Danio rerio

0 known processes

neil3

nei endonuclease VIII-like 3 (E. coli)

(Aliases: zgc:103553)

neil3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cellular process GO:0048523 283 0.167
signal transduction GO:0007165 455 0.159
cellular macromolecule metabolic process GO:0044260 391 0.109
Mouse
nitrogen compound metabolic process GO:0006807 319 0.105
Mouse
cellular nitrogen compound metabolic process GO:0034641 290 0.091
Mouse
meiotic nuclear division GO:0007126 4 0.090
double strand break repair GO:0006302 3 0.090
heterocycle metabolic process GO:0046483 290 0.084
Mouse
immune system process GO:0002376 241 0.076
positive regulation of cell cycle GO:0045787 3 0.066
regulation of cell communication GO:0010646 232 0.064
negative regulation of biological process GO:0048519 304 0.062
organic cyclic compound biosynthetic process GO:1901362 223 0.061
microtubule organizing center organization GO:0031023 1 0.061
response to chemical GO:0042221 320 0.059
nucleic acid metabolic process GO:0090304 244 0.057
Mouse
regulation of response to stimulus GO:0048583 269 0.054
immune system development GO:0002520 191 0.052
organic cyclic compound metabolic process GO:1901360 301 0.051
Mouse
cellular response to chemical stimulus GO:0070887 157 0.043
cell cycle GO:0007049 93 0.042
epithelial cilium movement involved in determination of left right asymmetry GO:0060287 8 0.042
viral process GO:0016032 1 0.042
organonitrogen compound metabolic process GO:1901564 74 0.041
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.041
hemopoiesis GO:0030097 183 0.040
multi organism cellular process GO:0044764 2 0.040
hematopoietic or lymphoid organ development GO:0048534 191 0.039
meiotic cell cycle process GO:1903046 3 0.039
positive regulation of biological process GO:0048518 253 0.039
regulation of multicellular organism growth GO:0040014 4 0.038
regulation of nucleocytoplasmic transport GO:0046822 2 0.038
nucleocytoplasmic transport GO:0006913 4 0.038
cell morphogenesis GO:0000902 289 0.037
cellular component assembly GO:0022607 170 0.037
biosynthetic process GO:0009058 294 0.037
response to organic substance GO:0010033 153 0.036
regulation of signaling GO:0023051 235 0.036
stem cell maintenance GO:0019827 4 0.036
response to stress GO:0006950 263 0.035
Mouse
regulation of metabolic process GO:0019222 359 0.035
cellular biosynthetic process GO:0044249 286 0.035
locomotion GO:0040011 313 0.034
phagocytosis GO:0006909 3 0.034
macromolecule biosynthetic process GO:0009059 227 0.034
cellular component movement GO:0006928 335 0.033
homeostatic process GO:0042592 142 0.033
regulation of primary metabolic process GO:0080090 311 0.033
regulation of gene expression GO:0010468 265 0.033
nuclear transport GO:0051169 4 0.033
single organism metabolic process GO:0044710 217 0.033
Mouse
positive regulation of cell activation GO:0050867 1 0.032
morphogenesis of an epithelium GO:0002009 333 0.032
mitotic cell cycle GO:0000278 64 0.032
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.032
regulation of protein complex assembly GO:0043254 3 0.032
multicellular organism growth GO:0035264 4 0.030
cellular component biogenesis GO:0044085 178 0.030
atp catabolic process GO:0006200 4 0.030
cellular response to organic substance GO:0071310 105 0.029
negative regulation of kinase activity GO:0033673 4 0.029
nucleobase containing compound metabolic process GO:0006139 274 0.029
Mouse
cell surface receptor signaling pathway GO:0007166 325 0.029
response to hexose GO:0009746 3 0.028
response to carbohydrate GO:0009743 3 0.028
aging GO:0007568 2 0.028
negative regulation of protein phosphorylation GO:0001933 4 0.028
regulation of cellular response to growth factor stimulus GO:0090287 35 0.028
ribonucleoside monophosphate catabolic process GO:0009158 4 0.028
positive regulation of cellular process GO:0048522 201 0.027
nucleoside monophosphate catabolic process GO:0009125 4 0.027
regulation of biological quality GO:0065008 263 0.027
establishment of localization GO:0051234 244 0.027
phosphorus metabolic process GO:0006793 109 0.026
spermatid development GO:0007286 2 0.026
enzyme linked receptor protein signaling pathway GO:0007167 106 0.026
organelle organization GO:0006996 227 0.026
cellular amine metabolic process GO:0044106 2 0.025
dna catabolic process GO:0006308 1 0.025
Mouse
localization of cell GO:0051674 244 0.025
cytokinesis GO:0000910 3 0.025
regulation of cellular amine metabolic process GO:0033238 0 0.025
regulation of mrna processing GO:0050684 3 0.025
positive regulation of catabolic process GO:0009896 4 0.024
regulation of oocyte development GO:0060281 3 0.024
peptidyl serine phosphorylation GO:0018105 1 0.024
peptidyl serine modification GO:0018209 2 0.023
regulation of macromolecule metabolic process GO:0060255 317 0.023
kidney development GO:0001822 92 0.023
transcription dna templated GO:0006351 181 0.023
cellular nitrogen compound biosynthetic process GO:0044271 218 0.023
cellular component morphogenesis GO:0032989 336 0.023
regulation of signal transduction GO:0009966 225 0.023
muscle structure development GO:0061061 196 0.023
regulation of autophagy GO:0010506 3 0.022
cellular ketone metabolic process GO:0042180 11 0.022
meiosis i GO:0007127 1 0.022
gene expression GO:0010467 252 0.022
negative regulation of metabolic process GO:0009892 86 0.022
gtp metabolic process GO:0046039 4 0.022
heart development GO:0007507 313 0.022
regulation of nitrogen compound metabolic process GO:0051171 251 0.022
regulation of macromolecule biosynthetic process GO:0010556 225 0.022
guanosine containing compound catabolic process GO:1901069 2 0.022
small molecule metabolic process GO:0044281 77 0.021
transport GO:0006810 220 0.021
spermatid differentiation GO:0048515 2 0.021
response to growth factor GO:0070848 39 0.021
peptidyl lysine acetylation GO:0018394 2 0.021
double strand break repair via homologous recombination GO:0000724 1 0.021
negative regulation of protein complex assembly GO:0031333 1 0.021
regulation of stem cell differentiation GO:2000736 4 0.021
centrosome cycle GO:0007098 1 0.021
regulation of binding GO:0051098 3 0.021
positive regulation of cellular catabolic process GO:0031331 3 0.021
germ line stem cell maintenance GO:0030718 2 0.021
determination of left right symmetry GO:0007368 179 0.021
response to endogenous stimulus GO:0009719 83 0.021
amine metabolic process GO:0009308 2 0.020
cell projection organization GO:0030030 284 0.020
cellular protein catabolic process GO:0044257 4 0.020
single organism organelle organization GO:1902589 199 0.020
regulation of meiotic cell cycle GO:0051445 1 0.020
guanosine containing compound metabolic process GO:1901068 4 0.020
convergent extension GO:0060026 118 0.020
regulation of rna biosynthetic process GO:2001141 213 0.020
negative regulation of protein kinase activity GO:0006469 4 0.020
positive regulation of immune effector process GO:0002699 3 0.020
sensory organ development GO:0007423 393 0.019
pronephros development GO:0048793 69 0.019
anterior posterior pattern specification GO:0009952 152 0.019
regulation of cell activation GO:0050865 1 0.019
positive regulation of multi organism process GO:0043902 3 0.019
internal peptidyl lysine acetylation GO:0018393 2 0.019
digestive tract development GO:0048565 265 0.019
sensory organ morphogenesis GO:0090596 200 0.019
regulation of establishment of protein localization GO:0070201 4 0.018
cellular localization GO:0051641 97 0.018
regulation of rna metabolic process GO:0051252 224 0.018
recombinational repair GO:0000725 1 0.018
cytoskeleton dependent cytokinesis GO:0061640 3 0.018
regulation of biosynthetic process GO:0009889 250 0.018
programmed cell death GO:0012501 119 0.018
retina development in camera type eye GO:0060041 146 0.018
negative regulation of mapk cascade GO:0043409 4 0.018
b cell activation GO:0042113 2 0.018
multi organism process GO:0051704 134 0.018
developmental growth GO:0048589 166 0.018
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.018
nucleobase containing compound biosynthetic process GO:0034654 205 0.018
methylation GO:0032259 22 0.018
macromolecule modification GO:0043412 111 0.018
response to glucose GO:0009749 3 0.017
regulation of molecular function GO:0065009 70 0.017
convergent extension involved in gastrulation GO:0060027 71 0.017
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.017
cell part morphogenesis GO:0032990 246 0.017
mononuclear cell proliferation GO:0032943 1 0.017
protein acylation GO:0043543 3 0.017
cellular component disassembly GO:0022411 1 0.017
regulation of developmental process GO:0050793 247 0.017
gtp catabolic process GO:0006184 2 0.017
dorsal ventral pattern formation GO:0009953 125 0.017
organic substance biosynthetic process GO:1901576 289 0.017
specification of symmetry GO:0009799 204 0.017
oogenesis GO:0048477 14 0.017
cell projection morphogenesis GO:0048858 244 0.017
determination of bilateral symmetry GO:0009855 204 0.017
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.016
regulation of reproductive process GO:2000241 4 0.016
renal system development GO:0072001 94 0.016
embryonic digestive tract development GO:0048566 4 0.016
head development GO:0060322 303 0.016
central nervous system development GO:0007417 387 0.016
cell death GO:0008219 121 0.016
cellular amino acid metabolic process GO:0006520 7 0.016
rna biosynthetic process GO:0032774 181 0.016
centrosome localization GO:0051642 1 0.016
regulation of gtp catabolic process GO:0033124 2 0.016
retina morphogenesis in camera type eye GO:0060042 79 0.015
glucose homeostasis GO:0042593 1 0.015
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.015
camera type eye morphogenesis GO:0048593 108 0.015
growth GO:0040007 174 0.015
chromosome organization involved in meiosis GO:0070192 1 0.015
response to monosaccharide GO:0034284 3 0.015
eye development GO:0001654 277 0.015
hormone secretion GO:0046879 2 0.015
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.015
cellular macromolecule biosynthetic process GO:0034645 224 0.015
negative regulation of nucleic acid templated transcription GO:1903507 45 0.015
golgi vesicle transport GO:0048193 3 0.015
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.015
protein complex biogenesis GO:0070271 30 0.015
cellular protein metabolic process GO:0044267 129 0.015
peptide transport GO:0015833 1 0.015
regulation of cellular metabolic process GO:0031323 320 0.015
rna localization GO:0006403 4 0.015
nucleic acid templated transcription GO:0097659 181 0.015
neuron differentiation GO:0030182 353 0.015
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.014
cell morphogenesis involved in differentiation GO:0000904 195 0.014
cell motility GO:0048870 244 0.014
positive regulation of dna metabolic process GO:0051054 1 0.014
organic acid metabolic process GO:0006082 31 0.014
regulation of intracellular protein transport GO:0033157 3 0.014
regulation of ion transmembrane transporter activity GO:0032412 2 0.014
positive regulation of apoptotic signaling pathway GO:2001235 1 0.014
cellular aromatic compound metabolic process GO:0006725 295 0.014
Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.014
regulation of cell differentiation GO:0045595 142 0.014
leukocyte proliferation GO:0070661 1 0.014
cellular response to biotic stimulus GO:0071216 3 0.013
stem cell proliferation GO:0072089 4 0.013
regulation of neural precursor cell proliferation GO:2000177 3 0.013
b cell differentiation GO:0030183 1 0.013
regulation of nucleic acid templated transcription GO:1903506 213 0.013
larval development GO:0002164 2 0.013
organism emergence from protective structure GO:0071684 4 0.013
lipid storage GO:0019915 1 0.013
response to uv GO:0009411 3 0.013
protein modification process GO:0036211 100 0.013
myeloid cell differentiation GO:0030099 86 0.013
defense response to bacterium GO:0042742 22 0.013
phagocytosis engulfment GO:0006911 1 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
regulation of rho protein signal transduction GO:0035023 2 0.013
apoptotic process GO:0006915 116 0.013
death GO:0016265 121 0.013
cognition GO:0050890 1 0.013
positive regulation of oocyte development GO:0060282 1 0.013
interspecies interaction between organisms GO:0044419 4 0.013
carbohydrate derivative metabolic process GO:1901135 61 0.013
positive regulation of metabolic process GO:0009893 108 0.013
cellular response to oxygen levels GO:0071453 1 0.012
cell migration GO:0016477 237 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
protein acetylation GO:0006473 2 0.012
cellular response to external stimulus GO:0071496 2 0.012
blood circulation GO:0008015 87 0.012
regulation of cytoplasmic transport GO:1903649 4 0.012
regulation of cellular ketone metabolic process GO:0010565 7 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.012
blood vessel development GO:0001568 246 0.012
protein metabolic process GO:0019538 183 0.012
regulation of circadian rhythm GO:0042752 4 0.012
centrosome organization GO:0051297 1 0.012
regulation of transporter activity GO:0032409 2 0.012
protein localization to plasma membrane GO:0072659 1 0.012
spindle assembly GO:0051225 2 0.012
cellular response to stress GO:0033554 62 0.012
Mouse
maintenance of location GO:0051235 4 0.012
positive regulation of nucleotide catabolic process GO:0030813 1 0.012
hormone transport GO:0009914 2 0.012
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
chromatin modification GO:0016568 21 0.011
cellular response to growth factor stimulus GO:0071363 39 0.011
response to external stimulus GO:0009605 264 0.011
negative regulation of biosynthetic process GO:0009890 55 0.011
positive regulation of chromosome organization GO:2001252 1 0.011
hard palate development GO:0060022 4 0.011
diencephalon development GO:0021536 58 0.011
regulation of cellular biosynthetic process GO:0031326 245 0.011
ras protein signal transduction GO:0007265 7 0.011
tube morphogenesis GO:0035239 349 0.011
peptidyl lysine trimethylation GO:0018023 1 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.011
regulation of production of molecular mediator of immune response GO:0002700 1 0.011
carboxylic acid metabolic process GO:0019752 22 0.011
positive regulation of transport GO:0051050 2 0.011
negative regulation of rna biosynthetic process GO:1902679 45 0.011
intracellular mrna localization GO:0008298 1 0.011
stem cell division GO:0017145 1 0.011
intracellular signal transduction GO:0035556 85 0.011
mitochondrion organization GO:0007005 4 0.011
regulation of transcription dna templated GO:0006355 213 0.011
smad protein complex assembly GO:0007183 1 0.011
negative regulation of cellular metabolic process GO:0031324 77 0.011
aromatic compound biosynthetic process GO:0019438 217 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
regulation of cell death GO:0010941 103 0.011
cellular response to radiation GO:0071478 4 0.010
positive regulation of programmed cell death GO:0043068 29 0.010
myeloid cell development GO:0061515 32 0.010
negative regulation of ras protein signal transduction GO:0046580 1 0.010
vesicle mediated transport GO:0016192 22 0.010
nuclear import GO:0051170 3 0.010
negative regulation of cell communication GO:0010648 96 0.010
digestive tract morphogenesis GO:0048546 231 0.010
purine nucleoside monophosphate catabolic process GO:0009128 4 0.010
cortical cytoskeleton organization GO:0030865 1 0.010
negative regulation of signal transduction GO:0009968 94 0.010
regulation of protein depolymerization GO:1901879 1 0.010
negative regulation of multi organism process GO:0043901 3 0.010
ubiquitin dependent protein catabolic process GO:0006511 3 0.010
muscle organ development GO:0007517 101 0.010
regulation of microtubule cytoskeleton organization GO:0070507 3 0.010
regulation of epithelial to mesenchymal transition GO:0010717 3 0.010
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.010
lipid homeostasis GO:0055088 3 0.010

neil3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.055
aplastic anemia DOID:12449 0 0.055
disease of anatomical entity DOID:7 0 0.055
bone marrow disease DOID:4961 0 0.055
anemia DOID:2355 0 0.055
hematopoietic system disease DOID:74 0 0.055
cancer DOID:162 0 0.027
disease of cellular proliferation DOID:14566 0 0.027
organ system cancer DOID:0050686 0 0.027
disease of metabolism DOID:0014667 0 0.018
inherited metabolic disorder DOID:655 0 0.018
lipid storage disease DOID:9455 0 0.011
lysosomal storage disease DOID:3211 0 0.011