicellular organismal reproductive process GO:0048609 35 0.034
cellular homeostasis GO:0019725 26 0.034
Rat
primitive hemopoiesis GO:0060215 27 0.034
neuronal stem cell maintenance GO:0097150 2 0.034
pancreas development GO:0031016 84 0.034
Human Zebrafish Mouse Rat
morphogenesis of embryonic epithelium GO:0016331 30 0.034
lateral mesoderm development GO:0048368 23 0.034
heart field specification GO:0003128 1 0.034
neuron recognition GO:0008038 18 0.034
tube closure GO:0060606 1 0.033
reproduction GO:0000003 40 0.033
epidermis development GO:0008544 48 0.033
Mouse
sensory epithelium regeneration GO:0070654 14 0.033
response to drug GO:0042493 3 0.033
Rat
trigeminal nerve development GO:0021559 3 0.032
axon extension GO:0048675 45 0.032
response to lipid GO:0033993 60 0.032
Rat
exocrine system development GO:0035272 28 0.032
Mouse
pronephros development GO:0048793 69 0.031
localization of cell GO:0051674 244 0.031
Mouse Rat Fly
peripheral nervous system neuron axonogenesis GO:0048936 13 0.031
regulation of cytokine production GO:0001817 3 0.031
regulation of gliogenesis GO:0014013 6 0.031

pax6a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 0 0.383
Human
disease of anatomical entity DOID:7 0 0.383
Human
eye and adnexa disease DOID:1492 0 0.383
Human
nervous system disease DOID:863 0 0.383
Human
eye disease DOID:5614 0 0.383
Human
physical disorder DOID:0080015 0 0.242
congenital nervous system abnormality DOID:2490 0 0.242
disease of metabolism DOID:0014667 0 0.043
hemochromatosis DOID:2352 0 0.043
inherited metabolic disorder DOID:655 0 0.043
metal metabolism disorder DOID:896 0 0.043