Danio rerio

0 known processes

nots

nothepsin

(Aliases: zgc:103608,ctsel,LAP,MGC192423)

nots biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of response to stimulus GO:0048583 269 0.162
Yeast
regulation of cell communication GO:0010646 232 0.144
Yeast
regulation of multicellular organismal process GO:0051239 277 0.118
regulation of signal transduction GO:0009966 225 0.117
Yeast
aging GO:0007568 2 0.111
regulation of signaling GO:0023051 235 0.107
Yeast
regulation of biological quality GO:0065008 263 0.105
cell surface receptor signaling pathway GO:0007166 325 0.101
Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.086
larval development GO:0002164 2 0.083
embryonic organ development GO:0048568 381 0.076
regulation of metabolic process GO:0019222 359 0.074
muscle structure development GO:0061061 196 0.070
Zebrafish
heterocycle biosynthetic process GO:0018130 215 0.069
myeloid cell differentiation GO:0030099 86 0.067
enzyme linked receptor protein signaling pathway GO:0007167 106 0.066
ear development GO:0043583 127 0.065
response to lipid GO:0033993 60 0.064
cellular response to endogenous stimulus GO:0071495 68 0.064
response to chemical GO:0042221 320 0.063
Yeast
positive regulation of biological process GO:0048518 253 0.062
heterocycle metabolic process GO:0046483 290 0.061
cellular macromolecule metabolic process GO:0044260 391 0.060
cellular amine metabolic process GO:0044106 2 0.060
cellular response to estrogen stimulus GO:0071391 24 0.057
striated muscle cell development GO:0055002 108 0.056
head development GO:0060322 303 0.055
gene expression GO:0010467 252 0.054
Yeast
organonitrogen compound metabolic process GO:1901564 74 0.053
Yeast
response to growth factor GO:0070848 39 0.053
reproductive process GO:0022414 40 0.052
Yeast Fly
protein metabolic process GO:0019538 183 0.051
Yeast
regulation of multicellular organism growth GO:0040014 4 0.050
signal transduction GO:0007165 455 0.050
Yeast Fly
response to organic substance GO:0010033 153 0.048
Yeast
nucleobase containing compound metabolic process GO:0006139 274 0.046
organic cyclic compound metabolic process GO:1901360 301 0.046
regulation of cellular metabolic process GO:0031323 320 0.045
urogenital system development GO:0001655 97 0.045
phagocytosis GO:0006909 3 0.044
regulation of cellular amine metabolic process GO:0033238 0 0.044
cellular response to organic cyclic compound GO:0071407 38 0.044
inner ear development GO:0048839 126 0.043
single organism metabolic process GO:0044710 217 0.041
embryo development ending in birth or egg hatching GO:0009792 271 0.041
organelle assembly GO:0070925 110 0.041
regulation of cellular amino acid metabolic process GO:0006521 0 0.040
homeostatic process GO:0042592 142 0.040
cellular response to organic substance GO:0071310 105 0.040
Yeast
response to steroid hormone GO:0048545 35 0.040
positive regulation of cell cycle GO:0045787 3 0.040
regulation of multicellular organismal development GO:2000026 223 0.039
organic cyclic compound biosynthetic process GO:1901362 223 0.039
regulation of protein complex assembly GO:0043254 3 0.038
biosynthetic process GO:0009058 294 0.036
macromolecular complex assembly GO:0065003 35 0.036
multicellular organism growth GO:0035264 4 0.035
positive regulation of cellular component biogenesis GO:0044089 3 0.034
cellular response to growth factor stimulus GO:0071363 39 0.034
regulation of primary metabolic process GO:0080090 311 0.034
establishment of localization GO:0051234 244 0.033
cellular component assembly GO:0022607 170 0.033
transcription dna templated GO:0006351 181 0.033
phosphorus metabolic process GO:0006793 109 0.032
multi organism process GO:0051704 134 0.032
Yeast Zebrafish Fly
meiotic nuclear division GO:0007126 4 0.032
immune system process GO:0002376 241 0.032
positive regulation of catabolic process GO:0009896 4 0.031
cellular macromolecule biosynthetic process GO:0034645 224 0.031
response to estrogen GO:0043627 27 0.031
dorsal ventral pattern formation GO:0009953 125 0.031
oxoacid metabolic process GO:0043436 31 0.031
response to external stimulus GO:0009605 264 0.031
Zebrafish
transport GO:0006810 220 0.031
negative regulation of gene expression GO:0010629 65 0.030
digestive system development GO:0055123 289 0.030
nucleic acid metabolic process GO:0090304 244 0.029
cellular protein metabolic process GO:0044267 129 0.029
small molecule metabolic process GO:0044281 77 0.029
macromolecule modification GO:0043412 111 0.029
kidney development GO:0001822 92 0.029
cellular response to external stimulus GO:0071496 2 0.029
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.029
immune system development GO:0002520 191 0.029
nuclear transport GO:0051169 4 0.028
extrinsic apoptotic signaling pathway GO:0097191 3 0.028
phosphate containing compound metabolic process GO:0006796 108 0.028
regulation of transcription dna templated GO:0006355 213 0.028
response to stress GO:0006950 263 0.027
nitrogen compound metabolic process GO:0006807 319 0.027
Yeast
single organism transport GO:0044765 206 0.027
muscle cell differentiation GO:0042692 139 0.027
cellular amino acid metabolic process GO:0006520 7 0.026
growth GO:0040007 174 0.026
muscle cell development GO:0055001 115 0.026
negative regulation of macromolecule metabolic process GO:0010605 76 0.026
blood vessel morphogenesis GO:0048514 216 0.026
regulation of cellular ketone metabolic process GO:0010565 7 0.026
positive regulation of apoptotic signaling pathway GO:2001235 1 0.026
response to organic cyclic compound GO:0014070 51 0.026
cellular component biogenesis GO:0044085 178 0.026
central nervous system development GO:0007417 387 0.025
camera type eye development GO:0043010 222 0.025
Zebrafish
regeneration GO:0031099 91 0.025
regulation of molecular function GO:0065009 70 0.025
maintenance of location GO:0051235 4 0.025
hemopoiesis GO:0030097 183 0.024
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.024
morphogenesis of an epithelium GO:0002009 333 0.024
Fly
erythrocyte homeostasis GO:0034101 55 0.024
macromolecule biosynthetic process GO:0009059 227 0.024
cell death GO:0008219 121 0.024
Fly
striated muscle cell differentiation GO:0051146 129 0.024
cognition GO:0050890 1 0.024
nucleic acid templated transcription GO:0097659 181 0.023
regulation of catalytic activity GO:0050790 55 0.023
positive regulation of cellular catabolic process GO:0031331 3 0.023
positive regulation of transport GO:0051050 2 0.023
spindle assembly GO:0051225 2 0.023
alcohol biosynthetic process GO:0046165 2 0.023
response to external biotic stimulus GO:0043207 97 0.023
Zebrafish
macromolecular complex subunit organization GO:0043933 74 0.022
single organism reproductive process GO:0044702 40 0.022
Fly
developmental growth GO:0048589 166 0.022
cellular response to lipid GO:0071396 39 0.022
response to endogenous stimulus GO:0009719 83 0.022
mitochondrion organization GO:0007005 4 0.022
regulation of gene expression GO:0010468 265 0.021
vasculature development GO:0001944 278 0.021
tube morphogenesis GO:0035239 349 0.021
protein complex assembly GO:0006461 30 0.021
determination of dorsal ventral asymmetry GO:0048262 34 0.021
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.020
positive regulation of signaling GO:0023056 56 0.020
regulation of rna biosynthetic process GO:2001141 213 0.020
developmental process involved in reproduction GO:0003006 27 0.020
Fly
homeostasis of number of cells GO:0048872 62 0.020
single organism localization GO:1902578 225 0.020
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.020
cellular ketone metabolic process GO:0042180 11 0.020
renal system development GO:0072001 94 0.019
regulation of autophagy GO:0010506 3 0.019
regulation of cytokine production GO:0001817 3 0.019
regulation of protein catabolic process GO:0042176 1 0.019
amine metabolic process GO:0009308 2 0.019
carboxylic acid metabolic process GO:0019752 22 0.019
b cell differentiation GO:0030183 1 0.019
positive regulation of cellular metabolic process GO:0031325 94 0.019
sexual reproduction GO:0019953 36 0.019
Yeast Fly
response to hormone GO:0009725 48 0.019
negative regulation of apoptotic process GO:0043066 55 0.019
inositol lipid mediated signaling GO:0048017 2 0.019
positive regulation of response to stimulus GO:0048584 80 0.019
cellular response to steroid hormone stimulus GO:0071383 31 0.018
positive regulation of chromosome organization GO:2001252 1 0.018
regulation of cellular protein metabolic process GO:0032268 52 0.018
determination of ventral identity GO:0048264 21 0.018
eye development GO:0001654 277 0.018
Zebrafish
regulation of macromolecule metabolic process GO:0060255 317 0.018
regulation of meiotic cell cycle GO:0051445 1 0.018
regulation of jak stat cascade GO:0046425 3 0.018
cellular response to chemical stimulus GO:0070887 157 0.018
Yeast
meiotic cell cycle process GO:1903046 3 0.018
tissue regeneration GO:0042246 74 0.018
positive regulation of cell communication GO:0010647 56 0.018
negative regulation of signaling GO:0023057 96 0.018
determination of bilateral symmetry GO:0009855 204 0.018
gastrulation GO:0007369 208 0.018
germ line stem cell maintenance GO:0030718 2 0.018
embryonic organ morphogenesis GO:0048562 274 0.017
negative regulation of mitosis GO:0045839 3 0.017
appendage development GO:0048736 80 0.017
Fly
odontogenesis of dentin containing tooth GO:0042475 1 0.017
regulation of biosynthetic process GO:0009889 250 0.017
regulation of cellular response to growth factor stimulus GO:0090287 35 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
regulation of developmental process GO:0050793 247 0.017
intracellular signal transduction GO:0035556 85 0.017
positive regulation of metabolic process GO:0009893 108 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.017
negative regulation of response to stimulus GO:0048585 104 0.017
stem cell maintenance GO:0019827 4 0.016
negative regulation of nuclear division GO:0051784 3 0.016
protein acylation GO:0043543 3 0.016
organic substance biosynthetic process GO:1901576 289 0.016
regulation of rna metabolic process GO:0051252 224 0.016
rna biosynthetic process GO:0032774 181 0.016
aromatic compound biosynthetic process GO:0019438 217 0.016
regulation of calcium ion transport GO:0051924 2 0.016
wound healing GO:0042060 90 0.016
regulation of cellular component organization GO:0051128 86 0.016
rna metabolic process GO:0016070 219 0.016
cellular localization GO:0051641 97 0.016
muscle organ development GO:0007517 101 0.016
regulation of cellular protein catabolic process GO:1903362 1 0.016
organic acid metabolic process GO:0006082 31 0.015
cellular nitrogen compound metabolic process GO:0034641 290 0.015
Yeast
positive regulation of secretion GO:0051047 1 0.015
cellular aromatic compound metabolic process GO:0006725 295 0.015
epithelial tube morphogenesis GO:0060562 148 0.015
regulation of stem cell proliferation GO:0072091 2 0.015
positive regulation of cell activation GO:0050867 1 0.015
positive regulation of signal transduction GO:0009967 56 0.015
behavior GO:0007610 74 0.015
multicellular organism reproduction GO:0032504 35 0.015
Fly
multi organism reproductive process GO:0044703 36 0.015
Yeast Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
regulation of cell activation GO:0050865 1 0.015
erythrocyte differentiation GO:0030218 54 0.014
translational initiation GO:0006413 3 0.014
nephron morphogenesis GO:0072028 2 0.014
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.014
myeloid cell homeostasis GO:0002262 56 0.014
positive regulation of cytokine production GO:0001819 2 0.014
regulation of programmed cell death GO:0043067 101 0.014
proteasomal protein catabolic process GO:0010498 2 0.014
ovulation cycle process GO:0022602 2 0.014
mitotic cell cycle GO:0000278 64 0.014
neuromuscular synaptic transmission GO:0007274 2 0.014
establishment of localization in cell GO:0051649 77 0.014
cell migration involved in gastrulation GO:0042074 79 0.014
cell substrate adhesion GO:0031589 4 0.014
regulation of protein deacetylation GO:0090311 2 0.014
cell cycle GO:0007049 93 0.014
single fertilization GO:0007338 3 0.014
regulation of cell death GO:0010941 103 0.014
defense response GO:0006952 47 0.013
appendage morphogenesis GO:0035107 56 0.013
Fly
stem cell proliferation GO:0072089 4 0.013
ubiquitin dependent protein catabolic process GO:0006511 3 0.013
regulation of cellular biosynthetic process GO:0031326 245 0.013
cellular response to nutrient levels GO:0031669 2 0.013
regulation of reproductive process GO:2000241 4 0.013
regulation of response to stress GO:0080134 36 0.013
regulation of mitotic cell cycle GO:0007346 25 0.013
regulation of nucleic acid templated transcription GO:1903506 213 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.013
sensory organ development GO:0007423 393 0.013
Zebrafish
protein modification process GO:0036211 100 0.013
sensory organ morphogenesis GO:0090596 200 0.013
cellular component assembly involved in morphogenesis GO:0010927 107 0.013
Fly
fertilization GO:0009566 3 0.013
stem cell division GO:0017145 1 0.013
erk1 and erk2 cascade GO:0070371 4 0.013
apoptotic process GO:0006915 116 0.013
immune response GO:0006955 28 0.013
g1 s transition of mitotic cell cycle GO:0000082 1 0.013
positive regulation of protein complex assembly GO:0031334 2 0.013
lipid metabolic process GO:0006629 52 0.012
single organism organelle organization GO:1902589 199 0.012
actin filament based process GO:0030029 64 0.012
angiogenesis GO:0001525 158 0.012
skeletal muscle tissue development GO:0007519 67 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.012
synaptic vesicle transport GO:0048489 1 0.012
lipid storage GO:0019915 1 0.012
tissue remodeling GO:0048771 4 0.012
hematopoietic or lymphoid organ development GO:0048534 191 0.012
macromolecule localization GO:0033036 54 0.012
regulation of apoptotic process GO:0042981 98 0.012
regulation of cell differentiation GO:0045595 142 0.012
regulation of cell development GO:0060284 100 0.012
locomotion GO:0040011 313 0.012
mitotic nuclear division GO:0007067 18 0.012
hormone secretion GO:0046879 2 0.012
activation of mapk activity GO:0000187 3 0.012
phagocytosis engulfment GO:0006911 1 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.011
connective tissue development GO:0061448 99 0.011
digestive tract development GO:0048565 265 0.011
negative regulation of reproductive process GO:2000242 3 0.011
embryonic heart tube development GO:0035050 133 0.011
positive regulation of cellular protein metabolic process GO:0032270 22 0.011
regulation of localization GO:0032879 104 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
phosphorylation GO:0016310 69 0.011
reproduction GO:0000003 40 0.011
Yeast Fly
death GO:0016265 121 0.011
Fly
gland development GO:0048732 143 0.011
Fly
specification of symmetry GO:0009799 204 0.011
dna templated transcription initiation GO:0006352 1 0.011
regulation of phosphorus metabolic process GO:0051174 43 0.011
negative regulation of catabolic process GO:0009895 3 0.011
skeletal system development GO:0001501 181 0.011
nephron epithelium morphogenesis GO:0072088 1 0.010
regulation of intracellular signal transduction GO:1902531 57 0.010
cell cycle g1 s phase transition GO:0044843 1 0.010
cell morphogenesis GO:0000902 289 0.010
ovulation cycle GO:0042698 2 0.010
brain development GO:0007420 293 0.010
negative regulation of signal transduction GO:0009968 94 0.010
regulation of heart morphogenesis GO:2000826 17 0.010
response to xenobiotic stimulus GO:0009410 45 0.010
membrane invagination GO:0010324 1 0.010
response to corticosteroid GO:0031960 1 0.010
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.010

nots disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.077
cardiovascular system disease DOID:1287 0 0.037
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.017
bone development disease DOID:0080006 0 0.012
bone disease DOID:0080001 0 0.012
musculoskeletal system disease DOID:17 0 0.012
connective tissue disease DOID:65 0 0.012