Danio rerio

0 known processes

pik3r2

phosphoinositide-3-kinase, regulatory subunit, polypeptide 2

pik3r2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
lateral inhibition GO:0046331 1 0.090
central nervous system development GO:0007417 387 0.074
regulation of synapse organization GO:0050807 3 0.067
regulation of synapse assembly GO:0051963 3 0.064
negative regulation of synapse assembly GO:0051964 2 0.059
larval development GO:0002164 2 0.057
Worm
positive regulation of protein complex assembly GO:0031334 2 0.047
phagocytosis GO:0006909 3 0.046
regulation of protein transport GO:0051223 3 0.043
neuron differentiation GO:0030182 353 0.043
glial cell migration GO:0008347 3 0.042
axonal defasciculation GO:0007414 2 0.041
digestive system development GO:0055123 289 0.041
regulation of chromosome segregation GO:0051983 1 0.040
digestive tract mesoderm development GO:0007502 1 0.039
neuron projection development GO:0031175 180 0.039
multicellular organism growth GO:0035264 4 0.038
cell part morphogenesis GO:0032990 246 0.038
tube morphogenesis GO:0035239 349 0.038
cell projection organization GO:0030030 284 0.037
forebrain cell migration GO:0021885 1 0.036
outflow tract morphogenesis GO:0003151 1 0.035
positive regulation of transport GO:0051050 2 0.034
digestive tract development GO:0048565 265 0.034
single organism nuclear import GO:1902593 3 0.033
regulation of multicellular organism growth GO:0040014 4 0.032
neuron development GO:0048666 262 0.031
negative regulation of chemotaxis GO:0050922 4 0.031
organic acid metabolic process GO:0006082 31 0.030
regulation of cytokine production GO:0001817 3 0.030
digestive tract morphogenesis GO:0048546 231 0.030
protein acetylation GO:0006473 2 0.030
nuclear import GO:0051170 3 0.029
carboxylic acid metabolic process GO:0019752 22 0.029
cellular macromolecule metabolic process GO:0044260 391 0.028
negative regulation of biological process GO:0048519 304 0.027
peptidyl lysine acetylation GO:0018394 2 0.027
stem cell maintenance GO:0019827 4 0.027
chordate embryonic development GO:0043009 271 0.027
regulation of cellular amine metabolic process GO:0033238 0 0.025
regulation of establishment of protein localization GO:0070201 4 0.025
regulation of protein complex assembly GO:0043254 3 0.025
gastrulation GO:0007369 208 0.024
cellular component disassembly GO:0022411 1 0.024
modification dependent macromolecule catabolic process GO:0043632 3 0.024
protein acylation GO:0043543 3 0.024
meiotic nuclear division GO:0007126 4 0.024
establishment of protein localization to organelle GO:0072594 4 0.024
olfactory lobe development GO:0021988 4 0.024
cell morphogenesis involved in differentiation GO:0000904 195 0.023
determination of bilateral symmetry GO:0009855 204 0.023
olfactory bulb development GO:0021772 4 0.023
protein targeting to nucleus GO:0044744 3 0.023
ubiquitin dependent protein catabolic process GO:0006511 3 0.023
signal transduction GO:0007165 455 0.023
Worm
organonitrogen compound metabolic process GO:1901564 74 0.023
regulation of multicellular organismal development GO:2000026 223 0.023
female meiotic division GO:0007143 2 0.023
cellular component biogenesis GO:0044085 178 0.023
nucleocytoplasmic transport GO:0006913 4 0.023
regulation of anatomical structure morphogenesis GO:0022603 130 0.023
positive regulation of cellular component biogenesis GO:0044089 3 0.023
protein localization to nucleus GO:0034504 3 0.022
cell projection morphogenesis GO:0048858 244 0.022
regulation of cellular amino acid metabolic process GO:0006521 0 0.022
cellular aromatic compound metabolic process GO:0006725 295 0.022
regulation of cellular component organization GO:0051128 86 0.022
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.022
positive regulation of cell cycle GO:0045787 3 0.021
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.021
negative regulation of signaling GO:0023057 96 0.021
regulation of multicellular organismal process GO:0051239 277 0.021
endosomal transport GO:0016197 2 0.021
embryo development ending in birth or egg hatching GO:0009792 271 0.021
oxoacid metabolic process GO:0043436 31 0.021
amine metabolic process GO:0009308 2 0.021
cytokinesis GO:0000910 3 0.021
regulation of cytoplasmic transport GO:1903649 4 0.021
cell migration involved in gastrulation GO:0042074 79 0.020
protein import GO:0017038 3 0.020
protein import into nucleus GO:0006606 3 0.020
negative chemotaxis GO:0050919 1 0.020
axon development GO:0061564 166 0.020
positive regulation of dna metabolic process GO:0051054 1 0.020
proteasomal protein catabolic process GO:0010498 2 0.020
embryonic heart tube development GO:0035050 133 0.020
negative regulation of cellular process GO:0048523 283 0.020
embryonic organ development GO:0048568 381 0.020
internal protein amino acid acetylation GO:0006475 2 0.020
organelle localization GO:0051640 49 0.020
meiotic cell cycle process GO:1903046 3 0.020
axonogenesis GO:0007409 152 0.020
specification of symmetry GO:0009799 204 0.020
positive regulation of catabolic process GO:0009896 4 0.020
establishment of localization in cell GO:0051649 77 0.019
macromolecular complex disassembly GO:0032984 1 0.019
response to carbohydrate GO:0009743 3 0.019
negative regulation of protein phosphorylation GO:0001933 4 0.019
nitrogen compound metabolic process GO:0006807 319 0.019
actin polymerization or depolymerization GO:0008154 2 0.019
cellular nitrogen compound metabolic process GO:0034641 290 0.019
cell cycle arrest GO:0007050 1 0.019
cell morphogenesis GO:0000902 289 0.019
regulation of response to stimulus GO:0048583 269 0.018
gene expression GO:0010467 252 0.018
sensory organ development GO:0007423 393 0.018
lipid storage GO:0019915 1 0.018
regulation of nucleocytoplasmic transport GO:0046822 2 0.018
regionalization GO:0003002 274 0.018
macroautophagy GO:0016236 1 0.018
regulation of protein import into nucleus GO:0042306 2 0.018
response to hexose GO:0009746 3 0.018
nuclear transport GO:0051169 4 0.018
negative regulation of sequestering of calcium ion GO:0051283 4 0.018
regulation of cell development GO:0060284 100 0.018
cellular component movement GO:0006928 335 0.018
stem cell division GO:0017145 1 0.017
modification dependent protein catabolic process GO:0019941 3 0.017
response to glucocorticoid GO:0051384 1 0.017
cellular biosynthetic process GO:0044249 286 0.017
Mouse
regulation of dna replication GO:0006275 3 0.017
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.017
regulation of cell differentiation GO:0045595 142 0.017
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.017
axon midline choice point recognition GO:0016199 4 0.017
negative regulation of axon guidance GO:1902668 1 0.017
neuron projection guidance GO:0097485 86 0.017
internal peptidyl lysine acetylation GO:0018393 2 0.017
regulation of stem cell differentiation GO:2000736 4 0.017
positive regulation of blood circulation GO:1903524 2 0.017
regulation of cellular metabolic process GO:0031323 320 0.017
negative regulation of defense response GO:0031348 2 0.017
cellular amino acid metabolic process GO:0006520 7 0.017
protein complex disassembly GO:0043241 1 0.017
nucleobase containing compound metabolic process GO:0006139 274 0.016
protein homooligomerization GO:0051260 3 0.016
regulation of mrna processing GO:0050684 3 0.016
regulation of tube size GO:0035150 2 0.016
response to monosaccharide GO:0034284 3 0.016
aging GO:0007568 2 0.016
Worm
regulation of carbohydrate metabolic process GO:0006109 4 0.016
biosynthetic process GO:0009058 294 0.016
Mouse
cognition GO:0050890 1 0.016
regulation of cell activation GO:0050865 1 0.016
response to chemical GO:0042221 320 0.016
Worm
cellular localization GO:0051641 97 0.016
organelle organization GO:0006996 227 0.016
regulation of blood pressure GO:0008217 1 0.016
regulation of oocyte development GO:0060281 3 0.015
regulation of organelle assembly GO:1902115 4 0.015
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.015
heterocycle metabolic process GO:0046483 290 0.015
response to external stimulus GO:0009605 264 0.015
regulation of protein localization to nucleus GO:1900180 2 0.015
generation of neurons GO:0048699 385 0.015
brain development GO:0007420 293 0.015
regulation of developmental process GO:0050793 247 0.015
regulation of intracellular protein transport GO:0033157 3 0.015
convergent extension involved in gastrulation GO:0060027 71 0.015
blood vessel development GO:0001568 246 0.015
positive regulation of cellular catabolic process GO:0031331 3 0.015
positive regulation of secretion GO:0051047 1 0.015
cell cycle g1 s phase transition GO:0044843 1 0.015
regulation of sequestering of calcium ion GO:0051282 4 0.014
phosphatidylinositol mediated signaling GO:0048015 2 0.014
cellular component morphogenesis GO:0032989 336 0.014
oocyte maturation GO:0001556 4 0.014
central nervous system neuron differentiation GO:0021953 74 0.014
determination of left right symmetry GO:0007368 179 0.014
cellular carbohydrate metabolic process GO:0044262 4 0.014
cilium assembly GO:0042384 58 0.014
segment polarity determination GO:0007367 1 0.014
single organism localization GO:1902578 225 0.014
regulation of meiotic cell cycle GO:0051445 1 0.014
regulation of catenin import into nucleus GO:0035412 2 0.014
heart looping GO:0001947 94 0.014
cell migration GO:0016477 237 0.014
gtp catabolic process GO:0006184 2 0.014
positive regulation of cytoskeleton organization GO:0051495 3 0.014
sequestering of calcium ion GO:0051208 3 0.014
cellular ketone metabolic process GO:0042180 11 0.013
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.013
interspecies interaction between organisms GO:0044419 4 0.013
synaptic growth at neuromuscular junction GO:0051124 2 0.013
morphogenesis of an epithelium GO:0002009 333 0.013
neuroblast differentiation GO:0014016 1 0.013
single organism organelle organization GO:1902589 199 0.013
positive regulation of nucleoside metabolic process GO:0045979 1 0.013
regulation of cell communication GO:0010646 232 0.013
tube closure GO:0060606 1 0.013
regulation of protein targeting GO:1903533 2 0.013
negative regulation of cellular metabolic process GO:0031324 77 0.013
vasculature development GO:0001944 278 0.013
multicellular organismal signaling GO:0035637 22 0.013
mesoderm development GO:0007498 88 0.013
regulation of signaling GO:0023051 235 0.013
neuron neuron synaptic transmission GO:0007270 1 0.013
peptidyl threonine phosphorylation GO:0018107 1 0.013
axon guidance GO:0007411 86 0.013
taxis GO:0042330 109 0.013
positive regulation of cytokine production GO:0001819 2 0.013
macromolecule modification GO:0043412 111 0.013
positive regulation of stress activated mapk cascade GO:0032874 3 0.013
protein secretion GO:0009306 1 0.013
negative regulation of metabolic process GO:0009892 86 0.012
response to drug GO:0042493 3 0.012
regulation of rna metabolic process GO:0051252 224 0.012
single organism metabolic process GO:0044710 217 0.012
Mouse
cellular protein catabolic process GO:0044257 4 0.012
notch signaling pathway GO:0007219 35 0.012
keratinocyte differentiation GO:0030216 0 0.012
response to oxygen containing compound GO:1901700 55 0.012
Worm
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.012
regulation of protein polymerization GO:0032271 2 0.012
positive regulation of reproductive process GO:2000243 2 0.012
inositol lipid mediated signaling GO:0048017 2 0.012
segmentation GO:0035282 97 0.012
carbohydrate biosynthetic process GO:0016051 1 0.012
guanosine containing compound catabolic process GO:1901069 2 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
medulla oblongata development GO:0021550 4 0.012
cell recognition GO:0008037 19 0.012
cortical cytoskeleton organization GO:0030865 1 0.012
central nervous system neuron development GO:0021954 29 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.012
regulation of biosynthetic process GO:0009889 250 0.012
secondary metabolic process GO:0019748 3 0.012
neuron projection morphogenesis GO:0048812 161 0.012
response to glucose GO:0009749 3 0.012
single organism membrane fusion GO:0044801 2 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
activation of jun kinase activity GO:0007257 2 0.012
protein polymerization GO:0051258 4 0.012
growth GO:0040007 174 0.012
regulation of nucleoside metabolic process GO:0009118 2 0.012
ncrna catabolic process GO:0034661 1 0.012
response to corticosteroid GO:0031960 1 0.011
fatty acid biosynthetic process GO:0006633 4 0.011
regulation of metal ion transport GO:0010959 4 0.011
cytoskeleton organization GO:0007010 96 0.011
small molecule metabolic process GO:0044281 77 0.011
blood vessel morphogenesis GO:0048514 216 0.011
cellular response to nutrient levels GO:0031669 2 0.011
regulation of blood vessel size GO:0050880 2 0.011
meiotic chromosome segregation GO:0045132 3 0.011
mitotic cytokinesis GO:0000281 3 0.011
muscle structure development GO:0061061 196 0.011
regulation of binding GO:0051098 3 0.011
regulation of cellular ketone metabolic process GO:0010565 7 0.011
positive regulation of secretion by cell GO:1903532 1 0.011
sensory organ morphogenesis GO:0090596 200 0.011
regulation of cellular biosynthetic process GO:0031326 245 0.011
b cell activation GO:0042113 2 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.011
post golgi vesicle mediated transport GO:0006892 1 0.011
regulation of inflammatory response GO:0050727 2 0.011
regulation of response to oxidative stress GO:1902882 2 0.011
sulfur compound metabolic process GO:0006790 13 0.011
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
determination of heart left right asymmetry GO:0061371 117 0.011
endocardium morphogenesis GO:0003160 4 0.011
regulation of circadian rhythm GO:0042752 4 0.011
g1 s transition of mitotic cell cycle GO:0000082 1 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.011
somatic stem cell maintenance GO:0035019 1 0.011
guanosine containing compound metabolic process GO:1901068 4 0.011
regulation of cell shape GO:0008360 1 0.011
positive regulation of gtpase activity GO:0043547 1 0.011
regulation of cell migration involved in sprouting angiogenesis GO:0090049 3 0.011
maintenance of location GO:0051235 4 0.011
wnt signaling pathway GO:0016055 80 0.011
protein heterooligomerization GO:0051291 1 0.011
anterior posterior axon guidance GO:0033564 5 0.011
negative regulation of protein transport GO:0051224 3 0.011
regulation of reproductive process GO:2000241 4 0.011
central nervous system neuron axonogenesis GO:0021955 18 0.011
retina development in camera type eye GO:0060041 146 0.011
sequestering of metal ion GO:0051238 3 0.011
cellular response to oxygen levels GO:0071453 1 0.011
heterocycle biosynthetic process GO:0018130 215 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.011
peptidyl threonine modification GO:0018210 1 0.011
somitogenesis GO:0001756 87 0.011
sprouting angiogenesis GO:0002040 53 0.011
cellular protein metabolic process GO:0044267 129 0.011
autophagy GO:0006914 4 0.010
response to stress GO:0006950 263 0.010
adherens junction organization GO:0034332 4 0.010
cellular response to external stimulus GO:0071496 2 0.010
eye development GO:0001654 277 0.010
regulation of gene expression GO:0010468 265 0.010
regulation of metabolic process GO:0019222 359 0.010
response to biotic stimulus GO:0009607 97 0.010
dorsal ventral pattern formation GO:0009953 125 0.010
positive regulation of biological process GO:0048518 253 0.010
transcription from rna polymerase ii promoter GO:0006366 80 0.010
embryonic limb morphogenesis GO:0030326 2 0.010
negative regulation of translation GO:0017148 1 0.010
cytoskeleton dependent cytokinesis GO:0061640 3 0.010
spinal cord development GO:0021510 46 0.010
gliogenesis GO:0042063 45 0.010
forebrain regionalization GO:0021871 4 0.010
cellular amine metabolic process GO:0044106 2 0.010
regulation of protein catabolic process GO:0042176 1 0.010
microtubule organizing center organization GO:0031023 1 0.010
single organism cellular localization GO:1902580 46 0.010
proepicardium development GO:0003342 4 0.010
regulation of establishment of planar polarity GO:0090175 4 0.010
negative regulation of cytokine production GO:0001818 1 0.010
mesodermal cell migration GO:0008078 12 0.010
negative regulation of cellular catabolic process GO:0031330 3 0.010
regulation of canonical wnt signaling pathway GO:0060828 34 0.010
cellular nitrogen compound biosynthetic process GO:0044271 218 0.010

pik3r2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.029
disease of cellular proliferation DOID:14566 0 0.014
cancer DOID:162 0 0.014
organ system cancer DOID:0050686 0 0.014
immune system disease DOID:2914 0 0.014
nervous system disease DOID:863 0 0.014
muscular disease DOID:0080000 0 0.013
myopathy DOID:423 0 0.013
musculoskeletal system disease DOID:17 0 0.013
muscle tissue disease DOID:66 0 0.013
cardiovascular system disease DOID:1287 0 0.011
sensory system disease DOID:0050155 0 0.010