Danio rerio

62 known processes

ttk

ttk protein kinase

(Aliases: ncp,mps1)

ttk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
locomotion GO:0040011 313 0.498
meiotic nuclear division GO:0007126 4 0.381
larval development GO:0002164 2 0.287
microtubule organizing center organization GO:0031023 1 0.283
Yeast
mitotic nuclear division GO:0007067 18 0.281
Yeast
microtubule based process GO:0007017 60 0.262
Yeast
meiosis i GO:0007127 1 0.260
cell motility GO:0048870 244 0.242
cytokinesis GO:0000910 3 0.233
centrosome organization GO:0051297 1 0.173
establishment of localization GO:0051234 244 0.170
Yeast
spindle assembly GO:0051225 2 0.163
Yeast
hematopoietic or lymphoid organ development GO:0048534 191 0.159
establishment of protein localization to organelle GO:0072594 4 0.153
cytoskeleton organization GO:0007010 96 0.143
Yeast
microtubule cytoskeleton organization GO:0000226 33 0.141
Yeast
aging GO:0007568 2 0.137
embryo development ending in birth or egg hatching GO:0009792 271 0.131
regulation of synapse organization GO:0050807 3 0.123
regulation of cytoskeleton organization GO:0051493 11 0.123
Yeast
cell migration GO:0016477 237 0.120
cytokinetic process GO:0032506 2 0.120
organelle organization GO:0006996 227 0.118
digestive tract development GO:0048565 265 0.116
single organism localization GO:1902578 225 0.110
Yeast
spindle assembly involved in mitosis GO:0090307 1 0.110
positive regulation of cell cycle GO:0045787 3 0.109
cellular component movement GO:0006928 335 0.103
nucleobase containing compound metabolic process GO:0006139 274 0.103
oocyte maturation GO:0001556 4 0.102
negative regulation of mitosis GO:0045839 3 0.102
Yeast
regulation of biological quality GO:0065008 263 0.101
nuclear import GO:0051170 3 0.095
reproductive process GO:0022414 40 0.088
protein localization to nucleus GO:0034504 3 0.087
centrosome duplication GO:0051298 1 0.085
negative regulation of cellular process GO:0048523 283 0.084
cellular macromolecule metabolic process GO:0044260 391 0.082
Yeast
cleavage furrow formation GO:0036089 2 0.078
single organism nuclear import GO:1902593 3 0.077
nucleocytoplasmic transport GO:0006913 4 0.077
meiotic chromosome segregation GO:0045132 3 0.077
protein targeting to nucleus GO:0044744 3 0.075
nuclear transport GO:0051169 4 0.074
protein import into nucleus GO:0006606 3 0.073
single organism metabolic process GO:0044710 217 0.071
Yeast
modification dependent protein catabolic process GO:0019941 3 0.069
Yeast
regulation of primary metabolic process GO:0080090 311 0.069
Yeast
regulation of protein transport GO:0051223 3 0.067
regulation of protein localization to nucleus GO:1900180 2 0.067
transport GO:0006810 220 0.066
biosynthetic process GO:0009058 294 0.066
mitotic sister chromatid segregation GO:0000070 6 0.065
Yeast
regulation of intracellular protein transport GO:0033157 3 0.064
regulation of establishment of protein localization GO:0070201 4 0.063
regulation of metabolic process GO:0019222 359 0.062
Yeast
male meiosis GO:0007140 2 0.062
cell projection organization GO:0030030 284 0.062
meiotic cell cycle process GO:1903046 3 0.062
mitotic cell cycle process GO:1903047 48 0.062
stem cell proliferation GO:0072089 4 0.061
negative regulation of nuclear division GO:0051784 3 0.060
Yeast
regulation of protein import into nucleus GO:0042306 2 0.060
response to abiotic stimulus GO:0009628 122 0.060
stem cell maintenance GO:0019827 4 0.059
neuroblast proliferation GO:0007405 2 0.059
apoptotic process GO:0006915 116 0.056
negative regulation of biological process GO:0048519 304 0.056
cell division GO:0051301 20 0.056
Yeast
cellular component disassembly GO:0022411 1 0.056
nuclear division GO:0000280 23 0.056
macromolecular complex disassembly GO:0032984 1 0.055
regulation of nucleocytoplasmic transport GO:0046822 2 0.055
regulation of cellular component organization GO:0051128 86 0.054
Yeast
protein complex disassembly GO:0043241 1 0.051
single organism reproductive process GO:0044702 40 0.050
single organism organelle organization GO:1902589 199 0.050
Yeast
microtubule polymerization or depolymerization GO:0031109 3 0.050
single organism transport GO:0044765 206 0.050
cellular aromatic compound metabolic process GO:0006725 295 0.049
neuron projection development GO:0031175 180 0.049
fertilization GO:0009566 3 0.048
ubiquitin dependent protein catabolic process GO:0006511 3 0.048
Yeast
reproduction GO:0000003 40 0.047
nitrogen compound metabolic process GO:0006807 319 0.047
maintenance of location GO:0051235 4 0.047
Yeast
regulation of meiotic cell cycle GO:0051445 1 0.046
microtubule depolymerization GO:0007019 1 0.046
cell cycle GO:0007049 93 0.046
localization of cell GO:0051674 244 0.046
centrosome cycle GO:0007098 1 0.045
protein complex subunit organization GO:0071822 46 0.045
Yeast
blood vessel morphogenesis GO:0048514 216 0.044
regulation of chromosome segregation GO:0051983 1 0.043
Yeast
regulation of cytoplasmic transport GO:1903649 4 0.043
single organism cellular localization GO:1902580 46 0.041
single fertilization GO:0007338 3 0.040
cellular component biogenesis GO:0044085 178 0.040
Yeast
negative regulation of cytoplasmic transport GO:1903650 2 0.040
neuron development GO:0048666 262 0.040
negative regulation of protein localization to nucleus GO:1900181 2 0.040
regulation of neural precursor cell proliferation GO:2000177 3 0.040
regulation of macromolecule metabolic process GO:0060255 317 0.039
Yeast
regulation of multicellular organism growth GO:0040014 4 0.039
multicellular organism growth GO:0035264 4 0.038
organic cyclic compound metabolic process GO:1901360 301 0.038
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.038
Yeast
positive regulation of biological process GO:0048518 253 0.038
regulation of locomotion GO:0040012 55 0.036
death GO:0016265 121 0.035
positive regulation of catabolic process GO:0009896 4 0.035
mitotic metaphase plate congression GO:0007080 1 0.035
Yeast
regulation of protein catabolic process GO:0042176 1 0.035
Yeast
neural precursor cell proliferation GO:0061351 20 0.035
regulation of protein depolymerization GO:1901879 1 0.034
immune system development GO:0002520 191 0.034
protein polymerization GO:0051258 4 0.034
cell cycle process GO:0022402 53 0.033
heterocycle metabolic process GO:0046483 290 0.033
gene expression GO:0010467 252 0.033
Yeast
protein complex assembly GO:0006461 30 0.032
Yeast
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.032
Yeast
muscle structure development GO:0061061 196 0.032
modification dependent macromolecule catabolic process GO:0043632 3 0.031
Yeast
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.031
regulation of protein targeting GO:1903533 2 0.031
proteasomal protein catabolic process GO:0010498 2 0.031
Yeast
digestive system development GO:0055123 289 0.030
dna biosynthetic process GO:0071897 3 0.030
regulation of microtubule cytoskeleton organization GO:0070507 3 0.029
Yeast
g1 s transition of mitotic cell cycle GO:0000082 1 0.029
astral microtubule organization GO:0030953 1 0.029
cellular localization GO:0051641 97 0.028
Yeast
organelle fission GO:0048285 23 0.028
positive regulation of cell division GO:0051781 2 0.028
cellular nitrogen compound metabolic process GO:0034641 290 0.027
meiotic spindle organization GO:0000212 1 0.026
cell part morphogenesis GO:0032990 246 0.026
signal transduction GO:0007165 455 0.026
negative regulation of developmental process GO:0051093 65 0.026
regulation of organelle organization GO:0033043 29 0.026
Yeast
endocytosis GO:0006897 16 0.026
positive regulation of transport GO:0051050 2 0.025
generation of neurons GO:0048699 385 0.025
stem cell development GO:0048864 82 0.025
protein localization GO:0008104 40 0.024
Yeast
reciprocal dna recombination GO:0035825 1 0.024
regulation of protein binding GO:0043393 3 0.024
establishment of spindle localization GO:0051293 12 0.023
cell proliferation GO:0008283 80 0.023
actin cytoskeleton organization GO:0030036 63 0.023
regulation of signaling GO:0023051 235 0.023
meiosis ii GO:0007135 1 0.023
positive regulation of chromosome segregation GO:0051984 1 0.023
regulation of protein complex disassembly GO:0043244 1 0.022
somatic cell dna recombination GO:0016444 1 0.022
aromatic compound biosynthetic process GO:0019438 217 0.022
reciprocal meiotic recombination GO:0007131 1 0.022
protein depolymerization GO:0051261 1 0.022
regulation of cell cycle GO:0051726 52 0.022
sensory organ development GO:0007423 393 0.022
heterocycle biosynthetic process GO:0018130 215 0.021
cellular protein catabolic process GO:0044257 4 0.021
Yeast
hemopoiesis GO:0030097 183 0.021
positive regulation of cytoskeleton organization GO:0051495 3 0.021
cytoskeleton dependent cytokinesis GO:0061640 3 0.021
negative regulation of catabolic process GO:0009895 3 0.021
Yeast
organelle localization GO:0051640 49 0.021
Yeast
cellular component assembly GO:0022607 170 0.020
Yeast
regulation of protein ubiquitination GO:0031396 3 0.020
mitotic cell cycle GO:0000278 64 0.020
negative regulation of protein transport GO:0051224 3 0.020
developmental growth GO:0048589 166 0.020
action potential GO:0001508 19 0.020
regulation of cell cycle process GO:0010564 20 0.020
cellular biosynthetic process GO:0044249 286 0.020
phagocytosis GO:0006909 3 0.020
small molecule metabolic process GO:0044281 77 0.020
actin filament based process GO:0030029 64 0.019
cellular protein complex disassembly GO:0043624 1 0.019
microtubule based movement GO:0007018 33 0.019
positive regulation of mrna metabolic process GO:1903313 2 0.019
negative regulation of cell cycle process GO:0010948 9 0.019
peptidyl serine modification GO:0018209 2 0.019
regulation of microtubule polymerization or depolymerization GO:0031110 3 0.019
leukocyte proliferation GO:0070661 1 0.019
macromolecule localization GO:0033036 54 0.019
Yeast
peptidyl serine phosphorylation GO:0018105 1 0.019
organelle assembly GO:0070925 110 0.019
Yeast
organic substance biosynthetic process GO:1901576 289 0.019
negative regulation of macromolecule metabolic process GO:0010605 76 0.019
Yeast
multi organism process GO:0051704 134 0.018
immune system process GO:0002376 241 0.018
protein modification process GO:0036211 100 0.018
Yeast
somatic muscle development GO:0007525 4 0.018
actomyosin structure organization GO:0031032 53 0.018
eye development GO:0001654 277 0.018
epithelial cell differentiation GO:0030855 116 0.018
stem cell division GO:0017145 1 0.017
neuron differentiation GO:0030182 353 0.017
negative regulation of intracellular transport GO:0032387 3 0.017
vasculature development GO:0001944 278 0.017
chromosome localization GO:0050000 2 0.017
Yeast
cellular protein localization GO:0034613 20 0.017
Yeast
chromosome organization involved in meiosis GO:0070192 1 0.017
female meiotic division GO:0007143 2 0.016
sister chromatid segregation GO:0000819 6 0.016
Yeast
cellular response to chemical stimulus GO:0070887 157 0.016
guanosine containing compound metabolic process GO:1901068 4 0.016
nucleus localization GO:0051647 8 0.016
programmed cell death GO:0012501 119 0.016
single organism biosynthetic process GO:0044711 71 0.016
regulation of stem cell proliferation GO:0072091 2 0.016
regulation of apoptotic process GO:0042981 98 0.016
regulation of cell development GO:0060284 100 0.016
regulation of developmental process GO:0050793 247 0.016
regulation of nervous system development GO:0051960 90 0.016
cellular component assembly involved in morphogenesis GO:0010927 107 0.016
regulation of binding GO:0051098 3 0.016
regulation of localization GO:0032879 104 0.016
Yeast
negative regulation of protein import into nucleus GO:0042308 2 0.016
ribonucleoside monophosphate catabolic process GO:0009158 4 0.015
negative regulation of signal transduction GO:0009968 94 0.015
mitotic spindle organization GO:0007052 5 0.015
establishment of organelle localization GO:0051656 45 0.015
Yeast
behavior GO:0007610 74 0.015
cell death GO:0008219 121 0.015
growth GO:0040007 174 0.015
regulation of microtubule depolymerization GO:0031114 1 0.015
positive regulation of cellular catabolic process GO:0031331 3 0.015
cell morphogenesis GO:0000902 289 0.015
protein import GO:0017038 3 0.015
nucleobase containing compound biosynthetic process GO:0034654 205 0.015
establishment of localization in cell GO:0051649 77 0.014
Yeast
brain development GO:0007420 293 0.014
dna catabolic process GO:0006308 1 0.014
cellular component morphogenesis GO:0032989 336 0.014
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.014
negative regulation of intracellular protein transport GO:0090317 3 0.014
negative regulation of cellular component organization GO:0051129 16 0.014
Yeast
hatching GO:0035188 4 0.014
protein polyubiquitination GO:0000209 4 0.014
positive regulation of cellular process GO:0048522 201 0.014
response to stress GO:0006950 263 0.014
regulation of purine nucleotide catabolic process GO:0033121 2 0.014
regulation of protein complex assembly GO:0043254 3 0.014
angiogenesis GO:0001525 158 0.014
mitotic cell cycle embryonic GO:0045448 2 0.014
positive regulation of nucleotide catabolic process GO:0030813 1 0.014
regulation of cell communication GO:0010646 232 0.013
rna metabolic process GO:0016070 219 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.013
regulation of nucleoside metabolic process GO:0009118 2 0.013
protein complex biogenesis GO:0070271 30 0.013
Yeast
organic acid metabolic process GO:0006082 31 0.013
regionalization GO:0003002 274 0.013
gtp metabolic process GO:0046039 4 0.013
negative regulation of cellular catabolic process GO:0031330 3 0.013
Yeast
response to chemical GO:0042221 320 0.013
protein destabilization GO:0031648 1 0.013
heart development GO:0007507 313 0.013
striated muscle cell development GO:0055002 108 0.013
synaptic growth at neuromuscular junction GO:0051124 2 0.013
regulation of cellular protein catabolic process GO:1903362 1 0.013
Yeast
regulation of cellular ketone metabolic process GO:0010565 7 0.013
forebrain development GO:0030900 96 0.012
immunoglobulin mediated immune response GO:0016064 3 0.012
central nervous system development GO:0007417 387 0.012
multi organism reproductive process GO:0044703 36 0.012
carboxylic acid metabolic process GO:0019752 22 0.012
g2 m transition of mitotic cell cycle GO:0000086 4 0.012
cellular macromolecule localization GO:0070727 21 0.012
Yeast
response to drug GO:0042493 3 0.012
negative regulation of response to stimulus GO:0048585 104 0.012
cellular amine metabolic process GO:0044106 2 0.012
blood vessel development GO:0001568 246 0.012
positive regulation of synapse assembly GO:0051965 1 0.012
organism emergence from protective structure GO:0071684 4 0.012
regulation of cell shape GO:0008360 1 0.012
establishment of mitotic spindle localization GO:0040001 12 0.012
mitotic cytokinesis GO:0000281 3 0.012
protein metabolic process GO:0019538 183 0.012
Yeast
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
cellular response to growth factor stimulus GO:0071363 39 0.012
chromosome segregation GO:0007059 12 0.012
immunoglobulin production GO:0002377 1 0.012
rna localization GO:0006403 4 0.012
cellular macromolecule biosynthetic process GO:0034645 224 0.012
regulation of oocyte development GO:0060281 3 0.012
regulation of signal transduction GO:0009966 225 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.012
macromolecule biosynthetic process GO:0009059 227 0.012
digestive tract morphogenesis GO:0048546 231 0.011
muscle cell development GO:0055001 115 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.011
Yeast
multicellular organismal reproductive process GO:0048609 35 0.011
developmental process involved in reproduction GO:0003006 27 0.011
macromolecule catabolic process GO:0009057 15 0.011
Yeast
cellular response to stress GO:0033554 62 0.011
peptidyl threonine phosphorylation GO:0018107 1 0.011
regulation of neurogenesis GO:0050767 87 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.011
Yeast
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
regulation of cell differentiation GO:0045595 142 0.011
head development GO:0060322 303 0.011
regulation of proteolysis GO:0030162 24 0.011
Yeast
nucleoside monophosphate catabolic process GO:0009125 4 0.011
negative regulation of cell cycle phase transition GO:1901988 5 0.010
gamete generation GO:0007276 33 0.010
regulation of synapse assembly GO:0051963 3 0.010
positive regulation of apoptotic process GO:0043065 29 0.010
regulation of cellular metabolic process GO:0031323 320 0.010
Yeast
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.010
regulation of response to stimulus GO:0048583 269 0.010
oxoacid metabolic process GO:0043436 31 0.010
cell surface receptor signaling pathway GO:0007166 325 0.010
protein homooligomerization GO:0051260 3 0.010
response to oxygen levels GO:0070482 25 0.010
positive regulation of dna metabolic process GO:0051054 1 0.010

ttk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.030
disease of cellular proliferation DOID:14566 0 0.030
organ system cancer DOID:0050686 0 0.028
gastrointestinal system cancer DOID:3119 0 0.021
disease of anatomical entity DOID:7 0 0.010
nervous system disease DOID:863 0 0.010
large intestine cancer DOID:5672 0 0.010
intestinal cancer DOID:10155 0 0.010