Danio rerio

0 known processes

plekha1

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

(Aliases: wu:fc34a05,fc57h12,zgc:55676,wu:fc57h12,fc34a05)

plekha1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
meiotic cell cycle process GO:1903046 3 0.118
meiotic nuclear division GO:0007126 4 0.113
cellular amine metabolic process GO:0044106 2 0.106
meiotic chromosome segregation GO:0045132 3 0.092
cellular macromolecule metabolic process GO:0044260 391 0.089
regulation of primary metabolic process GO:0080090 311 0.087
aromatic compound biosynthetic process GO:0019438 217 0.086
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.083
regulation of cellular metabolic process GO:0031323 320 0.080
regulation of erk1 and erk2 cascade GO:0070372 4 0.061
nucleocytoplasmic transport GO:0006913 4 0.054
hematopoietic or lymphoid organ development GO:0048534 191 0.053
amine metabolic process GO:0009308 2 0.051
regulation of cellular amino acid metabolic process GO:0006521 0 0.051
regulation of metabolic process GO:0019222 359 0.051
cellular nitrogen compound metabolic process GO:0034641 290 0.051
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.049
regulation of cellular amine metabolic process GO:0033238 0 0.049
cell migration GO:0016477 237 0.048
regulation of macromolecule metabolic process GO:0060255 317 0.048
hemopoiesis GO:0030097 183 0.047
positive regulation of catabolic process GO:0009896 4 0.047
cellular ketone metabolic process GO:0042180 11 0.047
immune system process GO:0002376 241 0.046
proteasomal protein catabolic process GO:0010498 2 0.044
immune system development GO:0002520 191 0.044
female meiotic division GO:0007143 2 0.044
cellular amino acid metabolic process GO:0006520 7 0.044
negative regulation of protein phosphorylation GO:0001933 4 0.043
larval development GO:0002164 2 0.042
positive regulation of chromatin modification GO:1903310 1 0.042
rna metabolic process GO:0016070 219 0.042
cellular response to external stimulus GO:0071496 2 0.042
response to chemical GO:0042221 320 0.041
regulation of cellular ketone metabolic process GO:0010565 7 0.041
macromolecule modification GO:0043412 111 0.040
positive regulation of metabolic process GO:0009893 108 0.040
nuclear transport GO:0051169 4 0.040
cellular component movement GO:0006928 335 0.039
cytoskeleton dependent cytokinesis GO:0061640 3 0.039
cellular response to nutrient levels GO:0031669 2 0.039
protein localization to plasma membrane GO:0072659 1 0.038
maintenance of location GO:0051235 4 0.038
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.038
meiotic spindle organization GO:0000212 1 0.037
rna biosynthetic process GO:0032774 181 0.037
cellular nitrogen compound biosynthetic process GO:0044271 218 0.035
aging GO:0007568 2 0.035
peptidyl threonine phosphorylation GO:0018107 1 0.035
regulation of multicellular organismal process GO:0051239 277 0.035
oxoacid metabolic process GO:0043436 31 0.034
positive regulation of cellular amine metabolic process GO:0033240 0 0.034
locomotion GO:0040011 313 0.034
negative regulation of biological process GO:0048519 304 0.033
single organism organelle organization GO:1902589 199 0.032
erythrocyte differentiation GO:0030218 54 0.032
macromolecule biosynthetic process GO:0009059 227 0.032
positive regulation of cellular catabolic process GO:0031331 3 0.032
regulation of establishment of protein localization GO:0070201 4 0.031
multicellular organism growth GO:0035264 4 0.031
erk1 and erk2 cascade GO:0070371 4 0.031
protein metabolic process GO:0019538 183 0.031
cellular protein modification process GO:0006464 100 0.031
response to external stimulus GO:0009605 264 0.031
regulation of gene expression GO:0010468 265 0.030
regulation of intracellular protein transport GO:0033157 3 0.030
positive regulation of cellular process GO:0048522 201 0.030
regulation of reproductive process GO:2000241 4 0.030
peptidyl threonine modification GO:0018210 1 0.029
regionalization GO:0003002 274 0.029
modification dependent macromolecule catabolic process GO:0043632 3 0.029
regulation of localization GO:0032879 104 0.029
cortical actin cytoskeleton organization GO:0030866 1 0.029
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.029
cellular response to starvation GO:0009267 1 0.028
positive regulation of cellular metabolic process GO:0031325 94 0.028
establishment of protein localization to organelle GO:0072594 4 0.028
regulation of protein catabolic process GO:0042176 1 0.028
regulation of protein ubiquitination GO:0031396 3 0.028
meiosis i GO:0007127 1 0.028
modification dependent protein catabolic process GO:0019941 3 0.028
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.028
nucleic acid metabolic process GO:0090304 244 0.028
phosphorylation GO:0016310 69 0.027
cellular response to extracellular stimulus GO:0031668 2 0.027
lipid storage GO:0019915 1 0.027
positive regulation of macromolecule metabolic process GO:0010604 93 0.027
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.027
heart development GO:0007507 313 0.027
regulation of protein transport GO:0051223 3 0.027
single organism metabolic process GO:0044710 217 0.027
ubiquitin dependent protein catabolic process GO:0006511 3 0.027
response to stress GO:0006950 263 0.026
erythrocyte homeostasis GO:0034101 55 0.026
cytoskeleton organization GO:0007010 96 0.026
positive regulation of biological process GO:0048518 253 0.026
regulation of protein targeting GO:1903533 2 0.026
regulation of response to biotic stimulus GO:0002831 2 0.026
positive regulation of map kinase activity GO:0043406 3 0.025
response to organic substance GO:0010033 153 0.025
regulation of nitrogen compound metabolic process GO:0051171 251 0.025
cellular protein catabolic process GO:0044257 4 0.025
establishment of protein localization to plasma membrane GO:0090002 1 0.025
cell motility GO:0048870 244 0.025
signal transduction GO:0007165 455 0.025
organic cyclic compound biosynthetic process GO:1901362 223 0.024
localization of cell GO:0051674 244 0.024
single organism localization GO:1902578 225 0.024
regulation of response to stimulus GO:0048583 269 0.024
gene expression GO:0010467 252 0.023
single organism transport GO:0044765 206 0.023
cellular aromatic compound metabolic process GO:0006725 295 0.023
nucleobase containing compound biosynthetic process GO:0034654 205 0.023
primary neural tube formation GO:0014020 1 0.023
organelle fission GO:0048285 23 0.023
positive regulation of histone modification GO:0031058 1 0.023
positive regulation of protein complex assembly GO:0031334 2 0.023
positive regulation of multi organism process GO:0043902 3 0.023
mitotic cytokinesis GO:0000281 3 0.023
regulation of glucose transport GO:0010827 1 0.023
regulation of biosynthetic process GO:0009889 250 0.022
establishment of localization GO:0051234 244 0.022
autophagy GO:0006914 4 0.022
intracellular signal transduction GO:0035556 85 0.022
protein targeting to nucleus GO:0044744 3 0.022
double strand break repair GO:0006302 3 0.021
peptidyl serine phosphorylation GO:0018105 1 0.021
carboxylic acid metabolic process GO:0019752 22 0.021
regulation of cellular biosynthetic process GO:0031326 245 0.021
protein modification process GO:0036211 100 0.021
regulation of cellular component organization GO:0051128 86 0.021
cell cycle process GO:0022402 53 0.021
regulation of rna biosynthetic process GO:2001141 213 0.021
organelle organization GO:0006996 227 0.021
cellular response to chemical stimulus GO:0070887 157 0.021
nucleic acid templated transcription GO:0097659 181 0.021
odontogenesis of dentin containing tooth GO:0042475 1 0.021
regulation of oocyte development GO:0060281 3 0.021
positive regulation of cellular component biogenesis GO:0044089 3 0.021
b cell activation GO:0042113 2 0.021
i kappab kinase nf kappab signaling GO:0007249 4 0.021
embryonic organ development GO:0048568 381 0.020
positive regulation of chromosome organization GO:2001252 1 0.020
immune effector process GO:0002252 23 0.020
cell surface receptor signaling pathway GO:0007166 325 0.020
single organism nuclear import GO:1902593 3 0.020
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.020
positive regulation of transport GO:0051050 2 0.020
response to uv GO:0009411 3 0.020
negative regulation of protein complex assembly GO:0031333 1 0.020
heterocycle biosynthetic process GO:0018130 215 0.020
peptidyl serine modification GO:0018209 2 0.020
organelle fusion GO:0048284 3 0.020
cellular biosynthetic process GO:0044249 286 0.020
regulation of cytoplasmic transport GO:1903649 4 0.020
regulation of meiotic cell cycle GO:0051445 1 0.020
chromosome organization GO:0051276 31 0.020
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.020
stem cell division GO:0017145 1 0.020
histone phosphorylation GO:0016572 2 0.020
cytokinesis GO:0000910 3 0.020
regulation of stem cell proliferation GO:0072091 2 0.020
regulation of reactive oxygen species metabolic process GO:2000377 2 0.019
transcription dna templated GO:0006351 181 0.019
nuclear import GO:0051170 3 0.019
regulation of cellular protein catabolic process GO:1903362 1 0.019
heterocycle metabolic process GO:0046483 290 0.019
myeloid cell differentiation GO:0030099 86 0.019
regulation of cell communication GO:0010646 232 0.019
organic substance biosynthetic process GO:1901576 289 0.019
protein import GO:0017038 3 0.019
myeloid cell homeostasis GO:0002262 56 0.019
centrosome organization GO:0051297 1 0.019
production of molecular mediator of immune response GO:0002440 2 0.019
transcription from rna polymerase ii promoter GO:0006366 80 0.019
organic cyclic compound metabolic process GO:1901360 301 0.019
negative regulation of cellular process GO:0048523 283 0.018
endosomal transport GO:0016197 2 0.018
negative regulation of protein kinase activity GO:0006469 4 0.018
microtubule organizing center organization GO:0031023 1 0.018
antimicrobial humoral response GO:0019730 2 0.018
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.018
tube closure GO:0060606 1 0.018
embryonic heart tube development GO:0035050 133 0.017
regulation of protein complex assembly GO:0043254 3 0.017
regulation of defense response to virus by host GO:0050691 1 0.017
g protein coupled receptor signaling pathway GO:0007186 74 0.017
apoptotic process GO:0006915 116 0.017
positive regulation of immune effector process GO:0002699 3 0.017
positive regulation of dna metabolic process GO:0051054 1 0.017
regulation of molecular function GO:0065009 70 0.017
nuclear export GO:0051168 1 0.017
regulation of signal transduction GO:0009966 225 0.017
positive regulation of epithelial cell proliferation GO:0050679 1 0.017
rna localization GO:0006403 4 0.017
cell cycle GO:0007049 93 0.017
phosphate containing compound metabolic process GO:0006796 108 0.017
stem cell proliferation GO:0072089 4 0.017
tube morphogenesis GO:0035239 349 0.016
small molecule metabolic process GO:0044281 77 0.016
cellular component biogenesis GO:0044085 178 0.016
regulation of biological quality GO:0065008 263 0.016
myeloid cell development GO:0061515 32 0.016
lymphocyte proliferation GO:0046651 1 0.016
gtp metabolic process GO:0046039 4 0.016
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
purine nucleoside monophosphate catabolic process GO:0009128 4 0.016
establishment of epithelial cell polarity GO:0090162 2 0.016
female sex differentiation GO:0046660 4 0.016
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.016
regulation of synapse assembly GO:0051963 3 0.016
regulation of glucose import GO:0046324 1 0.016
cell aging GO:0007569 2 0.016
cellular response to endogenous stimulus GO:0071495 68 0.016
regulation of cellular protein metabolic process GO:0032268 52 0.016
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.016
reciprocal dna recombination GO:0035825 1 0.016
activation of mapk activity GO:0000187 3 0.016
regulation of protein localization to nucleus GO:1900180 2 0.016
regulation of production of molecular mediator of immune response GO:0002700 1 0.016
regulation of programmed cell death GO:0043067 101 0.016
germ line stem cell maintenance GO:0030718 2 0.015
regulation of anatomical structure morphogenesis GO:0022603 130 0.015
transport GO:0006810 220 0.015
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.015
anterior posterior pattern specification GO:0009952 152 0.015
lipid catabolic process GO:0016042 4 0.015
regulation of protein metabolic process GO:0051246 56 0.015
regulation of nucleoside metabolic process GO:0009118 2 0.015
erythrocyte development GO:0048821 24 0.015
regulation of nucleocytoplasmic transport GO:0046822 2 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.015
regulation of multicellular organismal development GO:2000026 223 0.015
positive regulation of cell division GO:0051781 2 0.015
mononuclear cell proliferation GO:0032943 1 0.015
protein complex subunit organization GO:0071822 46 0.015
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.015
regulation of transcription dna templated GO:0006355 213 0.015
regulation of carbohydrate metabolic process GO:0006109 4 0.015
transmembrane transport GO:0055085 120 0.015
regulation of cytokine production GO:0001817 3 0.015
regulation of nucleic acid templated transcription GO:1903506 213 0.015
regulation of protein import into nucleus GO:0042306 2 0.015
organonitrogen compound metabolic process GO:1901564 74 0.015
membrane fusion GO:0061025 2 0.014
nik nf kappab signaling GO:0038061 1 0.014
regulation of defense response to virus GO:0050688 2 0.014
carbohydrate biosynthetic process GO:0016051 1 0.014
protein phosphorylation GO:0006468 47 0.014
regulation of blood pressure GO:0008217 1 0.014
positive regulation of camp biosynthetic process GO:0030819 2 0.014
regulation of synapse organization GO:0050807 3 0.014
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.014
internal protein amino acid acetylation GO:0006475 2 0.014
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.014
chromatin modification GO:0016568 21 0.014
glucose import GO:0046323 2 0.014
vasculature development GO:0001944 278 0.014
positive regulation of cytokine production GO:0001819 2 0.014
regulation of organ growth GO:0046620 3 0.014
biosynthetic process GO:0009058 294 0.014
regulation of locomotion GO:0040012 55 0.014
positive regulation of oocyte development GO:0060282 1 0.014
nitrogen compound metabolic process GO:0006807 319 0.014
regulation of jun kinase activity GO:0043506 3 0.014
positive regulation of camp metabolic process GO:0030816 2 0.014
centrosome duplication GO:0051298 1 0.014
exocytosis GO:0006887 1 0.014
negative regulation of map kinase activity GO:0043407 2 0.013
cell cycle g1 s phase transition GO:0044843 1 0.013
positive regulation of embryonic development GO:0040019 3 0.013
rna 3 end processing GO:0031123 2 0.013
growth GO:0040007 174 0.013
positive regulation of jun kinase activity GO:0043507 2 0.013
reactive nitrogen species metabolic process GO:2001057 0 0.013
homeostasis of number of cells GO:0048872 62 0.013
cellular response to light stimulus GO:0071482 4 0.013
protein polymerization GO:0051258 4 0.013
g2 dna damage checkpoint GO:0031572 3 0.013
nuclear division GO:0000280 23 0.013
regulation of neural precursor cell proliferation GO:2000177 3 0.013
centrosome cycle GO:0007098 1 0.013
central nervous system development GO:0007417 387 0.013
negative regulation of catabolic process GO:0009895 3 0.013
histone modification GO:0016570 20 0.013
cellular response to organic substance GO:0071310 105 0.013
regulation of systemic arterial blood pressure GO:0003073 1 0.013
negative regulation of cellular catabolic process GO:0031330 3 0.013
spermatid development GO:0007286 2 0.013
regulation of chromosome segregation GO:0051983 1 0.013
medulla oblongata development GO:0021550 4 0.013
protein import into nucleus GO:0006606 3 0.013
response to nutrient GO:0007584 3 0.013
regulation of signaling GO:0023051 235 0.013
regulation of binding GO:0051098 3 0.013
cellular protein metabolic process GO:0044267 129 0.013
ion transmembrane transport GO:0034220 91 0.013
neuroblast proliferation GO:0007405 2 0.013
negative regulation of kinase activity GO:0033673 4 0.013
response to monosaccharide GO:0034284 3 0.013
blood vessel development GO:0001568 246 0.013
cellular amide metabolic process GO:0043603 4 0.012
leukocyte proliferation GO:0070661 1 0.012
regulation of cellular component movement GO:0051270 55 0.012
positive regulation of ras protein signal transduction GO:0046579 1 0.012
head development GO:0060322 303 0.012
cellular respiration GO:0045333 3 0.012
protein targeting to membrane GO:0006612 1 0.012
nephron epithelium morphogenesis GO:0072088 1 0.012
b cell differentiation GO:0030183 1 0.012
developmental programmed cell death GO:0010623 4 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.012
negative regulation of gene expression GO:0010629 65 0.012
positive regulation of apoptotic process GO:0043065 29 0.012
homeostatic process GO:0042592 142 0.012
somatic stem cell maintenance GO:0035019 1 0.012
polarized epithelial cell differentiation GO:0030859 4 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.012
regulation of cell shape GO:0008360 1 0.012
apoptotic process involved in development GO:1902742 2 0.012
microtubule cytoskeleton organization GO:0000226 33 0.012
g1 s transition of mitotic cell cycle GO:0000082 1 0.012
endocrine process GO:0050886 2 0.012
telomere maintenance GO:0000723 1 0.012
hormone transport GO:0009914 2 0.012
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.012
nephron tubule morphogenesis GO:0072078 1 0.012
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.012
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.012
regulation of stem cell differentiation GO:2000736 4 0.012
regulation of epithelial to mesenchymal transition GO:0010717 3 0.012
organic acid metabolic process GO:0006082 31 0.012
regulation of cell differentiation GO:0045595 142 0.012
single organism membrane fusion GO:0044801 2 0.012
chemosensory behavior GO:0007635 1 0.012
peptidyl lysine acetylation GO:0018394 2 0.012
actin filament based process GO:0030029 64 0.012
covalent chromatin modification GO:0016569 20 0.012
renal tubule morphogenesis GO:0061333 1 0.012
spindle assembly involved in mitosis GO:0090307 1 0.012
regulation of macromolecule biosynthetic process GO:0010556 225 0.012
protein polyubiquitination GO:0000209 4 0.012
negative regulation of defense response GO:0031348 2 0.012
hindbrain development GO:0030902 91 0.012
ion transport GO:0006811 114 0.012
nuclear migration GO:0007097 3 0.012
regulation of hormone secretion GO:0046883 2 0.012
mrna 3 end processing GO:0031124 2 0.012
adherens junction organization GO:0034332 4 0.012
regulation of jak stat cascade GO:0046425 3 0.012
adherens junction maintenance GO:0034334 2 0.011
cellular component disassembly GO:0022411 1 0.011
positive regulation of protein polymerization GO:0032273 2 0.011
chromatin organization GO:0006325 22 0.011
regulation of catalytic activity GO:0050790 55 0.011
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.011
osteoclast differentiation GO:0030316 1 0.011
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.011
actin cytoskeleton organization GO:0030036 63 0.011
macroautophagy GO:0016236 1 0.011
negative regulation of secretion by cell GO:1903531 2 0.011
programmed cell death GO:0012501 119 0.011
cortical cytoskeleton organization GO:0030865 1 0.011
cell death GO:0008219 121 0.011
stem cell maintenance GO:0019827 4 0.011
regulation of intracellular signal transduction GO:1902531 57 0.011
negative regulation of nuclear division GO:0051784 3 0.011
cellular response to stress GO:0033554 62 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.011
regulation of nucleotide catabolic process GO:0030811 2 0.011
negative regulation of mapk cascade GO:0043409 4 0.011
regulation of inflammatory response GO:0050727 2 0.011
positive regulation of cell cycle GO:0045787 3 0.011
synaptic growth at neuromuscular junction GO:0051124 2 0.011
regulation of multicellular organism growth GO:0040014 4 0.011
regulation of apoptotic process GO:0042981 98 0.011
generation of neurons GO:0048699 385 0.011
response to biotic stimulus GO:0009607 97 0.011
positive regulation of defense response to virus by host GO:0002230 0 0.011
gtp catabolic process GO:0006184 2 0.011
regulation of protein localization to plasma membrane GO:1903076 1 0.011
regulation of growth rate GO:0040009 1 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
positive regulation of jnk cascade GO:0046330 3 0.011
positive regulation of transcription dna templated GO:0045893 57 0.011
regulation of response to cytokine stimulus GO:0060759 3 0.011
telomere organization GO:0032200 1 0.011
heart looping GO:0001947 94 0.011
nucleobase containing compound metabolic process GO:0006139 274 0.011
regulation of gtpase activity GO:0043087 2 0.011
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.011
compound eye development GO:0048749 2 0.011
camera type eye morphogenesis GO:0048593 108 0.011
negative chemotaxis GO:0050919 1 0.011
protein localization to nucleus GO:0034504 3 0.011
neurotransmitter transport GO:0006836 2 0.011
negative regulation of multi organism process GO:0043901 3 0.011
cell death in response to oxidative stress GO:0036473 2 0.011
er nucleus signaling pathway GO:0006984 2 0.010
spermatid differentiation GO:0048515 2 0.010
negative regulation of i kappab kinase nf kappab signaling GO:0043124 1 0.010
brain development GO:0007420 293 0.010
regulation of developmental process GO:0050793 247 0.010
peptide metabolic process GO:0006518 1 0.010
chordate embryonic development GO:0043009 271 0.010
spindle assembly GO:0051225 2 0.010
regulation of rna metabolic process GO:0051252 224 0.010
organic substance transport GO:0071702 58 0.010
nucleoside monophosphate catabolic process GO:0009125 4 0.010
cellular response to biotic stimulus GO:0071216 3 0.010
oocyte maturation GO:0001556 4 0.010
vacuolar transport GO:0007034 2 0.010
golgi vesicle transport GO:0048193 3 0.010
hormone secretion GO:0046879 2 0.010
establishment or maintenance of polarity of embryonic epithelium GO:0016332 2 0.010
specification of axis polarity GO:0065001 4 0.010
regulation of cytokine biosynthetic process GO:0042035 1 0.010
proteolysis GO:0006508 38 0.010
cellular component morphogenesis GO:0032989 336 0.010
regulation of cell motility GO:2000145 46 0.010

plekha1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.044
immune system disease DOID:2914 0 0.020
nervous system disease DOID:863 0 0.018
musculoskeletal system disease DOID:17 0 0.012