Danio rerio

26 known processes

tnnc1a

troponin C type 1a (slow)

(Aliases: cTnC,tnnc1,zgc:103465)

tnnc1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
heart morphogenesis GO:0003007 156 0.762
Human
cellular component assembly GO:0022607 170 0.673
embryonic heart tube morphogenesis GO:0003143 108 0.638
striated muscle cell development GO:0055002 108 0.613
system process GO:0003008 185 0.571
striated muscle tissue development GO:0014706 110 0.504
Human
muscle cell development GO:0055001 115 0.498
heart development GO:0007507 313 0.490
heart looping GO:0001947 94 0.470
cardiac muscle cell development GO:0055013 20 0.447
embryonic heart tube development GO:0035050 133 0.430
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.430
muscle cell differentiation GO:0042692 139 0.424
striated muscle cell differentiation GO:0051146 129 0.421
cellular component biogenesis GO:0044085 178 0.420
cardiac myofibril assembly GO:0055003 9 0.414
single organism localization GO:1902578 225 0.400
specification of symmetry GO:0009799 204 0.371
transmembrane transport GO:0055085 120 0.360
muscle contraction GO:0006936 18 0.358
actomyosin structure organization GO:0031032 53 0.348
atrial ventricular junction remodeling GO:0003294 2 0.347
heart process GO:0003015 71 0.347
calcium ion import GO:0070509 4 0.337
tube morphogenesis GO:0035239 349 0.329
sarcomere organization GO:0045214 26 0.325
heart jogging GO:0003146 40 0.322
cardiac muscle tissue development GO:0048738 48 0.312
Human
muscle structure development GO:0061061 196 0.294
Human
muscle system process GO:0003012 20 0.293
organelle organization GO:0006996 227 0.292
myofibril assembly GO:0030239 48 0.275
blood circulation GO:0008015 87 0.270
embryonic organ morphogenesis GO:0048562 274 0.264
embryonic organ development GO:0048568 381 0.246
inorganic cation transmembrane transport GO:0098662 50 0.243
cation transport GO:0006812 81 0.240
embryo development ending in birth or egg hatching GO:0009792 271 0.239
cardiac muscle cell differentiation GO:0055007 30 0.229
calcium ion transport into cytosol GO:0060402 3 0.228
determination of left right symmetry GO:0007368 179 0.224
cellular component assembly involved in morphogenesis GO:0010927 107 0.224
cellular component morphogenesis GO:0032989 336 0.218
larval development GO:0002164 2 0.217
cardiac chamber formation GO:0003207 4 0.211
heart contraction GO:0060047 71 0.210
regulation of muscle contraction GO:0006937 3 0.206
Human Mouse
determination of bilateral symmetry GO:0009855 204 0.199
cation homeostasis GO:0055080 33 0.182
cardiac conduction system development GO:0003161 1 0.178
establishment of localization in cell GO:0051649 77 0.175
Mouse
purine nucleoside monophosphate catabolic process GO:0009128 4 0.170
Mouse
single organism organelle organization GO:1902589 199 0.163
cellular nitrogen compound metabolic process GO:0034641 290 0.151
Mouse
single organism transport GO:0044765 206 0.149
metal ion homeostasis GO:0055065 26 0.148
adult behavior GO:0030534 2 0.145
regulation of blood pressure GO:0008217 1 0.142
regulation of heart morphogenesis GO:2000826 17 0.134
regulation of heart contraction GO:0008016 32 0.133
circulatory system process GO:0003013 87 0.130
divalent inorganic cation homeostasis GO:0072507 22 0.130
sodium ion transmembrane transport GO:0035725 21 0.128
signal transduction GO:0007165 455 0.125
determination of heart left right asymmetry GO:0061371 117 0.124
cation transmembrane transport GO:0098655 65 0.122
cardiac atrium morphogenesis GO:0003209 2 0.114
regulation of blood circulation GO:1903522 32 0.108
response to alkaloid GO:0043279 2 0.106
actin filament based process GO:0030029 64 0.106
Mouse
mitochondrion organization GO:0007005 4 0.103
inorganic ion transmembrane transport GO:0098660 57 0.102
endocardial cushion formation GO:0003272 2 0.102
organelle assembly GO:0070925 110 0.100
cytokinesis GO:0000910 3 0.099
atrial cardiac muscle cell development GO:0055014 4 0.096
morphogenesis of an epithelium GO:0002009 333 0.096
cardiac cell development GO:0055006 21 0.096
ion transmembrane transport GO:0034220 91 0.095
calcium ion transmembrane transport GO:0070588 13 0.095
skeletal muscle organ development GO:0060538 78 0.094
epithelial tube morphogenesis GO:0060562 148 0.094
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.093
Human
muscle tissue development GO:0060537 110 0.092
Human
positive regulation of heart contraction GO:0045823 2 0.085
cytoskeleton dependent cytokinesis GO:0061640 3 0.082
ventricular cardiac muscle cell differentiation GO:0055012 6 0.082
establishment of localization GO:0051234 244 0.079
Mouse
muscle organ development GO:0007517 101 0.078
Human
glial cell migration GO:0008347 3 0.078
regulation of tube size GO:0035150 2 0.074
regulation of sequestering of calcium ion GO:0051282 4 0.073
cardiac muscle cell contraction GO:0086003 1 0.071
positive regulation of transport GO:0051050 2 0.068
negative regulation of heart contraction GO:0045822 2 0.067
actin cytoskeleton organization GO:0030036 63 0.066
cytosolic calcium ion transport GO:0060401 3 0.066
cellular aromatic compound metabolic process GO:0006725 295 0.066
Mouse
multi organism process GO:0051704 134 0.066
fluid transport GO:0042044 17 0.065
transport GO:0006810 220 0.064
Mouse
organonitrogen compound metabolic process GO:1901564 74 0.063
Mouse
regulation of cardiac muscle cell contraction GO:0086004 1 0.062
cellular response to organic cyclic compound GO:0071407 38 0.061
skeletal muscle tissue development GO:0007519 67 0.059
regulation of metabolic process GO:0019222 359 0.059
Mouse
intracellular transport GO:0046907 32 0.059
Mouse
cell surface receptor signaling pathway GO:0007166 325 0.058
establishment of protein localization to organelle GO:0072594 4 0.058
immune system process GO:0002376 241 0.057
cellular localization GO:0051641 97 0.056
Mouse
nucleoside monophosphate catabolic process GO:0009125 4 0.055
Mouse
endocardial cushion development GO:0003197 6 0.054
cell death GO:0008219 121 0.053
regulation of blood vessel size GO:0050880 2 0.053
ventricular cardiac myofibril assembly GO:0055005 4 0.053
cardiac chamber morphogenesis GO:0003206 12 0.053
Human
regulation of response to stimulus GO:0048583 269 0.053
Mouse
regulation of biological quality GO:0065008 263 0.052
Mouse
meiotic nuclear division GO:0007126 4 0.050
striated muscle contraction GO:0006941 12 0.050
cardiac ventricle formation GO:0003211 1 0.050
cardiocyte differentiation GO:0035051 44 0.049
phosphorus metabolic process GO:0006793 109 0.049
Mouse
aorta development GO:0035904 4 0.048
regulation of heart rate GO:0002027 5 0.048
cellular chemical homeostasis GO:0055082 17 0.048
atrioventricular valve formation GO:0003190 3 0.048
macromolecular complex assembly GO:0065003 35 0.047
cell motility GO:0048870 244 0.047
cellular amide metabolic process GO:0043603 4 0.047
cellular nitrogen compound biosynthetic process GO:0044271 218 0.047
regulation of mesenchymal cell proliferation GO:0010464 1 0.044
single organism metabolic process GO:0044710 217 0.043
Mouse
regulation of membrane potential GO:0042391 23 0.042
pharyngeal muscle development GO:0043282 4 0.041
tissue remodeling GO:0048771 4 0.041
ion transport GO:0006811 114 0.041
fatty acid catabolic process GO:0009062 1 0.040
endocardial cushion morphogenesis GO:0003203 3 0.040
regulation of system process GO:0044057 40 0.039
Human Mouse
protein complex subunit organization GO:0071822 46 0.039
spinal cord oligodendrocyte cell fate specification GO:0021530 2 0.039
regulation of cell communication GO:0010646 232 0.039
central nervous system development GO:0007417 387 0.037
embryonic skeletal joint development GO:0072498 3 0.037
heterocycle metabolic process GO:0046483 290 0.036
Mouse
cardiac atrium development GO:0003230 4 0.036
blood vessel endothelial cell differentiation GO:0060837 2 0.036
multi organism reproductive process GO:0044703 36 0.036
cell migration involved in heart development GO:0060973 22 0.035
erythrocyte development GO:0048821 24 0.035
heart valve formation GO:0003188 4 0.035
maintenance of location GO:0051235 4 0.034
regulation of transmembrane transport GO:0034762 18 0.034
macromolecular complex subunit organization GO:0043933 74 0.034
atrial cardiac myofibril assembly GO:0055004 2 0.034
cellular divalent inorganic cation homeostasis GO:0072503 13 0.033
regulation of cardiac chamber formation GO:1901210 2 0.033
protein targeting to nucleus GO:0044744 3 0.033
sensory organ development GO:0007423 393 0.033
cellular biosynthetic process GO:0044249 286 0.032
regulation of cardiac muscle contraction GO:0055117 2 0.031
cellular component movement GO:0006928 335 0.031
Mouse
death GO:0016265 121 0.031
regulation of membrane repolarization GO:0060306 1 0.031
nitrogen compound metabolic process GO:0006807 319 0.031
Mouse
regulation of stem cell proliferation GO:0072091 2 0.030
heart field specification GO:0003128 1 0.030
regulation of ion transmembrane transport GO:0034765 18 0.029
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.029
cardiac muscle contraction GO:0060048 6 0.029
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.029
monovalent inorganic cation transport GO:0015672 42 0.029
regulation of signal transduction GO:0009966 225 0.029
positive regulation of blood circulation GO:1903524 2 0.028
regulation of sodium ion transmembrane transporter activity GO:2000649 1 0.028
aging GO:0007568 2 0.028
fertilization GO:0009566 3 0.028
response to external stimulus GO:0009605 264 0.028
nuclear transport GO:0051169 4 0.028
cellular metal ion homeostasis GO:0006875 16 0.028
regulation of metal ion transport GO:0010959 4 0.028
catecholamine metabolic process GO:0006584 2 0.028
regulation of cell matrix adhesion GO:0001952 1 0.028
cytoskeleton organization GO:0007010 96 0.027
peptide metabolic process GO:0006518 1 0.027
gene expression GO:0010467 252 0.027
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.027
regulation of purine nucleotide catabolic process GO:0033121 2 0.027
Mouse
protein metabolic process GO:0019538 183 0.027
ribose phosphate metabolic process GO:0019693 27 0.027
Mouse
macromolecule localization GO:0033036 54 0.027
ion homeostasis GO:0050801 41 0.027
behavior GO:0007610 74 0.026
response to stress GO:0006950 263 0.026
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.026
artery development GO:0060840 22 0.026
heart valve development GO:0003170 14 0.026
organic acid catabolic process GO:0016054 3 0.026
cellular response to topologically incorrect protein GO:0035967 2 0.025
regulation of cytoplasmic transport GO:1903649 4 0.025
apoptotic process GO:0006915 116 0.025
locomotory behavior GO:0007626 34 0.025
nitric oxide biosynthetic process GO:0006809 2 0.025
detection of external stimulus GO:0009581 24 0.024
cellular response to steroid hormone stimulus GO:0071383 31 0.024
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.024
divalent inorganic cation transport GO:0072511 21 0.024
response to abiotic stimulus GO:0009628 122 0.024
sequestering of calcium ion GO:0051208 3 0.023
homeostasis of number of cells GO:0048872 62 0.023
brain development GO:0007420 293 0.023
calcium ion homeostasis GO:0055074 19 0.023
regulation of cellular biosynthetic process GO:0031326 245 0.023
response to hormone GO:0009725 48 0.023
positive regulation of striated muscle tissue development GO:0045844 1 0.023
lipid storage GO:0019915 1 0.023
exocytosis GO:0006887 1 0.022
catechol containing compound metabolic process GO:0009712 2 0.022
regulation of multicellular organismal process GO:0051239 277 0.022
Human Mouse
otolith development GO:0048840 32 0.022
regulation of nucleoside metabolic process GO:0009118 2 0.022
Mouse
regulation of macromolecule metabolic process GO:0060255 317 0.022
regulation of binding GO:0051098 3 0.022
ventricular cardiac muscle tissue development GO:0003229 3 0.022
Human
negative regulation of striated muscle tissue development GO:0045843 2 0.022
regulation of nitrogen compound metabolic process GO:0051171 251 0.021
Mouse
regulation of apoptotic process GO:0042981 98 0.021
nuclear import GO:0051170 3 0.021
neurotransmitter transport GO:0006836 2 0.021
neuron differentiation GO:0030182 353 0.021
regulation of cardiac muscle tissue development GO:0055024 1 0.021
chemical homeostasis GO:0048878 49 0.021
locomotion GO:0040011 313 0.020
lipid oxidation GO:0034440 1 0.020
calcium ion transport GO:0006816 18 0.020
regulation of receptor activity GO:0010469 2 0.020
homeostatic process GO:0042592 142 0.020
cellular homeostasis GO:0019725 26 0.020
neurological system process GO:0050877 62 0.020
specification of organ position GO:0010159 3 0.020
negative regulation of protein phosphorylation GO:0001933 4 0.020
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.019
Mouse
single organism intracellular transport GO:1902582 25 0.019
intracellular signal transduction GO:0035556 85 0.019
inner ear development GO:0048839 126 0.019
nucleobase containing compound metabolic process GO:0006139 274 0.019
Mouse
purine ribonucleoside metabolic process GO:0046128 10 0.019
Mouse
dopamine biosynthetic process GO:0042416 2 0.019
rna metabolic process GO:0016070 219 0.019
fatty acid oxidation GO:0019395 1 0.019
negative regulation of nuclear division GO:0051784 3 0.019
floor plate formation GO:0021508 12 0.019
fatty acid beta oxidation GO:0006635 1 0.018
ribonucleoside monophosphate catabolic process GO:0009158 4 0.018
Mouse
hematopoietic or lymphoid organ development GO:0048534 191 0.018
regulation of striated muscle contraction GO:0006942 2 0.018
regulation of ion transmembrane transporter activity GO:0032412 2 0.018
mesenchymal cell proliferation GO:0010463 1 0.018
leukocyte proliferation GO:0070661 1 0.018
localization of cell GO:0051674 244 0.018
multicellular organism reproduction GO:0032504 35 0.018
cardiac conduction GO:0061337 3 0.018
mitotic cytokinesis GO:0000281 3 0.018
trabecula morphogenesis GO:0061383 2 0.018
calcium ion dependent exocytosis GO:0017156 1 0.018
appendage development GO:0048736 80 0.017
positive regulation of catabolic process GO:0009896 4 0.017
sequestering of metal ion GO:0051238 3 0.017
negative regulation of apoptotic process GO:0043066 55 0.017
regulation of synapse organization GO:0050807 3 0.017
cell differentiation in spinal cord GO:0021515 40 0.017
regulation of cardiac chamber morphogenesis GO:1901219 2 0.017
heart valve morphogenesis GO:0003179 8 0.017
digestive system development GO:0055123 289 0.017
diencephalon development GO:0021536 58 0.017
action potential GO:0001508 19 0.016
renal system development GO:0072001 94 0.016
dorsal aorta development GO:0035907 4 0.016
protein import GO:0017038 3 0.016
extracellular structure organization GO:0043062 27 0.016
response to endogenous stimulus GO:0009719 83 0.016
transcription dna templated GO:0006351 181 0.016
heart formation GO:0060914 13 0.016
cardiac chamber development GO:0003205 19 0.016
programmed cell death GO:0012501 119 0.016
response to light stimulus GO:0009416 46 0.016
determination of left right asymmetry in nervous system GO:0035545 4 0.016
regulation of localization GO:0032879 104 0.016
Mouse
protein complex biogenesis GO:0070271 30 0.016
cellular cation homeostasis GO:0030003 17 0.015
myosin filament organization GO:0031033 6 0.015
regulation of transmembrane transporter activity GO:0022898 2 0.015
single fertilization GO:0007338 3 0.015
central nervous system neuron differentiation GO:0021953 74 0.015
regulation of synapse assembly GO:0051963 3 0.015
regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 1 0.015
protein activation cascade GO:0072376 6 0.015
embryonic cranial skeleton morphogenesis GO:0048701 90 0.015
regulation of transporter activity GO:0032409 2 0.015
craniofacial suture morphogenesis GO:0097094 2 0.015
immune system development GO:0002520 191 0.015
organelle localization GO:0051640 49 0.015
membrane repolarization GO:0086009 2 0.015
organic substance biosynthetic process GO:1901576 289 0.014
digestive tract development GO:0048565 265 0.014
carbohydrate homeostasis GO:0033500 1 0.014
cell cycle GO:0007049 93 0.014
sodium ion transport GO:0006814 24 0.014
embryonic skeletal system morphogenesis GO:0048704 93 0.014
endocrine pancreas development GO:0031018 27 0.014
nucleocytoplasmic transport GO:0006913 4 0.014
positive regulation of cytokine production GO:0001819 2 0.014
regulation of cellular component movement GO:0051270 55 0.014
Mouse
metal ion transport GO:0030001 58 0.014
glycosyl compound metabolic process GO:1901657 11 0.014
Mouse
protein heterooligomerization GO:0051291 1 0.014
ventral spinal cord development GO:0021517 35 0.014
small molecule metabolic process GO:0044281 77 0.014
Mouse
peptidyl serine modification GO:0018209 2 0.014
stem cell proliferation GO:0072089 4 0.014
regulation of signaling GO:0023051 235 0.014
regulation of protein transport GO:0051223 3 0.014
positive regulation of skeletal muscle tissue development GO:0048643 1 0.014
neuron development GO:0048666 262 0.014
amine metabolic process GO:0009308 2 0.014
cranial suture morphogenesis GO:0060363 1 0.013
regeneration GO:0031099 91 0.013
cell substrate adhesion GO:0031589 4 0.013
negative regulation of blood circulation GO:1903523 2 0.013
embryonic neurocranium morphogenesis GO:0048702 15 0.013
cellular response to chemical stimulus GO:0070887 157 0.013
endothelial cell fate commitment GO:0060839 3 0.013
regulation of cytokine production GO:0001817 3 0.013
organic cyclic compound metabolic process GO:1901360 301 0.013
Mouse
regulation of anatomical structure morphogenesis GO:0022603 130 0.013
synaptic growth at neuromuscular junction GO:0051124 2 0.013
retina development in camera type eye GO:0060041 146 0.013
regulation of meiotic cell cycle GO:0051445 1 0.013
protein complex assembly GO:0006461 30 0.013
small molecule catabolic process GO:0044282 3 0.013
ear development GO:0043583 127 0.013
protein import into nucleus GO:0006606 3 0.013
regulation of calcium ion transport GO:0051924 2 0.013
convergent extension GO:0060026 118 0.012
cytoplasmic transport GO:0016482 11 0.012
er nucleus signaling pathway GO:0006984 2 0.012
catecholamine biosynthetic process GO:0042423 2 0.012
regulation of rna biosynthetic process GO:2001141 213 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
cellular component disassembly GO:0022411 1 0.012
organic acid metabolic process GO:0006082 31 0.012
somatic muscle development GO:0007525 4 0.012
protein localization to nucleus GO:0034504 3 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.012
regulation of protein localization to nucleus GO:1900180 2 0.012
angiogenesis GO:0001525 158 0.012
tissue regeneration GO:0042246 74 0.012
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.012
antimicrobial humoral response GO:0019730 2 0.012
rna biosynthetic process GO:0032774 181 0.012
single organism cellular localization GO:1902580 46 0.012
response to unfolded protein GO:0006986 2 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.012
outflow tract morphogenesis GO:0003151 1 0.012
pigmentation GO:0043473 85 0.012
cell proliferation involved in heart morphogenesis GO:0061323 2 0.012
negative regulation of cellular process GO:0048523 283 0.012
photoreceptor cell fate commitment GO:0046552 1 0.012
regulation of glutamate receptor signaling pathway GO:1900449 1 0.012
cellular ion homeostasis GO:0006873 17 0.012
hard palate development GO:0060022 4 0.011
dna templated transcription initiation GO:0006352 1 0.011
muscle hypertrophy GO:0014896 2 0.011
negative regulation of kinase activity GO:0033673 4 0.011
monocyte differentiation GO:0030224 2 0.011
regulation of neurotransmitter transport GO:0051588 1 0.011
positive regulation of molecular function GO:0044093 33 0.011
endoplasmic reticulum unfolded protein response GO:0030968 2 0.011
aorta morphogenesis GO:0035909 3 0.011
regulation of organ growth GO:0046620 3 0.011
regulation of protein import into nucleus GO:0042306 2 0.011
muscle fiber development GO:0048747 52 0.011
atp metabolic process GO:0046034 5 0.011
Mouse
cellular calcium ion homeostasis GO:0006874 13 0.011
cellular amino acid metabolic process GO:0006520 7 0.011
negative regulation of synapse assembly GO:0051964 2 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
positive regulation of cell activation GO:0050867 1 0.011
cell death in response to oxidative stress GO:0036473 2 0.011
wnt signaling pathway GO:0016055 80 0.011
positive regulation of stem cell proliferation GO:2000648 1 0.010
biosynthetic process GO:0009058 294 0.010
regulation of cellular amine metabolic process GO:0033238 0 0.010
erythrocyte homeostasis GO:0034101 55 0.010
cellular amine metabolic process GO:0044106 2 0.010
gtp catabolic process GO:0006184 2 0.010
dopamine metabolic process GO:0042417 2 0.010
cell matrix adhesion GO:0007160 4 0.010
cardiac muscle tissue morphogenesis GO:0055008 7 0.010
Human
nitric oxide mediated signal transduction GO:0007263 2 0.010
chordate embryonic development GO:0043009 271 0.010
regulation of jak stat cascade GO:0046425 3 0.010
glutamate receptor signaling pathway GO:0007215 1 0.010
embryonic skeletal joint morphogenesis GO:0060272 3 0.010
cell part morphogenesis GO:0032990 246 0.010

tnnc1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.145
Human
myopathy DOID:423 0 0.026
Human
muscular disease DOID:0080000 0 0.026
Human
heart disease DOID:114 0 0.026
Human
cardiomyopathy DOID:0050700 0 0.026
Human
cardiovascular system disease DOID:1287 0 0.026
Human
musculoskeletal system disease DOID:17 0 0.026
Human
muscle tissue disease DOID:66 0 0.026
Human
intrinsic cardiomyopathy DOID:0060036 0 0.023
Human
disease of metabolism DOID:0014667 0 0.017
immune system disease DOID:2914 0 0.016
nervous system disease DOID:863 0 0.013