Danio rerio

0 known processes

plg

plasminogen

(Aliases: wu:fb70e09)

plg biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
blood coagulation GO:0007596 12 0.395
Human
cellular response to estrogen stimulus GO:0071391 24 0.387
blood coagulation fibrin clot formation GO:0072378 3 0.358
cell matrix adhesion GO:0007160 4 0.272
cellular macromolecule metabolic process GO:0044260 391 0.166
Rat
extrinsic apoptotic signaling pathway GO:0097191 3 0.155
response to hormone GO:0009725 48 0.149
hemostasis GO:0007599 13 0.137
Human
mycotoxin metabolic process GO:0043385 1 0.123
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.119
cell substrate adhesion GO:0031589 4 0.088
Human
regulation of response to stimulus GO:0048583 269 0.083
Human
response to estrogen GO:0043627 27 0.076
regulation of protein transport GO:0051223 3 0.076
protein activation cascade GO:0072376 6 0.072
nephron tubule morphogenesis GO:0072078 1 0.068
response to chemical GO:0042221 320 0.067
protein secretion GO:0009306 1 0.067
response to steroid hormone GO:0048545 35 0.067
cell motility GO:0048870 244 0.066
Zebrafish Mouse
response to organic substance GO:0010033 153 0.063
regulation of peptidase activity GO:0052547 23 0.062
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.060
wound healing GO:0042060 90 0.059
Human Mouse
aging GO:0007568 2 0.059
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.057
regulation of cytokine production GO:0001817 3 0.056
digestive system development GO:0055123 289 0.055
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.054
larval development GO:0002164 2 0.053
carboxylic acid metabolic process GO:0019752 22 0.051
protein metabolic process GO:0019538 183 0.050
Human Rat
response to lipid GO:0033993 60 0.048
negative regulation of protein processing GO:0010955 10 0.048
negative regulation of cellular process GO:0048523 283 0.047
Human
immune system process GO:0002376 241 0.045
Mouse
regulation of hemostasis GO:1900046 1 0.045
Human
cellular response to chemical stimulus GO:0070887 157 0.045
positive regulation of apoptotic signaling pathway GO:2001235 1 0.045
cellular amino acid metabolic process GO:0006520 7 0.042
cellular response to lipid GO:0071396 39 0.042
cellular component movement GO:0006928 335 0.042
Zebrafish Mouse
regulation of establishment of protein localization GO:0070201 4 0.041
small molecule metabolic process GO:0044281 77 0.041
blood circulation GO:0008015 87 0.041
regulation of inflammatory response GO:0050727 2 0.040
positive regulation of cellular amine metabolic process GO:0033240 0 0.040
signal transduction GO:0007165 455 0.040
cell surface receptor signaling pathway GO:0007166 325 0.039
regulation of blood vessel size GO:0050880 2 0.038
system process GO:0003008 185 0.037
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.037
positive regulation of transport GO:0051050 2 0.037
protein modification process GO:0036211 100 0.036
regulation of cellular metabolic process GO:0031323 320 0.036
cell adhesion GO:0007155 40 0.036
Human
female sex differentiation GO:0046660 4 0.036
positive regulation of secretion by cell GO:1903532 1 0.035
phosphorus metabolic process GO:0006793 109 0.034
cellular response to hormone stimulus GO:0032870 39 0.034
cellular amine metabolic process GO:0044106 2 0.034
regulation of cellular amino acid metabolic process GO:0006521 0 0.034
circulatory system process GO:0003013 87 0.033
regulation of signal transduction GO:0009966 225 0.033
regulation of cellular amine metabolic process GO:0033238 0 0.032
oxoacid metabolic process GO:0043436 31 0.032
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.032
regulation of defense response GO:0031347 14 0.031
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.031
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.031
peptidyl serine phosphorylation GO:0018105 1 0.031
regulation of cell substrate adhesion GO:0010810 1 0.030
Human
negative regulation of endopeptidase activity GO:0010951 10 0.030
regulation of protein metabolic process GO:0051246 56 0.030
programmed cell death GO:0012501 119 0.030
response to organic cyclic compound GO:0014070 51 0.030
regulation of cell adhesion GO:0030155 15 0.030
Human
protein polymerization GO:0051258 4 0.030
fertilization GO:0009566 3 0.030
development of primary female sexual characteristics GO:0046545 4 0.029
morphogenesis of an epithelium GO:0002009 333 0.029
regulation of multicellular organismal development GO:2000026 223 0.029
positive regulation of cell adhesion GO:0045785 1 0.029
response to wounding GO:0009611 116 0.029
Human Mouse
positive regulation of blood circulation GO:1903524 2 0.028
cellular response to endogenous stimulus GO:0071495 68 0.028
regulation of multicellular organismal process GO:0051239 277 0.028
Human
fatty acid biosynthetic process GO:0006633 4 0.028
digestive tract development GO:0048565 265 0.027
meiotic nuclear division GO:0007126 4 0.027
organic acid metabolic process GO:0006082 31 0.027
stem cell division GO:0017145 1 0.027
developmental growth GO:0048589 166 0.027
Mouse
positive regulation of exocytosis GO:0045921 1 0.027
tissue regeneration GO:0042246 74 0.027
Mouse
spermatid differentiation GO:0048515 2 0.027
apoptotic process involved in development GO:1902742 2 0.026
cellular component biogenesis GO:0044085 178 0.026
multi organism process GO:0051704 134 0.026
cellular response to external stimulus GO:0071496 2 0.026
single organism organelle organization GO:1902589 199 0.026
lipoprotein catabolic process GO:0042159 1 0.025
positive regulation of cytokine production GO:0001819 2 0.025
negative regulation of defense response GO:0031348 2 0.025
cellular response to organic cyclic compound GO:0071407 38 0.025
regulation of blood coagulation GO:0030193 1 0.025
Human
regulation of organ growth GO:0046620 3 0.025
regulation of protein processing GO:0070613 10 0.025
protein processing GO:0016485 12 0.024
cellular ketone metabolic process GO:0042180 11 0.024
response to biotic stimulus GO:0009607 97 0.024
amine metabolic process GO:0009308 2 0.024
monocarboxylic acid catabolic process GO:0072329 3 0.024
meiotic chromosome segregation GO:0045132 3 0.023
astrocyte differentiation GO:0048708 1 0.023
response to glucose GO:0009749 3 0.023
nuclear division GO:0000280 23 0.023
response to endogenous stimulus GO:0009719 83 0.023
positive regulation of secretion GO:0051047 1 0.023
response to external stimulus GO:0009605 264 0.023
Human
regulation of immune system process GO:0002682 34 0.023
regulation of multicellular organism growth GO:0040014 4 0.022
vasculature development GO:0001944 278 0.022
Mouse
epithelial tube morphogenesis GO:0060562 148 0.022
cellular component assembly GO:0022607 170 0.022
cellular response to organic substance GO:0071310 105 0.022
regulation of biological quality GO:0065008 263 0.022
Human Mouse
renal tubule morphogenesis GO:0061333 1 0.022
single organism localization GO:1902578 225 0.022
organic cyclic compound metabolic process GO:1901360 301 0.021
single organism metabolic process GO:0044710 217 0.021
regulation of cellular ketone metabolic process GO:0010565 7 0.021
phasic smooth muscle contraction GO:0014821 1 0.021
cellular response to nutrient levels GO:0031669 2 0.020
cellular protein metabolic process GO:0044267 129 0.020
Rat
death GO:0016265 121 0.020
regulation of wound healing GO:0061041 2 0.020
Human
regulation of endopeptidase activity GO:0052548 23 0.020
regulation of macromolecule metabolic process GO:0060255 317 0.020
heterocycle metabolic process GO:0046483 290 0.019
regulation of cell migration GO:0030334 40 0.019
central nervous system development GO:0007417 387 0.019
Zebrafish
nik nf kappab signaling GO:0038061 1 0.019
erk1 and erk2 cascade GO:0070371 4 0.019
response to stress GO:0006950 263 0.019
Human Mouse
lipid catabolic process GO:0016042 4 0.019
nephron epithelium morphogenesis GO:0072088 1 0.019
cellular response to extracellular stimulus GO:0031668 2 0.018
regulation of programmed cell death GO:0043067 101 0.018
negative regulation of protein maturation GO:1903318 10 0.018
blood vessel development GO:0001568 246 0.017
Mouse
regulation of tube size GO:0035150 2 0.017
heart morphogenesis GO:0003007 156 0.017
meiotic cell cycle process GO:1903046 3 0.017
female gonad development GO:0008585 4 0.017
rna metabolic process GO:0016070 219 0.017
cell morphogenesis GO:0000902 289 0.017
cellular lipid catabolic process GO:0044242 3 0.017
response to other organism GO:0051707 97 0.017
phagocytosis GO:0006909 3 0.016
response to cold GO:0009409 4 0.016
biological adhesion GO:0022610 40 0.016
Human
regulation of proteolysis GO:0030162 24 0.016
response to bacterium GO:0009617 58 0.016
regulation of hormone secretion GO:0046883 2 0.016
nephron morphogenesis GO:0072028 2 0.016
cellular macromolecular complex assembly GO:0034622 24 0.016
transport GO:0006810 220 0.016
positive regulation of response to stimulus GO:0048584 80 0.016
Human
regulation of fatty acid metabolic process GO:0019217 1 0.016
locomotion GO:0040011 313 0.015
Zebrafish Mouse
gland development GO:0048732 143 0.015
positive regulation of biological process GO:0048518 253 0.015
Human
lens fiber cell development GO:0070307 3 0.015
regulation of cell shape GO:0008360 1 0.015
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.015
b cell mediated immunity GO:0019724 3 0.015
regulation of metabolic process GO:0019222 359 0.015
muscle cell differentiation GO:0042692 139 0.015
Mouse
positive regulation of immune system process GO:0002684 17 0.015
inositol lipid mediated signaling GO:0048017 2 0.015
cell migration GO:0016477 237 0.015
Zebrafish Mouse
growth GO:0040007 174 0.015
Mouse
negative regulation of peptidase activity GO:0010466 10 0.014
positive regulation of striated muscle tissue development GO:0045844 1 0.014
intracellular signal transduction GO:0035556 85 0.014
response to nutrient GO:0007584 3 0.014
regulation of cell activation GO:0050865 1 0.014
regulation of protein maturation GO:1903317 10 0.014
multicellular organism growth GO:0035264 4 0.014
renal system development GO:0072001 94 0.014
epithelial cell differentiation GO:0030855 116 0.014
endothelial cell differentiation GO:0045446 20 0.014
immune effector process GO:0002252 23 0.014
phosphatidylinositol mediated signaling GO:0048015 2 0.014
response to external biotic stimulus GO:0043207 97 0.013
transcription dna templated GO:0006351 181 0.013
negative regulation of response to stimulus GO:0048585 104 0.013
Human
regulation of muscle hypertrophy GO:0014743 2 0.013
synaptic growth at neuromuscular junction GO:0051124 2 0.013
hormone secretion GO:0046879 2 0.013
digestive tract morphogenesis GO:0048546 231 0.013
localization of cell GO:0051674 244 0.013
Zebrafish Mouse
cell death GO:0008219 121 0.013
regulation of protein catabolic process GO:0042176 1 0.013
organic acid biosynthetic process GO:0016053 12 0.013
regulation of cell communication GO:0010646 232 0.013
maintenance of location GO:0051235 4 0.013
i kappab kinase nf kappab signaling GO:0007249 4 0.013
organonitrogen compound metabolic process GO:1901564 74 0.013
negative regulation of signal transduction GO:0009968 94 0.013
negative regulation of cell communication GO:0010648 96 0.013
peristalsis GO:0030432 1 0.013
cellular response to starvation GO:0009267 1 0.013
positive regulation of response to external stimulus GO:0032103 9 0.013
g protein coupled receptor signaling pathway GO:0007186 74 0.013
smooth muscle contraction GO:0006939 2 0.013
regulation of systemic arterial blood pressure GO:0003073 1 0.013
endothelium development GO:0003158 25 0.013
regulation of catalytic activity GO:0050790 55 0.012
peripheral nervous system development GO:0007422 55 0.012
macromolecule modification GO:0043412 111 0.012
muscle structure development GO:0061061 196 0.012
Mouse
sexual reproduction GO:0019953 36 0.012
regulation of body fluid levels GO:0050878 16 0.012
Human
response to carbohydrate GO:0009743 3 0.012
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.012
regulation of anatomical structure morphogenesis GO:0022603 130 0.012
autophagy GO:0006914 4 0.012
gastrulation GO:0007369 208 0.012
regulation of signaling GO:0023051 235 0.012
gamete generation GO:0007276 33 0.012
regulation of stem cell proliferation GO:0072091 2 0.012
organic cyclic compound biosynthetic process GO:1901362 223 0.012
regulation of biosynthetic process GO:0009889 250 0.012
cellular protein modification process GO:0006464 100 0.012
response to abiotic stimulus GO:0009628 122 0.012
apoptotic process GO:0006915 116 0.012
cellular nitrogen compound metabolic process GO:0034641 290 0.012
cerebellar granular layer morphogenesis GO:0021683 3 0.012
Zebrafish
regulation of response to stress GO:0080134 36 0.012
Human
cellular response to molecule of bacterial origin GO:0071219 3 0.012
antimicrobial humoral response GO:0019730 2 0.012
neuroblast proliferation GO:0007405 2 0.012
ovulation cycle process GO:0022602 2 0.011
embryonic heart tube morphogenesis GO:0003143 108 0.011
rhythmic process GO:0048511 21 0.011
negative regulation of hydrolase activity GO:0051346 10 0.011
g1 s transition of mitotic cell cycle GO:0000082 1 0.011
regulation of erk1 and erk2 cascade GO:0070372 4 0.011
lipid storage GO:0019915 1 0.011
generation of neurons GO:0048699 385 0.011
Zebrafish
humoral immune response mediated by circulating immunoglobulin GO:0002455 3 0.011
hepaticobiliary system development GO:0061008 98 0.011
negative regulation of proteolysis GO:0045861 10 0.011
tube morphogenesis GO:0035239 349 0.011
peptide transport GO:0015833 1 0.011
gene expression GO:0010467 252 0.011
glucocorticoid metabolic process GO:0008211 2 0.011
organic acid catabolic process GO:0016054 3 0.011
negative regulation of metabolic process GO:0009892 86 0.011
response to monosaccharide GO:0034284 3 0.011
positive regulation of cellular process GO:0048522 201 0.011
hematopoietic or lymphoid organ development GO:0048534 191 0.011
interspecies interaction between organisms GO:0044419 4 0.011
negative regulation of apoptotic process GO:0043066 55 0.010
cellular lipid metabolic process GO:0044255 36 0.010
phototransduction GO:0007602 2 0.010
extracellular structure organization GO:0043062 27 0.010
Human
muscle organ development GO:0007517 101 0.010
blood vessel morphogenesis GO:0048514 216 0.010
cell chemotaxis GO:0060326 17 0.010
regulation of translational initiation GO:0006446 1 0.010
defense response to fungus GO:0050832 2 0.010
peptidyl serine modification GO:0018209 2 0.010
cellular protein complex assembly GO:0043623 19 0.010
multicellular organismal reproductive process GO:0048609 35 0.010
negative regulation of gene expression GO:0010629 65 0.010
positive regulation of jak stat cascade GO:0046427 2 0.010
regulation of intracellular signal transduction GO:1902531 57 0.010
defense response GO:0006952 47 0.010
neural crest cell development GO:0014032 62 0.010
regulation of apoptotic process GO:0042981 98 0.010
rna biosynthetic process GO:0032774 181 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.010
Rat
response to ketone GO:1901654 1 0.010

plg disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.083
disease of metabolism DOID:0014667 0 0.076
amyloidosis DOID:9120 0 0.076
acquired metabolic disease DOID:0060158 0 0.076
immune system disease DOID:2914 0 0.055
hematopoietic system disease DOID:74 0 0.055
congenital hypoplastic anemia DOID:1342 0 0.021
aplastic anemia DOID:12449 0 0.021
bone marrow disease DOID:4961 0 0.021
anemia DOID:2355 0 0.021