Danio rerio

42 known processes

sparc

secreted acidic cysteine rich glycoprotein

(Aliases: hm:zeh0062)

sparc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ear development GO:0043583 127 0.987
inner ear development GO:0048839 126 0.921
sensory organ development GO:0007423 393 0.863
embryonic organ development GO:0048568 381 0.850
collagen fibril organization GO:0030199 1 0.812
collagen metabolic process GO:0032963 2 0.761
collagen biosynthetic process GO:0032964 2 0.680
cellular response to lipid GO:0071396 39 0.670
direct ossification GO:0036072 3 0.652
chondrocyte development GO:0002063 4 0.627
multicellular organismal metabolic process GO:0044236 2 0.609
response to amino acid GO:0043200 2 0.596
notochord development GO:0030903 54 0.577
intramembranous ossification GO:0001957 3 0.549
multicellular organismal macromolecule metabolic process GO:0044259 2 0.543
cellular response to chemical stimulus GO:0070887 157 0.520
Mouse
response to hormone GO:0009725 48 0.503
Rat
response to chemical GO:0042221 320 0.492
Mouse Rat
regulation of chondrocyte differentiation GO:0032330 1 0.470
protein trimerization GO:0070206 4 0.440
mesenchymal cell proliferation GO:0010463 1 0.432
regulation of signaling GO:0023051 235 0.407
ossification GO:0001503 23 0.386
Rat
head development GO:0060322 303 0.365
negative regulation of heart contraction GO:0045822 2 0.365
signal transduction GO:0007165 455 0.349
cellular response to organic substance GO:0071310 105 0.343
Mouse
regulation of wnt signaling pathway GO:0030111 53 0.337
embryonic organ morphogenesis GO:0048562 274 0.322
response to molecule of bacterial origin GO:0002237 14 0.318
Rat
otolith development GO:0048840 32 0.313
nucleobase containing compound biosynthetic process GO:0034654 205 0.312
positive regulation of cell communication GO:0010647 56 0.306
positive regulation of signaling GO:0023056 56 0.306
regulation of response to stimulus GO:0048583 269 0.297
cellular response to retinoic acid GO:0071300 1 0.296
morphogenesis of an epithelium GO:0002009 333 0.292
sensory organ morphogenesis GO:0090596 200 0.286
response to organic substance GO:0010033 153 0.279
Mouse Rat
aging GO:0007568 2 0.268
positive regulation of proteolysis GO:0045862 10 0.267
skeletal system development GO:0001501 181 0.264
positive regulation of response to stimulus GO:0048584 80 0.262
regulation of cgmp metabolic process GO:0030823 6 0.260
wound healing GO:0042060 90 0.258
Rat
positive regulation of signal transduction GO:0009967 56 0.250
cellular response to organic cyclic compound GO:0071407 38 0.247
single organism metabolic process GO:0044710 217 0.241
craniofacial suture morphogenesis GO:0097094 2 0.239
cranial suture morphogenesis GO:0060363 1 0.233
extracellular matrix organization GO:0030198 27 0.233
Fly
response to external stimulus GO:0009605 264 0.212
Rat
skeletal system morphogenesis GO:0048705 102 0.211
embryonic skeletal system development GO:0048706 97 0.206
response to wounding GO:0009611 116 0.206
Rat
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.192
cellular response to fibroblast growth factor stimulus GO:0044344 22 0.181
otic vesicle morphogenesis GO:0071600 34 0.180
liver development GO:0001889 96 0.178
medial fin morphogenesis GO:0035141 14 0.173
response to oxygen containing compound GO:1901700 55 0.172
Rat
determination of bilateral symmetry GO:0009855 204 0.165
locomotion GO:0040011 313 0.161
Human
canonical wnt signaling pathway GO:0060070 48 0.152
vasculature development GO:0001944 278 0.144
Human
cytosolic calcium ion transport GO:0060401 3 0.133
regulation of epithelial to mesenchymal transition GO:0010717 3 0.132
positive regulation of molecular function GO:0044093 33 0.124
regulation of cellular metabolic process GO:0031323 320 0.124
cellular response to xenobiotic stimulus GO:0071466 35 0.122
pectoral fin development GO:0033339 50 0.119
cellular component assembly GO:0022607 170 0.118
skin development GO:0043588 54 0.114
wnt signaling pathway GO:0016055 80 0.109
fin development GO:0033333 77 0.109
extracellular structure organization GO:0043062 27 0.103
Fly
inner ear morphogenesis GO:0042472 63 0.102
positive regulation of developmental process GO:0051094 50 0.101
Worm
ion homeostasis GO:0050801 41 0.100
response to abiotic stimulus GO:0009628 122 0.099
Rat
cellular response to endogenous stimulus GO:0071495 68 0.098
regulation of hydrolase activity GO:0051336 28 0.096
regulation of signal transduction GO:0009966 225 0.095
heart morphogenesis GO:0003007 156 0.095
regulation of developmental process GO:0050793 247 0.094
Human Worm
regulation of cell communication GO:0010646 232 0.094
regulation of erk1 and erk2 cascade GO:0070372 4 0.092
response to lipid GO:0033993 60 0.091
Rat
regulation of biosynthetic process GO:0009889 250 0.090
eye development GO:0001654 277 0.089
tissue remodeling GO:0048771 4 0.087
visual perception GO:0007601 17 0.086
embryonic limb morphogenesis GO:0030326 2 0.086
regeneration GO:0031099 91 0.084
positive regulation of wnt signaling pathway GO:0030177 13 0.080
regulation of locomotion GO:0040012 55 0.079
Human
glomerulus vasculature development GO:0072012 2 0.079
negative regulation of endodermal cell fate specification GO:0042664 8 0.079
semicircular canal formation GO:0060876 4 0.078
positive regulation of hydrolase activity GO:0051345 13 0.077
erk1 and erk2 cascade GO:0070371 4 0.076
protein complex subunit organization GO:0071822 46 0.075
nitrogen compound metabolic process GO:0006807 319 0.075
negative regulation of biological process GO:0048519 304 0.075
Human
response to retinoic acid GO:0032526 6 0.075
ear morphogenesis GO:0042471 64 0.074
regulation of stem cell differentiation GO:2000736 4 0.073
angiogenesis GO:0001525 158 0.071
Human
negative regulation of embryonic development GO:0045992 11 0.071
response to growth factor GO:0070848 39 0.070
Mouse
otic vesicle formation GO:0030916 27 0.069
tissue regeneration GO:0042246 74 0.065
response to stress GO:0006950 263 0.064
Rat
response to inorganic substance GO:0010035 38 0.064
Rat
specification of symmetry GO:0009799 204 0.060
cellular response to oxygen containing compound GO:1901701 20 0.058
nucleobase containing compound metabolic process GO:0006139 274 0.058
membrane repolarization GO:0086009 2 0.056
regulation of molecular function GO:0065009 70 0.056
extracellular matrix constituent secretion GO:0070278 3 0.056
Fly
blood vessel development GO:0001568 246 0.054
Human
regulation of insulin like growth factor receptor signaling pathway GO:0043567 1 0.054
bone remodeling GO:0046849 2 0.054
single organism transport GO:0044765 206 0.053
Fly
basement membrane assembly GO:0070831 3 0.053
negative regulation of endodermal cell differentiation GO:1903225 8 0.051
negative regulation of gastrulation GO:2000542 11 0.050
cartilage development GO:0051216 96 0.050
regulation of dna replication GO:0006275 3 0.049
protein heterooligomerization GO:0051291 1 0.048
developmental growth GO:0048589 166 0.048
Worm
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.048
response to nutrient GO:0007584 3 0.048
Rat
cellular response to external stimulus GO:0071496 2 0.047
hemostasis GO:0007599 13 0.046
cell surface receptor signaling pathway GO:0007166 325 0.045
endodermal cell differentiation GO:0035987 19 0.045
positive regulation of cellular process GO:0048522 201 0.044
Human
regulation of cell differentiation GO:0045595 142 0.044
negative regulation of dna replication GO:0008156 2 0.043
purine nucleotide biosynthetic process GO:0006164 20 0.043
positive regulation of muscle organ development GO:0048636 1 0.043
oligodendrocyte differentiation GO:0048709 23 0.042
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.042
regulation of canonical wnt signaling pathway GO:0060828 34 0.041
trabecula formation GO:0060343 2 0.041
regulation of innate immune response GO:0045088 11 0.041
regulation of endothelial cell proliferation GO:0001936 1 0.040
Human
tube morphogenesis GO:0035239 349 0.040
limb bud formation GO:0060174 2 0.040
response to external biotic stimulus GO:0043207 97 0.039
Rat
transport GO:0006810 220 0.039
Fly
negative regulation of signaling GO:0023057 96 0.039
organic substance biosynthetic process GO:1901576 289 0.038
cell death GO:0008219 121 0.037
muscle cell differentiation GO:0042692 139 0.036
response to drug GO:0042493 3 0.035
response to fibroblast growth factor GO:0071774 22 0.034
cell cell signaling GO:0007267 52 0.033
reflex GO:0060004 2 0.033
bone morphogenesis GO:0060349 11 0.033
neural nucleus development GO:0048857 15 0.033
fin regeneration GO:0031101 51 0.033
response to arsenic containing substance GO:0046685 5 0.031
nucleoside phosphate metabolic process GO:0006753 28 0.030
cellular macromolecule biosynthetic process GO:0034645 224 0.030
fin morphogenesis GO:0033334 53 0.030
response to steroid hormone GO:0048545 35 0.030
Rat
response to estrogen GO:0043627 27 0.030
blood vessel morphogenesis GO:0048514 216 0.029
Human
regulation of multicellular organismal metabolic process GO:0044246 2 0.029
regulation of multicellular organismal development GO:2000026 223 0.029
Human
regulation of cellular biosynthetic process GO:0031326 245 0.029
cellular response to prostaglandin stimulus GO:0071379 3 0.029
proteoglycan metabolic process GO:0006029 14 0.029
cytoskeleton organization GO:0007010 96 0.029
response to bacterium GO:0009617 58 0.029
Rat
response to carbohydrate GO:0009743 3 0.028
Rat
phosphate containing compound metabolic process GO:0006796 108 0.028
cellular response to acid chemical GO:0071229 8 0.028
regulation of cellular protein metabolic process GO:0032268 52 0.028
response to acid chemical GO:0001101 17 0.028
Rat
nucleoside biosynthetic process GO:0009163 2 0.028
regulation of cartilage development GO:0061035 7 0.028
regulation of cell activation GO:0050865 1 0.027
endodermal cell fate determination GO:0007493 2 0.027
regulation of macromolecule metabolic process GO:0060255 317 0.027
gene expression GO:0010467 252 0.027
hindbrain development GO:0030902 91 0.026
regulation of cellular amine metabolic process GO:0033238 0 0.026
cartilage condensation GO:0001502 3 0.026
aminoglycan metabolic process GO:0006022 9 0.026
positive regulation of protein metabolic process GO:0051247 23 0.026
endothelial cell morphogenesis GO:0001886 1 0.026
regulation of cell motility GO:2000145 46 0.026
Human
cellular component morphogenesis GO:0032989 336 0.025
Human
cellular response to lipopolysaccharide GO:0071222 3 0.025
response to hexose GO:0009746 3 0.025
regulation of receptor mediated endocytosis GO:0048259 4 0.025
defense response to fungus GO:0050832 2 0.024
single organism organelle organization GO:1902589 199 0.024
homeostatic process GO:0042592 142 0.024
cell morphogenesis involved in differentiation GO:0000904 195 0.024
hepaticobiliary system development GO:0061008 98 0.024
positive regulation of macromolecule metabolic process GO:0010604 93 0.023
camera type eye development GO:0043010 222 0.023
cellular nitrogen compound biosynthetic process GO:0044271 218 0.023
eye morphogenesis GO:0048592 144 0.023
embryonic eye morphogenesis GO:0048048 30 0.023
multicellular organism growth GO:0035264 4 0.023
Worm
regulation of gastrulation GO:0010470 24 0.023
cellular protein modification process GO:0006464 100 0.022
establishment of localization GO:0051234 244 0.022
Fly
endochondral bone morphogenesis GO:0060350 8 0.022
positive regulation of cellular component biogenesis GO:0044089 3 0.022
regulation of cardiac muscle cell contraction GO:0086004 1 0.022
limb development GO:0060173 8 0.022
positive regulation of translation GO:0045727 1 0.022
intracellular signal transduction GO:0035556 85 0.021
formation of primary germ layer GO:0001704 62 0.021
positive regulation of metabolic process GO:0009893 108 0.021
ion transport GO:0006811 114 0.021
response to lipopolysaccharide GO:0032496 13 0.021
Rat
spemann organizer formation at the embryonic shield GO:0060063 2 0.021
negative regulation of nuclear division GO:0051784 3 0.021
regulation of cellular component movement GO:0051270 55 0.021
Human
regulation of protein localization to nucleus GO:1900180 2 0.020
regulation of cardiac muscle contraction GO:0055117 2 0.020
small molecule metabolic process GO:0044281 77 0.020
chondrocyte differentiation GO:0002062 7 0.020
response to xenobiotic stimulus GO:0009410 45 0.020
regulation of bone mineralization GO:0030500 2 0.019
cellular response to growth factor stimulus GO:0071363 39 0.019
Mouse
midbrain development GO:0030901 28 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
appendage development GO:0048736 80 0.019
cartilage morphogenesis GO:0060536 13 0.019
embryonic camera type eye development GO:0031076 29 0.019
cell fate specification GO:0001708 68 0.019
purine ribonucleoside biosynthetic process GO:0046129 2 0.019
macromolecular complex subunit organization GO:0043933 74 0.019
positive regulation of catalytic activity GO:0043085 25 0.019
ribonucleoside biosynthetic process GO:0042455 2 0.019
purine containing compound metabolic process GO:0072521 29 0.019
negative regulation of cell fate specification GO:0009996 11 0.018
cellular protein metabolic process GO:0044267 129 0.018
appendage morphogenesis GO:0035107 56 0.018
meiotic nuclear division GO:0007126 4 0.018
connective tissue development GO:0061448 99 0.017
regulation of epithelial cell proliferation GO:0050678 3 0.017
Human
i kappab kinase nf kappab signaling GO:0007249 4 0.017
respiratory system development GO:0060541 5 0.017
Rat Fly
response to oxygen levels GO:0070482 25 0.017
otic vesicle development GO:0071599 42 0.017
bone development GO:0060348 14 0.017
Mouse
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.016
macromolecule biosynthetic process GO:0009059 227 0.016
cellular response to nitrogen compound GO:1901699 6 0.016
heterocycle biosynthetic process GO:0018130 215 0.016
glucose homeostasis GO:0042593 1 0.016
positive regulation of cellular metabolic process GO:0031325 94 0.016
positive regulation of cellular protein metabolic process GO:0032270 22 0.015
response to decreased oxygen levels GO:0036293 25 0.015
cell projection morphogenesis GO:0048858 244 0.015
digestive system development GO:0055123 289 0.015
Fly
regulation of skeletal muscle tissue development GO:0048641 4 0.015
carbohydrate derivative metabolic process GO:1901135 61 0.015
cellular aromatic compound metabolic process GO:0006725 295 0.015
embryonic appendage morphogenesis GO:0035113 30 0.015
bmp signaling pathway GO:0030509 52 0.015
embryonic skeletal system morphogenesis GO:0048704 93 0.015
negative regulation of multicellular organismal process GO:0051241 69 0.015
Human
regulation of ossification GO:0030278 5 0.015
regulation of response to stress GO:0080134 36 0.015
rna metabolic process GO:0016070 219 0.015
positive regulation of cell differentiation GO:0045597 30 0.015
embryonic skeletal joint morphogenesis GO:0060272 3 0.015
skin morphogenesis GO:0043589 7 0.014
regulation of multicellular organismal process GO:0051239 277 0.014
Human Worm
regulation of protein targeting GO:1903533 2 0.014
positive regulation of cell adhesion GO:0045785 1 0.014
regulation of mesodermal cell fate specification GO:0042661 9 0.014
inner ear receptor cell differentiation GO:0060113 29 0.014
negative regulation of dna metabolic process GO:0051053 4 0.014
regulation of cell death GO:0010941 103 0.014
regulation of gene expression GO:0010468 265 0.014
positive regulation of catabolic process GO:0009896 4 0.014
protein modification process GO:0036211 100 0.014
olfactory lobe development GO:0021988 4 0.014
cellular response to topologically incorrect protein GO:0035967 2 0.014
heart development GO:0007507 313 0.014
Rat
insulin like growth factor receptor signaling pathway GO:0048009 4 0.014
heterocycle metabolic process GO:0046483 290 0.013
positive regulation of multicellular organismal process GO:0051240 52 0.013
Human Worm
homeostasis of number of cells GO:0048872 62 0.013
epithelial cell differentiation GO:0030855 116 0.013
cellular response to steroid hormone stimulus GO:0071383 31 0.013
gliogenesis GO:0042063 45 0.013
positive regulation of immune system process GO:0002684 17 0.013
cell adhesion GO:0007155 40 0.013
organonitrogen compound metabolic process GO:1901564 74 0.013
neuroblast fate commitment GO:0014017 1 0.013
cardiac ventricle development GO:0003231 9 0.012
cellular response to hormone stimulus GO:0032870 39 0.012
intestinal absorption GO:0050892 2 0.012
cell substrate adhesion GO:0031589 4 0.012
negative regulation of blood circulation GO:1903523 2 0.012
mesenchyme development GO:0060485 127 0.012
regulation of striated muscle contraction GO:0006942 2 0.012
proteolysis GO:0006508 38 0.012
vascular endothelial growth factor receptor signaling pathway GO:0048010 13 0.012
chondroitin sulfate metabolic process GO:0030204 2 0.012
response to other organism GO:0051707 97 0.012
Rat
regulation of bone remodeling GO:0046850 2 0.012
negative regulation of signal transduction GO:0009968 94 0.012
glucocorticoid metabolic process GO:0008211 2 0.012
death GO:0016265 121 0.012
glial cell fate determination GO:0007403 1 0.012
response to endogenous stimulus GO:0009719 83 0.012
Rat
positive regulation of apoptotic process GO:0043065 29 0.012
regulation of protein import into nucleus GO:0042306 2 0.012
regulation of cell substrate adhesion GO:0010810 1 0.012
extrinsic apoptotic signaling pathway GO:0097191 3 0.012
stem cell proliferation GO:0072089 4 0.012
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.012
positive regulation of cytokine production GO:0001819 2 0.012
chemotaxis GO:0006935 104 0.012
negative regulation of wnt signaling pathway involved in heart development GO:0003308 2 0.012
cellular component biogenesis GO:0044085 178 0.012
actin filament based process GO:0030029 64 0.011
glycosaminoglycan metabolic process GO:0030203 9 0.011
positive regulation of cell development GO:0010720 25 0.011
renal system vasculature development GO:0061437 2 0.011
positive regulation of biological process GO:0048518 253 0.011
Human Worm
regulation of cell migration GO:0030334 40 0.011
Human
endoderm formation GO:0001706 29 0.011
biosynthetic process GO:0009058 294 0.011
pathway restricted smad protein phosphorylation GO:0060389 1 0.011
regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 1 0.011
zymogen activation GO:0031638 3 0.011
cell migration GO:0016477 237 0.011
Human
ectodermal placode development GO:0071696 37 0.011
multi organism process GO:0051704 134 0.011
Rat
regulation of protein transport GO:0051223 3 0.010
negative regulation of mitosis GO:0045839 3 0.010
negative regulation of response to stimulus GO:0048585 104 0.010
sensory perception of mechanical stimulus GO:0050954 16 0.010
regulation of mapk cascade GO:0043408 14 0.010
neurological system process GO:0050877 62 0.010
muscle structure development GO:0061061 196 0.010
cardiac conduction system development GO:0003161 1 0.010
response to vitamin GO:0033273 3 0.010
Rat
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.010
notch signaling pathway GO:0007219 35 0.010
negative regulation of muscle tissue development GO:1901862 2 0.010

sparc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
bone development disease DOID:0080006 0 0.989
bone disease DOID:0080001 0 0.989
disease of anatomical entity DOID:7 0 0.989
musculoskeletal system disease DOID:17 0 0.989
connective tissue disease DOID:65 0 0.989
osteochondrodysplasia DOID:2256 0 0.833
osteogenesis imperfecta DOID:12347 0 0.833
osteoporosis DOID:11476 0 0.243
bone remodeling disease DOID:0080005 0 0.243
bone resorption disease DOID:0080011 0 0.243
dysostosis DOID:1934 0 0.117
synostosis DOID:11971 0 0.117
charcot marie tooth disease type 4 DOID:0050541 0 0.019
neuromuscular disease DOID:440 0 0.019
charcot marie tooth disease DOID:10595 0 0.019
nervous system disease DOID:863 0 0.019
neuropathy DOID:870 0 0.019
central nervous system disease DOID:331 0 0.010
neurodegenerative disease DOID:1289 0 0.010