Danio rerio

20 known processes

c9

complement component 9

(Aliases: wu:fd50e04,wu:fb60b05,zgc:112272)

c9 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
blood coagulation fibrin clot formation GO:0072378 3 0.445
cell matrix adhesion GO:0007160 4 0.231
cell substrate adhesion GO:0031589 4 0.228
blood coagulation GO:0007596 12 0.192
regulation of cell substrate adhesion GO:0010810 1 0.176
protein polymerization GO:0051258 4 0.175
cellular macromolecule metabolic process GO:0044260 391 0.173
regulation of wound healing GO:0061041 2 0.173
positive regulation of cell adhesion GO:0045785 1 0.168
hemostasis GO:0007599 13 0.136
cellular protein catabolic process GO:0044257 4 0.133
cerebellar granular layer development GO:0021681 3 0.119
cerebellar granular layer formation GO:0021684 3 0.106
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.096
regulation of cellular metabolic process GO:0031323 320 0.093
peptide transport GO:0015833 1 0.091
regulation of cell adhesion GO:0030155 15 0.090
protein metabolic process GO:0019538 183 0.087
cellular response to estrogen stimulus GO:0071391 24 0.082
regulation of metabolic process GO:0019222 359 0.082
cell adhesion GO:0007155 40 0.081
erk1 and erk2 cascade GO:0070371 4 0.080
cell motility GO:0048870 244 0.079
cell surface receptor signaling pathway GO:0007166 325 0.079
cellular response to external stimulus GO:0071496 2 0.078
response to external stimulus GO:0009605 264 0.075
response to organic substance GO:0010033 153 0.072
positive regulation of cell substrate adhesion GO:0010811 1 0.071
positive regulation of exocytosis GO:0045921 1 0.070
negative regulation of cellular process GO:0048523 283 0.069
response to biotic stimulus GO:0009607 97 0.068
wound healing GO:0042060 90 0.067
regulation of hemostasis GO:1900046 1 0.066
regulation of protein transport GO:0051223 3 0.066
response to chemical GO:0042221 320 0.063
biological adhesion GO:0022610 40 0.062
regulation of biological quality GO:0065008 263 0.060
extrinsic apoptotic signaling pathway GO:0097191 3 0.059
positive regulation of secretion GO:0051047 1 0.057
regulation of response to stimulus GO:0048583 269 0.056
cellular component disassembly GO:0022411 1 0.055
regulation of response to external stimulus GO:0032101 31 0.055
lipoprotein catabolic process GO:0042159 1 0.053
protein secretion GO:0009306 1 0.053
positive regulation of secretion by cell GO:1903532 1 0.053
coagulation GO:0050817 13 0.052
negative regulation of response to stimulus GO:0048585 104 0.052
central nervous system development GO:0007417 387 0.052
regulation of establishment of protein localization GO:0070201 4 0.050
regulation of blood vessel size GO:0050880 2 0.049
response to stress GO:0006950 263 0.048
meiotic cell cycle process GO:1903046 3 0.045
positive regulation of wound healing GO:0090303 1 0.044
astrocyte differentiation GO:0048708 1 0.044
cellular response to organic cyclic compound GO:0071407 38 0.043
defense response to fungus GO:0050832 2 0.042
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.042
regulation of exocytosis GO:0017157 1 0.042
response to wounding GO:0009611 116 0.041
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.041
extracellular structure organization GO:0043062 27 0.041
nephron tubule morphogenesis GO:0072078 1 0.040
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.039
regulation of body fluid levels GO:0050878 16 0.039
circulatory system process GO:0003013 87 0.038
regulation of blood coagulation GO:0030193 1 0.037
signal transduction GO:0007165 455 0.037
negative regulation of protein processing GO:0010955 10 0.036
positive regulation of blood circulation GO:1903524 2 0.036
regulation of cell shape GO:0008360 1 0.036
negative regulation of signaling GO:0023057 96 0.036
meiotic nuclear division GO:0007126 4 0.036
regulation of primary metabolic process GO:0080090 311 0.035
cellular component movement GO:0006928 335 0.035
female sex differentiation GO:0046660 4 0.035
regulation of macromolecule metabolic process GO:0060255 317 0.035
exocytosis GO:0006887 1 0.035
cellular amine metabolic process GO:0044106 2 0.035
larval development GO:0002164 2 0.034
regulation of erk1 and erk2 cascade GO:0070372 4 0.034
regulation of signal transduction GO:0009966 225 0.034
response to other organism GO:0051707 97 0.034
positive regulation of transport GO:0051050 2 0.033
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.033
regulation of biosynthetic process GO:0009889 250 0.032
peptidyl serine phosphorylation GO:0018105 1 0.032
regulation of inflammatory response GO:0050727 2 0.031
amine metabolic process GO:0009308 2 0.031
negative regulation of biological process GO:0048519 304 0.031
growth GO:0040007 174 0.031
regulation of protein processing GO:0070613 10 0.031
multicellular organism growth GO:0035264 4 0.031
regulation of systemic arterial blood pressure GO:0003073 1 0.031
positive regulation of cellular process GO:0048522 201 0.030
extracellular matrix organization GO:0030198 27 0.030
cerebellar granular layer morphogenesis GO:0021683 3 0.030
gene expression GO:0010467 252 0.030
positive regulation of response to stimulus GO:0048584 80 0.030
smooth muscle contraction GO:0006939 2 0.029
spermatid differentiation GO:0048515 2 0.029
cell migration GO:0016477 237 0.029
blood vessel development GO:0001568 246 0.028
developmental growth GO:0048589 166 0.028
programmed cell death GO:0012501 119 0.028
regeneration GO:0031099 91 0.028
g protein coupled receptor signaling pathway GO:0007186 74 0.028
cellular protein metabolic process GO:0044267 129 0.027
transcription dna templated GO:0006351 181 0.027
positive regulation of biological process GO:0048518 253 0.027
ovulation cycle process GO:0022602 2 0.026
regulation of cellular ketone metabolic process GO:0010565 7 0.026
regulation of gene expression GO:0010468 265 0.026
cellular response to nutrient levels GO:0031669 2 0.026
intracellular signal transduction GO:0035556 85 0.025
regulation of multicellular organism growth GO:0040014 4 0.025
vasculature development GO:0001944 278 0.025
regulation of dna replication GO:0006275 3 0.025
negative regulation of wound healing GO:0061045 1 0.025
positive regulation of cellular amine metabolic process GO:0033240 0 0.025
system process GO:0003008 185 0.024
localization of cell GO:0051674 244 0.024
regulation of cytokine production GO:0001817 3 0.024
response to inorganic substance GO:0010035 38 0.024
homeostatic process GO:0042592 142 0.024
regulation of response to stress GO:0080134 36 0.024
organic substance biosynthetic process GO:1901576 289 0.023
epiboly GO:0090504 41 0.023
blood vessel morphogenesis GO:0048514 216 0.023
apoptotic process GO:0006915 116 0.023
generation of neurons GO:0048699 385 0.023
proteolysis GO:0006508 38 0.023
multi organism process GO:0051704 134 0.023
defense response to other organism GO:0098542 33 0.023
phosphatidylinositol mediated signaling GO:0048015 2 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.022
positive regulation of signal transduction GO:0009967 56 0.022
response to hormone GO:0009725 48 0.022
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.022
regulation of cell communication GO:0010646 232 0.022
morphogenesis of an epithelium GO:0002009 333 0.022
female gonad development GO:0008585 4 0.022
synaptic growth at neuromuscular junction GO:0051124 2 0.022
blood circulation GO:0008015 87 0.022
negative regulation of defense response GO:0031348 2 0.022
phosphorus metabolic process GO:0006793 109 0.021
negative regulation of signal transduction GO:0009968 94 0.021
response to external biotic stimulus GO:0043207 97 0.021
cellular component assembly GO:0022607 170 0.021
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.021
positive regulation of cytokine production GO:0001819 2 0.021
cerebellum development GO:0021549 17 0.021
skeletal system development GO:0001501 181 0.021
protein activation cascade GO:0072376 6 0.020
negative regulation of protein maturation GO:1903318 10 0.020
hormone secretion GO:0046879 2 0.020
central nervous system neuron differentiation GO:0021953 74 0.020
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.019
inositol lipid mediated signaling GO:0048017 2 0.019
maintenance of location GO:0051235 4 0.019
immune system process GO:0002376 241 0.018
regulation of organ growth GO:0046620 3 0.018
regulation of phosphorus metabolic process GO:0051174 43 0.018
cerebellar cortex development GO:0021695 5 0.018
regulation of proteolysis GO:0030162 24 0.018
negative regulation of cell communication GO:0010648 96 0.018
cellular response to unfolded protein GO:0034620 2 0.018
peptidyl serine modification GO:0018209 2 0.018
response to bacterium GO:0009617 58 0.018
positive regulation of muscle organ development GO:0048636 1 0.018
regulation of cell death GO:0010941 103 0.018
regulation of cellular amine metabolic process GO:0033238 0 0.018
i kappab kinase nf kappab signaling GO:0007249 4 0.018
death GO:0016265 121 0.018
negative regulation of protein complex assembly GO:0031333 1 0.018
neuron differentiation GO:0030182 353 0.018
regulation of intracellular signal transduction GO:1902531 57 0.018
nuclear migration GO:0007097 3 0.018
sequestering of calcium ion GO:0051208 3 0.017
cellular amino acid metabolic process GO:0006520 7 0.017
regulation of hormone secretion GO:0046883 2 0.017
regulation of anatomical structure morphogenesis GO:0022603 130 0.017
nucleocytoplasmic transport GO:0006913 4 0.017
regulation of protein metabolic process GO:0051246 56 0.017
rna metabolic process GO:0016070 219 0.017
phosphate containing compound metabolic process GO:0006796 108 0.017
positive regulation of cellular metabolic process GO:0031325 94 0.016
cellular response to starvation GO:0009267 1 0.016
regulation of response to wounding GO:1903034 11 0.016
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.016
cellular nitrogen compound metabolic process GO:0034641 290 0.016
tissue remodeling GO:0048771 4 0.016
negative regulation of apoptotic process GO:0043066 55 0.016
cellular response to extracellular stimulus GO:0031668 2 0.016
regulation of signaling GO:0023051 235 0.016
regulation of apoptotic process GO:0042981 98 0.016
negative regulation of cell adhesion GO:0007162 6 0.016
brain development GO:0007420 293 0.016
macromolecule biosynthetic process GO:0009059 227 0.016
cell proliferation GO:0008283 80 0.015
single organism metabolic process GO:0044710 217 0.015
fatty acid biosynthetic process GO:0006633 4 0.015
fertilization GO:0009566 3 0.015
nuclear import GO:0051170 3 0.015
hindbrain development GO:0030902 91 0.015
peripheral nervous system development GO:0007422 55 0.015
negative regulation of programmed cell death GO:0043069 58 0.015
gastrulation GO:0007369 208 0.015
regulation of coagulation GO:0050818 2 0.015
development of primary female sexual characteristics GO:0046545 4 0.014
response to glucose GO:0009749 3 0.014
response to hexose GO:0009746 3 0.014
hatching gland development GO:0048785 3 0.014
cellular component biogenesis GO:0044085 178 0.014
phagocytosis GO:0006909 3 0.014
gastrulation with mouth forming second GO:0001702 44 0.014
negative regulation of metabolic process GO:0009892 86 0.014
regulation of synapse organization GO:0050807 3 0.014
cerebellar cortex morphogenesis GO:0021696 5 0.014
regulation of cellular protein metabolic process GO:0032268 52 0.014
regulation of peptidase activity GO:0052547 23 0.014
epidermal cell fate specification GO:0009957 4 0.014
organic cyclic compound biosynthetic process GO:1901362 223 0.014
cellular response to organic substance GO:0071310 105 0.014
epithelial tube morphogenesis GO:0060562 148 0.014
modification dependent macromolecule catabolic process GO:0043632 3 0.014
pyruvate metabolic process GO:0006090 1 0.013
muscle structure development GO:0061061 196 0.013
collagen metabolic process GO:0032963 2 0.013
aging GO:0007568 2 0.013
positive regulation of jnk cascade GO:0046330 3 0.013
positive regulation of cellular catabolic process GO:0031331 3 0.013
digestive system development GO:0055123 289 0.013
carbohydrate biosynthetic process GO:0016051 1 0.013
endothelial cell development GO:0001885 12 0.013
positive regulation of apoptotic signaling pathway GO:2001235 1 0.013
negative regulation of endopeptidase activity GO:0010951 10 0.013
heart morphogenesis GO:0003007 156 0.013
protein import into nucleus GO:0006606 3 0.013
response to nutrient GO:0007584 3 0.013
negative regulation of proteolysis GO:0045861 10 0.013
enzyme linked receptor protein signaling pathway GO:0007167 106 0.013
positive regulation of multicellular organismal process GO:0051240 52 0.013
establishment of localization GO:0051234 244 0.013
response to monosaccharide GO:0034284 3 0.013
s adenosylmethionine metabolic process GO:0046500 1 0.012
cytoskeleton organization GO:0007010 96 0.012
phasic smooth muscle contraction GO:0014821 1 0.012
epithelial cell differentiation GO:0030855 116 0.012
regulation of transcription from rna polymerase iii promoter GO:0006359 1 0.012
ventricular cardiac muscle tissue development GO:0003229 3 0.012
neuron migration GO:0001764 22 0.012
regulation of macromolecule biosynthetic process GO:0010556 225 0.012
meiotic chromosome segregation GO:0045132 3 0.012
intestinal cholesterol absorption GO:0030299 2 0.012
cellular protein modification process GO:0006464 100 0.012
inner ear development GO:0048839 126 0.012
regulation of programmed cell death GO:0043067 101 0.012
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.012
regulation of meiotic cell cycle GO:0051445 1 0.012
response to steroid hormone GO:0048545 35 0.012
regulation of localization GO:0032879 104 0.012
antimicrobial humoral response GO:0019730 2 0.012
stem cell division GO:0017145 1 0.012
nucleic acid templated transcription GO:0097659 181 0.012
heart development GO:0007507 313 0.012
muscle cell differentiation GO:0042692 139 0.012
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.012
macromolecule modification GO:0043412 111 0.012
establishment of protein localization to organelle GO:0072594 4 0.012
positive regulation of map kinase activity GO:0043406 3 0.012
rna biosynthetic process GO:0032774 181 0.012
apoptotic process involved in development GO:1902742 2 0.011
activation of mapk activity GO:0000187 3 0.011
regulation of cell projection assembly GO:0060491 4 0.011
peristalsis GO:0030432 1 0.011
digestive tract development GO:0048565 265 0.011
regulation of endopeptidase activity GO:0052548 23 0.011
regulation of phosphate metabolic process GO:0019220 43 0.011
negative regulation of response to external stimulus GO:0032102 9 0.011
nitrogen compound metabolic process GO:0006807 319 0.011
oxoacid metabolic process GO:0043436 31 0.011
regulation of cell activation GO:0050865 1 0.011
ribosome assembly GO:0042255 1 0.011
negative regulation of cellular metabolic process GO:0031324 77 0.011
activation of jun kinase activity GO:0007257 2 0.011
regulation of tissue remodeling GO:0034103 2 0.011
glucocorticoid metabolic process GO:0008211 2 0.011
tube morphogenesis GO:0035239 349 0.011
head development GO:0060322 303 0.011
regulation of stem cell differentiation GO:2000736 4 0.011
single organismal cell cell adhesion GO:0016337 29 0.011
cellular macromolecule biosynthetic process GO:0034645 224 0.011
heterocycle metabolic process GO:0046483 290 0.011
regulation of dendrite development GO:0050773 3 0.011
regulation of developmental process GO:0050793 247 0.011
multicellular organismal reproductive process GO:0048609 35 0.011
regulation of cellular component movement GO:0051270 55 0.011
angiogenesis GO:0001525 158 0.011
nucleic acid metabolic process GO:0090304 244 0.011
regulation of protein complex assembly GO:0043254 3 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.010
heterocycle biosynthetic process GO:0018130 215 0.010
leukocyte proliferation GO:0070661 1 0.010
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.010
nik nf kappab signaling GO:0038061 1 0.010
regulation of blood pressure GO:0008217 1 0.010
hormone transport GO:0009914 2 0.010
regulation of multicellular organismal development GO:2000026 223 0.010
renal system development GO:0072001 94 0.010
negative regulation of kinase activity GO:0033673 4 0.010
g1 s transition of mitotic cell cycle GO:0000082 1 0.010
positive regulation of jun kinase activity GO:0043507 2 0.010
cellular localization GO:0051641 97 0.010
regulation of neuronal synaptic plasticity GO:0048168 1 0.010
regulation of response to biotic stimulus GO:0002831 2 0.010
regulation of cell cell adhesion GO:0022407 13 0.010
regulation of cellular biosynthetic process GO:0031326 245 0.010
interspecies interaction between organisms GO:0044419 4 0.010
hard palate development GO:0060022 4 0.010
gtp catabolic process GO:0006184 2 0.010
aromatic compound biosynthetic process GO:0019438 217 0.010
cell morphogenesis GO:0000902 289 0.010
negative regulation of catabolic process GO:0009895 3 0.010
ovulation cycle GO:0042698 2 0.010
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.010
regulation of nitrogen compound metabolic process GO:0051171 251 0.010
developmental programmed cell death GO:0010623 4 0.010

c9 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.058
immune system disease DOID:2914 0 0.054
hematopoietic system disease DOID:74 0 0.054
disease of metabolism DOID:0014667 0 0.049
cardiovascular system disease DOID:1287 0 0.013
inherited metabolic disorder DOID:655 0 0.012