Danio rerio

13 known processes

tie2

endothelium-specific receptor tyrosine kinase 2

(Aliases: tie-2)

tie2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
vasculature development GO:0001944 278 0.923
Human Zebrafish Mouse Rat
blood vessel morphogenesis GO:0048514 216 0.915
Human Mouse Rat
blood vessel development GO:0001568 246 0.847
Human Zebrafish Mouse Rat
sprouting angiogenesis GO:0002040 53 0.805
Human
angiogenesis GO:0001525 158 0.722
Human Mouse Rat
regulation of endothelial cell proliferation GO:0001936 1 0.558
vascular endothelial growth factor receptor signaling pathway GO:0048010 13 0.498
regulation of neural retina development GO:0061074 2 0.494
patterning of blood vessels GO:0001569 15 0.406
vasculogenesis GO:0001570 41 0.404
Mouse
cell motility GO:0048870 244 0.397
Human Mouse
regulation of retina development in camera type eye GO:1902866 2 0.365
lymph vessel morphogenesis GO:0036303 25 0.345
endothelial cell proliferation GO:0001935 11 0.331
Mouse
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.324
Human
locomotion GO:0040011 313 0.317
Human Mouse
cellular component movement GO:0006928 335 0.316
Human Mouse
osteoclast development GO:0036035 1 0.311
regulation of multicellular organismal process GO:0051239 277 0.302
Human Mouse Rat
regulation of cell shape GO:0008360 1 0.300
regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 8 0.296
xanthophore differentiation GO:0050936 3 0.281
cell migration GO:0016477 237 0.273
Human Mouse
positive regulation of endothelial cell proliferation GO:0001938 1 0.267
macrophage chemotaxis GO:0048246 3 0.264
hematopoietic or lymphoid organ development GO:0048534 191 0.252
Mouse
neuron development GO:0048666 262 0.246
positive regulation of macrophage chemotaxis GO:0010759 1 0.233
venous blood vessel development GO:0060841 9 0.233
regulation of mononuclear cell migration GO:0071675 1 0.232
regulation of anatomical structure morphogenesis GO:0022603 130 0.232
Human Mouse Rat
positive regulation of epithelial cell proliferation GO:0050679 1 0.227
venous endothelial cell migration involved in lymph vessel development GO:0060855 4 0.220
regulation of epithelial cell proliferation GO:0050678 3 0.218
ameboidal type cell migration GO:0001667 143 0.206
Human
cell migration involved in sprouting angiogenesis GO:0002042 8 0.205
lymphangiogenesis GO:0001946 25 0.200
regulation of cellular metabolic process GO:0031323 320 0.187
Human Mouse
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.185
Human
hemopoiesis GO:0030097 183 0.184
Mouse
positive regulation of phospholipase c activity GO:0010863 1 0.183
heart development GO:0007507 313 0.182
positive regulation of cell matrix adhesion GO:0001954 1 0.176
Human
melanocyte migration GO:0097324 4 0.176
regulation of cell motility GO:2000145 46 0.170
Human Mouse
positive regulation of cellular component movement GO:0051272 11 0.168
Human
positive regulation of leukocyte chemotaxis GO:0002690 1 0.165
positive regulation of map kinase activity GO:0043406 3 0.162
immune system process GO:0002376 241 0.161
Mouse
epithelial cell differentiation GO:0030855 116 0.158
regulation of endothelial cell differentiation GO:0045601 3 0.157
smooth muscle contraction GO:0006939 2 0.148
blood circulation GO:0008015 87 0.146
regulation of developmental process GO:0050793 247 0.142
Human Mouse Rat
regulation of multicellular organismal development GO:2000026 223 0.142
Human Mouse Rat
regulation of metabolic process GO:0019222 359 0.141
Human Mouse
taxis GO:0042330 109 0.136
vascular endothelial growth factor signaling pathway GO:0038084 3 0.132
selective angioblast sprouting GO:0035474 5 0.127
regulation of phospholipase c activity GO:1900274 1 0.125
microglia differentiation GO:0014004 1 0.124
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.121
lymph vessel development GO:0001945 27 0.120
regulation of cellular component movement GO:0051270 55 0.116
Human Mouse
morphogenesis of an epithelium GO:0002009 333 0.114
positive regulation of developmental process GO:0051094 50 0.109
Human Rat
positive regulation of leukocyte migration GO:0002687 2 0.109
axon development GO:0061564 166 0.107
positive regulation of endothelial cell migration GO:0010595 2 0.106
Human
negative regulation of cell migration GO:0030336 17 0.105
regulation of erk1 and erk2 cascade GO:0070372 4 0.104
Human
gene expression GO:0010467 252 0.104
cellular response to vascular endothelial growth factor stimulus GO:0035924 3 0.101
heterocycle biosynthetic process GO:0018130 215 0.100
regulation of cell migration GO:0030334 40 0.100
Human Mouse
regulation of protein catabolic process GO:0042176 1 0.099
neuron projection morphogenesis GO:0048812 161 0.099
thyroid gland development GO:0030878 12 0.095
positive regulation of positive chemotaxis GO:0050927 4 0.095
myeloid leukocyte differentiation GO:0002573 15 0.094
endocrine system development GO:0035270 65 0.093
regulation of chemotaxis GO:0050920 18 0.092
pigmentation GO:0043473 85 0.091
regulation of localization GO:0032879 104 0.090
Human Mouse
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.090
ubiquitin dependent protein catabolic process GO:0006511 3 0.090
regulation of angiogenesis GO:0045765 26 0.089
Human Mouse Rat
angioblast cell migration involved in selective angioblast sprouting GO:0035475 4 0.089
tissue migration GO:0090130 37 0.087
Human
cell morphogenesis GO:0000902 289 0.087
Human
cellular protein catabolic process GO:0044257 4 0.087
gland development GO:0048732 143 0.086
phosphatidylinositol mediated signaling GO:0048015 2 0.086
Human
positive regulation of cytokine production GO:0001819 2 0.084
Mouse
localization of cell GO:0051674 244 0.084
Human Mouse
endocardium development GO:0003157 9 0.082
regulation of biological quality GO:0065008 263 0.081
cellular component morphogenesis GO:0032989 336 0.079
Human
heart contraction GO:0060047 71 0.079
positive regulation of epithelial cell migration GO:0010634 2 0.078
Human
regulation of mesenchymal cell proliferation GO:0010464 1 0.077
circulatory system process GO:0003013 87 0.075
mononuclear cell migration GO:0071674 1 0.074
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.073
negative regulation of protein phosphorylation GO:0001933 4 0.073
muscle system process GO:0003012 20 0.073
neuron differentiation GO:0030182 353 0.073
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.072
sensory organ development GO:0007423 393 0.071
tissue remodeling GO:0048771 4 0.070
organelle organization GO:0006996 227 0.069
Human
macrophage differentiation GO:0030225 7 0.068
morphogenesis of an epithelial sheet GO:0002011 49 0.066
single organism organelle organization GO:1902589 199 0.064
Human
regulation of cell morphogenesis GO:0022604 42 0.064
osteoclast differentiation GO:0030316 1 0.064
positive regulation of stem cell proliferation GO:2000648 1 0.063
regulation of leukocyte migration GO:0002685 8 0.063
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.062
inositol lipid mediated signaling GO:0048017 2 0.062
Human
regulation of cell death GO:0010941 103 0.062
Mouse
mechanosensory behavior GO:0007638 2 0.062
spindle assembly GO:0051225 2 0.062
guanosine containing compound metabolic process GO:1901068 4 0.061
antimicrobial humoral response GO:0019730 2 0.060
negative regulation of biological process GO:0048519 304 0.059
Human Mouse
positive regulation of gtp catabolic process GO:0033126 1 0.059
positive regulation of chemotaxis GO:0050921 5 0.059
granulocyte chemotaxis GO:0071621 11 0.059
blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 4 0.058
regulation of vasculogenesis GO:2001212 1 0.058
regulation of phospholipase activity GO:0010517 2 0.058
negative regulation of angiogenesis GO:0016525 7 0.057
Human
regulation of vasculature development GO:1901342 33 0.057
Human Mouse Rat
negative regulation of cellular process GO:0048523 283 0.056
Mouse
positive regulation of neural retina development GO:0061075 1 0.056
regulation of muscle contraction GO:0006937 3 0.055
aromatic compound biosynthetic process GO:0019438 217 0.055
regulation of rna biosynthetic process GO:2001141 213 0.055
epithelial cell migration GO:0010631 25 0.055
Human
immune system development GO:0002520 191 0.054
Mouse
endothelium development GO:0003158 25 0.054
regulation of cell migration involved in sprouting angiogenesis GO:0090049 3 0.053
response to chemical GO:0042221 320 0.053
Mouse Rat
cell part morphogenesis GO:0032990 246 0.053
cellular macromolecule metabolic process GO:0044260 391 0.053
Human Mouse
positive regulation of lipase activity GO:0060193 1 0.053
central nervous system development GO:0007417 387 0.052
reproduction GO:0000003 40 0.052
regulation of macromolecule metabolic process GO:0060255 317 0.052
Human Mouse
pericardium development GO:0060039 1 0.052
establishment of protein localization to organelle GO:0072594 4 0.052
Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.051
cell projection organization GO:0030030 284 0.051
myeloid leukocyte migration GO:0097529 12 0.051
response to external stimulus GO:0009605 264 0.050
actin mediated cell contraction GO:0070252 1 0.050
venous blood vessel morphogenesis GO:0048845 3 0.050
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.049
regulation of locomotion GO:0040012 55 0.049
Human Mouse
endothelial cell migration GO:0043542 19 0.049
Human
nitrogen compound metabolic process GO:0006807 319 0.049
generation of neurons GO:0048699 385 0.048
regulation of blood circulation GO:1903522 32 0.048
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.047
ras protein signal transduction GO:0007265 7 0.046
lens fiber cell development GO:0070307 3 0.046
positive regulation of stress activated mapk cascade GO:0032874 3 0.045
actin filament bundle assembly GO:0051017 6 0.045
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.045
regulation of blood vessel size GO:0050880 2 0.044
axonogenesis GO:0007409 152 0.044
erk1 and erk2 cascade GO:0070371 4 0.044
Human
cell projection assembly GO:0030031 64 0.044
regulation of circadian rhythm GO:0042752 4 0.043
leukocyte chemotaxis GO:0030595 12 0.043
regulation of stem cell proliferation GO:0072091 2 0.042
endothelial cell differentiation GO:0045446 20 0.042
phagocytosis GO:0006909 3 0.041
modification dependent protein catabolic process GO:0019941 3 0.041
aorta development GO:0035904 4 0.041
rna biosynthetic process GO:0032774 181 0.041
synaptic growth at neuromuscular junction GO:0051124 2 0.041
myeloid cell differentiation GO:0030099 86 0.040
intracellular signal transduction GO:0035556 85 0.040
Human Mouse Rat
epithelial tube morphogenesis GO:0060562 148 0.039
cell migration involved in heart formation GO:0060974 10 0.039
ovulation cycle process GO:0022602 2 0.038
chemotaxis GO:0006935 104 0.038
modification dependent macromolecule catabolic process GO:0043632 3 0.038
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.038
tube morphogenesis GO:0035239 349 0.038
protein heterooligomerization GO:0051291 1 0.037
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.037
regulation of macromolecule biosynthetic process GO:0010556 225 0.037
regulation of leukocyte chemotaxis GO:0002688 6 0.037
regulation of response to stimulus GO:0048583 269 0.037
Human Mouse
gliogenesis GO:0042063 45 0.036
larval development GO:0002164 2 0.036
positive regulation of catabolic process GO:0009896 4 0.036
single organism metabolic process GO:0044710 217 0.035
Human
positive regulation of cell substrate adhesion GO:0010811 1 0.035
Human
negative regulation of cell motility GO:2000146 17 0.035
regulation of positive chemotaxis GO:0050926 4 0.035
retina development in camera type eye GO:0060041 146 0.035
regulation of lipase activity GO:0060191 2 0.035
negative regulation of multicellular organismal process GO:0051241 69 0.034
Human
blood vessel endothelial cell migration GO:0043534 18 0.034
positive regulation of cell motility GO:2000147 11 0.034
Human
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.034
artery morphogenesis GO:0048844 14 0.034
positive regulation of epithelial cell differentiation GO:0030858 2 0.034
response to decreased oxygen levels GO:0036293 25 0.034
Rat
regulation of heart contraction GO:0008016 32 0.033
regulation of erythrocyte differentiation GO:0045646 2 0.033
positive regulation of cellular process GO:0048522 201 0.033
Human Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.033
Human
posttranscriptional gene silencing GO:0016441 3 0.033
phosphorus metabolic process GO:0006793 109 0.033
Human Mouse
stem cell maintenance GO:0019827 4 0.032
regulation of nucleotide catabolic process GO:0030811 2 0.032
positive regulation of macromolecule metabolic process GO:0010604 93 0.032
Human Mouse
positive regulation of cell migration GO:0030335 11 0.032
Human
ovulation cycle GO:0042698 2 0.032
regulation of synapse organization GO:0050807 3 0.031
hypothalamus cell differentiation GO:0021979 4 0.031
nucleocytoplasmic transport GO:0006913 4 0.031
Mouse
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.031
primitive hemopoiesis GO:0060215 27 0.031
nucleobase containing compound biosynthetic process GO:0034654 205 0.031
epithelial cell development GO:0002064 42 0.031
positive regulation of multicellular organismal process GO:0051240 52 0.031
Human Mouse Rat
stem cell proliferation GO:0072089 4 0.031
proteasomal protein catabolic process GO:0010498 2 0.030
heart process GO:0003015 71 0.030
organic substance biosynthetic process GO:1901576 289 0.030
leukocyte differentiation GO:0002521 25 0.030
activation of jun kinase activity GO:0007257 2 0.030
positive regulation of myeloid cell differentiation GO:0045639 2 0.030
cellular response to organic substance GO:0071310 105 0.030
cell substrate junction assembly GO:0007044 2 0.030
Human
cellular component disassembly GO:0022411 1 0.030
regulation of neural precursor cell proliferation GO:2000177 3 0.029
positive regulation of locomotion GO:0040017 14 0.029
Human
epithelium migration GO:0090132 25 0.029
Human
regulation of protein ubiquitination GO:0031396 3 0.029
negative regulation of reproductive process GO:2000242 3 0.029
pericardium morphogenesis GO:0003344 1 0.029
mitotic cell cycle GO:0000278 64 0.029
dorsal aorta morphogenesis GO:0035912 3 0.028
regulation of cell matrix adhesion GO:0001952 1 0.028
Human
positive regulation of cell adhesion GO:0045785 1 0.028
Human Mouse
positive regulation of retina development in camera type eye GO:1902868 1 0.028
response to growth factor GO:0070848 39 0.028
regulation of nitrogen compound metabolic process GO:0051171 251 0.028
definitive hemopoiesis GO:0060216 18 0.028
system process GO:0003008 185 0.028
female sex differentiation GO:0046660 4 0.028
regulation of gene expression GO:0010468 265 0.028
cell projection morphogenesis GO:0048858 244 0.028
determination of left right symmetry GO:0007368 179 0.027
regulation of granulocyte chemotaxis GO:0071622 6 0.027
positive regulation of cellular component biogenesis GO:0044089 3 0.027
Human
axon guidance GO:0007411 86 0.027
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.027
tor signaling GO:0031929 7 0.027
cell chemotaxis GO:0060326 17 0.027
cellular response to growth factor stimulus GO:0071363 39 0.027
cell migration to the midline involved in heart development GO:0003318 12 0.027
regulation of cell differentiation GO:0045595 142 0.027
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.027
cellular response to hormone stimulus GO:0032870 39 0.026
response to organic substance GO:0010033 153 0.026
Mouse Rat
camera type eye development GO:0043010 222 0.026
regulation of purine nucleotide catabolic process GO:0033121 2 0.026
microtubule organizing center organization GO:0031023 1 0.026
embryonic heart tube development GO:0035050 133 0.026
protein targeting to nucleus GO:0044744 3 0.026
Mouse
germ line stem cell maintenance GO:0030718 2 0.026
regulation of lymphangiogenesis GO:1901490 4 0.026
regulation of dna templated transcription elongation GO:0032784 3 0.026
cell morphogenesis involved in differentiation GO:0000904 195 0.025
Human
myeloid cell development GO:0061515 32 0.025
cell substrate adhesion GO:0031589 4 0.025
Human Mouse
centrosome organization GO:0051297 1 0.025
positive regulation of nucleoside metabolic process GO:0045979 1 0.025
post embryonic organ development GO:0048569 4 0.025
positive regulation of jnk cascade GO:0046330 3 0.025
determination of bilateral symmetry GO:0009855 204 0.024
positive regulation of jun kinase activity GO:0043507 2 0.024
mesenchymal cell proliferation GO:0010463 1 0.024
regulation of cellular protein catabolic process GO:1903362 1 0.024
guanosine containing compound catabolic process GO:1901069 2 0.024
negative regulation of synapse assembly GO:0051964 2 0.024
microtubule based process GO:0007017 60 0.024
eye development GO:0001654 277 0.024
negative regulation of secretion GO:0051048 2 0.024
programmed cell death GO:0012501 119 0.024
Mouse
negative regulation of kinase activity GO:0033673 4 0.024
pathway restricted smad protein phosphorylation GO:0060389 1 0.024
negative regulation of myeloid cell differentiation GO:0045638 1 0.024
cellular protein metabolic process GO:0044267 129 0.024
Human Mouse
regulation of transcription dna templated GO:0006355 213 0.024
small gtpase mediated signal transduction GO:0007264 8 0.023
regulation of dna replication GO:0006275 3 0.023
regulation of cytoplasmic transport GO:1903649 4 0.023
Mouse
positive regulation of biological process GO:0048518 253 0.023
Human Mouse Rat
negative regulation of protein kinase activity GO:0006469 4 0.023
protein acetylation GO:0006473 2 0.023
negative regulation of blood circulation GO:1903523 2 0.023
regulation of cellular component organization GO:0051128 86 0.023
Human
lens fiber cell morphogenesis GO:0070309 3 0.023
meiotic chromosome segregation GO:0045132 3 0.022
positive regulation of transport GO:0051050 2 0.022
Mouse
hormone biosynthetic process GO:0042446 3 0.022
signal transduction GO:0007165 455 0.022
Human Mouse Rat
cell migration involved in heart development GO:0060973 22 0.022
embryonic organ morphogenesis GO:0048562 274 0.022
regulation of signaling GO:0023051 235 0.022
Human Mouse
embryonic hemopoiesis GO:0035162 53 0.022
behavior GO:0007610 74 0.022
regulation of cellular biosynthetic process GO:0031326 245 0.022
circadian sleep wake cycle sleep GO:0050802 1 0.022
skeletal muscle organ development GO:0060538 78 0.022
positive regulation of cellular catabolic process GO:0031331 3 0.022
aging GO:0007568 2 0.022
transcription from rna polymerase ii promoter GO:0006366 80 0.021
protein import into nucleus GO:0006606 3 0.021
Mouse
amine metabolic process GO:0009308 2 0.021
granulocyte migration GO:0097530 11 0.021
response to hypoxia GO:0001666 25 0.021
Rat
positive regulation of neural precursor cell proliferation GO:2000179 1 0.021
regulation of biosynthetic process GO:0009889 250 0.021
homeostatic process GO:0042592 142 0.021
negative regulation of programmed cell death GO:0043069 58 0.021
Mouse
cell matrix adhesion GO:0007160 4 0.021
Human Mouse
protein localization to nucleus GO:0034504 3 0.021
Mouse
negative regulation of vasculature development GO:1901343 8 0.021
Human
multicellular organism growth GO:0035264 4 0.021
aorta morphogenesis GO:0035909 3 0.020
regulation of cell development GO:0060284 100 0.020
renal system vasculature development GO:0061437 2 0.020
artery development GO:0060840 22 0.020
negative regulation of neural precursor cell proliferation GO:2000178 1 0.020
regulation of apoptotic process GO:0042981 98 0.020
Mouse
female meiotic division GO:0007143 2 0.020
regulation of tube size GO:0035150 2 0.020
response to abiotic stimulus GO:0009628 122 0.020
Rat
neuron projection development GO:0031175 180 0.020
nucleobase containing compound metabolic process GO:0006139 274 0.020
circadian sleep wake cycle GO:0042745 2 0.020
enzyme linked receptor protein signaling pathway GO:0007167 106 0.020
Human
innervation GO:0060384 3 0.020
actin filament based movement GO:0030048 1 0.020
endocardium morphogenesis GO:0003160 4 0.020
regulation of multicellular organism growth GO:0040014 4 0.020
endocrine process GO:0050886 2 0.019
regulation of axonogenesis GO:0050770 32 0.019
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.019
neuroepithelial cell differentiation GO:0060563 26 0.019
regulation of circadian sleep wake cycle GO:0042749 1 0.019
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.019
cardiac atrium morphogenesis GO:0003209 2 0.019
regulation of synaptic plasticity GO:0048167 1 0.019
gtp metabolic process GO:0046039 4 0.019
positive regulation of response to external stimulus GO:0032103 9 0.019
response to oxygen levels GO:0070482 25 0.019
Rat
angioblast cell migration GO:0035476 9 0.019
cellular response to radiation GO:0071478 4 0.019
exocrine system development GO:0035272 28 0.019
glial cell migration GO:0008347 3 0.019
sensory system development GO:0048880 76 0.019
muscle contraction GO:0006936 18 0.019
negative regulation of developmental process GO:0051093 65 0.019
Human
erythrocyte homeostasis GO:0034101 55 0.019
regulation of organ growth GO:0046620 3 0.019
multicellular organismal reproductive process GO:0048609 35 0.019
regulation of cellular response to growth factor stimulus GO:0090287 35 0.019
organonitrogen compound metabolic process GO:1901564 74 0.019
positive regulation of inflammatory response GO:0050729 1 0.019
glial cell proliferation GO:0014009 4 0.018
regulation of macrophage chemotaxis GO:0010758 1 0.018
positive regulation of ras protein signal transduction GO:0046579 1 0.018
cellular component assembly GO:0022607 170 0.018
Human
spinal cord development GO:0021510 46 0.018
adrenal gland development GO:0030325 10 0.018
development of primary female sexual characteristics GO:0046545 4 0.018
actin filament based process GO:0030029 64 0.018
Human
ovarian follicle development GO:0001541 2 0.018
nuclear transport GO:0051169 4 0.018
Mouse
cardiac cell fate commitment GO:0060911 1 0.018
negative regulation of apoptotic process GO:0043066 55 0.018
Mouse
regulation of reproductive process GO:2000241 4 0.018
tetrapyrrole metabolic process GO:0033013 10 0.018
organic cyclic compound metabolic process GO:1901360 301 0.017
cell differentiation in spinal cord GO:0021515 40 0.017
meiosis ii GO:0007135 1 0.017
regulation of synapse assembly GO:0051963 3 0.017
photoreceptor cell fate commitment GO:0046552 1 0.017
nucleic acid metabolic process GO:0090304 244 0.017
regulation of gtpase activity GO:0043087 2 0.017
melanocyte apoptotic process GO:1902362 2 0.017
secondary metabolic process GO:0019748 3 0.017
exocytosis GO:0006887 1 0.017
regulation of programmed cell death GO:0043067 101 0.017
Mouse
phosphorylation GO:0016310 69 0.017
Human Mouse
developmental maturation GO:0021700 34 0.017
maintenance of location GO:0051235 4 0.017
specification of symmetry GO:0009799 204 0.017
positive regulation of molecular function GO:0044093 33 0.017
Human
regulation of receptor mediated endocytosis GO:0048259 4 0.017
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.017
glial cell differentiation GO:0010001 42 0.016
glomerular visceral epithelial cell fate commitment GO:0072149 4 0.016
transcription dna templated GO:0006351 181 0.016
embryo development ending in birth or egg hatching GO:0009792 271 0.016
cell substrate adherens junction assembly GO:0007045 1 0.016
Human
circadian sleep wake cycle process GO:0022410 2 0.016
spindle assembly involved in mitosis GO:0090307 1 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.016
heterocycle metabolic process GO:0046483 290 0.016
anatomical structure homeostasis GO:0060249 36 0.016
macromolecule modification GO:0043412 111 0.016
Human Mouse
positive regulation of gtpase activity GO:0043547 1 0.016
dorsal aorta development GO:0035907 4 0.016
regulation of cytokine production GO:0001817 3 0.016
Mouse
positive regulation of cell proliferation GO:0008284 15 0.016
negative chemotaxis GO:0050919 1 0.016
lipid storage GO:0019915 1 0.016
neuroblast proliferation GO:0007405 2 0.016
negative regulation of map kinase activity GO:0043407 2 0.016
somatic stem cell maintenance GO:0035019 1 0.016
cellular response to external stimulus GO:0071496 2 0.016
branching morphogenesis of an epithelial tube GO:0048754 15 0.016
embryonic organ development GO:0048568 381 0.016
motor neuron axon guidance GO:0008045 23 0.016
glucose homeostasis GO:0042593 1 0.016
death GO:0016265 121 0.016
Mouse
posttranscriptional gene silencing by rna GO:0035194 3 0.016
establishment of endothelial barrier GO:0061028 3 0.016
cellular macromolecule biosynthetic process GO:0034645 224 0.016
regulation of primary metabolic process GO:0080090 311 0.015
Human Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.015
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.015
locomotor rhythm GO:0045475 3 0.015
regulation of cell proliferation GO:0042127 37 0.015
pigment cell differentiation GO:0050931 38 0.015
dna templated transcription elongation GO:0006354 3 0.015
developmental growth GO:0048589 166 0.015
nuclear import GO:0051170 3 0.015
Mouse
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.015
cardiogenic plate morphogenesis GO:0003142 1 0.015
interspecies interaction between organisms GO:0044419 4 0.015
energy reserve metabolic process GO:0006112 2 0.015
peptidyl tyrosine phosphorylation GO:0018108 5 0.015
Human Mouse
sensory perception of smell GO:0007608 2 0.015
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.015
regulation of neuron projection development GO:0010975 40 0.015
gtp catabolic process GO:0006184 2 0.015
developmental pigmentation GO:0048066 48 0.015
cytokinesis GO:0000910 3 0.015
ventricular cardiac muscle tissue development GO:0003229 3 0.015
positive regulation of nucleic acid templated transcription GO:1903508 57 0.015
regulation of dendrite morphogenesis GO:0048814 3 0.015
regulation of bone remodeling GO:0046850 2 0.014
meiotic nuclear division GO:0007126 4 0.014
embryonic heart tube formation GO:0003144 1 0.014
kidney development GO:0001822 92 0.014
endocardial cushion formation GO:0003272 2 0.014
cellular protein modification process GO:0006464 100 0.014
Human Mouse
negative regulation of metabolic process GO:0009892 86 0.014
innate immune response GO:0045087 13 0.014
regulation of tissue remodeling GO:0034103 2 0.014
response to alkaloid GO:0043279 2 0.014
response to oxygen containing compound GO:1901700 55 0.014
Mouse Rat
negative regulation of epithelial cell migration GO:0010633 1 0.014
centrosome duplication GO:0051298 1 0.014
transport GO:0006810 220 0.014
Mouse
signal transduction by phosphorylation GO:0023014 18 0.014
Human
cell proliferation GO:0008283 80 0.014
Mouse
regulation of catalytic activity GO:0050790 55 0.014
Human
negative regulation of chemotaxis GO:0050922 4 0.014
cellular response to chemical stimulus GO:0070887 157 0.013
organic cyclic compound biosynthetic process GO:1901362 223 0.013
negative regulation of cell differentiation GO:0045596 46 0.013
regulation of dendrite development GO:0050773 3 0.013
gastrulation with mouth forming second GO:0001702 44 0.013
carbohydrate homeostasis GO:0033500 1 0.013
regulation of immune system process GO:0002682 34 0.013
Mouse
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.013
chromosome localization GO:0050000 2 0.013
chordate embryonic development GO:0043009 271 0.013
cellular nitrogen compound metabolic process GO:0034641 290 0.013

tie2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
muscular disease DOID:0080000 0 0.026
disease of anatomical entity DOID:7 0 0.026
musculoskeletal system disease DOID:17 0 0.026
muscle tissue disease DOID:66 0 0.014
nervous system disease DOID:863 0 0.013
sensory system disease DOID:0050155 0 0.013