Danio rerio

0 known processes

pikfyve

phosphoinositide kinase, FYVE finger containing

(Aliases: pip5k3,wu:fo93c03)

pikfyve biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sensory organ development GO:0007423 393 0.620
cellular component biogenesis GO:0044085 178 0.492
regulation of fatty acid metabolic process GO:0019217 1 0.366
establishment of localization GO:0051234 244 0.274
Fly
neuron neuron synaptic transmission GO:0007270 1 0.213
cellular component assembly GO:0022607 170 0.197
regulation of membrane potential GO:0042391 23 0.192
system process GO:0003008 185 0.178
actin cytoskeleton organization GO:0030036 63 0.163
central nervous system development GO:0007417 387 0.160
head development GO:0060322 303 0.154
response to vitamin b3 GO:0033552 2 0.151
regulation of sarcomere organization GO:0060297 2 0.140
macromolecular complex subunit organization GO:0043933 74 0.131
single organism metabolic process GO:0044710 217 0.129
Yeast Mouse Fly
actin filament based process GO:0030029 64 0.113
homeostatic process GO:0042592 142 0.098
multicellular organismal signaling GO:0035637 22 0.097
protein complex assembly GO:0006461 30 0.095
lipid storage GO:0019915 1 0.092
regulation of cellular response to oxidative stress GO:1900407 2 0.088
neurological system process GO:0050877 62 0.087
maintenance of location GO:0051235 4 0.085
protein metabolic process GO:0019538 183 0.078
regulation of synapse organization GO:0050807 3 0.077
cell matrix adhesion GO:0007160 4 0.075
brain development GO:0007420 293 0.075
regionalization GO:0003002 274 0.075
epithelial cell differentiation GO:0030855 116 0.070
transport GO:0006810 220 0.069
Fly
phagocytosis GO:0006909 3 0.069
positive regulation of transport GO:0051050 2 0.068
organonitrogen compound metabolic process GO:1901564 74 0.068
negative regulation of cellular metabolic process GO:0031324 77 0.065
response to oxygen containing compound GO:1901700 55 0.062
aging GO:0007568 2 0.061
hydrogen peroxide metabolic process GO:0042743 2 0.059
cellular macromolecule metabolic process GO:0044260 391 0.059
regulation of biological quality GO:0065008 263 0.058
single organism transport GO:0044765 206 0.057
Fly
response to hormone GO:0009725 48 0.056
regulation of actin cytoskeleton organization GO:0032956 8 0.055
striated muscle cell development GO:0055002 108 0.054
urogenital system development GO:0001655 97 0.054
acylglycerol homeostasis GO:0055090 2 0.054
macromolecule modification GO:0043412 111 0.052
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.052
adult behavior GO:0030534 2 0.051
cation transmembrane transport GO:0098655 65 0.051
actin filament organization GO:0007015 15 0.049
regulation of inflammatory response GO:0050727 2 0.048
negative regulation of protein kinase activity GO:0006469 4 0.047
organelle organization GO:0006996 227 0.047
Fly
cellular macromolecular complex assembly GO:0034622 24 0.046
cellular response to chemical stimulus GO:0070887 157 0.044
response to oxidative stress GO:0006979 11 0.044
response to organic substance GO:0010033 153 0.043
positive regulation of lipid metabolic process GO:0045834 1 0.043
regulation of synapse assembly GO:0051963 3 0.043
regulation of cellular ketone metabolic process GO:0010565 7 0.042
negative regulation of protein phosphorylation GO:0001933 4 0.042
histone h3 k4 methylation GO:0051568 2 0.042
cellular carbohydrate metabolic process GO:0044262 4 0.041
cell substrate adhesion GO:0031589 4 0.040
cellular component assembly involved in morphogenesis GO:0010927 107 0.040
Mouse
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.040
transmission of nerve impulse GO:0019226 19 0.040
cytoskeleton organization GO:0007010 96 0.040
cellular response to endogenous stimulus GO:0071495 68 0.039
neuronal action potential GO:0019228 18 0.039
glial cell proliferation GO:0014009 4 0.039
sarcomere organization GO:0045214 26 0.038
actomyosin structure organization GO:0031032 53 0.037
cellular component morphogenesis GO:0032989 336 0.037
Mouse
protein complex subunit organization GO:0071822 46 0.036
single organism localization GO:1902578 225 0.036
Fly
protein modification process GO:0036211 100 0.035
regulation of cell communication GO:0010646 232 0.035
regulation of oxidative stress induced cell death GO:1903201 2 0.034
skeletal muscle organ development GO:0060538 78 0.034
response to oxygen levels GO:0070482 25 0.034
cell substrate adherens junction assembly GO:0007045 1 0.034
regulation of carbohydrate metabolic process GO:0006109 4 0.034
regulation of organelle assembly GO:1902115 4 0.033
regulation of rna biosynthetic process GO:2001141 213 0.033
macromolecular complex assembly GO:0065003 35 0.032
response to nutrient GO:0007584 3 0.031
cellular ketone metabolic process GO:0042180 11 0.031
cellular aromatic compound metabolic process GO:0006725 295 0.031
regulation of dendrite development GO:0050773 3 0.030
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.029
regulation of epithelial cell proliferation GO:0050678 3 0.029
lipid metabolic process GO:0006629 52 0.029
Yeast Mouse Fly
regulation of heart growth GO:0060420 2 0.029
peptide metabolic process GO:0006518 1 0.029
protein homooligomerization GO:0051260 3 0.029
regulation of synaptic plasticity GO:0048167 1 0.028
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.028
regulation of signaling GO:0023051 235 0.028
cell death in response to oxidative stress GO:0036473 2 0.028
organic substance biosynthetic process GO:1901576 289 0.028
response to biotic stimulus GO:0009607 97 0.028
growth GO:0040007 174 0.027
cellular response to oxygen containing compound GO:1901701 20 0.027
neuromuscular synaptic transmission GO:0007274 2 0.026
eye development GO:0001654 277 0.026
cellular lipid metabolic process GO:0044255 36 0.025
Yeast Mouse Fly
cartilage morphogenesis GO:0060536 13 0.025
digestive system process GO:0022600 9 0.025
negative regulation of defense response GO:0031348 2 0.025
response to stress GO:0006950 263 0.024
Fly
protein secretion GO:0009306 1 0.024
i kappab kinase nf kappab signaling GO:0007249 4 0.024
brain morphogenesis GO:0048854 18 0.024
regulation of cellular component organization GO:0051128 86 0.024
positive regulation of glucose transport GO:0010828 1 0.024
calcium ion transport into cytosol GO:0060402 3 0.023
negative regulation of cellular process GO:0048523 283 0.023
cellular amine metabolic process GO:0044106 2 0.023
cellular response to molecule of bacterial origin GO:0071219 3 0.022
negative regulation of kinase activity GO:0033673 4 0.022
neurotransmitter secretion GO:0007269 2 0.022
carbohydrate homeostasis GO:0033500 1 0.021
regulation of lipase activity GO:0060191 2 0.021
rna metabolic process GO:0016070 219 0.021
regulation of postsynaptic membrane potential GO:0060078 1 0.021
lipid oxidation GO:0034440 1 0.020
cardiac muscle cell development GO:0055013 20 0.020
chordate embryonic development GO:0043009 271 0.020
cell proliferation GO:0008283 80 0.020
multicellular organism growth GO:0035264 4 0.020
negative regulation of response to stimulus GO:0048585 104 0.020
carboxylic acid metabolic process GO:0019752 22 0.020
cellular protein modification process GO:0006464 100 0.020
antimicrobial humoral response GO:0019730 2 0.019
protein complex biogenesis GO:0070271 30 0.019
neurotransmitter transport GO:0006836 2 0.019
cellular biogenic amine metabolic process GO:0006576 2 0.019
regulation of cell matrix adhesion GO:0001952 1 0.019
glucose homeostasis GO:0042593 1 0.019
organelle fusion GO:0048284 3 0.019
Fly
small molecule metabolic process GO:0044281 77 0.019
muscle organ development GO:0007517 101 0.019
biosynthetic process GO:0009058 294 0.018
cell migration GO:0016477 237 0.018
response to amino acid GO:0043200 2 0.018
regulation of neurotransmitter transport GO:0051588 1 0.018
regulation of ph GO:0006885 3 0.018
regulation of metabolic process GO:0019222 359 0.018
regulation of transcription dna templated GO:0006355 213 0.018
oxoacid metabolic process GO:0043436 31 0.018
response to ketone GO:1901654 1 0.018
response to chemical GO:0042221 320 0.018
single organism organelle organization GO:1902589 199 0.018
Fly
adherens junction organization GO:0034332 4 0.018
regulation of receptor activity GO:0010469 2 0.017
myelination GO:0042552 18 0.017
Mouse
regulation of multicellular organismal process GO:0051239 277 0.017
negative regulation of secretion by cell GO:1903531 2 0.017
adherens junction assembly GO:0034333 1 0.017
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.017
regulation of cellular biosynthetic process GO:0031326 245 0.017
regulation of developmental process GO:0050793 247 0.017
locomotory behavior GO:0007626 34 0.017
regulation of cell death GO:0010941 103 0.017
guanosine containing compound metabolic process GO:1901068 4 0.017
synapsis GO:0007129 1 0.017
regulation of protein complex assembly GO:0043254 3 0.017
cellular response to biotic stimulus GO:0071216 3 0.017
chemical homeostasis GO:0048878 49 0.017
cell substrate junction assembly GO:0007044 2 0.016
ion transmembrane transport GO:0034220 91 0.016
cellular nitrogen compound metabolic process GO:0034641 290 0.016
small molecule catabolic process GO:0044282 3 0.016
regulation of cellular component biogenesis GO:0044087 12 0.016
neuron development GO:0048666 262 0.016
regulation of rac protein signal transduction GO:0035020 1 0.016
cellular nitrogen compound biosynthetic process GO:0044271 218 0.016
nucleobase containing compound metabolic process GO:0006139 274 0.016
regulation of filopodium assembly GO:0051489 2 0.016
negative regulation of reproductive process GO:2000242 3 0.016
dna biosynthetic process GO:0071897 3 0.016
protein dephosphorylation GO:0006470 3 0.016
regulation of cell shape GO:0008360 1 0.016
skeletal muscle thin filament assembly GO:0030240 4 0.015
centrosome localization GO:0051642 1 0.015
negative regulation of epithelial cell proliferation GO:0050680 1 0.015
pigmentation GO:0043473 85 0.015
membrane fusion GO:0061025 2 0.015
Fly
cell projection organization GO:0030030 284 0.015
protein localization to plasma membrane GO:0072659 1 0.015
regulation of reproductive process GO:2000241 4 0.015
cellular response to decreased oxygen levels GO:0036294 1 0.015
positive regulation of muscle cell differentiation GO:0051149 1 0.015
striated muscle tissue development GO:0014706 110 0.015
chromosome organization GO:0051276 31 0.015
apical junction assembly GO:0043297 1 0.015
regulation of establishment of protein localization GO:0070201 4 0.015
negative regulation of biological process GO:0048519 304 0.015
regulation of transmembrane transporter activity GO:0022898 2 0.015
organic acid metabolic process GO:0006082 31 0.015
muscle tissue development GO:0060537 110 0.015
positive regulation of striated muscle cell differentiation GO:0051155 1 0.015
response to nitrogen compound GO:1901698 19 0.015
heterocycle metabolic process GO:0046483 290 0.015
amine metabolic process GO:0009308 2 0.014
multi organism process GO:0051704 134 0.014
negative regulation of mapk cascade GO:0043409 4 0.014
organism emergence from protective structure GO:0071684 4 0.014
peptidyl serine phosphorylation GO:0018105 1 0.014
intracellular signal transduction GO:0035556 85 0.014
Mouse
regulation of signal transduction GO:0009966 225 0.014
cellular protein metabolic process GO:0044267 129 0.014
regulation of protein transport GO:0051223 3 0.014
glycerolipid biosynthetic process GO:0045017 1 0.014
fertilization GO:0009566 3 0.014
cellular response to hypoxia GO:0071456 1 0.014
water homeostasis GO:0030104 4 0.013
rna localization GO:0006403 4 0.013
inflammatory response GO:0006954 8 0.013
regulation of cell activation GO:0050865 1 0.013
negative regulation of macromolecule metabolic process GO:0010605 76 0.013
response to bacterium GO:0009617 58 0.013
cellular response to oxygen levels GO:0071453 1 0.013
schwann cell development GO:0014044 9 0.013
nitrogen compound metabolic process GO:0006807 319 0.013
regulation of phosphate metabolic process GO:0019220 43 0.013
peptidyl lysine methylation GO:0018022 3 0.013
osteoclast differentiation GO:0030316 1 0.013
synaptic vesicle transport GO:0048489 1 0.013
stem cell division GO:0017145 1 0.013
inorganic cation transmembrane transport GO:0098662 50 0.013
gtp catabolic process GO:0006184 2 0.012
regulation of stem cell proliferation GO:0072091 2 0.012
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 2 0.012
response to radiation GO:0009314 51 0.012
cell junction organization GO:0034330 11 0.012
cellular response to organic substance GO:0071310 105 0.012
phagocytosis engulfment GO:0006911 1 0.012
programmed cell death GO:0012501 119 0.012
skeletal myofibril assembly GO:0014866 7 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.012
fatty acid oxidation GO:0019395 1 0.012
exocytosis GO:0006887 1 0.012
kidney development GO:0001822 92 0.012
positive regulation of cell communication GO:0010647 56 0.012
cellular component disassembly GO:0022411 1 0.012
membrane invagination GO:0010324 1 0.011
phosphate containing compound metabolic process GO:0006796 108 0.011
Yeast Mouse Fly
response to hypoxia GO:0001666 25 0.011
regulation of rho protein signal transduction GO:0035023 2 0.011
cellular protein complex assembly GO:0043623 19 0.011
regulation of multicellular organism growth GO:0040014 4 0.011
inorganic ion transmembrane transport GO:0098660 57 0.011
regulation of mitochondrion organization GO:0010821 1 0.011
regulation of response to oxidative stress GO:1902882 2 0.011
determination of left right symmetry GO:0007368 179 0.011
regulation of circadian rhythm GO:0042752 4 0.011
centrosome organization GO:0051297 1 0.011
cell death GO:0008219 121 0.011
protein polyubiquitination GO:0000209 4 0.011
protein localization to cell surface GO:0034394 3 0.011
organic substance transport GO:0071702 58 0.011
death GO:0016265 121 0.011
response to endogenous stimulus GO:0009719 83 0.011
muscle system process GO:0003012 20 0.011
hormone secretion GO:0046879 2 0.011
meiotic cell cycle process GO:1903046 3 0.011
muscle structure development GO:0061061 196 0.011
renal system development GO:0072001 94 0.011
regulation of skeletal muscle fiber development GO:0048742 2 0.011
nucleic acid metabolic process GO:0090304 244 0.011
regulation of apoptotic process GO:0042981 98 0.011
pigment granule organization GO:0048753 4 0.011
cell motility GO:0048870 244 0.011
response to corticosteroid GO:0031960 1 0.011
regulation of cell substrate adhesion GO:0010810 1 0.010
cellular macromolecule biosynthetic process GO:0034645 224 0.010
cellular protein catabolic process GO:0044257 4 0.010
positive regulation of epithelial cell proliferation GO:0050679 1 0.010
negative regulation of multi organism process GO:0043901 3 0.010
regulation of production of molecular mediator of immune response GO:0002700 1 0.010
cytosolic calcium ion transport GO:0060401 3 0.010
protein acetylation GO:0006473 2 0.010
aorta development GO:0035904 4 0.010
histone lysine demethylation GO:0070076 2 0.010
extrinsic apoptotic signaling pathway GO:0097191 3 0.010
regulation of cytoplasmic transport GO:1903649 4 0.010
negative regulation of gene expression GO:0010629 65 0.010
positive regulation of immune effector process GO:0002699 3 0.010
regulation of nitrogen compound metabolic process GO:0051171 251 0.010
response to decreased oxygen levels GO:0036293 25 0.010
cardiac muscle myosin thick filament assembly GO:0071690 1 0.010

pikfyve disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.017
inherited metabolic disorder DOID:655 0 0.017
myopathy DOID:423 0 0.012
muscular disease DOID:0080000 0 0.012
heart disease DOID:114 0 0.012
cardiomyopathy DOID:0050700 0 0.012
disease of anatomical entity DOID:7 0 0.012
intrinsic cardiomyopathy DOID:0060036 0 0.012
cardiovascular system disease DOID:1287 0 0.012
musculoskeletal system disease DOID:17 0 0.012
muscle tissue disease DOID:66 0 0.012