Danio rerio

11 known processes

smtnl

smoothelin, like

(Aliases: wu:fc73c08,zgc:101796)

smtnl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular component morphogenesis GO:0032989 336 0.626
signal transduction GO:0007165 455 0.567
cell part morphogenesis GO:0032990 246 0.541
regulation of response to stimulus GO:0048583 269 0.527
skeletal muscle organ development GO:0060538 78 0.482
regulation of signaling GO:0023051 235 0.436
cell motility GO:0048870 244 0.427
regulation of anatomical structure morphogenesis GO:0022603 130 0.394
cell morphogenesis GO:0000902 289 0.380
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.375
cell substrate adhesion GO:0031589 4 0.354
axonogenesis GO:0007409 152 0.343
cell projection organization GO:0030030 284 0.335
regulation of signal transduction GO:0009966 225 0.335
embryonic organ morphogenesis GO:0048562 274 0.325
establishment of localization GO:0051234 244 0.294
cell projection morphogenesis GO:0048858 244 0.293
neuron projection development GO:0031175 180 0.266
cell morphogenesis involved in differentiation GO:0000904 195 0.259
cell migration GO:0016477 237 0.247
regulation of protein localization to nucleus GO:1900180 2 0.216
notochord development GO:0030903 54 0.182
cell surface receptor signaling pathway GO:0007166 325 0.173
regulation of multicellular organismal process GO:0051239 277 0.166
positive regulation of transport GO:0051050 2 0.159
gene expression GO:0010467 252 0.148
sensory organ development GO:0007423 393 0.145
single organism localization GO:1902578 225 0.144
locomotion GO:0040011 313 0.140
localization of cell GO:0051674 244 0.137
embryonic organ development GO:0048568 381 0.137
larval development GO:0002164 2 0.129
embryo development ending in birth or egg hatching GO:0009792 271 0.127
neuron development GO:0048666 262 0.121
muscle organ development GO:0007517 101 0.120
regulation of cellular component organization GO:0051128 86 0.120
striated muscle tissue development GO:0014706 110 0.116
biological adhesion GO:0022610 40 0.115
skeletal system development GO:0001501 181 0.113
neuron projection morphogenesis GO:0048812 161 0.108
cell adhesion GO:0007155 40 0.107
regulation of cell communication GO:0010646 232 0.105
positive regulation of biological process GO:0048518 253 0.104
generation of neurons GO:0048699 385 0.104
positive regulation of cell adhesion GO:0045785 1 0.102
cellular component movement GO:0006928 335 0.100
nucleobase containing compound metabolic process GO:0006139 274 0.099
stem cell development GO:0048864 82 0.096
cellular component assembly GO:0022607 170 0.096
stem cell maintenance GO:0019827 4 0.095
aging GO:0007568 2 0.095
long chain fatty acid metabolic process GO:0001676 1 0.094
fin development GO:0033333 77 0.094
regulation of cell substrate adhesion GO:0010810 1 0.093
transport GO:0006810 220 0.093
regulation of cellular metabolic process GO:0031323 320 0.092
single organism metabolic process GO:0044710 217 0.092
positive regulation of cellular process GO:0048522 201 0.090
organic cyclic compound metabolic process GO:1901360 301 0.089
skeletal muscle tissue development GO:0007519 67 0.087
muscle tissue development GO:0060537 110 0.086
axon development GO:0061564 166 0.084
heart development GO:0007507 313 0.084
maintenance of location GO:0051235 4 0.078
regulation of intracellular protein transport GO:0033157 3 0.077
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.075
response to drug GO:0042493 3 0.075
small molecule metabolic process GO:0044281 77 0.074
germ line stem cell maintenance GO:0030718 2 0.073
wnt signaling pathway GO:0016055 80 0.073
cell matrix adhesion GO:0007160 4 0.073
neuron differentiation GO:0030182 353 0.073
regulation of tube size GO:0035150 2 0.071
regulation of epithelial cell proliferation GO:0050678 3 0.069
water homeostasis GO:0030104 4 0.066
single organism transport GO:0044765 206 0.066
regulation of biological quality GO:0065008 263 0.066
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.065
regulation of nucleocytoplasmic transport GO:0046822 2 0.060
regulation of metal ion transport GO:0010959 4 0.060
ear development GO:0043583 127 0.058
biosynthetic process GO:0009058 294 0.058
somite development GO:0061053 96 0.056
specification of symmetry GO:0009799 204 0.056
regulation of macromolecule biosynthetic process GO:0010556 225 0.054
cytoskeleton organization GO:0007010 96 0.054
response to external stimulus GO:0009605 264 0.052
establishment of protein localization to plasma membrane GO:0090002 1 0.051
ameboidal type cell migration GO:0001667 143 0.051
nucleic acid templated transcription GO:0097659 181 0.051
head development GO:0060322 303 0.050
cell migration involved in gastrulation GO:0042074 79 0.050
organic acid metabolic process GO:0006082 31 0.050
regulation of binding GO:0051098 3 0.049
establishment of localization in cell GO:0051649 77 0.049
cell recognition GO:0008037 19 0.048
regulation of calcium ion transport GO:0051924 2 0.048
lipid storage GO:0019915 1 0.048
blood coagulation GO:0007596 12 0.047
negative regulation of response to stimulus GO:0048585 104 0.047
blood vessel development GO:0001568 246 0.047
cellular biosynthetic process GO:0044249 286 0.046
organelle organization GO:0006996 227 0.046
monocarboxylic acid biosynthetic process GO:0072330 12 0.046
response to chemical GO:0042221 320 0.046
regulation of localization GO:0032879 104 0.045
embryonic heart tube morphogenesis GO:0003143 108 0.044
muscle structure development GO:0061061 196 0.044
establishment of protein localization to organelle GO:0072594 4 0.043
regulation of cytoplasmic transport GO:1903649 4 0.043
epiboly GO:0090504 41 0.042
positive regulation of cell substrate adhesion GO:0010811 1 0.042
cellular protein metabolic process GO:0044267 129 0.042
nucleobase containing compound biosynthetic process GO:0034654 205 0.042
embryonic heart tube development GO:0035050 133 0.042
system process GO:0003008 185 0.041
taxis GO:0042330 109 0.041
cartilage development GO:0051216 96 0.040
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.040
determination of bilateral symmetry GO:0009855 204 0.040
nuclear transport GO:0051169 4 0.040
regulation of cell shape GO:0008360 1 0.040
stem cell differentiation GO:0048863 117 0.040
positive regulation of cellular component biogenesis GO:0044089 3 0.039
embryonic skeletal system morphogenesis GO:0048704 93 0.038
embryonic skeletal system development GO:0048706 97 0.038
cellular ketone metabolic process GO:0042180 11 0.038
protein import into nucleus GO:0006606 3 0.038
single organism organelle organization GO:1902589 199 0.037
negative regulation of gene expression GO:0010629 65 0.037
intracellular signal transduction GO:0035556 85 0.037
phosphorus metabolic process GO:0006793 109 0.036
determination of heart left right asymmetry GO:0061371 117 0.035
neuron projection guidance GO:0097485 86 0.035
developmental growth involved in morphogenesis GO:0060560 86 0.035
regulation of cell differentiation GO:0045595 142 0.035
phagocytosis engulfment GO:0006911 1 0.035
regulation of primary metabolic process GO:0080090 311 0.035
response to organic substance GO:0010033 153 0.034
regulation of skeletal muscle fiber development GO:0048742 2 0.034
gastrulation GO:0007369 208 0.034
nitrogen compound metabolic process GO:0006807 319 0.034
heart looping GO:0001947 94 0.034
cellular nitrogen compound metabolic process GO:0034641 290 0.033
regulation of dendrite development GO:0050773 3 0.033
axonal fasciculation GO:0007413 11 0.033
regulation of skeletal muscle tissue development GO:0048641 4 0.033
cell migration involved in heart development GO:0060973 22 0.033
heterocycle metabolic process GO:0046483 290 0.033
mesenchyme development GO:0060485 127 0.032
negative regulation of cellular process GO:0048523 283 0.032
regulation of cell adhesion GO:0030155 15 0.032
regulation of metabolic process GO:0019222 359 0.032
homeostatic process GO:0042592 142 0.032
heart morphogenesis GO:0003007 156 0.031
determination of left right symmetry GO:0007368 179 0.031
growth GO:0040007 174 0.031
negative regulation of signal transduction GO:0009968 94 0.031
regulation of rna metabolic process GO:0051252 224 0.031
aromatic compound biosynthetic process GO:0019438 217 0.030
regulation of biosynthetic process GO:0009889 250 0.030
sensory organ morphogenesis GO:0090596 200 0.030
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.030
nucleocytoplasmic transport GO:0006913 4 0.030
negative regulation of epithelial cell proliferation GO:0050680 1 0.030
cell adhesion mediated by integrin GO:0033627 1 0.029
regulation of protein import into nucleus GO:0042306 2 0.029
protein metabolic process GO:0019538 183 0.029
nuclear import GO:0051170 3 0.029
endodermal cell differentiation GO:0035987 19 0.029
regionalization GO:0003002 274 0.029
brain development GO:0007420 293 0.029
cellular aromatic compound metabolic process GO:0006725 295 0.028
enzyme linked receptor protein signaling pathway GO:0007167 106 0.028
developmental growth GO:0048589 166 0.028
morphogenesis of an epithelium GO:0002009 333 0.028
oxoacid metabolic process GO:0043436 31 0.028
camera type eye development GO:0043010 222 0.028
actin filament based process GO:0030029 64 0.028
striated muscle cell differentiation GO:0051146 129 0.028
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.028
cellular localization GO:0051641 97 0.028
regulation of cellular biosynthetic process GO:0031326 245 0.027
regulation of cell matrix adhesion GO:0001952 1 0.027
negative regulation of nucleic acid templated transcription GO:1903507 45 0.027
hematopoietic or lymphoid organ development GO:0048534 191 0.027
cellular response to chemical stimulus GO:0070887 157 0.027
mesenchymal cell differentiation GO:0048762 87 0.027
skin development GO:0043588 54 0.027
cellular component biogenesis GO:0044085 178 0.027
regulation of stem cell differentiation GO:2000736 4 0.026
metal ion transport GO:0030001 58 0.026
embryonic cranial skeleton morphogenesis GO:0048701 90 0.026
regulation of cell development GO:0060284 100 0.026
circulatory system process GO:0003013 87 0.026
single organism intracellular transport GO:1902582 25 0.026
calcium ion homeostasis GO:0055074 19 0.026
regulation of blood vessel size GO:0050880 2 0.026
cellular component assembly involved in morphogenesis GO:0010927 107 0.025
muscle attachment GO:0016203 9 0.025
central nervous system development GO:0007417 387 0.025
regulation of meiotic cell cycle GO:0051445 1 0.025
programmed cell death GO:0012501 119 0.025
divalent metal ion transport GO:0070838 20 0.025
protein localization to nucleus GO:0034504 3 0.025
regulation of epithelial to mesenchymal transition GO:0010717 3 0.025
mesenchymal cell development GO:0014031 78 0.025
rna metabolic process GO:0016070 219 0.025
neuron projection extension GO:1990138 45 0.025
neuron recognition GO:0008038 18 0.024
inner ear development GO:0048839 126 0.024
cation transport GO:0006812 81 0.024
behavior GO:0007610 74 0.024
intracellular transport GO:0046907 32 0.024
eye development GO:0001654 277 0.024
protein import GO:0017038 3 0.024
positive regulation of multicellular organismal process GO:0051240 52 0.024
eye morphogenesis GO:0048592 144 0.023
carboxylic acid metabolic process GO:0019752 22 0.023
transmembrane transport GO:0055085 120 0.023
alcohol biosynthetic process GO:0046165 2 0.023
ion transport GO:0006811 114 0.023
regulation of multicellular organismal development GO:2000026 223 0.023
tube morphogenesis GO:0035239 349 0.023
negative regulation of locomotion GO:0040013 18 0.023
epithelial tube morphogenesis GO:0060562 148 0.023
transcription from rna polymerase ii promoter GO:0006366 80 0.022
fin morphogenesis GO:0033334 53 0.022
wound healing GO:0042060 90 0.022
regulation of cytokine production GO:0001817 3 0.022
cellular nitrogen compound biosynthetic process GO:0044271 218 0.022
epidermis development GO:0008544 48 0.022
endoderm development GO:0007492 49 0.022
skeletal system morphogenesis GO:0048705 102 0.022
anterior posterior pattern specification GO:0009952 152 0.022
regulation of macromolecule metabolic process GO:0060255 317 0.022
heart valve formation GO:0003188 4 0.021
protein targeting to nucleus GO:0044744 3 0.021
cellular macromolecule biosynthetic process GO:0034645 224 0.021
reproduction GO:0000003 40 0.021
cell fate commitment GO:0045165 99 0.021
macromolecule modification GO:0043412 111 0.021
actin cytoskeleton organization GO:0030036 63 0.021
regulation of cellular amino acid metabolic process GO:0006521 0 0.021
regulation of cell growth GO:0001558 29 0.021
organonitrogen compound metabolic process GO:1901564 74 0.021
positive regulation of signal transduction GO:0009967 56 0.021
negative regulation of metabolic process GO:0009892 86 0.021
single organism biosynthetic process GO:0044711 71 0.021
somitogenesis GO:0001756 87 0.020
nucleic acid metabolic process GO:0090304 244 0.020
positive regulation of muscle organ development GO:0048636 1 0.020
chordate embryonic development GO:0043009 271 0.020
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.020
heart jogging GO:0003146 40 0.020
regulation of cell proliferation GO:0042127 37 0.020
regulation of cell activation GO:0050865 1 0.020
regulation of gene expression GO:0010468 265 0.020
stem cell division GO:0017145 1 0.020
regulation of rho protein signal transduction GO:0035023 2 0.020
cellular response to extracellular stimulus GO:0031668 2 0.020
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.020
developmental cell growth GO:0048588 52 0.019
regulation of transport GO:0051049 45 0.019
kidney development GO:0001822 92 0.019
negative regulation of phosphate metabolic process GO:0045936 13 0.019
muscle cell development GO:0055001 115 0.019
meiotic nuclear division GO:0007126 4 0.019
neurotransmitter transport GO:0006836 2 0.019
cellular response to nutrient levels GO:0031669 2 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.019
cell projection assembly GO:0030031 64 0.019
appendage development GO:0048736 80 0.019
release of sequestered calcium ion into cytosol GO:0051209 3 0.019
bmp signaling pathway GO:0030509 52 0.019
positive regulation of signaling GO:0023056 56 0.019
phagocytosis GO:0006909 3 0.019
regulation of behavior GO:0050795 24 0.018
regulation of cell migration GO:0030334 40 0.018
negative regulation of sequestering of calcium ion GO:0051283 4 0.018
regulation of intracellular signal transduction GO:1902531 57 0.018
positive regulation of cell communication GO:0010647 56 0.018
organ formation GO:0048645 17 0.018
negative regulation of biological process GO:0048519 304 0.018
cellular response to external stimulus GO:0071496 2 0.018
cellular response to organic cyclic compound GO:0071407 38 0.018
convergent extension GO:0060026 118 0.018
forebrain cell migration GO:0021885 1 0.018
otic vesicle development GO:0071599 42 0.018
positive regulation of developmental process GO:0051094 50 0.018
cellular macromolecule metabolic process GO:0044260 391 0.018
heterocycle biosynthetic process GO:0018130 215 0.018
organic cyclic compound biosynthetic process GO:1901362 223 0.018
regulation of sequestering of calcium ion GO:0051282 4 0.018
fatty acid biosynthetic process GO:0006633 4 0.017
cellular protein catabolic process GO:0044257 4 0.017
response to inorganic substance GO:0010035 38 0.017
sensory perception of chemical stimulus GO:0007606 3 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.017
regulation of rna biosynthetic process GO:2001141 213 0.017
organic substance biosynthetic process GO:1901576 289 0.017
extrinsic apoptotic signaling pathway GO:0097191 3 0.017
cell substrate junction assembly GO:0007044 2 0.017
cellular response to endogenous stimulus GO:0071495 68 0.017
response to nutrient GO:0007584 3 0.017
cellular response to lipopolysaccharide GO:0071222 3 0.017
positive regulation of cell morphogenesis involved in differentiation GO:0010770 6 0.017
negative regulation of translation GO:0017148 1 0.016
organelle assembly GO:0070925 110 0.016
hemostasis GO:0007599 13 0.016
inner ear morphogenesis GO:0042472 63 0.016
regulation of apoptotic process GO:0042981 98 0.016
single organism cell adhesion GO:0098602 29 0.016
response to abiotic stimulus GO:0009628 122 0.016
regulation of cell morphogenesis GO:0022604 42 0.016
cellular response to xenobiotic stimulus GO:0071466 35 0.016
negative chemotaxis GO:0050919 1 0.016
cell death GO:0008219 121 0.016
cellular amine metabolic process GO:0044106 2 0.016
sequestering of metal ion GO:0051238 3 0.016
cardiac muscle tissue development GO:0048738 48 0.015
regulation of neuron projection development GO:0010975 40 0.015
positive regulation of macromolecule metabolic process GO:0010604 93 0.015
positive regulation of response to stimulus GO:0048584 80 0.015
cognition GO:0050890 1 0.015
medial fin development GO:0033338 16 0.015
regulation of purine nucleotide catabolic process GO:0033121 2 0.015
death GO:0016265 121 0.015
outflow tract morphogenesis GO:0003151 1 0.015
detection of chemical stimulus GO:0009593 4 0.015
protein localization to plasma membrane GO:0072659 1 0.015
regulation of neuron differentiation GO:0045664 56 0.015
negative regulation of protein phosphorylation GO:0001933 4 0.015
angiogenesis GO:0001525 158 0.015
cellular carbohydrate metabolic process GO:0044262 4 0.014
somatic muscle development GO:0007525 4 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.014
cation homeostasis GO:0055080 33 0.014
negative regulation of programmed cell death GO:0043069 58 0.014
digestive tract development GO:0048565 265 0.014
cell proliferation GO:0008283 80 0.014
regulation of epidermis development GO:0045682 2 0.014
digestive system development GO:0055123 289 0.014
divalent inorganic cation transport GO:0072511 21 0.014
connective tissue development GO:0061448 99 0.014
regulation of blood coagulation GO:0030193 1 0.014
single organism nuclear import GO:1902593 3 0.014
gastrulation with mouth forming second GO:0001702 44 0.014
apoptotic process GO:0006915 116 0.014
regulation of reproductive process GO:2000241 4 0.014
carbohydrate derivative metabolic process GO:1901135 61 0.013
regulation of synapse assembly GO:0051963 3 0.013
regulation of nervous system development GO:0051960 90 0.013
sequestering of calcium ion GO:0051208 3 0.013
endoderm formation GO:0001706 29 0.013
negative regulation of macromolecule metabolic process GO:0010605 76 0.013
retina morphogenesis in camera type eye GO:0060042 79 0.013
negative regulation of signaling GO:0023057 96 0.013
neurological system process GO:0050877 62 0.013
cytosolic calcium ion transport GO:0060401 3 0.013
trabecula morphogenesis GO:0061383 2 0.013
small gtpase mediated signal transduction GO:0007264 8 0.013
cilium morphogenesis GO:0060271 85 0.013
regulation of molecular function GO:0065009 70 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.013
rna biosynthetic process GO:0032774 181 0.013
cellular response to organic substance GO:0071310 105 0.013
response to oxygen levels GO:0070482 25 0.013
neuronal action potential GO:0019228 18 0.013
regulation of wnt signaling pathway GO:0030111 53 0.013
digestive tract morphogenesis GO:0048546 231 0.013
kupffer s vesicle development GO:0070121 50 0.013
ear morphogenesis GO:0042471 64 0.013
embryonic limb morphogenesis GO:0030326 2 0.013
transcription dna templated GO:0006351 181 0.013
adult behavior GO:0030534 2 0.013
macromolecule biosynthetic process GO:0009059 227 0.013
coagulation GO:0050817 13 0.013
regulation of transcription dna templated GO:0006355 213 0.013
negative regulation of bmp signaling pathway GO:0030514 13 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
renal system development GO:0072001 94 0.013
cellular response to molecule of bacterial origin GO:0071219 3 0.013
synaptic growth at neuromuscular junction GO:0051124 2 0.012
calcium ion transport into cytosol GO:0060402 3 0.012
muscle fiber development GO:0048747 52 0.012
muscle cell fate determination GO:0007521 1 0.012
guanosine containing compound metabolic process GO:1901068 4 0.012
cell migration to the midline involved in heart development GO:0003318 12 0.012
negative regulation of cell death GO:0060548 60 0.012
sodium ion transport GO:0006814 24 0.012
negative regulation of rna biosynthetic process GO:1902679 45 0.012
b cell activation GO:0042113 2 0.012
positive regulation of catabolic process GO:0009896 4 0.012
regulation of protein targeting GO:1903533 2 0.012
membrane raft organization GO:0031579 1 0.012
cilium organization GO:0044782 71 0.012
regulation of neurotransmitter transport GO:0051588 1 0.012
protein secretion GO:0009306 1 0.012
regulation of transmembrane transporter activity GO:0022898 2 0.012
cellular amino acid metabolic process GO:0006520 7 0.012
bone remodeling GO:0046849 2 0.012
notochord morphogenesis GO:0048570 17 0.011
gtp metabolic process GO:0046039 4 0.011
blood circulation GO:0008015 87 0.011
negative regulation of cell communication GO:0010648 96 0.011
ion transmembrane transport GO:0034220 91 0.011
activation of mapk activity GO:0000187 3 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
cellular response to unfolded protein GO:0034620 2 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.011
regulation of cellular component movement GO:0051270 55 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
rna stabilization GO:0043489 4 0.011
transmission of nerve impulse GO:0019226 19 0.011
regulation of ion transport GO:0043269 22 0.011
lipid biosynthetic process GO:0008610 22 0.011
positive regulation of metabolic process GO:0009893 108 0.011
stem cell proliferation GO:0072089 4 0.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.011
camera type eye morphogenesis GO:0048593 108 0.011
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.011
cell junction organization GO:0034330 11 0.011
membrane invagination GO:0010324 1 0.011
positive regulation of muscle tissue development GO:1901863 1 0.011
energy reserve metabolic process GO:0006112 2 0.010
regulation of locomotion GO:0040012 55 0.010
regulation of multicellular organism growth GO:0040014 4 0.010
regulation of cellular protein metabolic process GO:0032268 52 0.010
regulation of transporter activity GO:0032409 2 0.010
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.010
vasculature development GO:0001944 278 0.010
ras protein signal transduction GO:0007265 7 0.010
protein complex assembly GO:0006461 30 0.010
gtp catabolic process GO:0006184 2 0.010
amine metabolic process GO:0009308 2 0.010
response to fluid shear stress GO:0034405 2 0.010
negative regulation of cell morphogenesis involved in differentiation GO:0010771 8 0.010
striated muscle cell development GO:0055002 108 0.010
multicellular organismal metabolic process GO:0044236 2 0.010
regulation of protein binding GO:0043393 3 0.010
positive regulation of cellular component organization GO:0051130 13 0.010

smtnl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.123
musculoskeletal system disease DOID:17 0 0.025