Danio rerio

0 known processes

klhl8

kelch-like 8 (Drosophila)

(Aliases: zgc:158266)

klhl8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
maintenance of location GO:0051235 4 0.049
larval development GO:0002164 2 0.048
aging GO:0007568 2 0.040
response to chemical GO:0042221 320 0.034
adult behavior GO:0030534 2 0.034
signal transduction GO:0007165 455 0.032
positive regulation of transport GO:0051050 2 0.032
sensory organ development GO:0007423 393 0.030
multicellular organism growth GO:0035264 4 0.030
lipid storage GO:0019915 1 0.030
regulation of multicellular organism growth GO:0040014 4 0.029
eye development GO:0001654 277 0.029
tube morphogenesis GO:0035239 349 0.029
positive regulation of cell cycle GO:0045787 3 0.029
regulation of cellular amine metabolic process GO:0033238 0 0.028
regulation of biological quality GO:0065008 263 0.027
amine metabolic process GO:0009308 2 0.027
stem cell maintenance GO:0019827 4 0.027
cellular amine metabolic process GO:0044106 2 0.026
nitrogen compound metabolic process GO:0006807 319 0.026
positive regulation of catabolic process GO:0009896 4 0.026
cellular nitrogen compound metabolic process GO:0034641 290 0.026
regulation of synaptic plasticity GO:0048167 1 0.025
cell surface receptor signaling pathway GO:0007166 325 0.025
positive regulation of cellular catabolic process GO:0031331 3 0.025
heterocycle metabolic process GO:0046483 290 0.024
neuron differentiation GO:0030182 353 0.024
regulation of reproductive process GO:2000241 4 0.024
cellular response to external stimulus GO:0071496 2 0.024
cellular biosynthetic process GO:0044249 286 0.023
system process GO:0003008 185 0.023
meiotic cell cycle process GO:1903046 3 0.023
gtp catabolic process GO:0006184 2 0.023
guanosine containing compound metabolic process GO:1901068 4 0.023
cellular macromolecule metabolic process GO:0044260 391 0.023
Human
guanosine containing compound catabolic process GO:1901069 2 0.023
phagocytosis GO:0006909 3 0.022
embryonic organ morphogenesis GO:0048562 274 0.022
autophagy GO:0006914 4 0.022
regionalization GO:0003002 274 0.022
negative regulation of biological process GO:0048519 304 0.022
regulation of nitrogen compound metabolic process GO:0051171 251 0.022
regulation of cellular metabolic process GO:0031323 320 0.021
regulation of gene expression GO:0010468 265 0.021
establishment of protein localization to organelle GO:0072594 4 0.021
carboxylic acid metabolic process GO:0019752 22 0.021
gene expression GO:0010467 252 0.021
nucleobase containing compound metabolic process GO:0006139 274 0.021
regulation of cellular amino acid metabolic process GO:0006521 0 0.021
negative regulation of protein phosphorylation GO:0001933 4 0.021
organic cyclic compound metabolic process GO:1901360 301 0.021
synaptic growth at neuromuscular junction GO:0051124 2 0.021
regulation of metabolic process GO:0019222 359 0.021
sensory perception of chemical stimulus GO:0007606 3 0.021
cytokinesis GO:0000910 3 0.020
morphogenesis of an epithelium GO:0002009 333 0.020
response to drug GO:0042493 3 0.020
cellular response to extracellular stimulus GO:0031668 2 0.020
camera type eye development GO:0043010 222 0.020
protein localization to nucleus GO:0034504 3 0.020
heterocycle biosynthetic process GO:0018130 215 0.020
response to hexose GO:0009746 3 0.020
generation of neurons GO:0048699 385 0.020
cellular ketone metabolic process GO:0042180 11 0.020
g protein coupled receptor signaling pathway GO:0007186 74 0.020
chemosensory behavior GO:0007635 1 0.020
hormone secretion GO:0046879 2 0.020
stem cell proliferation GO:0072089 4 0.020
embryonic organ development GO:0048568 381 0.020
response to monosaccharide GO:0034284 3 0.020
response to carbohydrate GO:0009743 3 0.020
gtp metabolic process GO:0046039 4 0.020
cellular aromatic compound metabolic process GO:0006725 295 0.020
nucleocytoplasmic transport GO:0006913 4 0.020
compound eye development GO:0048749 2 0.020
hormone transport GO:0009914 2 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.019
Human
heart development GO:0007507 313 0.019
regulation of sequestering of calcium ion GO:0051282 4 0.019
golgi vesicle transport GO:0048193 3 0.019
cognition GO:0050890 1 0.019
cellular component movement GO:0006928 335 0.019
regulation of cellular ketone metabolic process GO:0010565 7 0.019
modification dependent macromolecule catabolic process GO:0043632 3 0.019
Human
small molecule metabolic process GO:0044281 77 0.019
rna metabolic process GO:0016070 219 0.019
cellular component morphogenesis GO:0032989 336 0.019
regulation of signaling GO:0023051 235 0.019
response to stress GO:0006950 263 0.019
chordate embryonic development GO:0043009 271 0.019
biosynthetic process GO:0009058 294 0.019
organic substance biosynthetic process GO:1901576 289 0.019
regulation of protein catabolic process GO:0042176 1 0.019
rna biosynthetic process GO:0032774 181 0.019
organic acid metabolic process GO:0006082 31 0.019
mitochondrion organization GO:0007005 4 0.018
digestive system development GO:0055123 289 0.018
regulation of macromolecule metabolic process GO:0060255 317 0.018
cellular nitrogen compound biosynthetic process GO:0044271 218 0.018
regulation of blood pressure GO:0008217 1 0.018
sequestering of calcium ion GO:0051208 3 0.018
transport GO:0006810 220 0.018
single organism metabolic process GO:0044710 217 0.018
specification of symmetry GO:0009799 204 0.018
single organism transport GO:0044765 206 0.018
digestive tract morphogenesis GO:0048546 231 0.018
regulation of primary metabolic process GO:0080090 311 0.018
cellular response to nutrient levels GO:0031669 2 0.018
regulation of protein complex assembly GO:0043254 3 0.018
cellular protein catabolic process GO:0044257 4 0.018
Human
neurotransmitter transport GO:0006836 2 0.018
regulation of metal ion transport GO:0010959 4 0.018
nucleic acid metabolic process GO:0090304 244 0.018
establishment of localization GO:0051234 244 0.018
aromatic compound biosynthetic process GO:0019438 217 0.018
protein targeting to nucleus GO:0044744 3 0.018
sequestering of metal ion GO:0051238 3 0.018
regulation of synapse assembly GO:0051963 3 0.017
regulation of establishment of protein localization GO:0070201 4 0.017
response to glucose GO:0009749 3 0.017
nuclear import GO:0051170 3 0.017
homeostatic process GO:0042592 142 0.017
regulation of endocrine process GO:0044060 2 0.017
endocrine process GO:0050886 2 0.017
nuclear transport GO:0051169 4 0.017
peptide transport GO:0015833 1 0.017
regulation of cytoplasmic transport GO:1903649 4 0.017
regulation of purine nucleotide catabolic process GO:0033121 2 0.017
negative regulation of sequestering of calcium ion GO:0051283 4 0.017
modification dependent protein catabolic process GO:0019941 3 0.017
Human
heart looping GO:0001947 94 0.017
single organism localization GO:1902578 225 0.016
neuron neuron synaptic transmission GO:0007270 1 0.016
macromolecule biosynthetic process GO:0009059 227 0.016
determination of left right symmetry GO:0007368 179 0.016
organic cyclic compound biosynthetic process GO:1901362 223 0.016
regulation of tube size GO:0035150 2 0.016
response to organic substance GO:0010033 153 0.016
oxoacid metabolic process GO:0043436 31 0.016
regulation of nucleoside metabolic process GO:0009118 2 0.016
cellular component disassembly GO:0022411 1 0.016
cellular amino acid metabolic process GO:0006520 7 0.016
organonitrogen compound metabolic process GO:1901564 74 0.016
cellular response to starvation GO:0009267 1 0.016
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.016
regulation of dendrite development GO:0050773 3 0.016
negative regulation of cellular process GO:0048523 283 0.016
ion transmembrane transport GO:0034220 91 0.016
meiotic nuclear division GO:0007126 4 0.016
regulation of binding GO:0051098 3 0.016
neurotransmitter secretion GO:0007269 2 0.016
nucleobase containing compound biosynthetic process GO:0034654 205 0.016
female sex differentiation GO:0046660 4 0.016
regulation of cell activation GO:0050865 1 0.016
digestive tract development GO:0048565 265 0.016
rna localization GO:0006403 4 0.016
gastrulation GO:0007369 208 0.016
response to corticosteroid GO:0031960 1 0.016
regulation of synapse organization GO:0050807 3 0.016
ribonucleoside monophosphate catabolic process GO:0009158 4 0.016
epithelial tube morphogenesis GO:0060562 148 0.015
regulation of neural precursor cell proliferation GO:2000177 3 0.015
negative regulation of catabolic process GO:0009895 3 0.015
head development GO:0060322 303 0.015
locomotion GO:0040011 313 0.015
regulation of cellular biosynthetic process GO:0031326 245 0.015
nucleic acid templated transcription GO:0097659 181 0.015
smooth muscle contraction GO:0006939 2 0.015
regulation of cytokine production GO:0001817 3 0.015
organelle fusion GO:0048284 3 0.015
development of primary female sexual characteristics GO:0046545 4 0.015
central nervous system development GO:0007417 387 0.015
regulation of protein transport GO:0051223 3 0.015
negative regulation of protein kinase activity GO:0006469 4 0.015
response to external stimulus GO:0009605 264 0.015
synaptic vesicle localization GO:0097479 1 0.015
female gonad development GO:0008585 4 0.015
amino acid transport GO:0006865 2 0.015
regulation of developmental process GO:0050793 247 0.015
carbohydrate homeostasis GO:0033500 1 0.015
regulation of biosynthetic process GO:0009889 250 0.015
single organism nuclear import GO:1902593 3 0.015
cellular response to radiation GO:0071478 4 0.015
regulation of sodium ion transport GO:0002028 2 0.015
determination of bilateral symmetry GO:0009855 204 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.015
glucose homeostasis GO:0042593 1 0.015
regulation of multicellular organismal development GO:2000026 223 0.015
lipid catabolic process GO:0016042 4 0.015
cellular carbohydrate metabolic process GO:0044262 4 0.015
cellular response to molecule of bacterial origin GO:0071219 3 0.015
regulation of blood vessel size GO:0050880 2 0.015
brain development GO:0007420 293 0.015
positive regulation of secretion by cell GO:1903532 1 0.014
membrane fusion GO:0061025 2 0.014
regulation of hormone secretion GO:0046883 2 0.014
protein import into nucleus GO:0006606 3 0.014
cell part morphogenesis GO:0032990 246 0.014
positive regulation of nucleotide catabolic process GO:0030813 1 0.014
cell projection organization GO:0030030 284 0.014
regulation of macromolecule biosynthetic process GO:0010556 225 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.014
proteasomal protein catabolic process GO:0010498 2 0.014
regulation of nucleotide catabolic process GO:0030811 2 0.014
protein import GO:0017038 3 0.014
response to amino acid GO:0043200 2 0.014
neuroblast proliferation GO:0007405 2 0.014
regulation of circadian rhythm GO:0042752 4 0.014
calcium ion transport into cytosol GO:0060402 3 0.014
negative regulation of kinase activity GO:0033673 4 0.014
cellular response to light stimulus GO:0071482 4 0.014
embryonic heart tube development GO:0035050 133 0.014
transmembrane transport GO:0055085 120 0.014
cellular response to chemical stimulus GO:0070887 157 0.014
transcription from rna polymerase ii promoter GO:0006366 80 0.014
ion transport GO:0006811 114 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.014
endosomal transport GO:0016197 2 0.014
exocytosis GO:0006887 1 0.014
retina development in camera type eye GO:0060041 146 0.014
cell projection morphogenesis GO:0048858 244 0.014
regulation of gtp catabolic process GO:0033124 2 0.014
lipid homeostasis GO:0055088 3 0.014
phagocytosis engulfment GO:0006911 1 0.014
tissue remodeling GO:0048771 4 0.014
positive regulation of cellular component biogenesis GO:0044089 3 0.014
protein acetylation GO:0006473 2 0.014
atp catabolic process GO:0006200 4 0.013
regulation of inflammatory response GO:0050727 2 0.013
protein localization to plasma membrane GO:0072659 1 0.013
positive regulation of nucleoside metabolic process GO:0045979 1 0.013
regulation of signal transduction GO:0009966 225 0.013
extrinsic apoptotic signaling pathway GO:0097191 3 0.013
anterior posterior pattern specification GO:0009952 152 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
positive regulation of biological process GO:0048518 253 0.013
response to nutrient GO:0007584 3 0.013
response to vitamin GO:0033273 3 0.013
regulation of protein ubiquitination GO:0031396 3 0.013
positive regulation of gtpase activity GO:0043547 1 0.013
positive regulation of reproductive process GO:2000243 2 0.013
germ line stem cell maintenance GO:0030718 2 0.013
positive regulation of gtp catabolic process GO:0033126 1 0.013
actin polymerization or depolymerization GO:0008154 2 0.013
b cell activation GO:0042113 2 0.013
cellular response to lipopolysaccharide GO:0071222 3 0.013
cellular macromolecule biosynthetic process GO:0034645 224 0.013
cellular response to biotic stimulus GO:0071216 3 0.013
regulation of gtpase activity GO:0043087 2 0.013
positive regulation of cell division GO:0051781 2 0.013
purine nucleoside monophosphate catabolic process GO:0009128 4 0.013
transcription dna templated GO:0006351 181 0.013
cytosolic calcium ion transport GO:0060401 3 0.013
cellular response to organic substance GO:0071310 105 0.013
protein complex disassembly GO:0043241 1 0.013
cell morphogenesis GO:0000902 289 0.013
stem cell division GO:0017145 1 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.013
meiotic chromosome segregation GO:0045132 3 0.013
cell morphogenesis involved in differentiation GO:0000904 195 0.013
internal protein amino acid acetylation GO:0006475 2 0.012
establishment of synaptic vesicle localization GO:0097480 1 0.012
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.012
regulation of cellular protein catabolic process GO:1903362 1 0.012
epithelial cell differentiation GO:0030855 116 0.012
heart morphogenesis GO:0003007 156 0.012
membrane invagination GO:0010324 1 0.012
peptidyl lysine acetylation GO:0018394 2 0.012
protein polymerization GO:0051258 4 0.012
regulation of mrna processing GO:0050684 3 0.012
positive regulation of secretion GO:0051047 1 0.012
internal peptidyl lysine acetylation GO:0018393 2 0.012
maternal determination of anterior posterior axis embryo GO:0008358 4 0.012
regulation of nucleic acid templated transcription GO:1903506 213 0.012
macromolecular complex disassembly GO:0032984 1 0.012
cytoskeleton dependent cytokinesis GO:0061640 3 0.012
leukocyte mediated cytotoxicity GO:0001909 1 0.012
nucleoside monophosphate catabolic process GO:0009125 4 0.012
protein homooligomerization GO:0051260 3 0.012
small molecule catabolic process GO:0044282 3 0.012
regulation of intracellular protein transport GO:0033157 3 0.012
segmentation GO:0035282 97 0.012
alcohol biosynthetic process GO:0046165 2 0.012
somatic muscle development GO:0007525 4 0.012
carbohydrate biosynthetic process GO:0016051 1 0.012
regulation of cell communication GO:0010646 232 0.012
positive regulation of dna metabolic process GO:0051054 1 0.012
secondary metabolic process GO:0019748 3 0.012
macroautophagy GO:0016236 1 0.012
regulation of ion transmembrane transporter activity GO:0032412 2 0.012
positive regulation of cytoskeleton organization GO:0051495 3 0.012
water homeostasis GO:0030104 4 0.012
response to uv GO:0009411 3 0.012
regulation of transmembrane transporter activity GO:0022898 2 0.012
intracellular mrna localization GO:0008298 1 0.012
organelle organization GO:0006996 227 0.012
regulation of ph GO:0006885 3 0.012
cell motility GO:0048870 244 0.012
muscle structure development GO:0061061 196 0.012
somite development GO:0061053 96 0.012
cell migration GO:0016477 237 0.012
monovalent inorganic cation transport GO:0015672 42 0.012
regulation of meiotic cell cycle GO:0051445 1 0.012
negative regulation of chromosome organization GO:2001251 1 0.012
single organism membrane fusion GO:0044801 2 0.012
positive regulation of blood circulation GO:1903524 2 0.012
hemopoiesis GO:0030097 183 0.012
regulation of neuronal synaptic plasticity GO:0048168 1 0.012
regulation of systemic arterial blood pressure GO:0003073 1 0.012
embryonic heart tube morphogenesis GO:0003143 108 0.012
cellular aldehyde metabolic process GO:0006081 4 0.012
cellular lipid catabolic process GO:0044242 3 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.011
ubiquitin dependent protein catabolic process GO:0006511 3 0.011
Human
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.011
catechol containing compound metabolic process GO:0009712 2 0.011
eye morphogenesis GO:0048592 144 0.011
regulation of dendrite morphogenesis GO:0048814 3 0.011
endocrine hormone secretion GO:0060986 2 0.011
skeletal system development GO:0001501 181 0.011
regulation of transporter activity GO:0032409 2 0.011
mesenchyme development GO:0060485 127 0.011
response to alkaloid GO:0043279 2 0.011
spermatid development GO:0007286 2 0.011
regulation of autophagy GO:0010506 3 0.011
gland development GO:0048732 143 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
protein acylation GO:0043543 3 0.011
synaptic vesicle transport GO:0048489 1 0.011
response to glucocorticoid GO:0051384 1 0.011
positive regulation of protein complex assembly GO:0031334 2 0.011
developmental growth GO:0048589 166 0.011
phototransduction GO:0007602 2 0.011
regulation of neurotransmitter transport GO:0051588 1 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
regulation of wound healing GO:0061041 2 0.011
water transport GO:0006833 15 0.011
growth GO:0040007 174 0.011
regulation of multicellular organismal process GO:0051239 277 0.011
negative regulation of synapse assembly GO:0051964 2 0.011
negative regulation of secretion GO:0051048 2 0.011
actin filament polymerization GO:0030041 2 0.011
interspecies interaction between organisms GO:0044419 4 0.011
i kappab kinase nf kappab signaling GO:0007249 4 0.011
regulation of epithelial cell proliferation GO:0050678 3 0.011
sensory organ morphogenesis GO:0090596 200 0.011
glial cell migration GO:0008347 3 0.011
positive regulation of myeloid cell differentiation GO:0045639 2 0.011
immune system development GO:0002520 191 0.011
positive regulation of immune effector process GO:0002699 3 0.011
lateral inhibition GO:0046331 1 0.011
sensory perception of pain GO:0019233 1 0.011
cellular amide metabolic process GO:0043603 4 0.011
mechanosensory behavior GO:0007638 2 0.011
organism emergence from protective structure GO:0071684 4 0.011
ovulation cycle process GO:0022602 2 0.011
cortical cytoskeleton organization GO:0030865 1 0.011
regulation of cell differentiation GO:0045595 142 0.011
blood circulation GO:0008015 87 0.011
leukocyte proliferation GO:0070661 1 0.011
actin filament based movement GO:0030048 1 0.011
stem cell differentiation GO:0048863 117 0.011
protein stabilization GO:0050821 2 0.010
cell cycle g1 s phase transition GO:0044843 1 0.010
neuron development GO:0048666 262 0.010
circulatory system process GO:0003013 87 0.010
positive regulation of cell killing GO:0031343 2 0.010
negative regulation of defense response GO:0031348 2 0.010
regulation of anatomical structure morphogenesis GO:0022603 130 0.010
positive regulation of apoptotic signaling pathway GO:2001235 1 0.010
lens fiber cell morphogenesis GO:0070309 3 0.010
regulation of oocyte development GO:0060281 3 0.010
embryo development ending in birth or egg hatching GO:0009792 271 0.010
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.010
single fertilization GO:0007338 3 0.010
somitogenesis GO:0001756 87 0.010
establishment of protein localization to plasma membrane GO:0090002 1 0.010
response to endogenous stimulus GO:0009719 83 0.010
tube closure GO:0060606 1 0.010
cell killing GO:0001906 2 0.010
adherens junction organization GO:0034332 4 0.010
regulation of lipid transport GO:0032368 4 0.010
rna 3 end processing GO:0031123 2 0.010
fat soluble vitamin metabolic process GO:0006775 4 0.010
muscle cell differentiation GO:0042692 139 0.010
mononuclear cell proliferation GO:0032943 1 0.010
vacuolar transport GO:0007034 2 0.010
inositol lipid mediated signaling GO:0048017 2 0.010
negative regulation of secretion by cell GO:1903531 2 0.010
multicellular organismal response to stress GO:0033555 2 0.010
positive regulation of epithelial cell differentiation GO:0030858 2 0.010

klhl8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
nervous system disease DOID:863 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
cancer DOID:162 0 0.015
musculoskeletal system disease DOID:17 0 0.014
disease of metabolism DOID:0014667 0 0.014
organ system cancer DOID:0050686 0 0.014
eye disease DOID:5614 0 0.010
eye and adnexa disease DOID:1492 0 0.010
sensory system disease DOID:0050155 0 0.010