Danio rerio

0 known processes

unc50

unc-50 homolog (C. elegans)

(Aliases: MGC56114,zgc:56114)

unc50 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
golgi vesicle transport GO:0048193 3 0.128
larval development GO:0002164 2 0.061
ubiquitin dependent protein catabolic process GO:0006511 3 0.061
aging GO:0007568 2 0.053
homeostatic process GO:0042592 142 0.051
organelle fusion GO:0048284 3 0.048
cellular macromolecule metabolic process GO:0044260 391 0.043
modification dependent protein catabolic process GO:0019941 3 0.042
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.042
cellular response to starvation GO:0009267 1 0.040
regulation of biological quality GO:0065008 263 0.040
membrane fusion GO:0061025 2 0.039
cellular response to external stimulus GO:0071496 2 0.037
modification dependent macromolecule catabolic process GO:0043632 3 0.034
response to stress GO:0006950 263 0.034
cellular protein catabolic process GO:0044257 4 0.033
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.032
cellular response to nutrient levels GO:0031669 2 0.032
er nucleus signaling pathway GO:0006984 2 0.032
single organism transport GO:0044765 206 0.031
negative regulation of biological process GO:0048519 304 0.031
proteasomal protein catabolic process GO:0010498 2 0.029
single organism localization GO:1902578 225 0.028
positive regulation of apoptotic signaling pathway GO:2001235 1 0.027
positive regulation of catabolic process GO:0009896 4 0.026
transport GO:0006810 220 0.026
positive regulation of protein complex assembly GO:0031334 2 0.025
cellular response to extracellular stimulus GO:0031668 2 0.025
multicellular organism growth GO:0035264 4 0.025
protein localization to plasma membrane GO:0072659 1 0.025
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.025
regulation of protein catabolic process GO:0042176 1 0.025
synaptic vesicle recycling GO:0036465 1 0.025
maintenance of location GO:0051235 4 0.025
cellular biosynthetic process GO:0044249 286 0.024
negative regulation of cellular catabolic process GO:0031330 3 0.024
endosomal transport GO:0016197 2 0.024
response to unfolded protein GO:0006986 2 0.023
chemical homeostasis GO:0048878 49 0.023
synaptic vesicle localization GO:0097479 1 0.023
regulation of cytokine production GO:0001817 3 0.023
cytoskeleton dependent cytokinesis GO:0061640 3 0.023
death GO:0016265 121 0.023
meiotic nuclear division GO:0007126 4 0.022
regulation of protein complex assembly GO:0043254 3 0.022
phagocytosis GO:0006909 3 0.022
autophagy GO:0006914 4 0.022
macromolecule modification GO:0043412 111 0.022
synaptic vesicle transport GO:0048489 1 0.021
establishment of localization GO:0051234 244 0.021
establishment of protein localization to organelle GO:0072594 4 0.021
lipid storage GO:0019915 1 0.021
regulation of intracellular ph GO:0051453 1 0.021
response to topologically incorrect protein GO:0035966 2 0.021
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.020
meiotic cell cycle process GO:1903046 3 0.020
cell death GO:0008219 121 0.020
negative regulation of catabolic process GO:0009895 3 0.020
macroautophagy GO:0016236 1 0.020
organonitrogen compound metabolic process GO:1901564 74 0.019
single organism metabolic process GO:0044710 217 0.019
protein import GO:0017038 3 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
programmed cell death GO:0012501 119 0.019
response to chemical GO:0042221 320 0.019
protein polyubiquitination GO:0000209 4 0.018
heterocycle metabolic process GO:0046483 290 0.018
regulation of multicellular organism growth GO:0040014 4 0.018
regulation of nucleocytoplasmic transport GO:0046822 2 0.018
locomotion GO:0040011 313 0.018
regulation of cellular ketone metabolic process GO:0010565 7 0.018
stem cell division GO:0017145 1 0.018
negative regulation of cell death GO:0060548 60 0.018
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.018
guanosine containing compound metabolic process GO:1901068 4 0.018
er to golgi vesicle mediated transport GO:0006888 1 0.018
cellular response to unfolded protein GO:0034620 2 0.017
synaptic vesicle endocytosis GO:0048488 1 0.017
establishment of synaptic vesicle localization GO:0097480 1 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
cellular transition metal ion homeostasis GO:0046916 3 0.017
tube morphogenesis GO:0035239 349 0.017
extrinsic apoptotic signaling pathway GO:0097191 3 0.017
gland development GO:0048732 143 0.017
cell surface receptor signaling pathway GO:0007166 325 0.017
protein metabolic process GO:0019538 183 0.017
regulation of carbohydrate metabolic process GO:0006109 4 0.017
regulation of hormone secretion GO:0046883 2 0.017
i kappab kinase nf kappab signaling GO:0007249 4 0.017
compound eye development GO:0048749 2 0.016
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.016
lipid catabolic process GO:0016042 4 0.016
regulation of binding GO:0051098 3 0.016
organelle organization GO:0006996 227 0.016
regulation of ph GO:0006885 3 0.016
biosynthetic process GO:0009058 294 0.016
protein n linked glycosylation GO:0006487 1 0.016
establishment of protein localization to plasma membrane GO:0090002 1 0.016
negative regulation of cellular process GO:0048523 283 0.016
regulation of apoptotic process GO:0042981 98 0.016
xenobiotic metabolic process GO:0006805 4 0.016
regulation of nucleotide catabolic process GO:0030811 2 0.016
apoptotic process GO:0006915 116 0.016
cellular protein modification process GO:0006464 100 0.016
embryo development ending in birth or egg hatching GO:0009792 271 0.016
protein secretion GO:0009306 1 0.015
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.015
golgi organization GO:0007030 1 0.015
morphogenesis of an epithelium GO:0002009 333 0.015
regulation of macromolecule metabolic process GO:0060255 317 0.015
cell motility GO:0048870 244 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
cation homeostasis GO:0055080 33 0.015
regulation of programmed cell death GO:0043067 101 0.015
positive regulation of cellular catabolic process GO:0031331 3 0.015
endoplasmic reticulum unfolded protein response GO:0030968 2 0.015
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.015
positive regulation of transport GO:0051050 2 0.015
organic cyclic compound metabolic process GO:1901360 301 0.014
amine metabolic process GO:0009308 2 0.014
specification of symmetry GO:0009799 204 0.014
hemopoiesis GO:0030097 183 0.014
organic substance biosynthetic process GO:1901576 289 0.014
regulation of cellular amine metabolic process GO:0033238 0 0.014
cellular carbohydrate metabolic process GO:0044262 4 0.014
regulation of protein transport GO:0051223 3 0.014
erythrocyte homeostasis GO:0034101 55 0.014
interspecies interaction between organisms GO:0044419 4 0.014
cellular ketone metabolic process GO:0042180 11 0.014
ion homeostasis GO:0050801 41 0.014
oxoacid metabolic process GO:0043436 31 0.013
regulation of intracellular protein transport GO:0033157 3 0.013
notch signaling pathway GO:0007219 35 0.013
embryonic organ development GO:0048568 381 0.013
cellular amine metabolic process GO:0044106 2 0.013
regulation of cellular metabolic process GO:0031323 320 0.013
determination of left right symmetry GO:0007368 179 0.013
nuclear import GO:0051170 3 0.013
cellular modified amino acid metabolic process GO:0006575 3 0.013
single organism nuclear import GO:1902593 3 0.013
ion transmembrane transport GO:0034220 91 0.012
cellular amino acid metabolic process GO:0006520 7 0.012
lipoprotein metabolic process GO:0042157 4 0.012
pole plasm assembly GO:0007315 4 0.012
positive regulation of map kinase activity GO:0043406 3 0.012
regulation of cellular protein catabolic process GO:1903362 1 0.012
cell cycle g2 m phase transition GO:0044839 4 0.012
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.012
guanosine containing compound catabolic process GO:1901069 2 0.012
secondary metabolic process GO:0019748 3 0.012
negative regulation of protein complex assembly GO:0031333 1 0.012
cell death in response to oxidative stress GO:0036473 2 0.012
organic acid metabolic process GO:0006082 31 0.012
response to drug GO:0042493 3 0.012
regulation of cell death GO:0010941 103 0.012
nephron epithelium morphogenesis GO:0072088 1 0.012
spindle assembly involved in mitosis GO:0090307 1 0.012
nucleobase containing compound metabolic process GO:0006139 274 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.012
cell part morphogenesis GO:0032990 246 0.012
negative regulation of programmed cell death GO:0043069 58 0.012
nucleic acid transport GO:0050657 2 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.012
positive regulation of cell cycle GO:0045787 3 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
growth GO:0040007 174 0.012
cellular response to topologically incorrect protein GO:0035967 2 0.012
cellular respiration GO:0045333 3 0.012
heart morphogenesis GO:0003007 156 0.012
primary neural tube formation GO:0014020 1 0.012
single organism membrane fusion GO:0044801 2 0.012
regulation of reproductive process GO:2000241 4 0.012
cellular component morphogenesis GO:0032989 336 0.012
hormone transport GO:0009914 2 0.011
regulation of nucleoside metabolic process GO:0009118 2 0.011
regulation of synaptic plasticity GO:0048167 1 0.011
determination of bilateral symmetry GO:0009855 204 0.011
sensory organ development GO:0007423 393 0.011
nitrogen compound metabolic process GO:0006807 319 0.011
negative regulation of nuclear division GO:0051784 3 0.011
regulation of metal ion transport GO:0010959 4 0.011
aromatic compound biosynthetic process GO:0019438 217 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.011
cellular component movement GO:0006928 335 0.011
regulation of response to oxidative stress GO:1902882 2 0.011
meiotic chromosome segregation GO:0045132 3 0.011
small molecule metabolic process GO:0044281 77 0.011
head development GO:0060322 303 0.011
mitochondrion organization GO:0007005 4 0.011
lytic vacuole organization GO:0080171 1 0.011
rna biosynthetic process GO:0032774 181 0.011
spermatid differentiation GO:0048515 2 0.011
protein polymerization GO:0051258 4 0.011
heart development GO:0007507 313 0.011
multi organism process GO:0051704 134 0.011
positive regulation of cytokine production GO:0001819 2 0.011
regulation of metabolic process GO:0019222 359 0.011
regulation of jun kinase activity GO:0043506 3 0.011
regulation of protein import into nucleus GO:0042306 2 0.011
atp catabolic process GO:0006200 4 0.011
cell projection organization GO:0030030 284 0.011
regulation of microtubule cytoskeleton organization GO:0070507 3 0.011
ion transport GO:0006811 114 0.011
hepaticobiliary system development GO:0061008 98 0.011
antimicrobial humoral response GO:0019730 2 0.011
glial cell migration GO:0008347 3 0.011
rna localization GO:0006403 4 0.011
activation of mapk activity GO:0000187 3 0.011
olfactory lobe development GO:0021988 4 0.010
somatic stem cell maintenance GO:0035019 1 0.010
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.010
cell migration GO:0016477 237 0.010
type b pancreatic cell development GO:0003323 4 0.010
regulation of protein targeting GO:1903533 2 0.010
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.010
blood vessel development GO:0001568 246 0.010
single organism organelle organization GO:1902589 199 0.010
gtp catabolic process GO:0006184 2 0.010
regulation of epithelial cell proliferation GO:0050678 3 0.010
mitotic cytokinesis GO:0000281 3 0.010
regulation of meiotic cell cycle GO:0051445 1 0.010
cellular cation homeostasis GO:0030003 17 0.010
brain development GO:0007420 293 0.010
exocytosis GO:0006887 1 0.010
response to alkaloid GO:0043279 2 0.010
regulation of primary metabolic process GO:0080090 311 0.010
cellular response to molecule of bacterial origin GO:0071219 3 0.010
cellular protein metabolic process GO:0044267 129 0.010
adult behavior GO:0030534 2 0.010
negative regulation of apoptotic process GO:0043066 55 0.010
ribonucleoside monophosphate catabolic process GO:0009158 4 0.010
regulation of purine nucleotide catabolic process GO:0033121 2 0.010
negative regulation of multi organism process GO:0043901 3 0.010
protein k48 linked ubiquitination GO:0070936 1 0.010

unc50 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
nervous system disease DOID:863 0 0.028
disease of cellular proliferation DOID:14566 0 0.023
disease of metabolism DOID:0014667 0 0.020
inherited metabolic disorder DOID:655 0 0.018
lysosomal storage disease DOID:3211 0 0.016
cancer DOID:162 0 0.014
organ system cancer DOID:0050686 0 0.013
musculoskeletal system disease DOID:17 0 0.011