Danio rerio

0 known processes

ptplb

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b

(Aliases: zgc:55421,wu:fi32c08)

ptplb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
lipid catabolic process GO:0016042 4 0.124
maintenance of location GO:0051235 4 0.118
regulation of protein complex assembly GO:0043254 3 0.099
protein polymerization GO:0051258 4 0.093
cellular lipid catabolic process GO:0044242 3 0.083
negative regulation of biological process GO:0048519 304 0.067
lipid storage GO:0019915 1 0.064
modification dependent protein catabolic process GO:0019941 3 0.062
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.061
protein polyubiquitination GO:0000209 4 0.060
aging GO:0007568 2 0.058
cellular protein catabolic process GO:0044257 4 0.057
negative regulation of protein complex assembly GO:0031333 1 0.057
modification dependent macromolecule catabolic process GO:0043632 3 0.050
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.048
regulation of protein catabolic process GO:0042176 1 0.046
meiotic nuclear division GO:0007126 4 0.045
positive regulation of catabolic process GO:0009896 4 0.044
proteasomal protein catabolic process GO:0010498 2 0.042
small molecule metabolic process GO:0044281 77 0.041
actin polymerization or depolymerization GO:0008154 2 0.041
phagocytosis GO:0006909 3 0.041
larval development GO:0002164 2 0.040
Worm
positive regulation of cell cycle GO:0045787 3 0.040
fatty acid catabolic process GO:0009062 1 0.039
regulation of protein transport GO:0051223 3 0.039
nitrogen compound metabolic process GO:0006807 319 0.038
regulation of biological quality GO:0065008 263 0.038
multicellular organism growth GO:0035264 4 0.036
ubiquitin dependent protein catabolic process GO:0006511 3 0.036
cellular ketone metabolic process GO:0042180 11 0.035
actin filament polymerization GO:0030041 2 0.035
carboxylic acid catabolic process GO:0046395 3 0.033
single organism organelle organization GO:1902589 199 0.033
regulation of establishment of protein localization GO:0070201 4 0.033
negative regulation of cellular process GO:0048523 283 0.032
response to chemical GO:0042221 320 0.032
small molecule catabolic process GO:0044282 3 0.031
stem cell maintenance GO:0019827 4 0.031
protein complex disassembly GO:0043241 1 0.031
organelle organization GO:0006996 227 0.031
positive regulation of transport GO:0051050 2 0.031
cellular respiration GO:0045333 3 0.030
regulation of multicellular organism growth GO:0040014 4 0.030
lipid oxidation GO:0034440 1 0.030
regulation of carbohydrate metabolic process GO:0006109 4 0.030
cellular carbohydrate metabolic process GO:0044262 4 0.030
fatty acid beta oxidation GO:0006635 1 0.030
regulation of binding GO:0051098 3 0.029
energy reserve metabolic process GO:0006112 2 0.029
negative regulation of catabolic process GO:0009895 3 0.029
regulation of cellular ketone metabolic process GO:0010565 7 0.029
response to organic substance GO:0010033 153 0.029
cellular component disassembly GO:0022411 1 0.028
protein metabolic process GO:0019538 183 0.028
amine metabolic process GO:0009308 2 0.028
monocarboxylic acid catabolic process GO:0072329 3 0.028
rna localization GO:0006403 4 0.028
cellular nitrogen compound metabolic process GO:0034641 290 0.027
cellular amine metabolic process GO:0044106 2 0.027
regulation of oocyte development GO:0060281 3 0.026
organic acid metabolic process GO:0006082 31 0.026
regulation of nitrogen compound metabolic process GO:0051171 251 0.026
nucleoside monophosphate catabolic process GO:0009125 4 0.026
single organism localization GO:1902578 225 0.025
Worm
response to stress GO:0006950 263 0.025
single organism metabolic process GO:0044710 217 0.025
regulation of metal ion transport GO:0010959 4 0.025
signal transduction GO:0007165 455 0.025
cellular response to external stimulus GO:0071496 2 0.025
positive regulation of cellular catabolic process GO:0031331 3 0.024
regulation of response to stimulus GO:0048583 269 0.024
response to drug GO:0042493 3 0.024
cellular macromolecule biosynthetic process GO:0034645 224 0.024
ribonucleoside monophosphate catabolic process GO:0009158 4 0.024
peptidyl threonine phosphorylation GO:0018107 1 0.024
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.023
protein secretion GO:0009306 1 0.023
positive regulation of cellular component biogenesis GO:0044089 3 0.023
positive regulation of cytoskeleton organization GO:0051495 3 0.023
cellular component assembly GO:0022607 170 0.022
biosynthetic process GO:0009058 294 0.022
carboxylic acid metabolic process GO:0019752 22 0.022
heterocycle metabolic process GO:0046483 290 0.022
regulation of reproductive process GO:2000241 4 0.022
cellular macromolecule metabolic process GO:0044260 391 0.022
regulation of cellular biosynthetic process GO:0031326 245 0.022
establishment of rna localization GO:0051236 3 0.021
cellular biosynthetic process GO:0044249 286 0.021
oocyte maturation GO:0001556 4 0.021
regulation of intracellular protein transport GO:0033157 3 0.021
organic substance biosynthetic process GO:1901576 289 0.021
extrinsic apoptotic signaling pathway GO:0097191 3 0.021
rna transport GO:0050658 2 0.021
cellular response to chemical stimulus GO:0070887 157 0.021
protein localization to plasma membrane GO:0072659 1 0.021
regulation of circadian rhythm GO:0042752 4 0.021
cellular response to starvation GO:0009267 1 0.021
regulation of cytoplasmic transport GO:1903649 4 0.020
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.020
regulation of chromosome segregation GO:0051983 1 0.020
protein localization to nucleus GO:0034504 3 0.020
cellular nitrogen compound biosynthetic process GO:0044271 218 0.019
regulation of protein complex disassembly GO:0043244 1 0.019
regulation of primary metabolic process GO:0080090 311 0.019
negative regulation of protein phosphorylation GO:0001933 4 0.019
oxoacid metabolic process GO:0043436 31 0.019
regulation of cellular protein catabolic process GO:1903362 1 0.019
cellular component biogenesis GO:0044085 178 0.019
macromolecular complex disassembly GO:0032984 1 0.019
regulation of cell shape GO:0008360 1 0.019
positive regulation of secretion by cell GO:1903532 1 0.019
growth GO:0040007 174 0.019
single organism biosynthetic process GO:0044711 71 0.019
protein import GO:0017038 3 0.019
nucleic acid transport GO:0050657 2 0.019
response to other organism GO:0051707 97 0.019
protein import into nucleus GO:0006606 3 0.018
fatty acid oxidation GO:0019395 1 0.018
cellular response to nutrient levels GO:0031669 2 0.018
positive regulation of apoptotic signaling pathway GO:2001235 1 0.018
membrane invagination GO:0010324 1 0.018
death GO:0016265 121 0.018
regulation of cytokine production GO:0001817 3 0.018
meiosis i GO:0007127 1 0.018
regulation of protein ubiquitination GO:0031396 3 0.018
system process GO:0003008 185 0.018
oxidation reduction process GO:0055114 41 0.018
regulation of signaling GO:0023051 235 0.018
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.018
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.018
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
regulation of developmental process GO:0050793 247 0.017
regulation of organ growth GO:0046620 3 0.017
pronuclear migration GO:0035046 1 0.017
endoplasmic reticulum unfolded protein response GO:0030968 2 0.017
cognition GO:0050890 1 0.017
single organism transport GO:0044765 206 0.017
Worm
lipid metabolic process GO:0006629 52 0.017
cellular protein modification process GO:0006464 100 0.017
response to topologically incorrect protein GO:0035966 2 0.017
organic acid catabolic process GO:0016054 3 0.017
nucleocytoplasmic transport GO:0006913 4 0.017
regulation of cellular component organization GO:0051128 86 0.017
purine nucleoside monophosphate catabolic process GO:0009128 4 0.017
regulation of organelle assembly GO:1902115 4 0.016
cellular aromatic compound metabolic process GO:0006725 295 0.016
atp catabolic process GO:0006200 4 0.016
response to endogenous stimulus GO:0009719 83 0.016
nuclear transport GO:0051169 4 0.016
phagocytosis engulfment GO:0006911 1 0.016
germ line stem cell maintenance GO:0030718 2 0.016
guanosine containing compound metabolic process GO:1901068 4 0.016
establishment of protein localization to organelle GO:0072594 4 0.016
mitotic dna integrity checkpoint GO:0044774 4 0.016
positive regulation of cell division GO:0051781 2 0.016
nuclear import GO:0051170 3 0.016
regulation of protein polymerization GO:0032271 2 0.016
signal transduction in absence of ligand GO:0038034 1 0.016
regulation of gene expression GO:0010468 265 0.016
gtp metabolic process GO:0046039 4 0.015
cellular response to extracellular stimulus GO:0031668 2 0.015
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.015
locomotion GO:0040011 313 0.015
Worm
cellular amino acid metabolic process GO:0006520 7 0.015
apoptotic process GO:0006915 116 0.015
nucleobase containing compound transport GO:0015931 2 0.015
negative regulation of cellular component organization GO:0051129 16 0.015
single organism nuclear import GO:1902593 3 0.015
negative regulation of chromosome organization GO:2001251 1 0.015
secondary metabolic process GO:0019748 3 0.015
cell death GO:0008219 121 0.015
nucleic acid metabolic process GO:0090304 244 0.015
regulation of metabolic process GO:0019222 359 0.015
cation transmembrane transport GO:0098655 65 0.015
regulation of reactive oxygen species metabolic process GO:2000377 2 0.015
heterocycle biosynthetic process GO:0018130 215 0.015
gtp catabolic process GO:0006184 2 0.015
nucleobase containing compound metabolic process GO:0006139 274 0.015
tube morphogenesis GO:0035239 349 0.015
nucleobase containing compound biosynthetic process GO:0034654 205 0.015
positive regulation of secretion GO:0051047 1 0.015
digestive system development GO:0055123 289 0.015
pole plasm assembly GO:0007315 4 0.015
regulation of protein binding GO:0043393 3 0.015
homeostatic process GO:0042592 142 0.015
cation transport GO:0006812 81 0.014
cellular lipid metabolic process GO:0044255 36 0.014
lamellipodium organization GO:0097581 1 0.014
centrosome organization GO:0051297 1 0.014
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.014
programmed cell death GO:0012501 119 0.014
regulation of multicellular organismal process GO:0051239 277 0.014
regulation of protein depolymerization GO:1901879 1 0.014
cytoskeleton organization GO:0007010 96 0.014
carbohydrate biosynthetic process GO:0016051 1 0.014
regulation of cell communication GO:0010646 232 0.014
negative regulation of cellular catabolic process GO:0031330 3 0.014
regulation of synapse assembly GO:0051963 3 0.014
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.014
regulation of mrna processing GO:0050684 3 0.014
stem cell proliferation GO:0072089 4 0.014
regulation of biosynthetic process GO:0009889 250 0.014
morphogenesis of an epithelium GO:0002009 333 0.014
synaptic growth at neuromuscular junction GO:0051124 2 0.014
apoptotic process involved in morphogenesis GO:0060561 2 0.014
regulation of nucleocytoplasmic transport GO:0046822 2 0.014
regulation of localization GO:0032879 104 0.014
adherens junction organization GO:0034332 4 0.014
establishment of localization GO:0051234 244 0.014
Worm
response to external biotic stimulus GO:0043207 97 0.013
fertilization GO:0009566 3 0.013
cell substrate adhesion GO:0031589 4 0.013
meiotic chromosome segregation GO:0045132 3 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.013
regulation of cell death GO:0010941 103 0.013
guanosine containing compound catabolic process GO:1901069 2 0.013
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.013
trabecula morphogenesis GO:0061383 2 0.013
regulation of cellular metabolic process GO:0031323 320 0.013
regulation of cell maturation GO:1903429 1 0.013
peptidyl threonine modification GO:0018210 1 0.013
microtubule organizing center organization GO:0031023 1 0.013
macromolecule biosynthetic process GO:0009059 227 0.013
intracellular signal transduction GO:0035556 85 0.013
protein homooligomerization GO:0051260 3 0.013
single fertilization GO:0007338 3 0.013
macromolecule modification GO:0043412 111 0.013
regulation of response to biotic stimulus GO:0002831 2 0.013
electron transport chain GO:0022900 2 0.013
negative regulation of metabolic process GO:0009892 86 0.013
protein stabilization GO:0050821 2 0.013
transmission of nerve impulse GO:0019226 19 0.013
regulation of epithelial cell proliferation GO:0050678 3 0.013
meiotic cell cycle process GO:1903046 3 0.013
regulation of microtubule cytoskeleton organization GO:0070507 3 0.013
leukocyte proliferation GO:0070661 1 0.013
negative regulation of nuclear division GO:0051784 3 0.013
response to uv GO:0009411 3 0.013
long chain fatty acid metabolic process GO:0001676 1 0.013
cellular transition metal ion homeostasis GO:0046916 3 0.013
cellular response to endogenous stimulus GO:0071495 68 0.013
macromolecular complex assembly GO:0065003 35 0.013
regulation of cell activation GO:0050865 1 0.013
regulation of macromolecule metabolic process GO:0060255 317 0.013
mitotic g2 m transition checkpoint GO:0044818 3 0.013
somatic muscle development GO:0007525 4 0.013
developmental maturation GO:0021700 34 0.013
striated muscle cell differentiation GO:0051146 129 0.013
organic cyclic compound metabolic process GO:1901360 301 0.012
transmembrane transport GO:0055085 120 0.012
regulation of protein localization to plasma membrane GO:1903076 1 0.012
response to abiotic stimulus GO:0009628 122 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
regulation of apoptotic process GO:0042981 98 0.012
regulation of protein import into nucleus GO:0042306 2 0.012
regulation of rna metabolic process GO:0051252 224 0.012
gene expression GO:0010467 252 0.012
respiratory electron transport chain GO:0022904 2 0.012
regulation of meiotic cell cycle GO:0051445 1 0.012
negative regulation of cytokine production GO:0001818 1 0.012
rna biosynthetic process GO:0032774 181 0.012
nucleic acid templated transcription GO:0097659 181 0.012
negative regulation of dna metabolic process GO:0051053 4 0.012
positive regulation of ras protein signal transduction GO:0046579 1 0.012
protein targeting to nucleus GO:0044744 3 0.012
negative regulation of synapse assembly GO:0051964 2 0.012
alcohol biosynthetic process GO:0046165 2 0.012
maternal determination of anterior posterior axis embryo GO:0008358 4 0.012
cell substrate junction assembly GO:0007044 2 0.012
regulation of response to extracellular stimulus GO:0032104 1 0.012
negative regulation of intracellular transport GO:0032387 3 0.012
positive regulation of myeloid cell differentiation GO:0045639 2 0.012
macromolecule deacylation GO:0098732 3 0.012
sensory perception of chemical stimulus GO:0007606 3 0.012
cytosolic calcium ion transport GO:0060401 3 0.012
membrane fusion GO:0061025 2 0.012
cellular macromolecular complex assembly GO:0034622 24 0.012
regulation of response to nutrient levels GO:0032107 1 0.012
germ line stem cell division GO:0042078 1 0.012
neuronal action potential GO:0019228 18 0.012
response to unfolded protein GO:0006986 2 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
cellular amide metabolic process GO:0043603 4 0.012
transport GO:0006810 220 0.012
Worm
regulation of protein targeting GO:1903533 2 0.012
monoamine transport GO:0015844 1 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
protein depolymerization GO:0051261 1 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.011
cellular response to organic substance GO:0071310 105 0.011
embryonic organ morphogenesis GO:0048562 274 0.011
developmental programmed cell death GO:0010623 4 0.011
compound eye development GO:0048749 2 0.011
positive regulation of cell activation GO:0050867 1 0.011
aromatic compound biosynthetic process GO:0019438 217 0.011
spindle assembly GO:0051225 2 0.011
negative regulation of reproductive process GO:2000242 3 0.011
mitochondrion organization GO:0007005 4 0.011
lateral inhibition GO:0046331 1 0.011
phosphorus metabolic process GO:0006793 109 0.011
mononuclear cell proliferation GO:0032943 1 0.011
hematopoietic or lymphoid organ development GO:0048534 191 0.011
adult behavior GO:0030534 2 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
locomotor rhythm GO:0045475 3 0.011
regulation of macromolecule biosynthetic process GO:0010556 225 0.011
immune system process GO:0002376 241 0.011
cellular protein metabolic process GO:0044267 129 0.011
cell projection organization GO:0030030 284 0.011
regulation of calcium ion transport GO:0051924 2 0.011
cellular component maintenance GO:0043954 3 0.011
regulation of nucleoside metabolic process GO:0009118 2 0.011
regulation of synapse organization GO:0050807 3 0.011
negative regulation of multi organism process GO:0043901 3 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
negative regulation of protein transport GO:0051224 3 0.011
organelle fusion GO:0048284 3 0.011
regulation of mrna splicing via spliceosome GO:0048024 3 0.011
cell morphogenesis GO:0000902 289 0.011
positive regulation of map kinase activity GO:0043406 3 0.011
cellular response to biotic stimulus GO:0071216 3 0.011
regulation of organelle organization GO:0033043 29 0.011
multi organism process GO:0051704 134 0.011
positive regulation of protein polymerization GO:0032273 2 0.011
hemopoiesis GO:0030097 183 0.011
cellular response to topologically incorrect protein GO:0035967 2 0.011
response to hexose GO:0009746 3 0.011
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
i kappab kinase nf kappab signaling GO:0007249 4 0.010
epithelial cell morphogenesis GO:0003382 2 0.010
regulation of transcription dna templated GO:0006355 213 0.010
regulation of membrane potential GO:0042391 23 0.010
hormone secretion GO:0046879 2 0.010
inositol lipid mediated signaling GO:0048017 2 0.010
cell proliferation GO:0008283 80 0.010
regulation of transporter activity GO:0032409 2 0.010
positive regulation of chromosome organization GO:2001252 1 0.010
positive regulation of nucleotide catabolic process GO:0030813 1 0.010
regulation of cell substrate adhesion GO:0010810 1 0.010
cell cycle g2 m phase transition GO:0044839 4 0.010
muscle structure development GO:0061061 196 0.010
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.010
peptide transport GO:0015833 1 0.010
stem cell division GO:0017145 1 0.010
cell cycle GO:0007049 93 0.010
regulation of programmed cell death GO:0043067 101 0.010
response to biotic stimulus GO:0009607 97 0.010
cranial ganglion development GO:0061550 3 0.010
tube closure GO:0060606 1 0.010
response to corticosteroid GO:0031960 1 0.010
chordate embryonic development GO:0043009 271 0.010
apoptotic process involved in development GO:1902742 2 0.010
type b pancreatic cell development GO:0003323 4 0.010
regulation of wound healing GO:0061041 2 0.010
positive regulation of protein complex assembly GO:0031334 2 0.010

ptplb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.039
nervous system disease DOID:863 0 0.017
disease of metabolism DOID:0014667 0 0.017
musculoskeletal system disease DOID:17 0 0.017
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.014
inherited metabolic disorder DOID:655 0 0.012