Danio rerio

0 known processes

mknk2a

MAP kinase-interacting serine/threonine kinase 2a

(Aliases: zgc:55587,fi34c11,wu:fi41e12,wu:fi34c11)

mknk2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of biosynthetic process GO:0009889 250 0.122
nitrogen compound metabolic process GO:0006807 319 0.090
positive regulation of catabolic process GO:0009896 4 0.088
regulation of nitrogen compound metabolic process GO:0051171 251 0.088
positive regulation of cellular catabolic process GO:0031331 3 0.079
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.079
cellular nitrogen compound metabolic process GO:0034641 290 0.078
protein localization to nucleus GO:0034504 3 0.078
macromolecule biosynthetic process GO:0009059 227 0.072
nucleobase containing compound metabolic process GO:0006139 274 0.071
regulation of metabolic process GO:0019222 359 0.070
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.063
regulation of cellular biosynthetic process GO:0031326 245 0.062
organic cyclic compound metabolic process GO:1901360 301 0.061
regulation of primary metabolic process GO:0080090 311 0.056
gene expression GO:0010467 252 0.055
regulation of nucleoside metabolic process GO:0009118 2 0.054
negative regulation of cellular process GO:0048523 283 0.053
Fly
phosphorus metabolic process GO:0006793 109 0.052
Human Mouse Fly
autophagy GO:0006914 4 0.052
organelle organization GO:0006996 227 0.051
cellular nitrogen compound biosynthetic process GO:0044271 218 0.051
regulation of nucleotide catabolic process GO:0030811 2 0.050
establishment of protein localization to organelle GO:0072594 4 0.050
regulation of transcription dna templated GO:0006355 213 0.049
single organism localization GO:1902578 225 0.047
rna metabolic process GO:0016070 219 0.047
meiotic nuclear division GO:0007126 4 0.047
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.047
cellular component assembly GO:0022607 170 0.047
chordate embryonic development GO:0043009 271 0.047
organic substance biosynthetic process GO:1901576 289 0.046
guanosine containing compound catabolic process GO:1901069 2 0.045
single organism metabolic process GO:0044710 217 0.043
guanosine containing compound metabolic process GO:1901068 4 0.042
biosynthetic process GO:0009058 294 0.040
single organism biosynthetic process GO:0044711 71 0.040
protein import into nucleus GO:0006606 3 0.040
single organism nuclear import GO:1902593 3 0.039
single organism transport GO:0044765 206 0.039
regulation of protein complex assembly GO:0043254 3 0.039
nucleic acid templated transcription GO:0097659 181 0.039
rna biosynthetic process GO:0032774 181 0.038
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.037
heterocycle biosynthetic process GO:0018130 215 0.037
regulation of protein localization to nucleus GO:1900180 2 0.036
regulation of cellular metabolic process GO:0031323 320 0.036
larval development GO:0002164 2 0.035
positive regulation of nucleoside metabolic process GO:0045979 1 0.035
amine metabolic process GO:0009308 2 0.035
positive regulation of gtp catabolic process GO:0033126 1 0.035
nucleocytoplasmic transport GO:0006913 4 0.034
negative regulation of biological process GO:0048519 304 0.034
Fly
gtp catabolic process GO:0006184 2 0.034
regulation of signal transduction GO:0009966 225 0.034
Fly
gtp metabolic process GO:0046039 4 0.034
cell surface receptor signaling pathway GO:0007166 325 0.033
Mouse
nuclear transport GO:0051169 4 0.033
regulation of nucleic acid templated transcription GO:1903506 213 0.033
cellular macromolecule biosynthetic process GO:0034645 224 0.033
organic cyclic compound biosynthetic process GO:1901362 223 0.032
regulation of protein catabolic process GO:0042176 1 0.032
aging GO:0007568 2 0.032
regulation of rna metabolic process GO:0051252 224 0.032
embryo development ending in birth or egg hatching GO:0009792 271 0.032
nuclear import GO:0051170 3 0.031
response to stress GO:0006950 263 0.031
macromolecular complex subunit organization GO:0043933 74 0.031
regionalization GO:0003002 274 0.030
regulation of purine nucleotide catabolic process GO:0033121 2 0.030
positive regulation of cell cycle GO:0045787 3 0.030
embryonic organ development GO:0048568 381 0.030
positive regulation of gtpase activity GO:0043547 1 0.030
negative regulation of cell communication GO:0010648 96 0.030
Fly
organonitrogen compound metabolic process GO:1901564 74 0.030
maintenance of location GO:0051235 4 0.029
regulation of stem cell differentiation GO:2000736 4 0.029
nucleic acid metabolic process GO:0090304 244 0.029
protein import GO:0017038 3 0.029
positive regulation of cellular process GO:0048522 201 0.029
positive regulation of biological process GO:0048518 253 0.029
regulation of gtpase activity GO:0043087 2 0.029
regulation of developmental process GO:0050793 247 0.029
transcription dna templated GO:0006351 181 0.028
phosphate containing compound metabolic process GO:0006796 108 0.028
Human Mouse Fly
phagocytosis GO:0006909 3 0.028
regulation of multicellular organismal process GO:0051239 277 0.028
nucleobase containing compound biosynthetic process GO:0034654 205 0.028
regulation of gtp catabolic process GO:0033124 2 0.028
cellular amine metabolic process GO:0044106 2 0.027
tube morphogenesis GO:0035239 349 0.027
skeletal system development GO:0001501 181 0.027
cellular carbohydrate metabolic process GO:0044262 4 0.027
positive regulation of metabolic process GO:0009893 108 0.027
regulation of multicellular organism growth GO:0040014 4 0.027
negative regulation of protein phosphorylation GO:0001933 4 0.026
regulation of cell communication GO:0010646 232 0.026
Fly
cellular aromatic compound metabolic process GO:0006725 295 0.026
carbohydrate biosynthetic process GO:0016051 1 0.026
neuron differentiation GO:0030182 353 0.026
regulation of multicellular organismal development GO:2000026 223 0.026
cell part morphogenesis GO:0032990 246 0.026
stem cell division GO:0017145 1 0.026
regulation of protein transport GO:0051223 3 0.026
regulation of intracellular protein transport GO:0033157 3 0.025
positive regulation of nucleotide catabolic process GO:0030813 1 0.025
regulation of gene expression GO:0010468 265 0.025
carboxylic acid metabolic process GO:0019752 22 0.025
transport GO:0006810 220 0.025
cellular component biogenesis GO:0044085 178 0.024
localization of cell GO:0051674 244 0.024
regulation of cytoplasmic transport GO:1903649 4 0.024
central nervous system development GO:0007417 387 0.024
aromatic compound biosynthetic process GO:0019438 217 0.024
locomotion GO:0040011 313 0.024
long chain fatty acid transport GO:0015909 1 0.024
lipid storage GO:0019915 1 0.024
protein targeting to nucleus GO:0044744 3 0.024
small molecule metabolic process GO:0044281 77 0.024
centrosome organization GO:0051297 1 0.023
regulation of response to stimulus GO:0048583 269 0.023
Fly
endosomal transport GO:0016197 2 0.023
negative regulation of protein complex assembly GO:0031333 1 0.023
eye development GO:0001654 277 0.023
regulation of macromolecule metabolic process GO:0060255 317 0.023
apoptotic process involved in development GO:1902742 2 0.023
negative regulation of signaling GO:0023057 96 0.023
Fly
cellular component disassembly GO:0022411 1 0.023
single organism organelle organization GO:1902589 199 0.023
regulation of skeletal muscle fiber development GO:0048742 2 0.023
digestive system development GO:0055123 289 0.023
regulation of autophagy GO:0010506 3 0.022
cellular ketone metabolic process GO:0042180 11 0.022
negative regulation of signal transduction GO:0009968 94 0.022
Fly
regulation of lipid catabolic process GO:0050994 2 0.021
lipid metabolic process GO:0006629 52 0.021
multicellular organism growth GO:0035264 4 0.021
regulation of cellular ketone metabolic process GO:0010565 7 0.021
embryonic organ morphogenesis GO:0048562 274 0.021
regulation of rna biosynthetic process GO:2001141 213 0.021
modification dependent protein catabolic process GO:0019941 3 0.021
transcription from rna polymerase ii promoter GO:0006366 80 0.021
positive regulation of transport GO:0051050 2 0.020
regulation of biological quality GO:0065008 263 0.020
response to nutrient GO:0007584 3 0.020
meiotic cell cycle process GO:1903046 3 0.020
meiosis i GO:0007127 1 0.020
protein polymerization GO:0051258 4 0.020
regulation of cell differentiation GO:0045595 142 0.020
negative regulation of kinase activity GO:0033673 4 0.020
ubiquitin dependent protein catabolic process GO:0006511 3 0.020
negative regulation of catabolic process GO:0009895 3 0.020
positive regulation of protein complex assembly GO:0031334 2 0.020
alcohol biosynthetic process GO:0046165 2 0.020
signal transduction GO:0007165 455 0.020
Human Mouse Fly
cellular macromolecule metabolic process GO:0044260 391 0.019
Human Mouse Fly
generation of neurons GO:0048699 385 0.019
positive regulation of cellular component biogenesis GO:0044089 3 0.019
heart development GO:0007507 313 0.019
cellular protein metabolic process GO:0044267 129 0.019
Human Mouse Fly
negative regulation of dna metabolic process GO:0051053 4 0.019
intracellular signal transduction GO:0035556 85 0.019
Human Mouse Fly
negative regulation of cytokine production GO:0001818 1 0.019
regulation of cellular amine metabolic process GO:0033238 0 0.019
cell motility GO:0048870 244 0.019
cellular component movement GO:0006928 335 0.019
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.019
protein heterooligomerization GO:0051291 1 0.019
peptide transport GO:0015833 1 0.018
regulation of reproductive process GO:2000241 4 0.018
regulation of protein targeting GO:1903533 2 0.018
heterocycle metabolic process GO:0046483 290 0.018
negative regulation of cytoplasmic transport GO:1903650 2 0.018
g1 s transition of mitotic cell cycle GO:0000082 1 0.018
hormone secretion GO:0046879 2 0.018
cell projection organization GO:0030030 284 0.018
regulation of hormone secretion GO:0046883 2 0.018
muscle cell development GO:0055001 115 0.018
regulation of signaling GO:0023051 235 0.018
Fly
negative regulation of response to stimulus GO:0048585 104 0.018
Fly
microtubule organizing center organization GO:0031023 1 0.018
regulation of filopodium assembly GO:0051489 2 0.018
response to corticosteroid GO:0031960 1 0.017
cell cycle GO:0007049 93 0.017
stem cell maintenance GO:0019827 4 0.017
regulation of cytokine production GO:0001817 3 0.017
cartilage condensation GO:0001502 3 0.017
negative regulation of protein transport GO:0051224 3 0.017
organophosphate metabolic process GO:0019637 37 0.017
positive regulation of map kinase activity GO:0043406 3 0.017
oxoacid metabolic process GO:0043436 31 0.017
lipid catabolic process GO:0016042 4 0.017
response to endogenous stimulus GO:0009719 83 0.017
regulation of biomineral tissue development GO:0070167 2 0.017
muscle structure development GO:0061061 196 0.017
regulation of dendrite development GO:0050773 3 0.017
regulation of establishment of protein localization GO:0070201 4 0.017
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.016
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.016
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.016
stem cell proliferation GO:0072089 4 0.016
response to drug GO:0042493 3 0.016
negative regulation of intracellular transport GO:0032387 3 0.016
organic anion transport GO:0015711 15 0.016
central nervous system neuron differentiation GO:0021953 74 0.016
superoxide metabolic process GO:0006801 2 0.016
negative regulation of protein kinase activity GO:0006469 4 0.016
modification dependent macromolecule catabolic process GO:0043632 3 0.016
gastrulation GO:0007369 208 0.016
neuron development GO:0048666 262 0.016
lymphocyte proliferation GO:0046651 1 0.016
embryonic heart tube development GO:0035050 133 0.016
muscle cell differentiation GO:0042692 139 0.016
proteasomal protein catabolic process GO:0010498 2 0.015
cytokinesis GO:0000910 3 0.015
rhombomere 5 development GO:0021571 4 0.015
synaptic growth at neuromuscular junction GO:0051124 2 0.015
response to glucocorticoid GO:0051384 1 0.015
lateral inhibition GO:0046331 1 0.015
cell migration GO:0016477 237 0.015
cell morphogenesis GO:0000902 289 0.015
protein complex subunit organization GO:0071822 46 0.015
peptidyl lysine acetylation GO:0018394 2 0.015
regulation of epithelial to mesenchymal transition GO:0010717 3 0.015
single organism membrane fusion GO:0044801 2 0.015
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.015
positive regulation of macromolecule metabolic process GO:0010604 93 0.015
golgi vesicle transport GO:0048193 3 0.015
fatty acid transport GO:0015908 1 0.015
regulation of macromolecule biosynthetic process GO:0010556 225 0.015
digestive tract development GO:0048565 265 0.015
cell cycle g1 s phase transition GO:0044843 1 0.015
i kappab kinase nf kappab signaling GO:0007249 4 0.015
cellular response to organic substance GO:0071310 105 0.015
cellular response to chemical stimulus GO:0070887 157 0.015
Human
centrosome cycle GO:0007098 1 0.015
ameboidal type cell migration GO:0001667 143 0.015
response to hexose GO:0009746 3 0.015
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.015
cellular amino acid metabolic process GO:0006520 7 0.015
lipid homeostasis GO:0055088 3 0.015
positive regulation of cell adhesion GO:0045785 1 0.015
negative regulation of muscle cell differentiation GO:0051148 1 0.014
regulation of nucleocytoplasmic transport GO:0046822 2 0.014
chemosensory behavior GO:0007635 1 0.014
protein complex disassembly GO:0043241 1 0.014
hormone transport GO:0009914 2 0.014
cell projection morphogenesis GO:0048858 244 0.014
regulation of cell activation GO:0050865 1 0.014
regulation of chondrocyte differentiation GO:0032330 1 0.014
primary neural tube formation GO:0014020 1 0.014
cell matrix adhesion GO:0007160 4 0.014
regulation of molecular function GO:0065009 70 0.014
organelle fusion GO:0048284 3 0.014
regulation of dna replication GO:0006275 3 0.014
small molecule catabolic process GO:0044282 3 0.014
regulation of rho protein signal transduction GO:0035023 2 0.014
regulation of epithelial cell proliferation GO:0050678 3 0.014
cellular protein catabolic process GO:0044257 4 0.014
response to hormone GO:0009725 48 0.014
regulation of catalytic activity GO:0050790 55 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.014
response to xenobiotic stimulus GO:0009410 45 0.014
response to vitamin GO:0033273 3 0.014
regulation of glucose transport GO:0010827 1 0.014
cellular response to extracellular stimulus GO:0031668 2 0.014
cellular lipid catabolic process GO:0044242 3 0.014
gland development GO:0048732 143 0.014
positive regulation of cytoskeleton organization GO:0051495 3 0.014
blood vessel development GO:0001568 246 0.013
death GO:0016265 121 0.013
Mouse
membrane invagination GO:0010324 1 0.013
cellular catabolic process GO:0044248 27 0.013
protein acylation GO:0043543 3 0.013
tube closure GO:0060606 1 0.013
germ line stem cell maintenance GO:0030718 2 0.013
regulation of glucose import GO:0046324 1 0.013
embryonic heart tube morphogenesis GO:0003143 108 0.013
homeostatic process GO:0042592 142 0.013
regulation of carbohydrate metabolic process GO:0006109 4 0.013
response to chemical GO:0042221 320 0.013
Human
dorsal ventral pattern formation GO:0009953 125 0.013
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.013
vasculature development GO:0001944 278 0.013
brain development GO:0007420 293 0.013
female sex differentiation GO:0046660 4 0.013
activation of mapk activity GO:0000187 3 0.013
cellular lipid metabolic process GO:0044255 36 0.013
organic acid metabolic process GO:0006082 31 0.013
negative regulation of bmp signaling pathway GO:0030514 13 0.013
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.013
er to golgi vesicle mediated transport GO:0006888 1 0.013
membrane lipid biosynthetic process GO:0046467 2 0.013
regulation of cell matrix adhesion GO:0001952 1 0.013
dna templated transcription initiation GO:0006352 1 0.013
oocyte maturation GO:0001556 4 0.013
microtubule based process GO:0007017 60 0.013
Fly
response to fluid shear stress GO:0034405 2 0.013
extrinsic apoptotic signaling pathway GO:0097191 3 0.013
Mouse
regulation of production of molecular mediator of immune response GO:0002700 1 0.013
regulation of protein polymerization GO:0032271 2 0.012
negative regulation of metabolic process GO:0009892 86 0.012
regulation of phosphate metabolic process GO:0019220 43 0.012
macromolecular complex disassembly GO:0032984 1 0.012
mononuclear cell proliferation GO:0032943 1 0.012
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.012
cellular biosynthetic process GO:0044249 286 0.012
protein acetylation GO:0006473 2 0.012
cellular response to external stimulus GO:0071496 2 0.012
compound eye development GO:0048749 2 0.012
cellular response to endogenous stimulus GO:0071495 68 0.012
sensory organ development GO:0007423 393 0.012
protein complex assembly GO:0006461 30 0.012
response to monosaccharide GO:0034284 3 0.012
circadian sleep wake cycle GO:0042745 2 0.012
catechol containing compound metabolic process GO:0009712 2 0.012
determination of heart left right asymmetry GO:0061371 117 0.012
regulation of organelle assembly GO:1902115 4 0.012
b cell mediated immunity GO:0019724 3 0.012
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.012
response to alkaloid GO:0043279 2 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.012
convergent extension GO:0060026 118 0.012
carbohydrate homeostasis GO:0033500 1 0.012
regulation of synapse assembly GO:0051963 3 0.012
protein polyubiquitination GO:0000209 4 0.012
cellular response to starvation GO:0009267 1 0.012
organic substance transport GO:0071702 58 0.012
internal protein amino acid acetylation GO:0006475 2 0.012
regulation of cell development GO:0060284 100 0.012
internal peptidyl lysine acetylation GO:0018393 2 0.012
zymogen activation GO:0031638 3 0.012
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
inositol lipid mediated signaling GO:0048017 2 0.012
cell substrate adhesion GO:0031589 4 0.012
epithelial tube morphogenesis GO:0060562 148 0.011
positive regulation of muscle organ development GO:0048636 1 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.011
cell cycle arrest GO:0007050 1 0.011
neuroblast proliferation GO:0007405 2 0.011
camera type eye development GO:0043010 222 0.011
forebrain cell migration GO:0021885 1 0.011
catabolic process GO:0009056 32 0.011
regulation of protein import into nucleus GO:0042306 2 0.011
response to carbohydrate GO:0009743 3 0.011
negative regulation of mapk cascade GO:0043409 4 0.011
ceramide biosynthetic process GO:0046513 1 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.011
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.011
b cell activation GO:0042113 2 0.011
cell proliferation GO:0008283 80 0.011
negative regulation of protein localization to nucleus GO:1900181 2 0.011
cognition GO:0050890 1 0.011
liver development GO:0001889 96 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.011
cellular response to nutrient levels GO:0031669 2 0.011
angiogenesis GO:0001525 158 0.011
cellular protein modification process GO:0006464 100 0.011
Human Mouse Fly
mitotic cell cycle GO:0000278 64 0.011
regulation of cell shape GO:0008360 1 0.011
negative regulation of synapse assembly GO:0051964 2 0.011
cellular response to decreased oxygen levels GO:0036294 1 0.011
response to glucose GO:0009749 3 0.011
positive regulation of protein polymerization GO:0032273 2 0.011
actin polymerization or depolymerization GO:0008154 2 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.011
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 9 0.011
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.011
astrocyte differentiation GO:0048708 1 0.011
peptidyl serine modification GO:0018209 2 0.011
male meiosis GO:0007140 2 0.011
protein dephosphorylation GO:0006470 3 0.011
regulation of ras gtpase activity GO:0032318 2 0.010
cell death GO:0008219 121 0.010
Mouse
regulation of programmed cell death GO:0043067 101 0.010
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.010
bmp signaling pathway GO:0030509 52 0.010
response to amino acid GO:0043200 2 0.010
skeletal system morphogenesis GO:0048705 102 0.010
heart morphogenesis GO:0003007 156 0.010
intracellular transport GO:0046907 32 0.010
regulation of circadian sleep wake cycle GO:0042749 1 0.010
positive regulation of carbohydrate metabolic process GO:0045913 1 0.010
cellular localization GO:0051641 97 0.010
protein homooligomerization GO:0051260 3 0.010
female gonad development GO:0008585 4 0.010
axon development GO:0061564 166 0.010
cell cell recognition GO:0009988 1 0.010
ribonucleotide metabolic process GO:0009259 27 0.010
regulation of cell projection assembly GO:0060491 4 0.010
adult behavior GO:0030534 2 0.010
development of primary female sexual characteristics GO:0046545 4 0.010
negative regulation of defense response GO:0031348 2 0.010
membrane fusion GO:0061025 2 0.010
enzyme linked receptor protein signaling pathway GO:0007167 106 0.010
germ line stem cell division GO:0042078 1 0.010
long chain fatty acid metabolic process GO:0001676 1 0.010

mknk2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
disease of metabolism DOID:0014667 0 0.022
inherited metabolic disorder DOID:655 0 0.022
musculoskeletal system disease DOID:17 0 0.020
cardiovascular system disease DOID:1287 0 0.013
nervous system disease DOID:863 0 0.012
myopathy DOID:423 0 0.010
muscular disease DOID:0080000 0 0.010
muscle tissue disease DOID:66 0 0.010