Danio rerio

0 known processes

her2

hairy-related 2

(Aliases: HER-2)

her2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of macromolecule metabolic process GO:0060255 317 0.276
epidermal cell fate specification GO:0009957 4 0.161
embryo development ending in birth or egg hatching GO:0009792 271 0.154
cellular nitrogen compound metabolic process GO:0034641 290 0.151
cellular component morphogenesis GO:0032989 336 0.148
nitrogen compound metabolic process GO:0006807 319 0.146
negative regulation of biological process GO:0048519 304 0.138
nucleic acid templated transcription GO:0097659 181 0.135
larval development GO:0002164 2 0.134
gene expression GO:0010467 252 0.133
regulation of macromolecule biosynthetic process GO:0010556 225 0.132
cellular macromolecule metabolic process GO:0044260 391 0.128
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.127
cellular macromolecule biosynthetic process GO:0034645 224 0.123
regulation of gene expression GO:0010468 265 0.122
neuron development GO:0048666 262 0.120
regulation of metabolic process GO:0019222 359 0.112
positive regulation of neural precursor cell proliferation GO:2000179 1 0.108
regulation of cellular metabolic process GO:0031323 320 0.106
organic cyclic compound metabolic process GO:1901360 301 0.102
generation of neurons GO:0048699 385 0.101
regulation of stem cell proliferation GO:0072091 2 0.099
organelle organization GO:0006996 227 0.099
chordate embryonic development GO:0043009 271 0.097
positive regulation of stem cell proliferation GO:2000648 1 0.096
organic substance biosynthetic process GO:1901576 289 0.095
regulation of biosynthetic process GO:0009889 250 0.093
macromolecule biosynthetic process GO:0009059 227 0.091
locomotion GO:0040011 313 0.087
rna metabolic process GO:0016070 219 0.080
cellular aromatic compound metabolic process GO:0006725 295 0.078
cellular biosynthetic process GO:0044249 286 0.077
lens fiber cell morphogenesis GO:0070309 3 0.077
neuroblast proliferation GO:0007405 2 0.077
cell morphogenesis GO:0000902 289 0.077
stem cell proliferation GO:0072089 4 0.071
regulation of multicellular organismal process GO:0051239 277 0.071
positive regulation of biological process GO:0048518 253 0.070
cell migration GO:0016477 237 0.069
nucleobase containing compound metabolic process GO:0006139 274 0.069
biosynthetic process GO:0009058 294 0.065
glial cell migration GO:0008347 3 0.065
morphogenesis of an epithelium GO:0002009 333 0.065
glial cell fate specification GO:0021780 4 0.064
regulation of primary metabolic process GO:0080090 311 0.062
regulation of neural precursor cell proliferation GO:2000177 3 0.061
cell motility GO:0048870 244 0.059
regulation of nucleic acid templated transcription GO:1903506 213 0.059
eye morphogenesis GO:0048592 144 0.057
camera type eye development GO:0043010 222 0.056
regulation of nitrogen compound metabolic process GO:0051171 251 0.056
regulation of multicellular organism growth GO:0040014 4 0.056
oligodendrocyte cell fate specification GO:0021778 4 0.055
astrocyte differentiation GO:0048708 1 0.055
regulation of rna metabolic process GO:0051252 224 0.055
nucleic acid metabolic process GO:0090304 244 0.055
heterocycle metabolic process GO:0046483 290 0.054
regulation of cellular biosynthetic process GO:0031326 245 0.054
regulation of stem cell differentiation GO:2000736 4 0.053
regulation of epithelial cell proliferation GO:0050678 3 0.052
negative regulation of cellular process GO:0048523 283 0.051
rna biosynthetic process GO:0032774 181 0.051
cellular component movement GO:0006928 335 0.050
positive regulation of map kinase activity GO:0043406 3 0.050
positive regulation of cellular process GO:0048522 201 0.050
cellular amino acid metabolic process GO:0006520 7 0.049
regulation of dendrite development GO:0050773 3 0.049
central nervous system development GO:0007417 387 0.048
transcription dna templated GO:0006351 181 0.048
cellular amine metabolic process GO:0044106 2 0.048
heterocycle biosynthetic process GO:0018130 215 0.047
cell fate specification GO:0001708 68 0.046
embryonic organ development GO:0048568 381 0.046
regulation of response to stimulus GO:0048583 269 0.046
single organism metabolic process GO:0044710 217 0.045
keratinocyte differentiation GO:0030216 0 0.045
oxoacid metabolic process GO:0043436 31 0.045
amine metabolic process GO:0009308 2 0.044
cilium assembly GO:0042384 58 0.044
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.044
regulation of rna biosynthetic process GO:2001141 213 0.043
digestive tract development GO:0048565 265 0.043
system process GO:0003008 185 0.043
organic cyclic compound biosynthetic process GO:1901362 223 0.042
signal transduction GO:0007165 455 0.042
embryonic organ morphogenesis GO:0048562 274 0.041
negative regulation of gliogenesis GO:0014014 1 0.041
response to amino acid GO:0043200 2 0.041
meiotic nuclear division GO:0007126 4 0.041
regulation of cellular amine metabolic process GO:0033238 0 0.040
ventral spinal cord interneuron differentiation GO:0021514 12 0.040
neuron differentiation GO:0030182 353 0.040
aromatic compound biosynthetic process GO:0019438 217 0.040
aging GO:0007568 2 0.040
regionalization GO:0003002 274 0.039
auditory receptor cell fate determination GO:0042668 2 0.039
cardiac chamber formation GO:0003207 4 0.039
cellular protein modification process GO:0006464 100 0.039
axon development GO:0061564 166 0.038
regulation of cellular amino acid metabolic process GO:0006521 0 0.038
regulation of developmental process GO:0050793 247 0.037
cellular ketone metabolic process GO:0042180 11 0.037
nucleobase containing compound biosynthetic process GO:0034654 205 0.037
eye development GO:0001654 277 0.035
digestive tract morphogenesis GO:0048546 231 0.035
cell surface receptor signaling pathway GO:0007166 325 0.035
embryonic heart tube development GO:0035050 133 0.035
camera type eye morphogenesis GO:0048593 108 0.035
digestive system development GO:0055123 289 0.035
cell projection morphogenesis GO:0048858 244 0.035
negative regulation of protein phosphorylation GO:0001933 4 0.034
single organism organelle organization GO:1902589 199 0.034
skin development GO:0043588 54 0.034
epithelial cell differentiation GO:0030855 116 0.034
olfactory bulb development GO:0021772 4 0.033
ventral spinal cord interneuron fate commitment GO:0060579 3 0.033
regulation of dendrite morphogenesis GO:0048814 3 0.033
mesenchymal cell differentiation GO:0048762 87 0.032
localization of cell GO:0051674 244 0.032
cellular protein metabolic process GO:0044267 129 0.031
regulation of anatomical structure morphogenesis GO:0022603 130 0.031
organic acid metabolic process GO:0006082 31 0.031
carboxylic acid metabolic process GO:0019752 22 0.031
cell proliferation in forebrain GO:0021846 3 0.031
negative regulation of stem cell differentiation GO:2000737 2 0.030
positive regulation of cellular amine metabolic process GO:0033240 0 0.030
immune system process GO:0002376 241 0.030
positive regulation of notch signaling pathway GO:0045747 3 0.030
peripheral nervous system development GO:0007422 55 0.030
cellular nitrogen compound biosynthetic process GO:0044271 218 0.030
establishment of localization GO:0051234 244 0.030
brain development GO:0007420 293 0.029
inner ear receptor cell fate commitment GO:0060120 4 0.029
protein metabolic process GO:0019538 183 0.029
phosphate containing compound metabolic process GO:0006796 108 0.029
regulation of multicellular organismal development GO:2000026 223 0.029
regulation of dna replication GO:0006275 3 0.029
negative regulation of cell development GO:0010721 26 0.029
response to stress GO:0006950 263 0.029
protein modification process GO:0036211 100 0.029
regulation of binding GO:0051098 3 0.028
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.028
cell part morphogenesis GO:0032990 246 0.028
cell fate commitment GO:0045165 99 0.028
cell morphogenesis involved in differentiation GO:0000904 195 0.028
neuron fate determination GO:0048664 2 0.027
positive regulation of epithelial cell differentiation GO:0030858 2 0.027
regulation of jak stat cascade GO:0046425 3 0.027
lens development in camera type eye GO:0002088 22 0.027
axon ensheathment in central nervous system GO:0032291 2 0.027
regulation of cellular ketone metabolic process GO:0010565 7 0.027
endocrine pancreas development GO:0031018 27 0.027
stem cell differentiation GO:0048863 117 0.027
neuroblast fate determination GO:0007400 1 0.027
neuronal stem cell maintenance GO:0097150 2 0.027
neuron projection development GO:0031175 180 0.026
determination of bilateral symmetry GO:0009855 204 0.026
cell projection organization GO:0030030 284 0.026
central nervous system myelin formation GO:0032289 1 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.026
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.026
response to wounding GO:0009611 116 0.026
positive regulation of transport GO:0051050 2 0.025
response to chemical GO:0042221 320 0.025
negative regulation of epithelial cell proliferation GO:0050680 1 0.025
stem cell maintenance GO:0019827 4 0.025
negative regulation of histone modification GO:0031057 1 0.025
phagocytosis GO:0006909 3 0.025
cell fate specification involved in pattern specification GO:0060573 3 0.025
neural precursor cell proliferation GO:0061351 20 0.025
head development GO:0060322 303 0.025
central nervous system myelination GO:0022010 2 0.024
organonitrogen compound metabolic process GO:1901564 74 0.024
anterior posterior pattern specification GO:0009952 152 0.024
neuroblast fate commitment GO:0014017 1 0.024
embryonic skeletal system development GO:0048706 97 0.024
multicellular organism growth GO:0035264 4 0.024
regulation of cell differentiation GO:0045595 142 0.024
exocytosis GO:0006887 1 0.024
guanosine containing compound metabolic process GO:1901068 4 0.023
lens fiber cell development GO:0070307 3 0.023
positive regulation of secretion GO:0051047 1 0.023
regulation of signal transduction GO:0009966 225 0.023
positive regulation of epithelial cell proliferation GO:0050679 1 0.023
oocyte maturation GO:0001556 4 0.023
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.023
maintenance of location GO:0051235 4 0.023
macromolecule modification GO:0043412 111 0.023
cellular amide metabolic process GO:0043603 4 0.022
regulation of gtp catabolic process GO:0033124 2 0.022
regulation of endothelial cell differentiation GO:0045601 3 0.022
blood vessel morphogenesis GO:0048514 216 0.022
phosphorus metabolic process GO:0006793 109 0.022
negative regulation of biosynthetic process GO:0009890 55 0.022
stem cell fate determination GO:0048867 1 0.022
sister chromatid cohesion GO:0007062 2 0.022
multicellular organismal signaling GO:0035637 22 0.022
regulation of transcription dna templated GO:0006355 213 0.022
negative regulation of macromolecule metabolic process GO:0010605 76 0.022
determination of left right symmetry GO:0007368 179 0.021
regulation of signaling GO:0023051 235 0.021
regulation of histone methylation GO:0031060 3 0.021
photoreceptor cell differentiation GO:0046530 55 0.021
embryonic heart tube morphogenesis GO:0003143 108 0.021
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.021
blood vessel development GO:0001568 246 0.021
atp catabolic process GO:0006200 4 0.021
epidermis development GO:0008544 48 0.021
neuroblast differentiation GO:0014016 1 0.021
axonogenesis GO:0007409 152 0.021
gtp metabolic process GO:0046039 4 0.020
cellular component biogenesis GO:0044085 178 0.020
positive regulation of cell cycle GO:0045787 3 0.020
cell cell recognition GO:0009988 1 0.020
heart development GO:0007507 313 0.020
positive regulation of macromolecule metabolic process GO:0010604 93 0.020
medulla oblongata development GO:0021550 4 0.020
heart morphogenesis GO:0003007 156 0.020
regulation of dna templated transcription in response to stress GO:0043620 0 0.020
auditory receptor cell fate commitment GO:0009912 4 0.020
regulation of cardiac chamber formation GO:1901210 2 0.020
neuron projection morphogenesis GO:0048812 161 0.020
developmental growth GO:0048589 166 0.020
small molecule metabolic process GO:0044281 77 0.020
dna methylation on cytosine GO:0032776 3 0.020
regulation of cell cycle GO:0051726 52 0.020
regulation of cell development GO:0060284 100 0.020
compound eye development GO:0048749 2 0.020
polarized epithelial cell differentiation GO:0030859 4 0.019
endocrine system development GO:0035270 65 0.019
lipid storage GO:0019915 1 0.019
neuron neuron synaptic transmission GO:0007270 1 0.019
gtp catabolic process GO:0006184 2 0.019
cilium morphogenesis GO:0060271 85 0.019
rna localization GO:0006403 4 0.019
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.019
forebrain development GO:0030900 96 0.019
regulation of cell communication GO:0010646 232 0.018
striated muscle tissue development GO:0014706 110 0.018
g1 s transition of mitotic cell cycle GO:0000082 1 0.018
muscle structure development GO:0061061 196 0.018
ribonucleoside monophosphate catabolic process GO:0009158 4 0.018
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.018
positive regulation of developmental process GO:0051094 50 0.018
regulation of epithelial to mesenchymal transition GO:0010717 3 0.018
long chain fatty acid metabolic process GO:0001676 1 0.018
antimicrobial humoral response GO:0019730 2 0.018
positive regulation of rna biosynthetic process GO:1902680 57 0.018
oligodendrocyte differentiation GO:0048709 23 0.018
defense response to fungus GO:0050832 2 0.017
lymphatic endothelial cell fate commitment GO:0060838 1 0.017
photoreceptor cell development GO:0042461 40 0.017
guanosine containing compound catabolic process GO:1901069 2 0.017
regulation of histone h3 k9 methylation GO:0051570 2 0.017
negative regulation of dna metabolic process GO:0051053 4 0.017
regulation of protein metabolic process GO:0051246 56 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.017
phosphorylation GO:0016310 69 0.017
regulation of purine nucleotide catabolic process GO:0033121 2 0.017
epidermal cell differentiation GO:0009913 36 0.017
cardiocyte differentiation GO:0035051 44 0.017
chromosome organization GO:0051276 31 0.017
pancreas development GO:0031016 84 0.016
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.016
secondary metabolic process GO:0019748 3 0.016
positive regulation of endothelial cell differentiation GO:0045603 2 0.016
sensory organ morphogenesis GO:0090596 200 0.016
transport GO:0006810 220 0.016
septum transversum development GO:0003343 4 0.016
positive regulation of histone modification GO:0031058 1 0.016
heart looping GO:0001947 94 0.016
fin morphogenesis GO:0033334 53 0.016
protein phosphorylation GO:0006468 47 0.016
forebrain neuron fate commitment GO:0021877 1 0.016
synaptic growth at neuromuscular junction GO:0051124 2 0.016
negative regulation of metabolic process GO:0009892 86 0.016
epithelial tube morphogenesis GO:0060562 148 0.016
negative regulation of cell differentiation GO:0045596 46 0.016
gland development GO:0048732 143 0.016
regulation of cytoplasmic transport GO:1903649 4 0.016
neuronal action potential GO:0019228 18 0.016
spinal cord development GO:0021510 46 0.016
radial glial cell differentiation GO:0060019 2 0.016
response to external stimulus GO:0009605 264 0.016
organelle fission GO:0048285 23 0.016
mesenchyme development GO:0060485 127 0.015
wnt signaling pathway GO:0016055 80 0.015
regulation of production of molecular mediator of immune response GO:0002700 1 0.015
positive regulation of stress activated mapk cascade GO:0032874 3 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.015
tube morphogenesis GO:0035239 349 0.015
somitogenesis GO:0001756 87 0.015
dna alkylation GO:0006305 8 0.015
regulation of neurogenesis GO:0050767 87 0.015
regulation of cell activation GO:0050865 1 0.015
olfactory lobe development GO:0021988 4 0.014
response to external biotic stimulus GO:0043207 97 0.014
negative regulation of epithelial cell migration GO:0010633 1 0.014
anterior lateral line nerve development GO:0048909 4 0.014
cellular component assembly GO:0022607 170 0.014
dna templated transcription initiation GO:0006352 1 0.014
negative regulation of chromatin modification GO:1903309 1 0.014
regulation of nucleoside metabolic process GO:0009118 2 0.014
developmental programmed cell death GO:0010623 4 0.014
positive regulation of biosynthetic process GO:0009891 68 0.014
negative regulation of myeloid cell differentiation GO:0045638 1 0.014
fin development GO:0033333 77 0.014
negative regulation of neural precursor cell proliferation GO:2000178 1 0.014
regulation of immune system process GO:0002682 34 0.014
endocardium morphogenesis GO:0003160 4 0.014
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.014
dna modification GO:0006304 8 0.014
retina development in camera type eye GO:0060041 146 0.014
positive regulation of cytoskeleton organization GO:0051495 3 0.014
positive regulation of immune effector process GO:0002699 3 0.013
regulation of reproductive process GO:2000241 4 0.013
cell cycle GO:0007049 93 0.013
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.013
protein dephosphorylation GO:0006470 3 0.013
regulation of biological quality GO:0065008 263 0.013
multicellular organismal response to stress GO:0033555 2 0.013
regulation of exocytosis GO:0017157 1 0.013
regulation of mesenchymal cell proliferation GO:0010464 1 0.013
pancreatic a cell development GO:0003322 2 0.013
definitive hemopoiesis GO:0060216 18 0.013
hemopoiesis GO:0030097 183 0.013
protein acylation GO:0043543 3 0.013
mesoderm development GO:0007498 88 0.013
mitotic dna damage checkpoint GO:0044773 4 0.013
myelination GO:0042552 18 0.013
regulation of nucleotide catabolic process GO:0030811 2 0.013
extracellular matrix assembly GO:0085029 1 0.013
positive regulation of exocytosis GO:0045921 1 0.013
embryonic heart tube formation GO:0003144 1 0.013
regeneration GO:0031099 91 0.013
female sex differentiation GO:0046660 4 0.013
negative regulation of chromosome organization GO:2001251 1 0.013
hypochord development GO:0055016 3 0.013
histone h3 k4 methylation GO:0051568 2 0.013
transcription from rna polymerase ii promoter GO:0006366 80 0.013
dorsal ventral pattern formation GO:0009953 125 0.013
cell cycle g1 s phase transition GO:0044843 1 0.013
positive regulation of jnk cascade GO:0046330 3 0.013
regulation of photoreceptor cell differentiation GO:0046532 2 0.013
mitotic dna integrity checkpoint GO:0044774 4 0.013
vasculature development GO:0001944 278 0.013
neurological system process GO:0050877 62 0.013
negative regulation of gene expression GO:0010629 65 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.013
regulation of circadian rhythm GO:0042752 4 0.012
cilium organization GO:0044782 71 0.012
sensory organ development GO:0007423 393 0.012
notch signaling pathway GO:0007219 35 0.012
positive regulation of secretion by cell GO:1903532 1 0.012
myelin assembly GO:0032288 1 0.012
regulation of cellular component organization GO:0051128 86 0.012
embryonic skeletal system morphogenesis GO:0048704 93 0.012
regulation of neuron differentiation GO:0045664 56 0.012
floor plate development GO:0033504 15 0.012
fertilization GO:0009566 3 0.012
production of molecular mediator of immune response GO:0002440 2 0.012
neuron projection regeneration GO:0031102 16 0.012
response to oxygen levels GO:0070482 25 0.012
retina layer formation GO:0010842 24 0.012
locomotor rhythm GO:0045475 3 0.012
appendage development GO:0048736 80 0.012
immunoglobulin production GO:0002377 1 0.012
determination of heart left right asymmetry GO:0061371 117 0.012
cellular response to stress GO:0033554 62 0.012
negative regulation of cellular biosynthetic process GO:0031327 55 0.012
negative regulation of histone methylation GO:0031061 1 0.012
negative regulation of signaling GO:0023057 96 0.012
cell substrate adhesion GO:0031589 4 0.012
glial cell fate commitment GO:0021781 6 0.012
lateral inhibition GO:0046331 1 0.011
activation of mapk activity GO:0000187 3 0.011
skeletal system development GO:0001501 181 0.011
locomotory behavior GO:0007626 34 0.011
cell differentiation in spinal cord GO:0021515 40 0.011
positive regulation of gene expression GO:0010628 71 0.011
apoptotic process involved in development GO:1902742 2 0.011
oocyte anterior posterior axis specification GO:0007314 4 0.011
negative regulation of endothelial cell migration GO:0010596 1 0.011
specification of symmetry GO:0009799 204 0.011
purine nucleoside monophosphate catabolic process GO:0009128 4 0.011
regulation of gtpase activity GO:0043087 2 0.011
cytoskeleton organization GO:0007010 96 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
long chain fatty acid transport GO:0015909 1 0.011
glial cell proliferation GO:0014009 4 0.011
trabecula morphogenesis GO:0061383 2 0.011
establishment of protein localization to organelle GO:0072594 4 0.011
lymphocyte proliferation GO:0046651 1 0.011
cellular response to organic substance GO:0071310 105 0.011
response to carbohydrate GO:0009743 3 0.011
intracellular signal transduction GO:0035556 85 0.011
g2 m transition of mitotic cell cycle GO:0000086 4 0.011
peptidyl lysine acetylation GO:0018394 2 0.011
alternative mrna splicing via spliceosome GO:0000380 1 0.011
cellular component assembly involved in morphogenesis GO:0010927 107 0.011
negative regulation of dna replication GO:0008156 2 0.011
internal protein amino acid acetylation GO:0006475 2 0.011
proepicardium development GO:0003342 4 0.011
regulation of molecular function GO:0065009 70 0.011
cell proliferation GO:0008283 80 0.011
neuron projection guidance GO:0097485 86 0.011
immune system development GO:0002520 191 0.011
peripheral nervous system neuron axonogenesis GO:0048936 13 0.010
striated muscle cell differentiation GO:0051146 129 0.010
response to organic substance GO:0010033 153 0.010
photoreceptor cell fate commitment GO:0046552 1 0.010
cellular response to chemical stimulus GO:0070887 157 0.010
multi organism process GO:0051704 134 0.010
positive regulation of cellular metabolic process GO:0031325 94 0.010
positive regulation of jak stat cascade GO:0046427 2 0.010
cellular response to reactive oxygen species GO:0034614 2 0.010
positive regulation of multicellular organismal process GO:0051240 52 0.010
water homeostasis GO:0030104 4 0.010
forebrain anterior posterior pattern specification GO:0021797 3 0.010
ventral spinal cord interneuron specification GO:0021521 3 0.010
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.010
regulation of membrane potential GO:0042391 23 0.010
dorsal spinal cord development GO:0021516 1 0.010
positive regulation of cellular component biogenesis GO:0044089 3 0.010
dna methylation GO:0006306 8 0.010
hepaticobiliary system development GO:0061008 98 0.010

her2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
nervous system disease DOID:863 0 0.017
sensory system disease DOID:0050155 0 0.016
eye and adnexa disease DOID:1492 0 0.016
eye disease DOID:5614 0 0.016
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.013
bone disease DOID:0080001 0 0.012
musculoskeletal system disease DOID:17 0 0.012
connective tissue disease DOID:65 0 0.012