Danio rerio

60 known processes

sp8b

sp8 transcription factor b

(Aliases: Sp8,sp8l,zgc:77258,Sp8a,fc48e06,wu:fc48e06)

sp8b biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.289
cell part morphogenesis GO:0032990 246 0.198
pectoral fin morphogenesis GO:0035138 29 0.156
cell projection organization GO:0030030 284 0.146
forebrain cell migration GO:0021885 1 0.143
purine nucleoside monophosphate catabolic process GO:0009128 4 0.134
cellular component morphogenesis GO:0032989 336 0.127
regulation of transcription from rna polymerase iii promoter GO:0006359 1 0.119
cell projection morphogenesis GO:0048858 244 0.111
epithelial cell differentiation GO:0030855 116 0.108
gene expression GO:0010467 252 0.103
generation of neurons GO:0048699 385 0.102
regulation of glial cell differentiation GO:0045685 4 0.101
startle response GO:0001964 4 0.099
organic cyclic compound biosynthetic process GO:1901362 223 0.091
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.090
response to chemical GO:0042221 320 0.085
regulation of transcription dna templated GO:0006355 213 0.082
Fly
organic cyclic compound metabolic process GO:1901360 301 0.082
regulation of fatty acid metabolic process GO:0019217 1 0.081
neuron differentiation GO:0030182 353 0.075
cell morphogenesis GO:0000902 289 0.073
neuron development GO:0048666 262 0.073
axon ensheathment in central nervous system GO:0032291 2 0.073
aromatic compound biosynthetic process GO:0019438 217 0.072
nucleobase containing compound biosynthetic process GO:0034654 205 0.072
positive regulation of cellular process GO:0048522 201 0.070
cellular biosynthetic process GO:0044249 286 0.069
camera type eye development GO:0043010 222 0.068
wound healing GO:0042060 90 0.066
signal transduction GO:0007165 455 0.065
stem cell proliferation GO:0072089 4 0.064
regulation of nucleic acid templated transcription GO:1903506 213 0.062
Fly
maintenance of location GO:0051235 4 0.060
guanosine containing compound catabolic process GO:1901069 2 0.058
response to external stimulus GO:0009605 264 0.057
positive regulation of transport GO:0051050 2 0.057
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.057
heterocycle metabolic process GO:0046483 290 0.054
cellular nitrogen compound metabolic process GO:0034641 290 0.053
lymphatic endothelial cell fate commitment GO:0060838 1 0.053
astrocyte differentiation GO:0048708 1 0.052
single organism nuclear import GO:1902593 3 0.052
cell migration GO:0016477 237 0.052
endothelial cell fate commitment GO:0060839 3 0.052
response to stress GO:0006950 263 0.051
regulation of intracellular protein transport GO:0033157 3 0.051
cardioblast migration to the midline involved in heart field formation GO:0060975 7 0.051
adult behavior GO:0030534 2 0.050
rna metabolic process GO:0016070 219 0.050
lipid storage GO:0019915 1 0.049
cell surface receptor signaling pathway GO:0007166 325 0.048
protein targeting to nucleus GO:0044744 3 0.047
regulation of protein import into nucleus GO:0042306 2 0.047
inner ear receptor cell fate commitment GO:0060120 4 0.047
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.046
negative regulation of axon guidance GO:1902668 1 0.045
protein import into nucleus GO:0006606 3 0.045
regulation of nitrogen compound metabolic process GO:0051171 251 0.045
Fly
regulation of oligodendrocyte differentiation GO:0048713 1 0.044
localization of cell GO:0051674 244 0.043
cell substrate adhesion GO:0031589 4 0.043
pectoral fin development GO:0033339 50 0.042
macromolecule biosynthetic process GO:0009059 227 0.042
heterocycle biosynthetic process GO:0018130 215 0.041
skin development GO:0043588 54 0.041
nucleic acid metabolic process GO:0090304 244 0.040
transcription from rna polymerase iii promoter GO:0006383 1 0.039
peripheral nervous system neuron differentiation GO:0048934 28 0.039
eye development GO:0001654 277 0.038
positive regulation of cellular amine metabolic process GO:0033240 0 0.038
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.038
Fly
response to organic substance GO:0010033 153 0.038
nucleocytoplasmic transport GO:0006913 4 0.036
establishment of protein localization to organelle GO:0072594 4 0.036
regulation of protein targeting GO:1903533 2 0.036
cell cycle g1 s phase transition GO:0044843 1 0.036
regulation of myotube differentiation GO:0010830 2 0.036
regulation of gene expression GO:0010468 265 0.036
Fly
organic acid metabolic process GO:0006082 31 0.035
nephron morphogenesis GO:0072028 2 0.035
nitrogen compound metabolic process GO:0006807 319 0.034
regulation of neurogenesis GO:0050767 87 0.034
auditory receptor cell fate commitment GO:0009912 4 0.034
cellular component movement GO:0006928 335 0.033
regulation of rna biosynthetic process GO:2001141 213 0.033
Fly
regulation of protein localization to nucleus GO:1900180 2 0.032
cellular nitrogen compound biosynthetic process GO:0044271 218 0.032
regulation of rna metabolic process GO:0051252 224 0.031
Fly
axonogenesis GO:0007409 152 0.031
negative regulation of mapk cascade GO:0043409 4 0.031
locomotion GO:0040011 313 0.031
single organism metabolic process GO:0044710 217 0.031
rhombomere 5 development GO:0021571 4 0.031
embryonic limb morphogenesis GO:0030326 2 0.031
transcription from rna polymerase ii promoter GO:0006366 80 0.030
gtp catabolic process GO:0006184 2 0.030
regulation of protein transport GO:0051223 3 0.030
protein complex localization GO:0031503 1 0.030
cellular aromatic compound metabolic process GO:0006725 295 0.029
regulation of nucleocytoplasmic transport GO:0046822 2 0.029
cellular response to chemical stimulus GO:0070887 157 0.029
negative regulation of nuclear division GO:0051784 3 0.029
cortical cytoskeleton organization GO:0030865 1 0.029
renal tubule morphogenesis GO:0061333 1 0.028
extracellular structure organization GO:0043062 27 0.028
segmentation GO:0035282 97 0.028
epidermis development GO:0008544 48 0.028
cell motility GO:0048870 244 0.028
regulation of signal transduction GO:0009966 225 0.028
nucleobase containing compound metabolic process GO:0006139 274 0.027
regulation of metabolic process GO:0019222 359 0.027
Fly
protein import GO:0017038 3 0.027
neuron projection development GO:0031175 180 0.027
endocardial progenitor cell migration to the midline involved in heart field formation GO:0003262 4 0.027
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.027
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.026
central nervous system myelination GO:0022010 2 0.026
transcription dna templated GO:0006351 181 0.026
oxoacid metabolic process GO:0043436 31 0.025
lamellipodium assembly GO:0030032 1 0.025
regulation of multicellular organismal development GO:2000026 223 0.025
carbohydrate derivative biosynthetic process GO:1901137 43 0.025
cell fate commitment GO:0045165 99 0.025
positive regulation of cell communication GO:0010647 56 0.025
regulation of myelination GO:0031641 1 0.024
nuclear transport GO:0051169 4 0.024
mechanoreceptor differentiation GO:0042490 37 0.024
regulation of protein ubiquitination GO:0031396 3 0.024
tyrosine phosphorylation of stat protein GO:0007260 1 0.024
positive regulation of cell cycle GO:0045787 3 0.024
neuron projection morphogenesis GO:0048812 161 0.024
positive regulation of nucleoside metabolic process GO:0045979 1 0.024
organic substance biosynthetic process GO:1901576 289 0.023
regulation of establishment of protein localization GO:0070201 4 0.023
secondary metabolic process GO:0019748 3 0.023
aging GO:0007568 2 0.023
positive regulation of cell killing GO:0031343 2 0.022
regulation of cellular biosynthetic process GO:0031326 245 0.022
Fly
regulation of multicellular organismal process GO:0051239 277 0.022
nuclear import GO:0051170 3 0.022
leukocyte proliferation GO:0070661 1 0.022
microtubule polymerization or depolymerization GO:0031109 3 0.022
epidermal cell fate specification GO:0009957 4 0.022
sensory organ development GO:0007423 393 0.022
regulation of biological quality GO:0065008 263 0.021
estrogen metabolic process GO:0008210 2 0.021
intracellular signal transduction GO:0035556 85 0.021
regulation of cell activation GO:0050865 1 0.021
blood vessel development GO:0001568 246 0.021
morphogenesis of an epithelium GO:0002009 333 0.021
regulation of cell killing GO:0031341 2 0.021
positive regulation of gtpase activity GO:0043547 1 0.020
neuron neuron synaptic transmission GO:0007270 1 0.020
dendrite guidance GO:0070983 0 0.020
dendrite development GO:0016358 9 0.020
neuron fate determination GO:0048664 2 0.020
positive regulation of secretion GO:0051047 1 0.020
melanin metabolic process GO:0006582 2 0.020
somite development GO:0061053 96 0.020
mesenchymal cell development GO:0014031 78 0.020
positive regulation of nucleotide catabolic process GO:0030813 1 0.020
urogenital system development GO:0001655 97 0.020
appendage morphogenesis GO:0035107 56 0.019
multicellular organism growth GO:0035264 4 0.019
positive regulation of gtp catabolic process GO:0033126 1 0.019
regulation of macromolecule metabolic process GO:0060255 317 0.019
Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.019
segment specification GO:0007379 12 0.019
sympathetic nervous system development GO:0048485 3 0.019
positive regulation of biological process GO:0048518 253 0.019
response to wounding GO:0009611 116 0.019
wnt signaling pathway GO:0016055 80 0.019
neuroblast differentiation GO:0014016 1 0.019
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.019
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.019
viral process GO:0016032 1 0.019
cellular response to xenobiotic stimulus GO:0071466 35 0.018
microtubule polymerization GO:0046785 2 0.018
central nervous system development GO:0007417 387 0.018
regulation of cellular ketone metabolic process GO:0010565 7 0.018
single organism cellular localization GO:1902580 46 0.018
glial cell development GO:0021782 20 0.018
regulation of cell substrate adhesion GO:0010810 1 0.018
positive regulation of gliogenesis GO:0014015 2 0.018
regulation of macromolecule biosynthetic process GO:0010556 225 0.017
Fly
protein localization to nucleus GO:0034504 3 0.017
nephron tubule morphogenesis GO:0072078 1 0.017
cell proliferation GO:0008283 80 0.017
carboxylic acid metabolic process GO:0019752 22 0.017
multi organism cellular process GO:0044764 2 0.017
regulation of ph GO:0006885 3 0.017
skeletal system development GO:0001501 181 0.017
ribonucleoside monophosphate catabolic process GO:0009158 4 0.017
embryonic pectoral fin morphogenesis GO:0035118 24 0.017
mechanosensory lateral line system development GO:0048881 49 0.017
cellular component biogenesis GO:0044085 178 0.017
regulation of nervous system development GO:0051960 90 0.017
dorsal ventral pattern formation GO:0009953 125 0.016
Mouse
protein acetylation GO:0006473 2 0.016
protein polymerization GO:0051258 4 0.016
rna biosynthetic process GO:0032774 181 0.016
regulation of cellular amine metabolic process GO:0033238 0 0.016
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
cell proliferation in forebrain GO:0021846 3 0.016
cellular macromolecule biosynthetic process GO:0034645 224 0.016
peripheral nervous system neuron axonogenesis GO:0048936 13 0.016
positive regulation of cellular catabolic process GO:0031331 3 0.016
positive regulation of signaling GO:0023056 56 0.016
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.016
embryonic organ development GO:0048568 381 0.015
regulation of cell migration GO:0030334 40 0.015
peripheral nervous system development GO:0007422 55 0.015
response to vitamin GO:0033273 3 0.015
nucleoside monophosphate catabolic process GO:0009125 4 0.015
establishment or maintenance of cell polarity GO:0007163 29 0.015
positive regulation of response to stimulus GO:0048584 80 0.015
negative regulation of collateral sprouting GO:0048671 2 0.015
modification dependent protein catabolic process GO:0019941 3 0.015
regulation of inner ear receptor cell differentiation GO:2000980 1 0.015
regulation of filopodium assembly GO:0051489 2 0.015
cardioblast migration GO:0003260 7 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.015
gtp metabolic process GO:0046039 4 0.015
brain morphogenesis GO:0048854 18 0.015
developmental maturation GO:0021700 34 0.015
erk1 and erk2 cascade GO:0070371 4 0.015
small molecule metabolic process GO:0044281 77 0.015
regulation of purine nucleotide catabolic process GO:0033121 2 0.015
response to abiotic stimulus GO:0009628 122 0.015
cellular response to oxygen levels GO:0071453 1 0.014
biosynthetic process GO:0009058 294 0.014
cell migration to the midline involved in heart development GO:0003318 12 0.014
stem cell differentiation GO:0048863 117 0.014
cellular response to retinoic acid GO:0071300 1 0.014
regulation of cell communication GO:0010646 232 0.014
positive regulation of apoptotic signaling pathway GO:2001235 1 0.014
positive regulation of cell adhesion GO:0045785 1 0.014
regulation of dendrite morphogenesis GO:0048814 3 0.014
organonitrogen compound metabolic process GO:1901564 74 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.014
negative regulation of kinase activity GO:0033673 4 0.014
regulation of cellular protein catabolic process GO:1903362 1 0.014
phagocytosis GO:0006909 3 0.014
nucleic acid templated transcription GO:0097659 181 0.014
amine metabolic process GO:0009308 2 0.014
cell death GO:0008219 121 0.014
regulation of protein catabolic process GO:0042176 1 0.014
regulation of wound healing GO:0061041 2 0.014
establishment of endothelial blood brain barrier GO:0014045 2 0.014
single organism localization GO:1902578 225 0.013
regulation of cell fate commitment GO:0010453 22 0.013
regionalization GO:0003002 274 0.013
Mouse
negative regulation of stem cell differentiation GO:2000737 2 0.013
guanosine containing compound metabolic process GO:1901068 4 0.013
regulation of primary metabolic process GO:0080090 311 0.013
Fly
regulation of meiotic cell cycle GO:0051445 1 0.013
behavior GO:0007610 74 0.013
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 1 0.013
embryonic appendage morphogenesis GO:0035113 30 0.013
brain development GO:0007420 293 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.013
regulation of anatomical structure morphogenesis GO:0022603 130 0.013
ameboidal type cell migration GO:0001667 143 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.012
regulation of cell differentiation GO:0045595 142 0.012
cell morphogenesis involved in differentiation GO:0000904 195 0.012
lymphatic endothelial cell differentiation GO:0060836 1 0.012
positive regulation of stress activated mapk cascade GO:0032874 3 0.012
retina development in camera type eye GO:0060041 146 0.012
extracellular matrix organization GO:0030198 27 0.012
positive regulation of secretion by cell GO:1903532 1 0.012
positive regulation of signal transduction GO:0009967 56 0.012
cellular localization GO:0051641 97 0.012
regulation of response to stimulus GO:0048583 269 0.012
response to bacterium GO:0009617 58 0.012
carbohydrate derivative metabolic process GO:1901135 61 0.012
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 1 0.012
regulation of binding GO:0051098 3 0.012
heart morphogenesis GO:0003007 156 0.012
stem cell maintenance GO:0019827 4 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.011
negative regulation of wnt signaling pathway GO:0030178 30 0.011
regulation of cell projection organization GO:0031344 44 0.011
skeletal muscle organ development GO:0060538 78 0.011
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.011
cellular amine metabolic process GO:0044106 2 0.011
positive regulation of catabolic process GO:0009896 4 0.011
embryonic organ morphogenesis GO:0048562 274 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.011
cell cell recognition GO:0009988 1 0.011
dendrite morphogenesis GO:0048813 5 0.011
positive regulation of jnk cascade GO:0046330 3 0.011
fin morphogenesis GO:0033334 53 0.011
regulation of chemotaxis GO:0050920 18 0.011
neuron projection guidance GO:0097485 86 0.011
protein complex assembly GO:0006461 30 0.011
establishment of blood brain barrier GO:0060856 2 0.011
regulation of synaptic plasticity GO:0048167 1 0.011
nitric oxide metabolic process GO:0046209 2 0.011
smoothened signaling pathway GO:0007224 30 0.011
regulation of cell size GO:0008361 29 0.010
canonical wnt signaling pathway GO:0060070 48 0.010
dicarboxylic acid transport GO:0006835 1 0.010
fertilization GO:0009566 3 0.010
regulation of cell shape GO:0008360 1 0.010
regulation of multicellular organism growth GO:0040014 4 0.010
regulation of cytokine production GO:0001817 3 0.010
trabecula formation GO:0060343 2 0.010
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.010
atp catabolic process GO:0006200 4 0.010
regulation of cell projection assembly GO:0060491 4 0.010
regulation of signaling GO:0023051 235 0.010
negative regulation of transcription dna templated GO:0045892 45 0.010

sp8b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.051
nervous system disease DOID:863 0 0.051
cancer DOID:162 0 0.020
disease of cellular proliferation DOID:14566 0 0.020
organ system cancer DOID:0050686 0 0.020