Danio rerio

17 known processes

egf

epidermal growth factor

egf biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to external stimulus GO:0009605 264 0.115
signal transduction GO:0007165 455 0.093
Mouse Rat
ion transmembrane transport GO:0034220 91 0.091
anion transmembrane transport GO:0098656 12 0.089
response to mechanical stimulus GO:0009612 24 0.077
chloride transmembrane transport GO:1902476 4 0.076
regulation of biological quality GO:0065008 263 0.073
regulation of multicellular organism growth GO:0040014 4 0.068
multicellular organism growth GO:0035264 4 0.061
cell surface receptor signaling pathway GO:0007166 325 0.057
Mouse Rat
larval development GO:0002164 2 0.055
inorganic anion transmembrane transport GO:0098661 10 0.055
central nervous system development GO:0007417 387 0.054
Mouse
nucleocytoplasmic transport GO:0006913 4 0.047
Mouse
regionalization GO:0003002 274 0.045
monovalent inorganic cation transport GO:0015672 42 0.043
cellular macromolecule metabolic process GO:0044260 391 0.042
Mouse
glial cell migration GO:0008347 3 0.042
cognition GO:0050890 1 0.041
morphogenesis of an epithelium GO:0002009 333 0.040
Mouse
maintenance of location GO:0051235 4 0.040
cellular response to external stimulus GO:0071496 2 0.039
hemopoiesis GO:0030097 183 0.038
embryonic organ development GO:0048568 381 0.038
gtp metabolic process GO:0046039 4 0.037
rna biosynthetic process GO:0032774 181 0.037
regulation of nucleoside metabolic process GO:0009118 2 0.036
lipid storage GO:0019915 1 0.036
positive regulation of catabolic process GO:0009896 4 0.036
Mouse
nuclear import GO:0051170 3 0.035
Mouse
regulation of cellular amine metabolic process GO:0033238 0 0.035
aging GO:0007568 2 0.034
heterocycle biosynthetic process GO:0018130 215 0.034
positive regulation of map kinase activity GO:0043406 3 0.033
Mouse
guanosine containing compound catabolic process GO:1901069 2 0.033
regulation of cellular metabolic process GO:0031323 320 0.033
Mouse
regulation of protein transport GO:0051223 3 0.033
Rat
organic cyclic compound biosynthetic process GO:1901362 223 0.032
enzyme linked receptor protein signaling pathway GO:0007167 106 0.032
Mouse Rat
cellular amine metabolic process GO:0044106 2 0.032
gtp catabolic process GO:0006184 2 0.031
cellular response to extracellular stimulus GO:0031668 2 0.031
regulation of tube size GO:0035150 2 0.031
regulation of purine nucleotide catabolic process GO:0033121 2 0.031
guanosine containing compound metabolic process GO:1901068 4 0.031
amine metabolic process GO:0009308 2 0.031
single organism metabolic process GO:0044710 217 0.030
Mouse
positive regulation of transport GO:0051050 2 0.030
nitrogen compound metabolic process GO:0006807 319 0.030
determination of bilateral symmetry GO:0009855 204 0.030
positive regulation of cellular catabolic process GO:0031331 3 0.029
Mouse
regulation of signal transduction GO:0009966 225 0.029
Mouse
chemosensory behavior GO:0007635 1 0.029
somatic muscle development GO:0007525 4 0.029
stem cell maintenance GO:0019827 4 0.029
stem cell proliferation GO:0072089 4 0.029
specification of symmetry GO:0009799 204 0.029
sodium ion transport GO:0006814 24 0.029
regulation of nitrogen compound metabolic process GO:0051171 251 0.028
protein import GO:0017038 3 0.028
Mouse
regulation of cellular amino acid metabolic process GO:0006521 0 0.028
regulation of rna metabolic process GO:0051252 224 0.028
cellular amino acid metabolic process GO:0006520 7 0.028
single organism localization GO:1902578 225 0.028
Mouse Rat
cation transmembrane transport GO:0098655 65 0.027
biosynthetic process GO:0009058 294 0.027
protein targeting to nucleus GO:0044744 3 0.027
Mouse
regulation of protein complex assembly GO:0043254 3 0.027
regulation of cellular ketone metabolic process GO:0010565 7 0.026
reactive oxygen species biosynthetic process GO:1903409 1 0.026
regulation of signaling GO:0023051 235 0.026
Mouse
homeostatic process GO:0042592 142 0.026
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.026
fatty acid transport GO:0015908 1 0.026
cellular response to starvation GO:0009267 1 0.026
neuron development GO:0048666 262 0.026
neuron neuron synaptic transmission GO:0007270 1 0.025
monovalent inorganic anion homeostasis GO:0055083 6 0.025
sensory organ development GO:0007423 393 0.025
regulation of inflammatory response GO:0050727 2 0.025
regulation of reactive oxygen species metabolic process GO:2000377 2 0.025
nitric oxide biosynthetic process GO:0006809 2 0.025
regulation of macromolecule biosynthetic process GO:0010556 225 0.025
cellular component biogenesis GO:0044085 178 0.024
regulation of metabolic process GO:0019222 359 0.024
Mouse
dorsal ventral pattern formation GO:0009953 125 0.024
positive regulation of cellular component biogenesis GO:0044089 3 0.024
regulation of nucleotide catabolic process GO:0030811 2 0.024
germ line stem cell maintenance GO:0030718 2 0.024
regulation of macromolecule metabolic process GO:0060255 317 0.023
Mouse
positive regulation of immune effector process GO:0002699 3 0.023
cellular biosynthetic process GO:0044249 286 0.023
inner ear development GO:0048839 126 0.023
regulation of protein import into nucleus GO:0042306 2 0.023
immune system development GO:0002520 191 0.023
brain development GO:0007420 293 0.023
Mouse
response to glucocorticoid GO:0051384 1 0.022
tube morphogenesis GO:0035239 349 0.022
Mouse
cellular ketone metabolic process GO:0042180 11 0.022
aromatic compound biosynthetic process GO:0019438 217 0.022
positive regulation of gtp catabolic process GO:0033126 1 0.022
chloride transport GO:0006821 8 0.022
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.022
response to chemical GO:0042221 320 0.021
nucleobase containing compound metabolic process GO:0006139 274 0.021
regulation of wound healing GO:0061041 2 0.021
regulation of response to nutrient levels GO:0032107 1 0.021
small molecule metabolic process GO:0044281 77 0.021
positive regulation of cell cycle GO:0045787 3 0.021
regulation of metal ion transport GO:0010959 4 0.021
positive regulation of nucleotide catabolic process GO:0030813 1 0.021
transmembrane transport GO:0055085 120 0.021
single organism nuclear import GO:1902593 3 0.021
Mouse
angiogenesis GO:0001525 158 0.021
regulation of gtp catabolic process GO:0033124 2 0.021
transcription dna templated GO:0006351 181 0.021
regulation of gtpase activity GO:0043087 2 0.021
cellular response to nutrient levels GO:0031669 2 0.021
cell migration GO:0016477 237 0.021
regulation of nucleic acid templated transcription GO:1903506 213 0.021
inorganic anion transport GO:0015698 25 0.021
multi organism process GO:0051704 134 0.021
stem cell division GO:0017145 1 0.021
b cell activation GO:0042113 2 0.021
cellular component morphogenesis GO:0032989 336 0.021
negative regulation of protein phosphorylation GO:0001933 4 0.021
head development GO:0060322 303 0.021
Mouse
transport GO:0006810 220 0.020
Mouse Rat
organic substance biosynthetic process GO:1901576 289 0.020
response to amino acid GO:0043200 2 0.020
digestive system development GO:0055123 289 0.020
cell motility GO:0048870 244 0.020
regulation of blood vessel size GO:0050880 2 0.020
regulation of autophagy GO:0010506 3 0.020
epithelial cell differentiation GO:0030855 116 0.020
embryonic organ morphogenesis GO:0048562 274 0.020
establishment of protein localization to organelle GO:0072594 4 0.020
Mouse
long chain fatty acid metabolic process GO:0001676 1 0.020
response to uv GO:0009411 3 0.020
cellular response to molecule of bacterial origin GO:0071219 3 0.020
chloride ion homeostasis GO:0055064 1 0.019
generation of neurons GO:0048699 385 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
regulation of blood pressure GO:0008217 1 0.019
digestive tract morphogenesis GO:0048546 231 0.019
regulation of gene expression GO:0010468 265 0.019
regulation of protein targeting GO:1903533 2 0.019
regulation of intracellular protein transport GO:0033157 3 0.019
positive regulation of gtpase activity GO:0043547 1 0.019
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.019
Mouse
spermatid development GO:0007286 2 0.019
regulation of response to extracellular stimulus GO:0032104 1 0.019
anion homeostasis GO:0055081 9 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
development of primary female sexual characteristics GO:0046545 4 0.018
rna metabolic process GO:0016070 219 0.018
regulation of transporter activity GO:0032409 2 0.018
reactive nitrogen species metabolic process GO:2001057 0 0.018
gene expression GO:0010467 252 0.018
positive regulation of nucleoside metabolic process GO:0045979 1 0.018
regulation of rna biosynthetic process GO:2001141 213 0.018
cell morphogenesis GO:0000902 289 0.018
cellular response to lipopolysaccharide GO:0071222 3 0.018
regulation of developmental process GO:0050793 247 0.018
Mouse
neuron differentiation GO:0030182 353 0.018
determination of heart left right asymmetry GO:0061371 117 0.018
inorganic ion transmembrane transport GO:0098660 57 0.017
cytokinesis GO:0000910 3 0.017
localization of cell GO:0051674 244 0.017
compound eye development GO:0048749 2 0.017
regulation of cytokine production GO:0001817 3 0.017
cell projection organization GO:0030030 284 0.017
response to hexose GO:0009746 3 0.017
heterocycle metabolic process GO:0046483 290 0.017
response to corticosteroid GO:0031960 1 0.017
cellular response to organic substance GO:0071310 105 0.017
protein localization to plasma membrane GO:0072659 1 0.017
spermatid differentiation GO:0048515 2 0.017
carboxylic acid metabolic process GO:0019752 22 0.017
regulation of sodium ion transport GO:0002028 2 0.017
regulation of epithelial cell proliferation GO:0050678 3 0.017
nucleic acid templated transcription GO:0097659 181 0.017
oxoacid metabolic process GO:0043436 31 0.016
regulation of cell activation GO:0050865 1 0.016
regulation of protein localization to nucleus GO:1900180 2 0.016
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.016
cellular nitrogen compound metabolic process GO:0034641 290 0.016
stem cell fate commitment GO:0048865 1 0.016
lipid homeostasis GO:0055088 3 0.016
ras protein signal transduction GO:0007265 7 0.016
regulation of ion transmembrane transporter activity GO:0032412 2 0.016
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.016
macromolecule biosynthetic process GO:0009059 227 0.016
response to external biotic stimulus GO:0043207 97 0.016
regulation of cell differentiation GO:0045595 142 0.016
regulation of transcription dna templated GO:0006355 213 0.016
response to monosaccharide GO:0034284 3 0.016
posterior lateral line development GO:0048916 38 0.016
hematopoietic or lymphoid organ development GO:0048534 191 0.016
rho protein signal transduction GO:0007266 5 0.016
nuclear transport GO:0051169 4 0.016
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.016
determination of left right symmetry GO:0007368 179 0.016
regulation of binding GO:0051098 3 0.016
Mouse
smooth muscle contraction GO:0006939 2 0.015
phagocytosis engulfment GO:0006911 1 0.015
regulation of synaptic plasticity GO:0048167 1 0.015
regulation of cellular biosynthetic process GO:0031326 245 0.015
nitric oxide metabolic process GO:0046209 2 0.015
response to glucose GO:0009749 3 0.015
cellular macromolecule biosynthetic process GO:0034645 224 0.015
negative regulation of macromolecule metabolic process GO:0010605 76 0.015
female gonad development GO:0008585 4 0.015
epithelial tube morphogenesis GO:0060562 148 0.015
Mouse
embryonic heart tube morphogenesis GO:0003143 108 0.015
transcription from rna polymerase ii promoter GO:0006366 80 0.015
regulation of growth rate GO:0040009 1 0.015
establishment of protein localization to plasma membrane GO:0090002 1 0.015
g protein coupled receptor signaling pathway GO:0007186 74 0.015
meiotic nuclear division GO:0007126 4 0.015
positive regulation of multicellular organismal process GO:0051240 52 0.015
Mouse
nucleobase containing compound biosynthetic process GO:0034654 205 0.015
chemical homeostasis GO:0048878 49 0.015
negative regulation of catabolic process GO:0009895 3 0.015
response to nutrient GO:0007584 3 0.015
response to stress GO:0006950 263 0.014
regulation of transmembrane transporter activity GO:0022898 2 0.014
phagocytosis GO:0006909 3 0.014
chordate embryonic development GO:0043009 271 0.014
lateral line system development GO:0048925 76 0.014
regulation of multicellular organismal process GO:0051239 277 0.014
Mouse
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.014
negative regulation of defense response GO:0031348 2 0.014
single organism transport GO:0044765 206 0.014
Mouse Rat
positive regulation of cytokine production GO:0001819 2 0.014
hatching GO:0035188 4 0.014
positive regulation of inflammatory response GO:0050729 1 0.014
establishment of localization GO:0051234 244 0.014
Mouse Rat
protein secretion GO:0009306 1 0.014
Rat
positive regulation of blood circulation GO:1903524 2 0.014
small molecule catabolic process GO:0044282 3 0.014
cell projection morphogenesis GO:0048858 244 0.014
positive regulation of cell activation GO:0050867 1 0.014
kidney development GO:0001822 92 0.014
regulation of nucleocytoplasmic transport GO:0046822 2 0.014
response to ketone GO:1901654 1 0.014
organism emergence from protective structure GO:0071684 4 0.014
embryonic heart tube development GO:0035050 133 0.014
regulation of rho protein signal transduction GO:0035023 2 0.014
tissue remodeling GO:0048771 4 0.014
gastrulation GO:0007369 208 0.014
negative regulation of cellular catabolic process GO:0031330 3 0.014
negative regulation of autophagy GO:0010507 1 0.014
periodic partitioning GO:0007365 1 0.014
long chain fatty acid transport GO:0015909 1 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.014
macroautophagy GO:0016236 1 0.014
peptide transport GO:0015833 1 0.014
cation transport GO:0006812 81 0.014
response to carbohydrate GO:0009743 3 0.013
cell part morphogenesis GO:0032990 246 0.013
immune system process GO:0002376 241 0.013
regulation of ph GO:0006885 3 0.013
calcium ion import GO:0070509 4 0.013
protein import into nucleus GO:0006606 3 0.013
Mouse
cellular response to endogenous stimulus GO:0071495 68 0.013
mononuclear cell proliferation GO:0032943 1 0.013
positive regulation of wound healing GO:0090303 1 0.013
cellular carbohydrate metabolic process GO:0044262 4 0.013
intracellular signal transduction GO:0035556 85 0.013
Mouse
alcohol biosynthetic process GO:0046165 2 0.013
response to abiotic stimulus GO:0009628 122 0.013
heart looping GO:0001947 94 0.013
multicellular organismal macromolecule metabolic process GO:0044259 2 0.013
rna localization GO:0006403 4 0.013
nucleic acid metabolic process GO:0090304 244 0.013
regulation of establishment of protein localization GO:0070201 4 0.013
Rat
metal ion transport GO:0030001 58 0.013
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.013
regulation of erk1 and erk2 cascade GO:0070372 4 0.013
organic cyclic compound metabolic process GO:1901360 301 0.013
regulation of ras gtpase activity GO:0032318 2 0.013
synaptic growth at neuromuscular junction GO:0051124 2 0.013
energy reserve metabolic process GO:0006112 2 0.013
female sex differentiation GO:0046660 4 0.013
digestive tract development GO:0048565 265 0.013
segmentation GO:0035282 97 0.013
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.013
regulation of carbohydrate metabolic process GO:0006109 4 0.013
superoxide metabolic process GO:0006801 2 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.013
Mouse
regulation of protein catabolic process GO:0042176 1 0.013
Mouse
inorganic cation transmembrane transport GO:0098662 50 0.012
negative regulation of dna metabolic process GO:0051053 4 0.012
regulation of reproductive process GO:2000241 4 0.012
collagen metabolic process GO:0032963 2 0.012
b cell mediated immunity GO:0019724 3 0.012
regulation of dna replication GO:0006275 3 0.012
positive regulation of leukocyte mediated immunity GO:0002705 1 0.012
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
Mouse
ammonium transmembrane transport GO:0072488 2 0.012
g1 s transition of mitotic cell cycle GO:0000082 1 0.012
erk1 and erk2 cascade GO:0070371 4 0.012
regulation of biosynthetic process GO:0009889 250 0.012
cellular component movement GO:0006928 335 0.012
heart morphogenesis GO:0003007 156 0.012
organonitrogen compound metabolic process GO:1901564 74 0.012
regulation of photoreceptor cell differentiation GO:0046532 2 0.012
sodium ion transmembrane transport GO:0035725 21 0.012
i kappab kinase nf kappab signaling GO:0007249 4 0.012
regulation of response to stimulus GO:0048583 269 0.012
Mouse
phosphatidylinositol mediated signaling GO:0048015 2 0.012
bicarbonate transport GO:0015701 4 0.012
immunoglobulin mediated immune response GO:0016064 3 0.012
anion transport GO:0006820 38 0.012
urogenital system development GO:0001655 97 0.012
ion transport GO:0006811 114 0.012
cellular aromatic compound metabolic process GO:0006725 295 0.012
locomotion GO:0040011 313 0.012
adult behavior GO:0030534 2 0.012
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.012
protein localization to nucleus GO:0034504 3 0.012
Mouse
positive regulation of response to stimulus GO:0048584 80 0.012
Mouse
cellular component assembly GO:0022607 170 0.012
sex determination GO:0007530 1 0.012
antimicrobial humoral response GO:0019730 2 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.012
negative regulation of protein complex assembly GO:0031333 1 0.012
stem cell differentiation GO:0048863 117 0.012
positive regulation of dna metabolic process GO:0051054 1 0.012
autophagy GO:0006914 4 0.012
peptidyl lysine acetylation GO:0018394 2 0.012
regulation of dna recombination GO:0000018 2 0.011
modification dependent protein catabolic process GO:0019941 3 0.011
Mouse
inositol lipid mediated signaling GO:0048017 2 0.011
cellular component disassembly GO:0022411 1 0.011
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.011
response to alkaloid GO:0043279 2 0.011
somite development GO:0061053 96 0.011
multicellular organismal metabolic process GO:0044236 2 0.011
meiotic cell cycle process GO:1903046 3 0.011
response to biotic stimulus GO:0009607 97 0.011
regulation of cell development GO:0060284 100 0.011
carbohydrate biosynthetic process GO:0016051 1 0.011
cell killing GO:0001906 2 0.011
positive regulation of epithelial cell proliferation GO:0050679 1 0.011
response to bacterium GO:0009617 58 0.011
negative regulation of protein transport GO:0051224 3 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
small gtpase mediated signal transduction GO:0007264 8 0.011
production of molecular mediator of immune response GO:0002440 2 0.011
protein metabolic process GO:0019538 183 0.011
Mouse
negative regulation of metabolic process GO:0009892 86 0.011
regulation of muscle contraction GO:0006937 3 0.011
lymphocyte proliferation GO:0046651 1 0.011
cranial nerve development GO:0021545 42 0.011
synaptic transmission cholinergic GO:0007271 4 0.011
cell substrate junction assembly GO:0007044 2 0.011
axon development GO:0061564 166 0.011
lateral line development GO:0048882 66 0.011
positive regulation of leukocyte mediated cytotoxicity GO:0001912 1 0.011
positive regulation of secretion GO:0051047 1 0.011
negative regulation of cysteine type endopeptidase activity GO:2000117 8 0.011
organic acid metabolic process GO:0006082 31 0.011
response to vitamin GO:0033273 3 0.011
modulation by virus of host morphology or physiology GO:0019048 1 0.011
internal peptidyl lysine acetylation GO:0018393 2 0.011
regulation of lipase activity GO:0060191 2 0.011
forebrain cell migration GO:0021885 1 0.011
cellular response to biotic stimulus GO:0071216 3 0.011
embryo development ending in birth or egg hatching GO:0009792 271 0.011
fat soluble vitamin metabolic process GO:0006775 4 0.010
cellular nitrogen compound biosynthetic process GO:0044271 218 0.010
glucose homeostasis GO:0042593 1 0.010
adherens junction organization GO:0034332 4 0.010
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.010
peptide metabolic process GO:0006518 1 0.010
ion homeostasis GO:0050801 41 0.010
membrane repolarization GO:0086009 2 0.010
cell fate commitment GO:0045165 99 0.010
protein complex disassembly GO:0043241 1 0.010
ossification GO:0001503 23 0.010
regulation of cell death GO:0010941 103 0.010
protein polymerization GO:0051258 4 0.010
mitochondrion organization GO:0007005 4 0.010
complement activation GO:0006956 3 0.010
negative regulation of protein kinase activity GO:0006469 4 0.010
positive regulation of gliogenesis GO:0014015 2 0.010
internal protein amino acid acetylation GO:0006475 2 0.010
homeostasis of number of cells GO:0048872 62 0.010
protein acetylation GO:0006473 2 0.010
eye development GO:0001654 277 0.010
modification dependent macromolecule catabolic process GO:0043632 3 0.010
Mouse
sensory perception of chemical stimulus GO:0007606 3 0.010

egf disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.044
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
disease of metabolism DOID:0014667 0 0.013
musculoskeletal system disease DOID:17 0 0.013
inherited metabolic disorder DOID:655 0 0.012
bone disease DOID:0080001 0 0.011
connective tissue disease DOID:65 0 0.011