Danio rerio

0 known processes

nedd4l

neural precursor cell expressed, developmentally down-regulated 4-like

nedd4l biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular component movement GO:0006928 335 0.228
striated muscle cell development GO:0055002 108 0.212
regulation of nitrogen compound metabolic process GO:0051171 251 0.169
cellular aromatic compound metabolic process GO:0006725 295 0.161
organic substance biosynthetic process GO:1901576 289 0.155
organic cyclic compound metabolic process GO:1901360 301 0.154
response to chemical GO:0042221 320 0.148
striated muscle tissue development GO:0014706 110 0.144
nucleic acid templated transcription GO:0097659 181 0.139
central nervous system development GO:0007417 387 0.132
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.131
aromatic compound biosynthetic process GO:0019438 217 0.128
nucleobase containing compound biosynthetic process GO:0034654 205 0.125
biosynthetic process GO:0009058 294 0.124
cellular biosynthetic process GO:0044249 286 0.124
circadian sleep wake cycle process GO:0022410 2 0.117
circadian sleep wake cycle GO:0042745 2 0.103
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.101
nitrogen compound metabolic process GO:0006807 319 0.099
gene expression GO:0010467 252 0.095
skeletal muscle tissue development GO:0007519 67 0.092
cellular macromolecule biosynthetic process GO:0034645 224 0.090
striated muscle cell differentiation GO:0051146 129 0.089
aging GO:0007568 2 0.086
cellular nitrogen compound biosynthetic process GO:0044271 218 0.080
organic cyclic compound biosynthetic process GO:1901362 223 0.079
morphogenesis of an epithelial sheet GO:0002011 49 0.078
regulation of macromolecule metabolic process GO:0060255 317 0.076
regulation of circadian sleep wake cycle GO:0042749 1 0.069
protein localization to nucleus GO:0034504 3 0.069
regulation of metabolic process GO:0019222 359 0.068
cellular macromolecule metabolic process GO:0044260 391 0.066
Mouse
regulation of primary metabolic process GO:0080090 311 0.066
ion transport GO:0006811 114 0.065
Mouse
heterocycle biosynthetic process GO:0018130 215 0.065
sensory organ morphogenesis GO:0090596 200 0.061
guanosine containing compound metabolic process GO:1901068 4 0.060
regulation of circadian rhythm GO:0042752 4 0.060
sensory organ development GO:0007423 393 0.058
cellular nitrogen compound metabolic process GO:0034641 290 0.058
phagocytosis GO:0006909 3 0.056
cell projection organization GO:0030030 284 0.055
skeletal muscle fiber development GO:0048741 35 0.054
adult behavior GO:0030534 2 0.054
embryo development ending in birth or egg hatching GO:0009792 271 0.054
regulation of gene expression GO:0010468 265 0.051
generation of neurons GO:0048699 385 0.050
macromolecule biosynthetic process GO:0009059 227 0.048
nucleobase containing compound metabolic process GO:0006139 274 0.048
heterocycle metabolic process GO:0046483 290 0.047
response to radiation GO:0009314 51 0.046
guanosine containing compound catabolic process GO:1901069 2 0.046
muscle cell differentiation GO:0042692 139 0.045
multi organism process GO:0051704 134 0.045
positive regulation of cellular catabolic process GO:0031331 3 0.044
muscle cell development GO:0055001 115 0.044
single organism metabolic process GO:0044710 217 0.044
rna biosynthetic process GO:0032774 181 0.043
signal transduction GO:0007165 455 0.043
axonogenesis GO:0007409 152 0.043
skeletal muscle organ development GO:0060538 78 0.043
localization of cell GO:0051674 244 0.042
regulation of purine nucleotide catabolic process GO:0033121 2 0.041
negative regulation of cellular process GO:0048523 283 0.041
regulation of gtp catabolic process GO:0033124 2 0.041
neuron development GO:0048666 262 0.041
cellular response to chemical stimulus GO:0070887 157 0.041
response to light stimulus GO:0009416 46 0.040
myotube cell development GO:0014904 35 0.040
muscle structure development GO:0061061 196 0.039
muscle tissue development GO:0060537 110 0.038
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.037
organism emergence from protective structure GO:0071684 4 0.036
muscle fiber development GO:0048747 52 0.036
regulation of macromolecule biosynthetic process GO:0010556 225 0.036
medial fin morphogenesis GO:0035141 14 0.035
axon guidance GO:0007411 86 0.035
gtp metabolic process GO:0046039 4 0.034
regulation of nucleoside metabolic process GO:0009118 2 0.034
embryonic eye morphogenesis GO:0048048 30 0.032
negative regulation of biological process GO:0048519 304 0.032
Mouse
embryonic skeletal joint development GO:0072498 3 0.031
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.031
response to wounding GO:0009611 116 0.031
single organism organelle organization GO:1902589 199 0.030
sleep GO:0030431 1 0.030
regulation of signal transduction GO:0009966 225 0.030
neuron differentiation GO:0030182 353 0.030
regulation of axon extension GO:0030516 24 0.029
segmentation GO:0035282 97 0.029
regulation of signaling GO:0023051 235 0.029
blood vessel development GO:0001568 246 0.028
digestive tract morphogenesis GO:0048546 231 0.028
regulation of rna metabolic process GO:0051252 224 0.028
larval development GO:0002164 2 0.027
regulation of developmental process GO:0050793 247 0.027
positive regulation of catabolic process GO:0009896 4 0.027
regulation of nucleotide catabolic process GO:0030811 2 0.027
positive regulation of purine nucleotide metabolic process GO:1900544 9 0.026
rna metabolic process GO:0016070 219 0.026
regulation of synapse organization GO:0050807 3 0.026
axon extension GO:0048675 45 0.026
ear development GO:0043583 127 0.026
brain development GO:0007420 293 0.026
regulation of gtpase activity GO:0043087 2 0.025
head development GO:0060322 303 0.025
pigmentation GO:0043473 85 0.025
negative regulation of signaling GO:0023057 96 0.025
organic acid metabolic process GO:0006082 31 0.024
system process GO:0003008 185 0.024
Mouse
neurotransmitter transport GO:0006836 2 0.024
axon development GO:0061564 166 0.024
response to organic substance GO:0010033 153 0.024
regulation of protein localization to nucleus GO:1900180 2 0.024
immune system development GO:0002520 191 0.024
fin development GO:0033333 77 0.023
small molecule metabolic process GO:0044281 77 0.022
actin filament based process GO:0030029 64 0.022
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.022
developmental growth GO:0048589 166 0.022
epiboly GO:0090504 41 0.022
regulation of catalytic activity GO:0050790 55 0.022
response to temperature stimulus GO:0009266 15 0.022
nucleoside phosphate metabolic process GO:0006753 28 0.022
establishment of localization GO:0051234 244 0.022
Mouse
cellular response to organic substance GO:0071310 105 0.022
regulation of neurotransmitter transport GO:0051588 1 0.021
regulation of blood pressure GO:0008217 1 0.021
Mouse
single organism localization GO:1902578 225 0.021
Mouse
cartilage development GO:0051216 96 0.021
regulation of multicellular organismal process GO:0051239 277 0.021
organelle organization GO:0006996 227 0.021
locomotion GO:0040011 313 0.021
oxoacid metabolic process GO:0043436 31 0.020
regulation of cellular metabolic process GO:0031323 320 0.020
circadian sleep wake cycle sleep GO:0050802 1 0.020
regulation of cell communication GO:0010646 232 0.020
retina development in camera type eye GO:0060041 146 0.020
inner ear development GO:0048839 126 0.020
regulation of cellular component size GO:0032535 30 0.020
organonitrogen compound metabolic process GO:1901564 74 0.020
regulation of oocyte development GO:0060281 3 0.020
response to stress GO:0006950 263 0.020
Mouse
regulation of membrane potential GO:0042391 23 0.019
immune system process GO:0002376 241 0.019
neuromuscular synaptic transmission GO:0007274 2 0.019
regulation of intracellular protein transport GO:0033157 3 0.019
positive regulation of gtp catabolic process GO:0033126 1 0.019
extrinsic apoptotic signaling pathway GO:0097191 3 0.019
leukocyte differentiation GO:0002521 25 0.019
regulation of biological quality GO:0065008 263 0.019
Mouse
cell surface receptor signaling pathway GO:0007166 325 0.019
embryonic skeletal joint morphogenesis GO:0060272 3 0.018
neuron projection development GO:0031175 180 0.018
eye morphogenesis GO:0048592 144 0.018
cgmp metabolic process GO:0046068 7 0.018
monoamine transport GO:0015844 1 0.018
carboxylic acid metabolic process GO:0019752 22 0.018
embryonic organ morphogenesis GO:0048562 274 0.018
regulation of cell development GO:0060284 100 0.018
embryonic organ development GO:0048568 381 0.018
regulation of localization GO:0032879 104 0.018
Mouse
developmental maturation GO:0021700 34 0.017
positive regulation of transport GO:0051050 2 0.017
Mouse
response to abiotic stimulus GO:0009628 122 0.017
Mouse
hatching GO:0035188 4 0.017
gtp catabolic process GO:0006184 2 0.017
positive regulation of cellular component biogenesis GO:0044089 3 0.017
single organism transport GO:0044765 206 0.017
Mouse
positive regulation of protein complex assembly GO:0031334 2 0.017
nucleic acid metabolic process GO:0090304 244 0.017
nerve development GO:0021675 45 0.017
cellular component morphogenesis GO:0032989 336 0.017
neuron projection guidance GO:0097485 86 0.017
developmental pigmentation GO:0048066 48 0.017
response to monosaccharide GO:0034284 3 0.016
regulation of response to stimulus GO:0048583 269 0.016
urogenital system development GO:0001655 97 0.016
regulation of cell maturation GO:1903429 1 0.016
oocyte maturation GO:0001556 4 0.016
regulation of axonogenesis GO:0050770 32 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.016
cell migration GO:0016477 237 0.016
growth GO:0040007 174 0.016
response to external stimulus GO:0009605 264 0.016
proteasomal protein catabolic process GO:0010498 2 0.016
regeneration GO:0031099 91 0.016
chordate embryonic development GO:0043009 271 0.015
regulation of nucleocytoplasmic transport GO:0046822 2 0.015
cellular response to radiation GO:0071478 4 0.015
organic acid catabolic process GO:0016054 3 0.015
response to carbohydrate GO:0009743 3 0.015
eye development GO:0001654 277 0.015
internal protein amino acid acetylation GO:0006475 2 0.015
cell part morphogenesis GO:0032990 246 0.015
regulation of neuron differentiation GO:0045664 56 0.015
vasculature development GO:0001944 278 0.015
cellular amine metabolic process GO:0044106 2 0.015
single organism biosynthetic process GO:0044711 71 0.015
regulation of gastrulation GO:0010470 24 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.015
Mouse
hepaticobiliary system development GO:0061008 98 0.014
cellular response to topologically incorrect protein GO:0035967 2 0.014
ubiquitin dependent protein catabolic process GO:0006511 3 0.014
Mouse
tissue regeneration GO:0042246 74 0.014
organonitrogen compound biosynthetic process GO:1901566 47 0.014
neuron neuron synaptic transmission GO:0007270 1 0.014
maintenance of location GO:0051235 4 0.014
cardiocyte differentiation GO:0035051 44 0.014
action potential GO:0001508 19 0.014
positive regulation of nucleotide catabolic process GO:0030813 1 0.014
cytokinesis GO:0000910 3 0.014
camera type eye morphogenesis GO:0048593 108 0.014
regulation of cell projection organization GO:0031344 44 0.014
programmed cell death GO:0012501 119 0.014
modification dependent protein catabolic process GO:0019941 3 0.014
Mouse
erythrocyte homeostasis GO:0034101 55 0.014
regulation of molecular function GO:0065009 70 0.014
Mouse
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.014
neurotransmitter secretion GO:0007269 2 0.014
positive regulation of biological process GO:0048518 253 0.014
Mouse
pathway restricted smad protein phosphorylation GO:0060389 1 0.014
transcription dna templated GO:0006351 181 0.013
renal system development GO:0072001 94 0.013
developmental cell growth GO:0048588 52 0.013
transmission of nerve impulse GO:0019226 19 0.013
carbohydrate derivative metabolic process GO:1901135 61 0.013
regulation of transcription dna templated GO:0006355 213 0.013
lymphocyte proliferation GO:0046651 1 0.013
positive regulation of nucleoside metabolic process GO:0045979 1 0.013
regulation of protein complex assembly GO:0043254 3 0.013
regulation of multicellular organism growth GO:0040014 4 0.013
regulation of ion transmembrane transporter activity GO:0032412 2 0.013
Mouse
regulation of sodium ion transport GO:0002028 2 0.013
Mouse
regulation of cellular biosynthetic process GO:0031326 245 0.013
cellular response to external stimulus GO:0071496 2 0.013
pharyngeal muscle development GO:0043282 4 0.013
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.013
response to alkaloid GO:0043279 2 0.013
cellular response to oxygen levels GO:0071453 1 0.013
protein acetylation GO:0006473 2 0.013
positive regulation of rna biosynthetic process GO:1902680 57 0.013
negative regulation of multicellular organismal process GO:0051241 69 0.013
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.013
regulation of rna biosynthetic process GO:2001141 213 0.013
positive regulation of muscle organ development GO:0048636 1 0.013
regulation of protein polymerization GO:0032271 2 0.013
response to hexose GO:0009746 3 0.012
spliceosomal snrnp assembly GO:0000387 2 0.012
compound eye development GO:0048749 2 0.012
regulation of neural precursor cell proliferation GO:2000177 3 0.012
centrosome organization GO:0051297 1 0.012
regulation of cell size GO:0008361 29 0.012
cellular component assembly involved in morphogenesis GO:0010927 107 0.012
purine ribonucleotide metabolic process GO:0009150 27 0.012
organelle assembly GO:0070925 110 0.012
somite development GO:0061053 96 0.012
establishment of protein localization to organelle GO:0072594 4 0.012
digestive system development GO:0055123 289 0.012
cell death GO:0008219 121 0.012
apoptotic process GO:0006915 116 0.012
positive regulation of ras gtpase activity GO:0032320 1 0.012
regulation of transporter activity GO:0032409 2 0.012
Mouse
water homeostasis GO:0030104 4 0.012
negative regulation of cell communication GO:0010648 96 0.012
protein targeting to nucleus GO:0044744 3 0.012
neuron projection extension GO:1990138 45 0.012
cell motility GO:0048870 244 0.012
cellular response to lipid GO:0071396 39 0.012
response to nicotine GO:0035094 2 0.012
camera type eye development GO:0043010 222 0.012
regulation of inflammatory response GO:0050727 2 0.012
cell cell signaling GO:0007267 52 0.012
carbohydrate homeostasis GO:0033500 1 0.012
embryonic skeletal system morphogenesis GO:0048704 93 0.012
circulatory system process GO:0003013 87 0.011
Mouse
regulation of skeletal muscle tissue development GO:0048641 4 0.011
ameboidal type cell migration GO:0001667 143 0.011
digestive tract development GO:0048565 265 0.011
response to oxygen levels GO:0070482 25 0.011
cellular response to unfolded protein GO:0034620 2 0.011
positive regulation of cell differentiation GO:0045597 30 0.011
response to endogenous stimulus GO:0009719 83 0.011
regulation of metal ion transport GO:0010959 4 0.011
Mouse
wound healing GO:0042060 90 0.011
regulation of cytoplasmic transport GO:1903649 4 0.011
regulation of transmembrane transporter activity GO:0022898 2 0.011
Mouse
response to topologically incorrect protein GO:0035966 2 0.011
negative regulation of multi organism process GO:0043901 3 0.011
dna templated transcription elongation GO:0006354 3 0.011
tube morphogenesis GO:0035239 349 0.011
regulation of cell differentiation GO:0045595 142 0.011
b cell activation GO:0042113 2 0.011
locomotor rhythm GO:0045475 3 0.011
negative regulation of biosynthetic process GO:0009890 55 0.011
response to decreased oxygen levels GO:0036293 25 0.011
angiogenesis GO:0001525 158 0.011
nuclear transport GO:0051169 4 0.011
multicellular organismal signaling GO:0035637 22 0.011
cranial ganglion development GO:0061550 3 0.011
entrainment of circadian clock GO:0009649 2 0.011
transport GO:0006810 220 0.011
Mouse
regulation of establishment of protein localization GO:0070201 4 0.011
cellular response to stress GO:0033554 62 0.011
response to hypoxia GO:0001666 25 0.010
regulation of growth GO:0040008 42 0.010
somitogenesis GO:0001756 87 0.010
heart jogging GO:0003146 40 0.010
nitrogen compound transport GO:0071705 23 0.010
protein import into nucleus GO:0006606 3 0.010
i kappab kinase nf kappab signaling GO:0007249 4 0.010
cell projection morphogenesis GO:0048858 244 0.010
negative regulation of blood circulation GO:1903523 2 0.010
cellular response to steroid hormone stimulus GO:0071383 31 0.010
embryonic skeletal system development GO:0048706 97 0.010
response to uv GO:0009411 3 0.010
lipid catabolic process GO:0016042 4 0.010
meiotic chromosome segregation GO:0045132 3 0.010
signal transduction in absence of ligand GO:0038034 1 0.010
intracellular signal transduction GO:0035556 85 0.010
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.010

nedd4l disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.027
musculoskeletal system disease DOID:17 0 0.017
bone development disease DOID:0080006 0 0.014
bone disease DOID:0080001 0 0.014
connective tissue disease DOID:65 0 0.014
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010
organ system cancer DOID:0050686 0 0.010