Danio rerio

37 known processes

dpysl3

dihydropyrimidinase-like 3

(Aliases: CRMP-4)

dpysl3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuron development GO:0048666 262 0.964
axonogenesis GO:0007409 152 0.948
generation of neurons GO:0048699 385 0.917
neuron projection morphogenesis GO:0048812 161 0.888
cell projection morphogenesis GO:0048858 244 0.821
neuron differentiation GO:0030182 353 0.802
cell part morphogenesis GO:0032990 246 0.791
cellular component morphogenesis GO:0032989 336 0.791
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.746
cell projection organization GO:0030030 284 0.722
cell morphogenesis involved in differentiation GO:0000904 195 0.655
neuron projection regeneration GO:0031102 16 0.584
Zebrafish
axon development GO:0061564 166 0.581
peripheral nervous system development GO:0007422 55 0.569
neuron projection development GO:0031175 180 0.557
cell morphogenesis GO:0000902 289 0.534
neuron projection guidance GO:0097485 86 0.454
negative regulation of biological process GO:0048519 304 0.440
cellular component biogenesis GO:0044085 178 0.408
embryonic organ development GO:0048568 381 0.334
regulation of multicellular organismal development GO:2000026 223 0.291
regulation of developmental process GO:0050793 247 0.291
protein localization to membrane GO:0072657 9 0.288
peripheral nervous system neuron development GO:0048935 22 0.267
regulation of signaling GO:0023051 235 0.251
response to stress GO:0006950 263 0.237
Zebrafish
locomotion GO:0040011 313 0.235
larval development GO:0002164 2 0.230
localization of cell GO:0051674 244 0.225
organelle organization GO:0006996 227 0.220
neural tube development GO:0021915 62 0.194
taxis GO:0042330 109 0.190
regulation of biological quality GO:0065008 263 0.179
regulation of protein complex assembly GO:0043254 3 0.177
neurological system process GO:0050877 62 0.165
reproduction GO:0000003 40 0.161
response to axon injury GO:0048678 14 0.161
Zebrafish
axon guidance GO:0007411 86 0.155
myotome development GO:0061055 1 0.149
regulation of neuron differentiation GO:0045664 56 0.143
regulation of neurogenesis GO:0050767 87 0.137
hormone transport GO:0009914 2 0.130
regulation of cell projection organization GO:0031344 44 0.130
cognition GO:0050890 1 0.130
positive regulation of cellular process GO:0048522 201 0.128
behavior GO:0007610 74 0.126
peripheral nervous system neuron axonogenesis GO:0048936 13 0.125
regulation of membrane potential GO:0042391 23 0.125
regulation of gene expression GO:0010468 265 0.124
chemotaxis GO:0006935 104 0.120
response to chemical GO:0042221 320 0.120
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.115
cellular component assembly GO:0022607 170 0.110
transmission of nerve impulse GO:0019226 19 0.110
cellular component movement GO:0006928 335 0.109
protein complex biogenesis GO:0070271 30 0.107
motor neuron axon guidance GO:0008045 23 0.104
endomembrane system organization GO:0010256 13 0.102
positive regulation of biological process GO:0048518 253 0.100
single organism membrane organization GO:0044802 20 0.098
response to organic substance GO:0010033 153 0.097
chordate embryonic development GO:0043009 271 0.090
response to abiotic stimulus GO:0009628 122 0.089
signal transduction GO:0007165 455 0.089
membrane organization GO:0061024 21 0.087
growth GO:0040007 174 0.086
response to external stimulus GO:0009605 264 0.083
organic cyclic compound biosynthetic process GO:1901362 223 0.082
cellular localization GO:0051641 97 0.082
system process GO:0003008 185 0.081
response to lipid GO:0033993 60 0.080
morphogenesis of an epithelium GO:0002009 333 0.080
innervation GO:0060384 3 0.080
cellular response to hormone stimulus GO:0032870 39 0.077
biological adhesion GO:0022610 40 0.077
central nervous system development GO:0007417 387 0.076
multicellular organism growth GO:0035264 4 0.074
regulation of cell communication GO:0010646 232 0.073
cellular macromolecule metabolic process GO:0044260 391 0.069
regulation of cellular component organization GO:0051128 86 0.068
regulation of neuron projection development GO:0010975 40 0.067
regulation of anatomical structure size GO:0090066 33 0.067
negative regulation of cellular process GO:0048523 283 0.066
protein complex assembly GO:0006461 30 0.066
cellular response to organic substance GO:0071310 105 0.064
single organism organelle organization GO:1902589 199 0.062
determination of bilateral symmetry GO:0009855 204 0.062
gene expression GO:0010467 252 0.061
cellular response to stress GO:0033554 62 0.061
Zebrafish
multicellular organismal signaling GO:0035637 22 0.060
lamellipodium organization GO:0097581 1 0.060
regeneration GO:0031099 91 0.058
Zebrafish
neuronal action potential GO:0019228 18 0.058
cell growth GO:0016049 57 0.056
regulation of binding GO:0051098 3 0.055
digestive tract development GO:0048565 265 0.054
cellular macromolecule biosynthetic process GO:0034645 224 0.054
organic substance biosynthetic process GO:1901576 289 0.053
myelination GO:0042552 18 0.053
brain development GO:0007420 293 0.052
tube morphogenesis GO:0035239 349 0.052
cell motility GO:0048870 244 0.052
peripheral nervous system neuron differentiation GO:0048934 28 0.050
cranial nerve development GO:0021545 42 0.049
embryonic organ morphogenesis GO:0048562 274 0.048
multicellular organism reproduction GO:0032504 35 0.048
regulation of nervous system development GO:0051960 90 0.048
cellular lipid metabolic process GO:0044255 36 0.048
oxoacid metabolic process GO:0043436 31 0.047
regulation of cell projection assembly GO:0060491 4 0.047
regulation of macromolecule metabolic process GO:0060255 317 0.047
eye development GO:0001654 277 0.046
regulation of signal transduction GO:0009966 225 0.046
positive regulation of multicellular organismal process GO:0051240 52 0.046
neuroblast proliferation GO:0007405 2 0.045
regulation of molecular function GO:0065009 70 0.045
optic nerve morphogenesis GO:0021631 6 0.044
transport GO:0006810 220 0.044
camera type eye development GO:0043010 222 0.043
mechanosensory behavior GO:0007638 2 0.043
cellular response to chemical stimulus GO:0070887 157 0.042
nitrogen compound metabolic process GO:0006807 319 0.042
cellular response to endogenous stimulus GO:0071495 68 0.042
regulation of cellular biosynthetic process GO:0031326 245 0.041
actin polymerization or depolymerization GO:0008154 2 0.041
hatching GO:0035188 4 0.040
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.040
cell death GO:0008219 121 0.040
negative regulation of gene expression GO:0010629 65 0.039
cardiac chamber formation GO:0003207 4 0.039
regulation of multicellular organism growth GO:0040014 4 0.039
regulation of cellular amino acid metabolic process GO:0006521 0 0.039
response to wounding GO:0009611 116 0.038
Zebrafish
single organism reproductive process GO:0044702 40 0.038
organic acid metabolic process GO:0006082 31 0.038
sensory organ morphogenesis GO:0090596 200 0.038
rna biosynthetic process GO:0032774 181 0.038
macromolecular complex subunit organization GO:0043933 74 0.037
protein localization to plasma membrane GO:0072659 1 0.037
negative regulation of cell death GO:0060548 60 0.037
negative regulation of apoptotic process GO:0043066 55 0.037
sensory organ development GO:0007423 393 0.037
single organism transport GO:0044765 206 0.036
action potential GO:0001508 19 0.036
regulation of primary metabolic process GO:0080090 311 0.036
rna modification GO:0009451 2 0.035
glucose import GO:0046323 2 0.034
apoptotic process GO:0006915 116 0.034
negative regulation of metabolic process GO:0009892 86 0.033
ameboidal type cell migration GO:0001667 143 0.032
medulla oblongata development GO:0021550 4 0.032
negative regulation of developmental process GO:0051093 65 0.032
macromolecular complex assembly GO:0065003 35 0.032
ribosomal small subunit biogenesis GO:0042274 2 0.032
response to radiation GO:0009314 51 0.031
negative regulation of neurogenesis GO:0050768 20 0.031
smooth muscle contraction GO:0006939 2 0.031
single organism metabolic process GO:0044710 217 0.031
regulation of nitrogen compound metabolic process GO:0051171 251 0.031
regulation of metabolic process GO:0019222 359 0.031
establishment of localization in cell GO:0051649 77 0.031
enzyme linked receptor protein signaling pathway GO:0007167 106 0.030
sympathetic nervous system development GO:0048485 3 0.030
negative regulation of neuron differentiation GO:0045665 10 0.030
establishment or maintenance of cell polarity GO:0007163 29 0.030
protein polymerization GO:0051258 4 0.030
positive regulation of neuron projection development GO:0010976 9 0.030
lamellipodium assembly GO:0030032 1 0.030
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.030
regulation of programmed cell death GO:0043067 101 0.029
cytoskeleton organization GO:0007010 96 0.029
protein metabolic process GO:0019538 183 0.029
nuclear migration GO:0007097 3 0.029
regulation of multicellular organismal process GO:0051239 277 0.029
angiogenesis GO:0001525 158 0.029
nucleobase containing compound biosynthetic process GO:0034654 205 0.029
positive regulation of translation GO:0045727 1 0.028
aging GO:0007568 2 0.028
negative regulation of secretion GO:0051048 2 0.028
regulation of hormone secretion GO:0046883 2 0.027
immune system development GO:0002520 191 0.027
mesoderm development GO:0007498 88 0.027
extrinsic apoptotic signaling pathway GO:0097191 3 0.027
morphogenesis of an epithelial sheet GO:0002011 49 0.027
negative regulation of cell communication GO:0010648 96 0.026
aorta development GO:0035904 4 0.026
microtubule based process GO:0007017 60 0.026
nucleobase containing compound metabolic process GO:0006139 274 0.026
optic nerve development GO:0021554 15 0.026
mitotic cell cycle embryonic GO:0045448 2 0.026
regulation of cell shape GO:0008360 1 0.025
regulation of protein metabolic process GO:0051246 56 0.025
transcription dna templated GO:0006351 181 0.025
programmed cell death GO:0012501 119 0.025
meiotic nuclear division GO:0007126 4 0.025
regulation of cellular component movement GO:0051270 55 0.025
ion transport GO:0006811 114 0.024
response to temperature stimulus GO:0009266 15 0.024
establishment of localization GO:0051234 244 0.024
embryonic heart tube development GO:0035050 133 0.024
development of primary female sexual characteristics GO:0046545 4 0.024
epithelial cell differentiation GO:0030855 116 0.024
photoreceptor cell differentiation GO:0046530 55 0.024
nucleic acid templated transcription GO:0097659 181 0.024
developmental growth GO:0048589 166 0.023
compound eye development GO:0048749 2 0.023
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.023
death GO:0016265 121 0.023
neuromast development GO:0048884 46 0.023
regulation of filopodium assembly GO:0051489 2 0.022
inner ear morphogenesis GO:0042472 63 0.022
regulation of localization GO:0032879 104 0.022
neural tube formation GO:0001841 16 0.022
midbrain development GO:0030901 28 0.022
stem cell proliferation GO:0072089 4 0.022
regulation of response to stimulus GO:0048583 269 0.022
mrna polyadenylation GO:0006378 2 0.022
spermatid differentiation GO:0048515 2 0.022
amine metabolic process GO:0009308 2 0.022
negative regulation of epithelial cell migration GO:0010633 1 0.021
macromolecule localization GO:0033036 54 0.021
regulation of blood pressure GO:0008217 1 0.021
lipid storage GO:0019915 1 0.021
regulation of rna biosynthetic process GO:2001141 213 0.021
regulation of cell death GO:0010941 103 0.021
single organism localization GO:1902578 225 0.021
cellular ketone metabolic process GO:0042180 11 0.021
regulation of cell morphogenesis GO:0022604 42 0.021
specification of symmetry GO:0009799 204 0.021
collateral sprouting GO:0048668 9 0.021
organism emergence from protective structure GO:0071684 4 0.020
multicellular organismal reproductive process GO:0048609 35 0.020
developmental pigmentation GO:0048066 48 0.020
single organism cell adhesion GO:0098602 29 0.020
synaptic growth at neuromuscular junction GO:0051124 2 0.020
nerve development GO:0021675 45 0.020
regulation of cell differentiation GO:0045595 142 0.019
cell migration GO:0016477 237 0.019
cell surface receptor signaling pathway GO:0007166 325 0.019
regulation of ion transmembrane transporter activity GO:0032412 2 0.019
multi organism process GO:0051704 134 0.018
positive regulation of signal transduction GO:0009967 56 0.018
female gonad development GO:0008585 4 0.018
response to organic cyclic compound GO:0014070 51 0.018
membrane invagination GO:0010324 1 0.018
organonitrogen compound metabolic process GO:1901564 74 0.018
positive regulation of response to stimulus GO:0048584 80 0.018
regulation of anatomical structure morphogenesis GO:0022603 130 0.018
glial cell differentiation GO:0010001 42 0.018
anterior posterior pattern specification GO:0009952 152 0.018
macromolecule biosynthetic process GO:0009059 227 0.018
cell adhesion mediated by integrin GO:0033627 1 0.018
axon regeneration GO:0031103 14 0.018
Zebrafish
heart development GO:0007507 313 0.017
cardiac atrium development GO:0003230 4 0.017
regulation of cellular ketone metabolic process GO:0010565 7 0.017
regulation of cell development GO:0060284 100 0.017
small molecule metabolic process GO:0044281 77 0.017
ion transmembrane transport GO:0034220 91 0.017
positive regulation of cell adhesion GO:0045785 1 0.017
cardiac atrium morphogenesis GO:0003209 2 0.017
chondrocyte development GO:0002063 4 0.017
regulation of cell migration GO:0030334 40 0.017
regulation of receptor activity GO:0010469 2 0.016
regulation of nucleic acid templated transcription GO:1903506 213 0.016
cellular amide metabolic process GO:0043603 4 0.016
rna metabolic process GO:0016070 219 0.016
regulation of dendrite development GO:0050773 3 0.016
skeletal system development GO:0001501 181 0.016
maintenance of location GO:0051235 4 0.016
hepaticobiliary system development GO:0061008 98 0.016
positive regulation of neuron differentiation GO:0045666 12 0.016
brain morphogenesis GO:0048854 18 0.016
gliogenesis GO:0042063 45 0.016
organic cyclic compound metabolic process GO:1901360 301 0.016
axon ensheathment GO:0008366 18 0.016
intracellular signal transduction GO:0035556 85 0.016
cardiac cell fate commitment GO:0060911 1 0.015
positive regulation of developmental process GO:0051094 50 0.015
negative regulation of macromolecule metabolic process GO:0010605 76 0.015
nucleic acid metabolic process GO:0090304 244 0.015
spindle assembly GO:0051225 2 0.015
cellular aromatic compound metabolic process GO:0006725 295 0.015
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.015
cell cell signaling GO:0007267 52 0.015
pigmentation GO:0043473 85 0.015
negative regulation of endothelial cell migration GO:0010596 1 0.015
regionalization GO:0003002 274 0.015
negative regulation of gliogenesis GO:0014014 1 0.014
regulation of macromolecule biosynthetic process GO:0010556 225 0.014
carboxylic acid metabolic process GO:0019752 22 0.014
rostrocaudal neural tube patterning GO:0021903 29 0.014
immune system process GO:0002376 241 0.014
homeostatic process GO:0042592 142 0.014
optic nerve formation GO:0021634 6 0.014
regulation of biosynthetic process GO:0009889 250 0.014
energy reserve metabolic process GO:0006112 2 0.014
neuromuscular process controlling balance GO:0050885 3 0.014
regulation of growth GO:0040008 42 0.014
protein complex subunit organization GO:0071822 46 0.014
negative regulation of programmed cell death GO:0043069 58 0.014
head development GO:0060322 303 0.014
cellular amine metabolic process GO:0044106 2 0.014
tissue regeneration GO:0042246 74 0.014
cell adhesion GO:0007155 40 0.013
phenol containing compound biosynthetic process GO:0046189 4 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.013
regulation of cellular metabolic process GO:0031323 320 0.013
protein localization GO:0008104 40 0.013
golgi vesicle transport GO:0048193 3 0.013
embryonic skeletal system development GO:0048706 97 0.013
synapse organization GO:0050808 21 0.013
central nervous system neuron differentiation GO:0021953 74 0.013
gland development GO:0048732 143 0.013
cranial nerve morphogenesis GO:0021602 15 0.013
establishment of nucleus localization GO:0040023 7 0.013
cellular response to lipid GO:0071396 39 0.013
aorta morphogenesis GO:0035909 3 0.013
inner ear development GO:0048839 126 0.013
rna processing GO:0006396 25 0.013
forebrain development GO:0030900 96 0.012
developmental maturation GO:0021700 34 0.012
regulation of cell motility GO:2000145 46 0.012
cellular macromolecular complex assembly GO:0034622 24 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.012
digestive tract morphogenesis GO:0048546 231 0.012
regulation of axon extension GO:0030516 24 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.012
regulation of locomotion GO:0040012 55 0.012
response to endogenous stimulus GO:0009719 83 0.012
phagocytosis GO:0006909 3 0.012
response to other organism GO:0051707 97 0.012
axon cargo transport GO:0008088 2 0.012
cellular carbohydrate metabolic process GO:0044262 4 0.012
hormone secretion GO:0046879 2 0.012
regulation of developmental growth GO:0048638 38 0.011
regulation of apoptotic process GO:0042981 98 0.011
regulation of protein binding GO:0043393 3 0.011
epithelial tube morphogenesis GO:0060562 148 0.011
single organism behavior GO:0044708 24 0.011
negative regulation of molecular function GO:0044092 23 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.011
morphogenesis of embryonic epithelium GO:0016331 30 0.011
macromolecular complex disassembly GO:0032984 1 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
regulation of protein polymerization GO:0032271 2 0.011
posttranscriptional regulation of gene expression GO:0010608 14 0.011
lipid metabolic process GO:0006629 52 0.011
specification of axis polarity GO:0065001 4 0.011
vasculature development GO:0001944 278 0.011
cell projection assembly GO:0030031 64 0.011
determination of left right symmetry GO:0007368 179 0.011
adult behavior GO:0030534 2 0.011
ear development GO:0043583 127 0.011
negative regulation of nervous system development GO:0051961 22 0.011
organelle assembly GO:0070925 110 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.011
response to hormone GO:0009725 48 0.011
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.011
response to external biotic stimulus GO:0043207 97 0.011
negative regulation of epithelial cell proliferation GO:0050680 1 0.011
digestive system development GO:0055123 289 0.010
locomotory behavior GO:0007626 34 0.010
epithelium migration GO:0090132 25 0.010
neurotransmitter transport GO:0006836 2 0.010
single organism cellular localization GO:1902580 46 0.010
melanosome organization GO:0032438 4 0.010
positive regulation of catabolic process GO:0009896 4 0.010
negative regulation of cell migration GO:0030336 17 0.010
regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 8 0.010
positive regulation of cellular amine metabolic process GO:0033240 0 0.010

dpysl3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
physical disorder DOID:0080015 0 0.067
lissencephaly DOID:0050453 0 0.067
congenital nervous system abnormality DOID:2490 0 0.067
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.026
bone development disease DOID:0080006 0 0.024
bone disease DOID:0080001 0 0.024
dysostosis DOID:1934 0 0.024
musculoskeletal system disease DOID:17 0 0.024
connective tissue disease DOID:65 0 0.024