Danio rerio

0 known processes

tlc

secreted frizzled-related protein

(Aliases: sfrp)

tlc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
forebrain regionalization GO:0021871 4 0.165
central nervous system development GO:0007417 387 0.115
sensory organ morphogenesis GO:0090596 200 0.081
embryonic organ morphogenesis GO:0048562 274 0.081
regionalization GO:0003002 274 0.078
embryonic organ development GO:0048568 381 0.078
protein localization to nucleus GO:0034504 3 0.076
sensory organ development GO:0007423 393 0.070
maintenance of location GO:0051235 4 0.067
determination of bilateral symmetry GO:0009855 204 0.064
head development GO:0060322 303 0.063
gene expression GO:0010467 252 0.061
regulation of stem cell proliferation GO:0072091 2 0.055
lipid storage GO:0019915 1 0.052
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.052
heart looping GO:0001947 94 0.048
eye morphogenesis GO:0048592 144 0.048
larval development GO:0002164 2 0.047
brain development GO:0007420 293 0.047
nucleic acid metabolic process GO:0090304 244 0.046
chordate embryonic development GO:0043009 271 0.045
organic cyclic compound metabolic process GO:1901360 301 0.044
retina morphogenesis in camera type eye GO:0060042 79 0.043
specification of symmetry GO:0009799 204 0.042
rna biosynthetic process GO:0032774 181 0.041
regulation of multicellular organism growth GO:0040014 4 0.041
heart morphogenesis GO:0003007 156 0.038
cell proliferation in forebrain GO:0021846 3 0.038
organic substance biosynthetic process GO:1901576 289 0.037
regulation of metabolic process GO:0019222 359 0.037
multicellular organism growth GO:0035264 4 0.037
vasculature development GO:0001944 278 0.037
embryonic heart tube development GO:0035050 133 0.036
camera type eye development GO:0043010 222 0.036
brain morphogenesis GO:0048854 18 0.035
biosynthetic process GO:0009058 294 0.035
generation of neurons GO:0048699 385 0.034
protein import into nucleus GO:0006606 3 0.033
determination of left right symmetry GO:0007368 179 0.033
somitogenesis GO:0001756 87 0.032
stem cell proliferation GO:0072089 4 0.032
neuroblast differentiation GO:0014016 1 0.032
tube morphogenesis GO:0035239 349 0.032
segmentation GO:0035282 97 0.032
neural crest cell differentiation GO:0014033 72 0.032
neuron differentiation GO:0030182 353 0.032
nucleocytoplasmic transport GO:0006913 4 0.031
regulation of multicellular organismal development GO:2000026 223 0.031
eye development GO:0001654 277 0.030
cellular aromatic compound metabolic process GO:0006725 295 0.030
cellular component movement GO:0006928 335 0.030
regulation of macromolecule metabolic process GO:0060255 317 0.028
regulation of signaling GO:0023051 235 0.028
phagocytosis GO:0006909 3 0.028
blood vessel development GO:0001568 246 0.028
positive regulation of cellular component biogenesis GO:0044089 3 0.028
protein import GO:0017038 3 0.028
response to drug GO:0042493 3 0.027
nuclear transport GO:0051169 4 0.027
morphogenesis of an epithelium GO:0002009 333 0.027
regulation of cellular biosynthetic process GO:0031326 245 0.026
regulation of organ growth GO:0046620 3 0.026
regulation of neural precursor cell proliferation GO:2000177 3 0.026
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.025
heart development GO:0007507 313 0.025
retina development in camera type eye GO:0060041 146 0.025
regulation of cytokine production GO:0001817 3 0.025
cellular nitrogen compound metabolic process GO:0034641 290 0.025
anterior posterior pattern specification GO:0009952 152 0.025
aging GO:0007568 2 0.025
establishment of protein localization to organelle GO:0072594 4 0.024
regulation of gene expression GO:0010468 265 0.024
transcription dna templated GO:0006351 181 0.023
proteasomal protein catabolic process GO:0010498 2 0.023
protein acetylation GO:0006473 2 0.023
embryonic skeletal system morphogenesis GO:0048704 93 0.023
muscle cell differentiation GO:0042692 139 0.023
wound healing GO:0042060 90 0.022
embryonic cranial skeleton morphogenesis GO:0048701 90 0.022
stem cell maintenance GO:0019827 4 0.022
regulation of protein catabolic process GO:0042176 1 0.022
positive regulation of catabolic process GO:0009896 4 0.022
inner ear development GO:0048839 126 0.022
response to chemical GO:0042221 320 0.021
embryonic heart tube morphogenesis GO:0003143 108 0.021
positive regulation of stress activated mapk cascade GO:0032874 3 0.021
locomotion GO:0040011 313 0.021
regulation of nitrogen compound metabolic process GO:0051171 251 0.021
amine metabolic process GO:0009308 2 0.020
mesenchyme development GO:0060485 127 0.020
protein targeting to nucleus GO:0044744 3 0.020
stem cell fate commitment GO:0048865 1 0.020
regulation of transcription dna templated GO:0006355 213 0.020
adult behavior GO:0030534 2 0.020
cell cycle g1 s phase transition GO:0044843 1 0.020
tube closure GO:0060606 1 0.019
rna metabolic process GO:0016070 219 0.019
nitrogen compound metabolic process GO:0006807 319 0.019
cellular nitrogen compound biosynthetic process GO:0044271 218 0.019
blood vessel morphogenesis GO:0048514 216 0.019
positive regulation of biological process GO:0048518 253 0.019
negative regulation of catabolic process GO:0009895 3 0.019
nucleobase containing compound biosynthetic process GO:0034654 205 0.019
macromolecule biosynthetic process GO:0009059 227 0.019
regulation of synapse organization GO:0050807 3 0.018
single organism nuclear import GO:1902593 3 0.018
negative regulation of cellular process GO:0048523 283 0.018
cell morphogenesis involved in differentiation GO:0000904 195 0.018
female sex differentiation GO:0046660 4 0.018
embryo development ending in birth or egg hatching GO:0009792 271 0.018
regulation of protein complex assembly GO:0043254 3 0.018
cell surface receptor signaling pathway GO:0007166 325 0.018
regulation of response to stimulus GO:0048583 269 0.018
blood circulation GO:0008015 87 0.018
response to other organism GO:0051707 97 0.017
cell morphogenesis GO:0000902 289 0.017
regulation of rna biosynthetic process GO:2001141 213 0.017
forebrain development GO:0030900 96 0.017
heterocycle biosynthetic process GO:0018130 215 0.017
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.017
positive regulation of transport GO:0051050 2 0.017
heterocycle metabolic process GO:0046483 290 0.017
signal transduction GO:0007165 455 0.017
peptidyl lysine acetylation GO:0018394 2 0.017
regulation of jun kinase activity GO:0043506 3 0.017
mesenchymal cell differentiation GO:0048762 87 0.017
ubiquitin dependent protein catabolic process GO:0006511 3 0.017
embryonic skeletal system development GO:0048706 97 0.017
mononuclear cell proliferation GO:0032943 1 0.017
compound eye development GO:0048749 2 0.016
embryonic hemopoiesis GO:0035162 53 0.016
negative regulation of cellular catabolic process GO:0031330 3 0.016
organic acid metabolic process GO:0006082 31 0.016
carboxylic acid metabolic process GO:0019752 22 0.016
camera type eye morphogenesis GO:0048593 108 0.016
cell motility GO:0048870 244 0.016
regulation of biological quality GO:0065008 263 0.016
regulation of cell activation GO:0050865 1 0.016
i kappab kinase nf kappab signaling GO:0007249 4 0.016
cellular macromolecule metabolic process GO:0044260 391 0.015
stem cell differentiation GO:0048863 117 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.015
negative regulation of biological process GO:0048519 304 0.015
organelle organization GO:0006996 227 0.015
positive regulation of cell activation GO:0050867 1 0.015
enzyme linked receptor protein signaling pathway GO:0007167 106 0.015
organic cyclic compound biosynthetic process GO:1901362 223 0.015
glial cell migration GO:0008347 3 0.015
angiogenesis GO:0001525 158 0.015
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.015
single organism metabolic process GO:0044710 217 0.015
protein acylation GO:0043543 3 0.015
cellular protein catabolic process GO:0044257 4 0.015
regulation of signal transduction GO:0009966 225 0.015
developmental growth GO:0048589 166 0.015
interspecies interaction between organisms GO:0044419 4 0.015
striated muscle cell differentiation GO:0051146 129 0.014
determination of heart left right asymmetry GO:0061371 117 0.014
regulation of nucleic acid templated transcription GO:1903506 213 0.014
cellular respiration GO:0045333 3 0.014
regulation of cellular metabolic process GO:0031323 320 0.014
female gonad development GO:0008585 4 0.014
golgi vesicle transport GO:0048193 3 0.014
regulation of protein localization to nucleus GO:1900180 2 0.014
aorta development GO:0035904 4 0.014
tissue regeneration GO:0042246 74 0.014
negative regulation of cytokine production GO:0001818 1 0.014
regulation of nucleoside metabolic process GO:0009118 2 0.014
transcription from rna polymerase ii promoter GO:0006366 80 0.014
transmission of nerve impulse GO:0019226 19 0.014
cell proliferation in hindbrain GO:0021534 4 0.014
g1 s transition of mitotic cell cycle GO:0000082 1 0.013
otolith development GO:0048840 32 0.013
positive regulation of jun kinase activity GO:0043507 2 0.013
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.013
nuclear import GO:0051170 3 0.013
wnt signaling pathway GO:0016055 80 0.013
epithelial tube morphogenesis GO:0060562 148 0.013
regulation of cell communication GO:0010646 232 0.013
regulation of reproductive process GO:2000241 4 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.013
extrinsic apoptotic signaling pathway GO:0097191 3 0.013
regulation of mrna processing GO:0050684 3 0.013
b cell activation GO:0042113 2 0.013
regulation of nucleocytoplasmic transport GO:0046822 2 0.013
muscle structure development GO:0061061 196 0.013
primary neural tube formation GO:0014020 1 0.013
neuroblast proliferation GO:0007405 2 0.013
nucleobase containing compound metabolic process GO:0006139 274 0.013
lateral inhibition GO:0046331 1 0.013
development of primary female sexual characteristics GO:0046545 4 0.013
apoptotic process involved in development GO:1902742 2 0.012
digestive system development GO:0055123 289 0.012
adherens junction organization GO:0034332 4 0.012
response to uv GO:0009411 3 0.012
cellular biosynthetic process GO:0044249 286 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.012
forebrain cell migration GO:0021885 1 0.012
nucleic acid templated transcription GO:0097659 181 0.012
leukocyte proliferation GO:0070661 1 0.012
positive regulation of cell cycle GO:0045787 3 0.012
stem cell division GO:0017145 1 0.012
gtp catabolic process GO:0006184 2 0.012
regulation of cytoplasmic transport GO:1903649 4 0.012
cellular macromolecule biosynthetic process GO:0034645 224 0.012
response to vitamin GO:0033273 3 0.012
regulation of macromolecule biosynthetic process GO:0010556 225 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.012
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.012
protein homooligomerization GO:0051260 3 0.012
autophagy GO:0006914 4 0.012
ear development GO:0043583 127 0.012
olfactory lobe development GO:0021988 4 0.011
positive regulation of protein complex assembly GO:0031334 2 0.011
oxoacid metabolic process GO:0043436 31 0.011
positive regulation of cytokine production GO:0001819 2 0.011
cellular response to oxygen levels GO:0071453 1 0.011
regulation of biosynthetic process GO:0009889 250 0.011
ameboidal type cell migration GO:0001667 143 0.011
regulation of stem cell differentiation GO:2000736 4 0.011
neuron projection development GO:0031175 180 0.011
negative regulation of cellular metabolic process GO:0031324 77 0.011
positive regulation of cellular catabolic process GO:0031331 3 0.011
sensory perception of chemical stimulus GO:0007606 3 0.011
hemopoiesis GO:0030097 183 0.011
positive regulation of immune effector process GO:0002699 3 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
intracellular signal transduction GO:0035556 85 0.011
endocrine process GO:0050886 2 0.011
axonogenesis GO:0007409 152 0.011
guanosine containing compound metabolic process GO:1901068 4 0.011
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.011
epidermal cell fate specification GO:0009957 4 0.011
positive regulation of developmental process GO:0051094 50 0.011
neuronal action potential GO:0019228 18 0.011
regulation of apoptotic process GO:0042981 98 0.011
pancreas development GO:0031016 84 0.010
stem cell development GO:0048864 82 0.010
muscle cell development GO:0055001 115 0.010
regulation of lipid transport GO:0032368 4 0.010
hindbrain development GO:0030902 91 0.010
dna templated transcription elongation GO:0006354 3 0.010
mesenchymal cell development GO:0014031 78 0.010
organonitrogen compound metabolic process GO:1901564 74 0.010
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.010
protein metabolic process GO:0019538 183 0.010
immune system process GO:0002376 241 0.010
axon guidance GO:0007411 86 0.010
central nervous system neuron differentiation GO:0021953 74 0.010
internal peptidyl lysine acetylation GO:0018393 2 0.010

tlc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.054
nervous system disease DOID:863 0 0.039
sensory system disease DOID:0050155 0 0.019
eye and adnexa disease DOID:1492 0 0.019
retinal disease DOID:5679 0 0.018
eye disease DOID:5614 0 0.018
disease of metabolism DOID:0014667 0 0.012
retinal degeneration DOID:8466 0 0.011