Danio rerio

0 known processes

ide

insulin-degrading enzyme

(Aliases: MGC162603,zgc:162603)

ide biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
purine nucleoside monophosphate catabolic process GO:0009128 4 0.126
larval development GO:0002164 2 0.091
cellular aromatic compound metabolic process GO:0006725 295 0.065
cellular macromolecule metabolic process GO:0044260 391 0.061
cellular nitrogen compound metabolic process GO:0034641 290 0.060
neuron development GO:0048666 262 0.056
ribonucleoside monophosphate catabolic process GO:0009158 4 0.056
cellular component morphogenesis GO:0032989 336 0.054
aging GO:0007568 2 0.052
nucleoside monophosphate catabolic process GO:0009125 4 0.051
organic cyclic compound metabolic process GO:1901360 301 0.050
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.043
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.043
modification dependent macromolecule catabolic process GO:0043632 3 0.042
positive regulation of biological process GO:0048518 253 0.039
generation of neurons GO:0048699 385 0.037
organelle organization GO:0006996 227 0.037
transport GO:0006810 220 0.037
cellular macromolecule biosynthetic process GO:0034645 224 0.036
nitrogen compound metabolic process GO:0006807 319 0.035
nucleocytoplasmic transport GO:0006913 4 0.035
heterocycle metabolic process GO:0046483 290 0.035
ubiquitin dependent protein catabolic process GO:0006511 3 0.035
cellular protein catabolic process GO:0044257 4 0.035
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.033
single organism metabolic process GO:0044710 217 0.033
maintenance of location GO:0051235 4 0.033
establishment of localization GO:0051234 244 0.032
guanosine containing compound metabolic process GO:1901068 4 0.032
signal transduction GO:0007165 455 0.031
mitochondrion organization GO:0007005 4 0.031
response to chemical GO:0042221 320 0.031
atp catabolic process GO:0006200 4 0.031
sensory organ development GO:0007423 393 0.031
actin polymerization or depolymerization GO:0008154 2 0.030
organonitrogen compound metabolic process GO:1901564 74 0.030
neuron differentiation GO:0030182 353 0.028
golgi vesicle transport GO:0048193 3 0.027
gene expression GO:0010467 252 0.027
guanosine containing compound catabolic process GO:1901069 2 0.027
proteasomal protein catabolic process GO:0010498 2 0.027
regulation of metabolic process GO:0019222 359 0.027
regulation of establishment of protein localization GO:0070201 4 0.027
head development GO:0060322 303 0.026
positive regulation of transport GO:0051050 2 0.025
nuclear transport GO:0051169 4 0.025
single organism organelle organization GO:1902589 199 0.025
modification dependent protein catabolic process GO:0019941 3 0.025
lipid storage GO:0019915 1 0.025
neuron projection morphogenesis GO:0048812 161 0.025
nucleobase containing compound metabolic process GO:0006139 274 0.025
positive regulation of cellular component biogenesis GO:0044089 3 0.024
gtp metabolic process GO:0046039 4 0.024
establishment of protein localization to organelle GO:0072594 4 0.024
mitochondrial transport GO:0006839 2 0.023
cell morphogenesis involved in differentiation GO:0000904 195 0.023
response to stress GO:0006950 263 0.023
cellular biosynthetic process GO:0044249 286 0.023
biosynthetic process GO:0009058 294 0.023
regulation of purine nucleotide catabolic process GO:0033121 2 0.022
cell part morphogenesis GO:0032990 246 0.022
regulation of protein complex assembly GO:0043254 3 0.022
positive regulation of cellular catabolic process GO:0031331 3 0.021
single organism localization GO:1902578 225 0.021
regulation of nucleotide catabolic process GO:0030811 2 0.021
organic substance biosynthetic process GO:1901576 289 0.021
protein import GO:0017038 3 0.020
regulation of binding GO:0051098 3 0.020
regulation of gene expression GO:0010468 265 0.020
protein polymerization GO:0051258 4 0.020
negative regulation of protein phosphorylation GO:0001933 4 0.020
cell projection morphogenesis GO:0048858 244 0.019
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.019
cell projection organization GO:0030030 284 0.019
gtp catabolic process GO:0006184 2 0.019
brain development GO:0007420 293 0.019
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.019
response to external stimulus GO:0009605 264 0.019
regulation of nucleoside metabolic process GO:0009118 2 0.019
positive regulation of cellular process GO:0048522 201 0.019
response to topologically incorrect protein GO:0035966 2 0.019
protein localization to plasma membrane GO:0072659 1 0.019
central nervous system development GO:0007417 387 0.018
rna metabolic process GO:0016070 219 0.018
chordate embryonic development GO:0043009 271 0.018
meiotic nuclear division GO:0007126 4 0.018
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.018
single organism transport GO:0044765 206 0.018
neurotransmitter transport GO:0006836 2 0.018
actin filament polymerization GO:0030041 2 0.018
cell morphogenesis GO:0000902 289 0.018
positive regulation of cytoskeleton organization GO:0051495 3 0.018
nucleic acid transport GO:0050657 2 0.018
positive regulation of immune effector process GO:0002699 3 0.018
cellular amine metabolic process GO:0044106 2 0.018
tube morphogenesis GO:0035239 349 0.018
morphogenesis of an epithelium GO:0002009 333 0.017
eye development GO:0001654 277 0.017
regulation of response to stimulus GO:0048583 269 0.017
protein metabolic process GO:0019538 183 0.017
regulation of sodium ion transport GO:0002028 2 0.017
positive regulation of nucleotide catabolic process GO:0030813 1 0.017
rna localization GO:0006403 4 0.017
amine metabolic process GO:0009308 2 0.017
compound eye development GO:0048749 2 0.016
single fertilization GO:0007338 3 0.016
positive regulation of catabolic process GO:0009896 4 0.016
regulation of dendrite morphogenesis GO:0048814 3 0.016
carboxylic acid metabolic process GO:0019752 22 0.016
positive regulation of protein complex assembly GO:0031334 2 0.016
nuclear export GO:0051168 1 0.016
programmed cell death GO:0012501 119 0.016
cellular component disassembly GO:0022411 1 0.016
regulation of macromolecule metabolic process GO:0060255 317 0.016
protein homooligomerization GO:0051260 3 0.015
small molecule metabolic process GO:0044281 77 0.015
negative regulation of protein kinase activity GO:0006469 4 0.015
cellular component movement GO:0006928 335 0.015
secondary metabolic process GO:0019748 3 0.015
nucleobase containing compound transport GO:0015931 2 0.015
regulation of protein import into nucleus GO:0042306 2 0.015
negative regulation of cell communication GO:0010648 96 0.015
somatic muscle development GO:0007525 4 0.015
positive regulation of nucleoside metabolic process GO:0045979 1 0.015
meiotic cell cycle process GO:1903046 3 0.015
phagocytosis GO:0006909 3 0.015
negative regulation of map kinase activity GO:0043407 2 0.015
cellular response to topologically incorrect protein GO:0035967 2 0.015
striated muscle cell development GO:0055002 108 0.015
nitric oxide metabolic process GO:0046209 2 0.015
positive regulation of secretion GO:0051047 1 0.015
regulation of primary metabolic process GO:0080090 311 0.015
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 4 0.015
negative regulation of biological process GO:0048519 304 0.014
establishment of protein localization to plasma membrane GO:0090002 1 0.014
single organism membrane fusion GO:0044801 2 0.014
aromatic compound biosynthetic process GO:0019438 217 0.014
regulation of protein polymerization GO:0032271 2 0.014
embryonic organ development GO:0048568 381 0.014
hormone transport GO:0009914 2 0.014
cellular amino acid metabolic process GO:0006520 7 0.014
oxoacid metabolic process GO:0043436 31 0.014
establishment of localization in cell GO:0051649 77 0.014
axon development GO:0061564 166 0.014
endosome organization GO:0007032 2 0.013
muscle structure development GO:0061061 196 0.013
single organism nuclear import GO:1902593 3 0.013
epithelial tube morphogenesis GO:0060562 148 0.013
protein localization to nucleus GO:0034504 3 0.013
peptide transport GO:0015833 1 0.013
nucleic acid templated transcription GO:0097659 181 0.013
cellular catabolic process GO:0044248 27 0.013
regulation of dendrite development GO:0050773 3 0.013
positive regulation of protein polymerization GO:0032273 2 0.013
macromolecule biosynthetic process GO:0009059 227 0.013
positive regulation of leukocyte mediated immunity GO:0002705 1 0.013
dna templated transcription initiation GO:0006352 1 0.013
regulation of cellular amine metabolic process GO:0033238 0 0.013
negative regulation of synapse assembly GO:0051964 2 0.013
nuclear import GO:0051170 3 0.013
regulation of cellular metabolic process GO:0031323 320 0.013
regulation of neurogenesis GO:0050767 87 0.013
regulation of intracellular protein transport GO:0033157 3 0.013
skeletal system development GO:0001501 181 0.013
neurotransmitter secretion GO:0007269 2 0.013
regulation of nitrogen compound metabolic process GO:0051171 251 0.013
regulation of synapse organization GO:0050807 3 0.013
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.013
antimicrobial humoral response GO:0019730 2 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
regulation of cell communication GO:0010646 232 0.013
cellular protein metabolic process GO:0044267 129 0.013
protein targeting to nucleus GO:0044744 3 0.013
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.013
regulation of multicellular organism growth GO:0040014 4 0.012
regulation of reproductive process GO:2000241 4 0.012
response to amphetamine GO:0001975 1 0.012
multicellular organism growth GO:0035264 4 0.012
positive regulation of cell cycle GO:0045787 3 0.012
response to organic substance GO:0010033 153 0.012
camera type eye development GO:0043010 222 0.012
rna biosynthetic process GO:0032774 181 0.012
female sex differentiation GO:0046660 4 0.012
cytoplasm organization GO:0007028 4 0.012
embryonic organ morphogenesis GO:0048562 274 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
regulation of neuronal synaptic plasticity GO:0048168 1 0.012
negative regulation of kinase activity GO:0033673 4 0.012
regulation of muscle contraction GO:0006937 3 0.012
locomotion GO:0040011 313 0.012
organic cyclic compound biosynthetic process GO:1901362 223 0.012
hormone secretion GO:0046879 2 0.012
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.012
negative regulation of mapk cascade GO:0043409 4 0.012
protein import into nucleus GO:0006606 3 0.012
female gonad development GO:0008585 4 0.012
cellular nitrogen compound biosynthetic process GO:0044271 218 0.012
response to other organism GO:0051707 97 0.012
dopamine metabolic process GO:0042417 2 0.012
extrinsic apoptotic signaling pathway GO:0097191 3 0.012
regulation of sodium ion transmembrane transport GO:1902305 1 0.012
reactive nitrogen species metabolic process GO:2001057 0 0.011
heterocycle biosynthetic process GO:0018130 215 0.011
regulation of tube size GO:0035150 2 0.011
negative regulation of signaling GO:0023057 96 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.011
regulation of cytokine production GO:0001817 3 0.011
protein complex disassembly GO:0043241 1 0.011
regulation of synapse assembly GO:0051963 3 0.011
ear development GO:0043583 127 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
b cell differentiation GO:0030183 1 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
muscle cell differentiation GO:0042692 139 0.011
exocytosis GO:0006887 1 0.011
response to drug GO:0042493 3 0.011
regulation of protein localization to plasma membrane GO:1903076 1 0.011
regulation of ion transmembrane transporter activity GO:0032412 2 0.011
zymogen activation GO:0031638 3 0.011
organic acid metabolic process GO:0006082 31 0.011
mesenchyme development GO:0060485 127 0.011
regulation of synaptic plasticity GO:0048167 1 0.011
meiotic chromosome segregation GO:0045132 3 0.011
positive regulation of secretion by cell GO:1903532 1 0.011
vasculature development GO:0001944 278 0.011
regulation of signaling GO:0023051 235 0.011
negative regulation of cellular process GO:0048523 283 0.011
response to biotic stimulus GO:0009607 97 0.011
catechol containing compound metabolic process GO:0009712 2 0.011
establishment of rna localization GO:0051236 3 0.011
nucleic acid metabolic process GO:0090304 244 0.011
striated muscle cell differentiation GO:0051146 129 0.011
mononuclear cell proliferation GO:0032943 1 0.011
pole plasm assembly GO:0007315 4 0.011
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.011
ovulation cycle process GO:0022602 2 0.011
cofactor biosynthetic process GO:0051188 10 0.011
cartilage development GO:0051216 96 0.011
membrane fusion GO:0061025 2 0.010
cytoskeleton dependent cytokinesis GO:0061640 3 0.010
rna transport GO:0050658 2 0.010
cellular response to chemical stimulus GO:0070887 157 0.010
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.010
nucleobase containing compound biosynthetic process GO:0034654 205 0.010
b cell activation GO:0042113 2 0.010
negative regulation of cytoplasmic transport GO:1903650 2 0.010
nitric oxide biosynthetic process GO:0006809 2 0.010
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.010
positive regulation of cytokine production GO:0001819 2 0.010
regulation of cell projection assembly GO:0060491 4 0.010
olfactory lobe development GO:0021988 4 0.010
cellular response to extracellular stimulus GO:0031668 2 0.010
regulation of multicellular organismal development GO:2000026 223 0.010

ide disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
disease of metabolism DOID:0014667 0 0.017
inherited metabolic disorder DOID:655 0 0.017
musculoskeletal system disease DOID:17 0 0.016
nervous system disease DOID:863 0 0.016
sensory system disease DOID:0050155 0 0.011
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011